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Q9BRK5

- CAB45_HUMAN

UniProt

Q9BRK5 - CAB45_HUMAN

Protein

45 kDa calcium-binding protein

Gene

SDF4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.By similarity
    Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi111 – 122121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi150 – 161122PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi209 – 220123PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi246 – 257124PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi291 – 302125PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi327 – 338126PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: BHF-UCL
    2. identical protein binding Source: BHF-UCL
    3. protein binding Source: BHF-UCL

    GO - Biological processi

    1. calcium ion-dependent exocytosis Source: BHF-UCL
    2. cerebellum development Source: BHF-UCL
    3. fat cell differentiation Source: BHF-UCL
    4. response to ethanol Source: BHF-UCL
    5. UV protection Source: BHF-UCL
    6. zymogen granule exocytosis Source: BHF-UCL

    Keywords - Biological processi

    Exocytosis

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    45 kDa calcium-binding protein
    Short name:
    Cab45
    Alternative name(s):
    Stromal cell-derived factor 4
    Short name:
    SDF-4
    Gene namesi
    Name:SDF4
    Synonyms:CAB45
    ORF Names:PSEC0034
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:24188. SDF4.

    Subcellular locationi

    Isoform 5 : Cytoplasm. Cell projectionbleb
    Note: Isoform 5 colocalizes with STX3 and STXBP1 isoform 2 at the plasma membrane and cell surface blebs.

    GO - Cellular componenti

    1. bleb Source: UniProtKB-SubCell
    2. cytoplasm Source: BHF-UCL
    3. extracellular vesicular exosome Source: UniProt
    4. Golgi apparatus Source: HPA
    5. Golgi lumen Source: BHF-UCL
    6. late endosome Source: BHF-UCL
    7. membrane Source: UniProtKB
    8. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Golgi apparatus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi257 – 2571E → Q: Does not affect calcium-binding. 1 Publication
    Mutagenesisi302 – 3021E → Q: Inhibits calcium-binding. 1 Publication
    Mutagenesisi338 – 3381E → Q: Does not affect calcium-binding. 1 Publication

    Organism-specific databases

    PharmGKBiPA142670940.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3636Sequence AnalysisAdd
    BLAST
    Chaini37 – 36232645 kDa calcium-binding proteinPRO_0000004156Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9BRK5.
    PaxDbiQ9BRK5.
    PRIDEiQ9BRK5.

    PTM databases

    PhosphoSiteiQ9BRK5.

    Expressioni

    Tissue specificityi

    Ubiquitous. Isoform 5 is expressed in pancreas.1 Publication

    Gene expression databases

    ArrayExpressiQ9BRK5.
    BgeeiQ9BRK5.
    CleanExiHS_SDF4.
    GenevestigatoriQ9BRK5.

    Organism-specific databases

    HPAiCAB015227.
    HPA011249.

    Interactioni

    Subunit structurei

    Isoform 5 interacts with STXBP1; the interaction is enhanced in presence of calcium. Isoform 5 interacts with STX3.1 Publication

    Protein-protein interaction databases

    BioGridi119334. 20 interactions.
    IntActiQ9BRK5. 20 interactions.
    MINTiMINT-1186958.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BRK5.
    SMRiQ9BRK5. Positions 104-163, 206-343.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini98 – 13336EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini137 – 17236EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini197 – 23236EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini233 – 26836EF-hand 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini278 – 31336EF-hand 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini314 – 34936EF-hand 6PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni309 – 36254Necessary for intracellular retention in Golgi apparatus lumenBy similarityAdd
    BLAST

    Domaini

    Binds calcium via its EF-hands By similarity. Isoform 5 binds calcium.By similarity

    Sequence similaritiesi

    Belongs to the CREC family.Curated
    Contains 6 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG277464.
    HOVERGENiHBG097344.
    InParanoidiQ9BRK5.
    OMAiKMHFRAV.
    OrthoDBiEOG7M0NSC.
    PhylomeDBiQ9BRK5.
    TreeFamiTF314849.

    Family and domain databases

    Gene3Di1.10.238.10. 3 hits.
    InterProiIPR027240. CAB45.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PANTHERiPTHR10827:SF39. PTHR10827:SF39. 1 hit.
    PfamiPF13202. EF-hand_5. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 5 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 5 hits.
    PS50222. EF_HAND_2. 5 hits.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BRK5-1) [UniParc]FASTAAdd to Basket

    Also known as: Cab45a, Cab45-G

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVWPWVAMAS RWGPLIGLAP CCLWLLGAVL LMDASARPAN HSSTRERVAN    50
    REENEILPPD HLNGVKLEMD GHLNRGFHQE VFLGKDLGGF DEDAEPRRSR 100
    RKLMVIFSKV DVNTDRKISA KEMQRWIMEK TAEHFQEAME ESKTHFRAVD 150
    PDGDGHVSWD EYKVKFLASK GHSEKEVADA IRLNEELKVD EETQEVLENL 200
    KDRWYQADSP PADLLLTEEE FLSFLHPEHS RGMLRFMVKE IVRDLDQDGD 250
    KQLSVPEFIS LPVGTVENQQ GQDIDDNWVK DRKKEFEELI DSNHDGIVTA 300
    EELESYMDPM NEYNALNEAK QMIAVADENQ NHHLEPEEVL KYSEFFTGSK 350
    LVDYARSVHE EF 362
    Length:362
    Mass (Da):41,807
    Last modified:June 1, 2001 - v1
    Checksum:i440C6990149AAE2C
    GO
    Isoform 2 (identifier: Q9BRK5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-103: Missing.

    Show »
    Length:259
    Mass (Da):30,197
    Checksum:i3745A23BB8FF6D40
    GO
    Isoform 3 (identifier: Q9BRK5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         193-254: TQEVLENLKD...LDQDGDKQLS → SCAPLSTGSP...GDRPGPGPGR
         255-362: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:254
    Mass (Da):27,826
    Checksum:i77FACCE59B472125
    GO
    Isoform 4 (identifier: Q9BRK5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         193-202: TQEVLENLKD → RHGPPGPRAL
         203-362: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:202
    Mass (Da):23,031
    Checksum:i5F208F14504756F7
    GO
    Isoform 5 (identifier: Q9BRK5-5) [UniParc]FASTAAdd to Basket

    Also known as: Cab45b, Cab45-C

    The sequence of this isoform differs from the canonical sequence as follows:
         1-232: Missing.

    Show »
    Length:130
    Mass (Da):15,139
    Checksum:i22545D121BB56827
    GO
    Isoform 6 (identifier: Q9BRK5-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         305-362: SYMDPMNEYN...DYARSVHEEF → NVPTLPLQPI...PLARRATWTP

    Show »
    Length:348
    Mass (Da):39,608
    Checksum:i1832BC4741A9506A
    GO

    Sequence cautioni

    The sequence AAL75950.1 differs from that shown. Reason: Frameshift at several positions.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti78 – 781H → Q in AAL75950. 1 PublicationCurated
    Sequence conflicti86 – 861D → N in AAL75950. 1 PublicationCurated
    Sequence conflicti89 – 891G → C in AAL75950. 1 PublicationCurated
    Sequence conflicti92 – 921E → R in AAL75950. 1 PublicationCurated
    Sequence conflicti94 – 941A → T in AAL75950. 1 PublicationCurated
    Sequence conflicti97 – 971R → P in AAL75950. 1 PublicationCurated
    Sequence conflicti117 – 1171K → R in BAC11563. (PubMed:16303743)Curated
    Sequence conflicti133 – 1331E → G in BAC11563. (PubMed:16303743)Curated
    Sequence conflicti150 – 1501D → G in AAL75950. 1 PublicationCurated
    Sequence conflicti188 – 1881K → R in BAG37898. (PubMed:14702039)Curated
    Sequence conflicti193 – 1931T → A in BAD96241. 1 PublicationCurated
    Sequence conflicti234 – 2341L → P in BAD96799. 1 PublicationCurated
    Sequence conflicti281 – 2822DR → KK in AAL75950. 1 PublicationCurated
    Sequence conflicti286 – 2861F → L in AAL75950. 1 PublicationCurated
    Sequence conflicti321 – 3211Q → R in BAD96799. 1 PublicationCurated
    Sequence conflicti356 – 3561R → S in AAL75950. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti50 – 501N → D.
    Corresponds to variant rs12745364 [ dbSNP | Ensembl ].
    VAR_048659
    Natural varianti148 – 1481A → T in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035461

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 232232Missing in isoform 5. CuratedVSP_037484Add
    BLAST
    Alternative sequencei1 – 103103Missing in isoform 2. 1 PublicationVSP_037485Add
    BLAST
    Alternative sequencei193 – 25462TQEVL…DKQLS → SCAPLSTGSPGEPEGPLVPG GQPPCRPAADGGGVPVGPPP RAQPGNAQVHGEGDRPGPGP GR in isoform 3. 1 PublicationVSP_037486Add
    BLAST
    Alternative sequencei193 – 20210TQEVLENLKD → RHGPPGPRAL in isoform 4. 1 PublicationVSP_037487
    Alternative sequencei203 – 362160Missing in isoform 4. 1 PublicationVSP_037488Add
    BLAST
    Alternative sequencei255 – 362108Missing in isoform 3. 1 PublicationVSP_037489Add
    BLAST
    Alternative sequencei305 – 36258SYMDP…VHEEF → NVPTLPLQPIGTLNSHFVRL AAELGGGKATLTCAPLARRA TWTP in isoform 6. 1 PublicationVSP_040559Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L79912 mRNA. Translation: AAL40084.1.
    AF132749 mRNA. Translation: AAL75950.1. Frameshift.
    AF153686 mRNA. Translation: AAD51612.1.
    AF178986 mRNA. Translation: AAF44350.1.
    AK027277 mRNA. Translation: BAB55012.1.
    AK299810 mRNA. Translation: BAG61683.1.
    AK315517 mRNA. Translation: BAG37898.1.
    AK075352 mRNA. Translation: BAC11563.1.
    AK222521 mRNA. Translation: BAD96241.1.
    AK223079 mRNA. Translation: BAD96799.1.
    AL162741 Genomic DNA. Translation: CAI23251.1.
    AL162741 Genomic DNA. Translation: CAI23252.1.
    CH471183 Genomic DNA. Translation: EAW56272.1.
    CH471183 Genomic DNA. Translation: EAW56273.1.
    BC006211 mRNA. Translation: AAH06211.1.
    BC007625 mRNA. Translation: AAH07625.1.
    BC008917 mRNA. Translation: AAH08917.1.
    BC011244 mRNA. Translation: AAH11244.1.
    BC022375 mRNA. Translation: AAH22375.1.
    CCDSiCCDS12.1. [Q9BRK5-6]
    CCDS30553.1. [Q9BRK5-1]
    RefSeqiNP_057260.2. NM_016176.3. [Q9BRK5-1]
    NP_057631.1. NM_016547.2. [Q9BRK5-6]
    UniGeneiHs.42806.

    Genome annotation databases

    EnsembliENST00000263741; ENSP00000263741; ENSG00000078808. [Q9BRK5-6]
    ENST00000360001; ENSP00000353094; ENSG00000078808. [Q9BRK5-1]
    GeneIDi51150.
    KEGGihsa:51150.
    UCSCiuc001adh.4. human. [Q9BRK5-1]
    uc001adi.4. human. [Q9BRK5-6]

    Polymorphism databases

    DMDMi21263447.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L79912 mRNA. Translation: AAL40084.1 .
    AF132749 mRNA. Translation: AAL75950.1 . Frameshift.
    AF153686 mRNA. Translation: AAD51612.1 .
    AF178986 mRNA. Translation: AAF44350.1 .
    AK027277 mRNA. Translation: BAB55012.1 .
    AK299810 mRNA. Translation: BAG61683.1 .
    AK315517 mRNA. Translation: BAG37898.1 .
    AK075352 mRNA. Translation: BAC11563.1 .
    AK222521 mRNA. Translation: BAD96241.1 .
    AK223079 mRNA. Translation: BAD96799.1 .
    AL162741 Genomic DNA. Translation: CAI23251.1 .
    AL162741 Genomic DNA. Translation: CAI23252.1 .
    CH471183 Genomic DNA. Translation: EAW56272.1 .
    CH471183 Genomic DNA. Translation: EAW56273.1 .
    BC006211 mRNA. Translation: AAH06211.1 .
    BC007625 mRNA. Translation: AAH07625.1 .
    BC008917 mRNA. Translation: AAH08917.1 .
    BC011244 mRNA. Translation: AAH11244.1 .
    BC022375 mRNA. Translation: AAH22375.1 .
    CCDSi CCDS12.1. [Q9BRK5-6 ]
    CCDS30553.1. [Q9BRK5-1 ]
    RefSeqi NP_057260.2. NM_016176.3. [Q9BRK5-1 ]
    NP_057631.1. NM_016547.2. [Q9BRK5-6 ]
    UniGenei Hs.42806.

    3D structure databases

    ProteinModelPortali Q9BRK5.
    SMRi Q9BRK5. Positions 104-163, 206-343.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119334. 20 interactions.
    IntActi Q9BRK5. 20 interactions.
    MINTi MINT-1186958.

    PTM databases

    PhosphoSitei Q9BRK5.

    Polymorphism databases

    DMDMi 21263447.

    Proteomic databases

    MaxQBi Q9BRK5.
    PaxDbi Q9BRK5.
    PRIDEi Q9BRK5.

    Protocols and materials databases

    DNASUi 51150.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263741 ; ENSP00000263741 ; ENSG00000078808 . [Q9BRK5-6 ]
    ENST00000360001 ; ENSP00000353094 ; ENSG00000078808 . [Q9BRK5-1 ]
    GeneIDi 51150.
    KEGGi hsa:51150.
    UCSCi uc001adh.4. human. [Q9BRK5-1 ]
    uc001adi.4. human. [Q9BRK5-6 ]

    Organism-specific databases

    CTDi 51150.
    GeneCardsi GC01M001143.
    HGNCi HGNC:24188. SDF4.
    HPAi CAB015227.
    HPA011249.
    MIMi 614282. gene.
    neXtProti NX_Q9BRK5.
    PharmGKBi PA142670940.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG277464.
    HOVERGENi HBG097344.
    InParanoidi Q9BRK5.
    OMAi KMHFRAV.
    OrthoDBi EOG7M0NSC.
    PhylomeDBi Q9BRK5.
    TreeFami TF314849.

    Miscellaneous databases

    ChiTaRSi SDF4. human.
    GeneWikii SDF4.
    GenomeRNAii 51150.
    NextBioi 54034.
    PROi Q9BRK5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BRK5.
    Bgeei Q9BRK5.
    CleanExi HS_SDF4.
    Genevestigatori Q9BRK5.

    Family and domain databases

    Gene3Di 1.10.238.10. 3 hits.
    InterProi IPR027240. CAB45.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    PANTHERi PTHR10827:SF39. PTHR10827:SF39. 1 hit.
    Pfami PF13202. EF-hand_5. 1 hit.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 5 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 5 hits.
    PS50222. EF_HAND_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of a human cDNA encoding Cab45, a Ca2+-binding protein with six EF-hand motifs."
      Koivu T., Laitinen S., Riento K., Olkkonen V.M.
      DNA Seq. 7:217-220(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
    2. "Cloning of a new human cDNA homologous to Mus musculus calcium-binding protein Cab45b."
      Yue P., Yu L., Zhao S.Y.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Novel human calcium-binding protein precursor."
      Zhang W., Wan T., Yuan Z., Cao X.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    4. "Identification of a novel calcium-binding protein Cab45 from dendritic cells."
      Zhang W., Wan T., Cao X.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4).
      Tissue: Brain and Tongue.
    6. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Teratocarcinoma.
    7. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Adipose tissue.
    8. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain, Pancreas and Prostate.
    11. "A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini."
      Lam P.P., Hyvaerinen K., Kauppi M., Cosen-Binker L., Laitinen S., Keraenen S., Gaisano H.Y., Olkkonen V.M.
      Mol. Biol. Cell 18:2473-2480(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH STX3 AND STXBP1, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING (ISOFORM 5), MUTAGENESIS OF GLU-257; GLU-302 AND GLU-338, TISSUE SPECIFICITY.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-148.

    Entry informationi

    Entry nameiCAB45_HUMAN
    AccessioniPrimary (citable) accession number: Q9BRK5
    Secondary accession number(s): B1AME5
    , B1AME6, B2RDF1, B4DSM1, Q53G52, Q53HQ9, Q8NBQ3, Q96AA1, Q9NZP7, Q9UN53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 27, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3