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Reviewed, UniProtKB/Swiss-Prot Q9BRK4 (LZTS2_HUMAN)

Last modified February 9, 2010. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Leucine zipper putative tumor suppressor 2
      Short name=hLZTS2
Alternative name(s):
    Protein LAPSER1
Gene names
Name: LZTS2
Synonyms: KIAA1813, LAPSER1
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length669 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Ref.7 Ref.8 Ref.9 Ref.10

Subunit structure

Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23. Ref.7 Ref.8

Subcellular location

Cytoplasm. Cytoplasm › cytoskeleton › centrosome. Note: Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis. Ref.7 Ref.8 Ref.10

Tissue specificity

Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon. Ref.5

Induction

Induced by inhibition of NF-kappa-B signaling. Ref.9

Sequence similarities

Belongs to the LZTS2 family.

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Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
Wnt signaling pathway
   Cellular componentCytoplasm
Cytoskeleton
Microtubule
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processWnt receptor signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

cell division

Inferred from electronic annotation. Source: UniProtKB-KW

mitosis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentmembrane

Inferred from electronic annotation. Source: InterPro

microtubule

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule organizing center

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 669669Leucine zipper putative tumor suppressor 2
PRO_0000182974

Regions

Region1 – 332332Required for centrosomal localization By similarity
Region447 – 669223Sufficient for interaction with CTNNB1
Region450 – 669220Sufficient for interaction with KATNB1 and for inhibition of katanin-mediated microtubule severing By similarity
Coiled coil328 – 649322 Potential
Motif631 – 64010Nuclear export signal
Compositional bias188 – 306119Ser-rich

Amino acid modifications

Modified residue5701Phosphoserine

Natural variations

Natural variant1211R → H in a colorectal cancer sample; somatic mutation. Ref.12
VAR_036364
Natural variant2911G → R in a breast cancer sample; somatic mutation. Ref.12
VAR_036365
Natural variant2991R → W: dbSNP rs2275381.
VAR_018277

Experimental info

Mutagenesis6381L → A: Induces nuclear accumulation. Impairs nuclear exclusion of beta-catenin; when associated with A-640. Ref.7
Mutagenesis6401L → A: Induces nuclear accumulation. Impairs nuclear exclusion of beta-catenin; when associated with A-38. Ref.7
Sequence conflict2891V → L in AAH58938. Ref.4

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Sequences

Sequence LengthMass (Da)Tools
Q9BRK4-1 [UniParc].

Last modified March 1, 2004. Version 2.
Checksum: 1274FD9A36A217E6

FASTA66972,759
        10         20         30         40         50         60 
MAIVQTLPVP LEPAPEAATA PQAPVMGSVS SLISGRPCPG GPAPPRHHGP PGPTFFRQQD 

        70         80         90        100        110        120 
GLLRGGYEAQ EPLCPAVPPR KAVPVTSFTY INEDFRTESP PSPSSDVEDA REQRAHNAHL 

       130        140        150        160        170        180 
RGPPPKLIPV SGKLEKNMEK ILIRPTAFKP VLPKPRGAPS LPSFMGPRAT GLSGSQGSLT 

       190        200        210        220        230        240 
QLFGGPASSS SSSSSSSAAD KPLAFSGWAS GCPSGTLSDS GRNSLSSLPT YSTGGAEPTT 

       250        260        270        280        290        300 
SSPGGHLPSH GSGRGALPGP ARGVPTGPSH SDSGRSSSSK STGSLGGRVA GGLLGSGTRA 

       310        320        330        340        350        360 
SPDSSSCGER SPPPPPPPPS DEALLHCVLE GKLRDREAEL QQLRDSLDEN EATMCQAYEE 

       370        380        390        400        410        420 
RQRHWQRERE ALREDCAAQA QRAQRAQQLL QLQVFQLQQE KRQLQDDFAQ LLQEREQLER 

       430        440        450        460        470        480 
RCATLEREQR ELGPRLEETK WEVCQKSGEI SLLKQQLKES QAELVQKGSE LVALRVALRE 

       490        500        510        520        530        540 
ARATLRVSEG RARGLQEAAR ARELELEACS QELQRHRQEA EQLREKAGQL DAEAAGLREP 

       550        560        570        580        590        600 
PVPPATADPF LLAESDEAKV QRAAAGVGGS LRAQVERLRV ELQRERRRGE EQRDSFEGER 

       610        620        630        640        650        660 
LAWQAEKEQV IRYQKQLQHN YIQMYRRNRQ LEQELQQLSL ELEARELADL GLAEQAPCIC 


LEEITATEI

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References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
DNA Res. 8:85-95(2001) [PubMed: 11347906] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed: 15164054] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Uterus.
[5]"LAPSER1: a novel candidate tumor suppressor gene from 10q24.3."
Cabeza-Arvelaiz Y., Thompson T.C., Sepulveda J.L., Chinault A.C.
Oncogene 20:6707-6717(2001) [PubMed: 11709705] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-669, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
Tissue: Prostate.
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 139-669.
Tissue: Amygdala.
[7]"LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin."
Thyssen G., Li T.-H., Lehmann L., Zhuo M., Sharma M., Sun Z.
Mol. Cell. Biol. 26:8857-8867(2006) [PubMed: 17000760] [Abstract]
Cited for: FUNCTION, INTERACTION WITH CTNNB1, SUBCELLULAR LOCATION, NUCLEAR EXPORT SIGNAL, MUTAGENESIS OF LEU-638 AND LEU-640.
[8]"LAPSER1 is a putative cytokinetic tumor suppressor that shows the same centrosome and midbody subcellular localization pattern as p80 katanin."
Sudo H., Maru Y.
FASEB J. 21:2086-2100(2007) [PubMed: 17351128] [Abstract]
Cited for: FUNCTION, INTERACTION WITH GAMMA-TUBULIN; KIF23 AND KATNB1, SUBCELLULAR LOCATION.
[9]"Crossregulation of beta-catenin/Tcf pathway by NF-kappaB is mediated by lzts2 in human adipose tissue-derived mesenchymal stem cells."
Cho H.H., Joo H.J., Song J.S., Bae Y.C., Jung J.S.
Biochim. Biophys. Acta 1783:419-428(2008) [PubMed: 17950943] [Abstract]
Cited for: FUNCTION, INDUCTION.
[10]"LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing."
Sudo H., Maru Y.
Hum. Mol. Genet. 17:2524-2540(2008) [PubMed: 18490357] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[11]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570, MASS SPECTROMETRY.
[12]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed: 16959974] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-121 AND ARG-291.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB058716 mRNA. Translation: BAB47442.1. Different initiation.
AL133215 Genomic DNA. Translation: CAI10929.1.
CH471066 Genomic DNA. Translation: EAW49790.1.
BC006212 mRNA. Translation: AAH06212.2.
BC058938 mRNA. Translation: AAH58938.1.
AY029201 mRNA. Translation: AAK31577.1.
AL834338 mRNA. Translation: CAD39005.1.
IPIIPI00101927.
RefSeqNP_115805.1.
UniGeneHs.523221

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ9BRK4. 10 interactions.
STRINGQ9BRK4.

PTM databases

PhosphoSiteQ9BRK4.

Proteomic databases

PRIDEQ9BRK4.

Genome annotation databases

EnsemblENST00000370220; ENSP00000359240; ENSG00000107816; Homo sapiens. [Genome view]
ENST00000370223; ENSP00000359243; ENSG00000107816; Homo sapiens. [Genome view]
GeneID84445.
KEGGhsa:84445.
UCSCuc001ksj.1. human.

Organism-specific databases

CTD84445.
GeneCardsGC10P102746.
HGNCHGNC:29381. LZTS2.
MIM610454. gene.
PharmGKBPA134944540.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG19150.
HOGENOMHBG713386.
HOVERGENQ9BRK4.
InParanoidQ9BRK4.
OMARRCATFE.
OrthoDBEOG9Z3906.
PhylomeDBQ9BRK4.

Gene expression databases

ArrayExpressQ9BRK4.
BgeeQ9BRK4.
CleanExHS_LZTS2.
GenevestigatorQ9BRK4.
GermOnlineENSG00000107816. Homo sapiens.

Family and domain databases

InterProIPR009638. Fez1.
[Graphical view]
PfamPF06818. Fez1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio74209.
SOURCESearch...

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Entry information

Entry nameLZTS2_HUMAN
AccessionPrimary (citable) accession number: Q9BRK4
Secondary accession number(s): B1AL14 expand/collapse secondary AC list , Q8N3I0, Q96J79, Q96JL2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2004
Last modified: February 9, 2010
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

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List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents