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Q9BRK5

- CAB45_HUMAN

UniProt

Q9BRK5 - CAB45_HUMAN

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Protein
45 kDa calcium-binding protein
Gene
SDF4, CAB45, PSEC0034
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment By similarity.
Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi111 – 122121 Reviewed prediction
Add
BLAST
Calcium bindingi150 – 161122 Reviewed prediction
Add
BLAST
Calcium bindingi209 – 220123 Reviewed prediction
Add
BLAST
Calcium bindingi246 – 257124 Reviewed prediction
Add
BLAST
Calcium bindingi291 – 302125 Reviewed prediction
Add
BLAST
Calcium bindingi327 – 338126 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: BHF-UCL
  2. identical protein binding Source: BHF-UCL
  3. protein binding Source: BHF-UCL
Complete GO annotation...

GO - Biological processi

  1. UV protection Source: BHF-UCL
  2. calcium ion-dependent exocytosis Source: BHF-UCL
  3. cerebellum development Source: BHF-UCL
  4. fat cell differentiation Source: BHF-UCL
  5. response to ethanol Source: BHF-UCL
  6. zymogen granule exocytosis Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Exocytosis

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
45 kDa calcium-binding protein
Short name:
Cab45
Alternative name(s):
Stromal cell-derived factor 4
Short name:
SDF-4
Gene namesi
Name:SDF4
Synonyms:CAB45
ORF Names:PSEC0034
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:24188. SDF4.

Subcellular locationi

Isoform 1 : Golgi apparatus lumen By similarity 1 Publication
Isoform 5 : Cytoplasm. Cell projectionbleb
Note: Isoform 5 colocalizes with STX3 and STXBP1 isoform 2 at the plasma membrane and cell surface blebs.1 Publication

GO - Cellular componenti

  1. Golgi apparatus Source: HPA
  2. Golgi lumen Source: BHF-UCL
  3. bleb Source: UniProtKB-SubCell
  4. cytoplasm Source: BHF-UCL
  5. extracellular vesicular exosome Source: UniProt
  6. late endosome Source: BHF-UCL
  7. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi257 – 2571E → Q: Does not affect calcium-binding. 1 Publication
Mutagenesisi302 – 3021E → Q: Inhibits calcium-binding. 1 Publication
Mutagenesisi338 – 3381E → Q: Does not affect calcium-binding. 1 Publication

Organism-specific databases

PharmGKBiPA142670940.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636 Reviewed prediction
Add
BLAST
Chaini37 – 36232645 kDa calcium-binding protein
PRO_0000004156Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9BRK5.
PaxDbiQ9BRK5.
PRIDEiQ9BRK5.

PTM databases

PhosphoSiteiQ9BRK5.

Expressioni

Tissue specificityi

Ubiquitous. Isoform 5 is expressed in pancreas.1 Publication

Gene expression databases

ArrayExpressiQ9BRK5.
BgeeiQ9BRK5.
CleanExiHS_SDF4.
GenevestigatoriQ9BRK5.

Organism-specific databases

HPAiCAB015227.
HPA011249.

Interactioni

Subunit structurei

Isoform 5 interacts with STXBP1; the interaction is enhanced in presence of calcium. Isoform 5 interacts with STX3.1 Publication

Protein-protein interaction databases

BioGridi119334. 20 interactions.
IntActiQ9BRK5. 20 interactions.
MINTiMINT-1186958.

Structurei

3D structure databases

ProteinModelPortaliQ9BRK5.
SMRiQ9BRK5. Positions 104-163, 206-343.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini98 – 13336EF-hand 1
Add
BLAST
Domaini137 – 17236EF-hand 2
Add
BLAST
Domaini197 – 23236EF-hand 3
Add
BLAST
Domaini233 – 26836EF-hand 4
Add
BLAST
Domaini278 – 31336EF-hand 5
Add
BLAST
Domaini314 – 34936EF-hand 6
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni309 – 36254Necessary for intracellular retention in Golgi apparatus lumen By similarity
Add
BLAST

Domaini

Binds calcium via its EF-hands By similarity. Isoform 5 binds calcium.

Sequence similaritiesi

Belongs to the CREC family.
Contains 6 EF-hand domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG277464.
HOVERGENiHBG097344.
InParanoidiQ9BRK5.
OMAiKMHFRAV.
OrthoDBiEOG7M0NSC.
PhylomeDBiQ9BRK5.
TreeFamiTF314849.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR027240. CAB45.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR10827:SF39. PTHR10827:SF39. 1 hit.
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BRK5-1) [UniParc]FASTAAdd to Basket

Also known as: Cab45a, Cab45-G

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVWPWVAMAS RWGPLIGLAP CCLWLLGAVL LMDASARPAN HSSTRERVAN    50
REENEILPPD HLNGVKLEMD GHLNRGFHQE VFLGKDLGGF DEDAEPRRSR 100
RKLMVIFSKV DVNTDRKISA KEMQRWIMEK TAEHFQEAME ESKTHFRAVD 150
PDGDGHVSWD EYKVKFLASK GHSEKEVADA IRLNEELKVD EETQEVLENL 200
KDRWYQADSP PADLLLTEEE FLSFLHPEHS RGMLRFMVKE IVRDLDQDGD 250
KQLSVPEFIS LPVGTVENQQ GQDIDDNWVK DRKKEFEELI DSNHDGIVTA 300
EELESYMDPM NEYNALNEAK QMIAVADENQ NHHLEPEEVL KYSEFFTGSK 350
LVDYARSVHE EF 362
Length:362
Mass (Da):41,807
Last modified:June 1, 2001 - v1
Checksum:i440C6990149AAE2C
GO
Isoform 2 (identifier: Q9BRK5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.

Show »
Length:259
Mass (Da):30,197
Checksum:i3745A23BB8FF6D40
GO
Isoform 3 (identifier: Q9BRK5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     193-254: TQEVLENLKD...LDQDGDKQLS → SCAPLSTGSP...GDRPGPGPGR
     255-362: Missing.

Note: No experimental confirmation available.

Show »
Length:254
Mass (Da):27,826
Checksum:i77FACCE59B472125
GO
Isoform 4 (identifier: Q9BRK5-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     193-202: TQEVLENLKD → RHGPPGPRAL
     203-362: Missing.

Note: No experimental confirmation available.

Show »
Length:202
Mass (Da):23,031
Checksum:i5F208F14504756F7
GO
Isoform 5 (identifier: Q9BRK5-5) [UniParc]FASTAAdd to Basket

Also known as: Cab45b, Cab45-C

The sequence of this isoform differs from the canonical sequence as follows:
     1-232: Missing.

Show »
Length:130
Mass (Da):15,139
Checksum:i22545D121BB56827
GO
Isoform 6 (identifier: Q9BRK5-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     305-362: SYMDPMNEYN...DYARSVHEEF → NVPTLPLQPI...PLARRATWTP

Show »
Length:348
Mass (Da):39,608
Checksum:i1832BC4741A9506A
GO

Sequence cautioni

The sequence AAL75950.1 differs from that shown. Reason: Frameshift at several positions.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501N → D.
Corresponds to variant rs12745364 [ dbSNP | Ensembl ].
VAR_048659
Natural varianti148 – 1481A → T in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035461

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 232232Missing in isoform 5.
VSP_037484Add
BLAST
Alternative sequencei1 – 103103Missing in isoform 2.
VSP_037485Add
BLAST
Alternative sequencei193 – 25462TQEVL…DKQLS → SCAPLSTGSPGEPEGPLVPG GQPPCRPAADGGGVPVGPPP RAQPGNAQVHGEGDRPGPGP GR in isoform 3.
VSP_037486Add
BLAST
Alternative sequencei193 – 20210TQEVLENLKD → RHGPPGPRAL in isoform 4.
VSP_037487
Alternative sequencei203 – 362160Missing in isoform 4.
VSP_037488Add
BLAST
Alternative sequencei255 – 362108Missing in isoform 3.
VSP_037489Add
BLAST
Alternative sequencei305 – 36258SYMDP…VHEEF → NVPTLPLQPIGTLNSHFVRL AAELGGGKATLTCAPLARRA TWTP in isoform 6.
VSP_040559Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781H → Q in AAL75950. 1 Publication
Sequence conflicti86 – 861D → N in AAL75950. 1 Publication
Sequence conflicti89 – 891G → C in AAL75950. 1 Publication
Sequence conflicti92 – 921E → R in AAL75950. 1 Publication
Sequence conflicti94 – 941A → T in AAL75950. 1 Publication
Sequence conflicti97 – 971R → P in AAL75950. 1 Publication
Sequence conflicti117 – 1171K → R in BAC11563. 1 Publication
Sequence conflicti133 – 1331E → G in BAC11563. 1 Publication
Sequence conflicti150 – 1501D → G in AAL75950. 1 Publication
Sequence conflicti188 – 1881K → R in BAG37898. 1 Publication
Sequence conflicti193 – 1931T → A in BAD96241. 1 Publication
Sequence conflicti234 – 2341L → P in BAD96799. 1 Publication
Sequence conflicti281 – 2822DR → KK in AAL75950. 1 Publication
Sequence conflicti286 – 2861F → L in AAL75950. 1 Publication
Sequence conflicti321 – 3211Q → R in BAD96799. 1 Publication
Sequence conflicti356 – 3561R → S in AAL75950. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L79912 mRNA. Translation: AAL40084.1.
AF132749 mRNA. Translation: AAL75950.1. Frameshift.
AF153686 mRNA. Translation: AAD51612.1.
AF178986 mRNA. Translation: AAF44350.1.
AK027277 mRNA. Translation: BAB55012.1.
AK299810 mRNA. Translation: BAG61683.1.
AK315517 mRNA. Translation: BAG37898.1.
AK075352 mRNA. Translation: BAC11563.1.
AK222521 mRNA. Translation: BAD96241.1.
AK223079 mRNA. Translation: BAD96799.1.
AL162741 Genomic DNA. Translation: CAI23251.1.
AL162741 Genomic DNA. Translation: CAI23252.1.
CH471183 Genomic DNA. Translation: EAW56272.1.
CH471183 Genomic DNA. Translation: EAW56273.1.
BC006211 mRNA. Translation: AAH06211.1.
BC007625 mRNA. Translation: AAH07625.1.
BC008917 mRNA. Translation: AAH08917.1.
BC011244 mRNA. Translation: AAH11244.1.
BC022375 mRNA. Translation: AAH22375.1.
CCDSiCCDS12.1. [Q9BRK5-6]
CCDS30553.1. [Q9BRK5-1]
RefSeqiNP_057260.2. NM_016176.3. [Q9BRK5-1]
NP_057631.1. NM_016547.2. [Q9BRK5-6]
UniGeneiHs.42806.

Genome annotation databases

EnsembliENST00000263741; ENSP00000263741; ENSG00000078808. [Q9BRK5-6]
ENST00000360001; ENSP00000353094; ENSG00000078808. [Q9BRK5-1]
ENST00000545427; ENSP00000444451; ENSG00000078808. [Q9BRK5-4]
GeneIDi51150.
KEGGihsa:51150.
UCSCiuc001adh.4. human. [Q9BRK5-1]
uc001adi.4. human. [Q9BRK5-6]

Polymorphism databases

DMDMi21263447.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L79912 mRNA. Translation: AAL40084.1 .
AF132749 mRNA. Translation: AAL75950.1 . Frameshift.
AF153686 mRNA. Translation: AAD51612.1 .
AF178986 mRNA. Translation: AAF44350.1 .
AK027277 mRNA. Translation: BAB55012.1 .
AK299810 mRNA. Translation: BAG61683.1 .
AK315517 mRNA. Translation: BAG37898.1 .
AK075352 mRNA. Translation: BAC11563.1 .
AK222521 mRNA. Translation: BAD96241.1 .
AK223079 mRNA. Translation: BAD96799.1 .
AL162741 Genomic DNA. Translation: CAI23251.1 .
AL162741 Genomic DNA. Translation: CAI23252.1 .
CH471183 Genomic DNA. Translation: EAW56272.1 .
CH471183 Genomic DNA. Translation: EAW56273.1 .
BC006211 mRNA. Translation: AAH06211.1 .
BC007625 mRNA. Translation: AAH07625.1 .
BC008917 mRNA. Translation: AAH08917.1 .
BC011244 mRNA. Translation: AAH11244.1 .
BC022375 mRNA. Translation: AAH22375.1 .
CCDSi CCDS12.1. [Q9BRK5-6 ]
CCDS30553.1. [Q9BRK5-1 ]
RefSeqi NP_057260.2. NM_016176.3. [Q9BRK5-1 ]
NP_057631.1. NM_016547.2. [Q9BRK5-6 ]
UniGenei Hs.42806.

3D structure databases

ProteinModelPortali Q9BRK5.
SMRi Q9BRK5. Positions 104-163, 206-343.
ModBasei Search...

Protein-protein interaction databases

BioGridi 119334. 20 interactions.
IntActi Q9BRK5. 20 interactions.
MINTi MINT-1186958.

PTM databases

PhosphoSitei Q9BRK5.

Polymorphism databases

DMDMi 21263447.

Proteomic databases

MaxQBi Q9BRK5.
PaxDbi Q9BRK5.
PRIDEi Q9BRK5.

Protocols and materials databases

DNASUi 51150.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263741 ; ENSP00000263741 ; ENSG00000078808 . [Q9BRK5-6 ]
ENST00000360001 ; ENSP00000353094 ; ENSG00000078808 . [Q9BRK5-1 ]
ENST00000545427 ; ENSP00000444451 ; ENSG00000078808 . [Q9BRK5-4 ]
GeneIDi 51150.
KEGGi hsa:51150.
UCSCi uc001adh.4. human. [Q9BRK5-1 ]
uc001adi.4. human. [Q9BRK5-6 ]

Organism-specific databases

CTDi 51150.
GeneCardsi GC01M001143.
HGNCi HGNC:24188. SDF4.
HPAi CAB015227.
HPA011249.
MIMi 614282. gene.
neXtProti NX_Q9BRK5.
PharmGKBi PA142670940.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG277464.
HOVERGENi HBG097344.
InParanoidi Q9BRK5.
OMAi KMHFRAV.
OrthoDBi EOG7M0NSC.
PhylomeDBi Q9BRK5.
TreeFami TF314849.

Miscellaneous databases

ChiTaRSi SDF4. human.
GeneWikii SDF4.
GenomeRNAii 51150.
NextBioi 54034.
PROi Q9BRK5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BRK5.
Bgeei Q9BRK5.
CleanExi HS_SDF4.
Genevestigatori Q9BRK5.

Family and domain databases

Gene3Di 1.10.238.10. 3 hits.
InterProi IPR027240. CAB45.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
PANTHERi PTHR10827:SF39. PTHR10827:SF39. 1 hit.
Pfami PF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 5 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a human cDNA encoding Cab45, a Ca2+-binding protein with six EF-hand motifs."
    Koivu T., Laitinen S., Riento K., Olkkonen V.M.
    DNA Seq. 7:217-220(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
  2. "Cloning of a new human cDNA homologous to Mus musculus calcium-binding protein Cab45b."
    Yue P., Yu L., Zhao S.Y.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Novel human calcium-binding protein precursor."
    Zhang W., Wan T., Yuan Z., Cao X.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  4. "Identification of a novel calcium-binding protein Cab45 from dendritic cells."
    Zhang W., Wan T., Cao X.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
    Tissue: Brain and Tongue.
  6. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Teratocarcinoma.
  7. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Adipose tissue.
  8. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain, Pancreas and Prostate.
  11. "A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini."
    Lam P.P., Hyvaerinen K., Kauppi M., Cosen-Binker L., Laitinen S., Keraenen S., Gaisano H.Y., Olkkonen V.M.
    Mol. Biol. Cell 18:2473-2480(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH STX3 AND STXBP1, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING (ISOFORM 5), MUTAGENESIS OF GLU-257; GLU-302 AND GLU-338, TISSUE SPECIFICITY.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-148.

Entry informationi

Entry nameiCAB45_HUMAN
AccessioniPrimary (citable) accession number: Q9BRK5
Secondary accession number(s): B1AME5
, B1AME6, B2RDF1, B4DSM1, Q53G52, Q53HQ9, Q8NBQ3, Q96AA1, Q9NZP7, Q9UN53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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