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Protein

Leucine zipper putative tumor suppressor 2

Gene

LZTS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.UniRule annotation4 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine zipper putative tumor suppressor 2UniRule annotation
Short name:
hLZTS2
Alternative name(s):
Protein LAPSER1UniRule annotation
Gene namesi
Name:LZTS2UniRule annotation
Synonyms:KIAA1813, LAPSER1UniRule annotation
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:29381. LZTS2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi638 – 6381L → A: Induces nuclear accumulation. Impairs nuclear exclusion of beta-catenin; when associated with A-640. 1 Publication
Mutagenesisi640 – 6401L → A: Induces nuclear accumulation. Impairs nuclear exclusion of beta-catenin; when associated with A-38. 1 Publication

Organism-specific databases

PharmGKBiPA134944540.

Polymorphism and mutation databases

BioMutaiLZTS2.
DMDMi46396501.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 669669Leucine zipper putative tumor suppressor 2PRO_0000182974Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei249 – 2491PhosphoserineBy similarity
Modified residuei296 – 2961PhosphoserineBy similarity
Modified residuei570 – 5701PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BRK4.
MaxQBiQ9BRK4.
PaxDbiQ9BRK4.
PRIDEiQ9BRK4.

PTM databases

iPTMnetiQ9BRK4.
PhosphoSiteiQ9BRK4.

Expressioni

Tissue specificityi

Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon.1 Publication

Inductioni

By inhibition of NF-kappa-B signaling.1 Publication

Gene expression databases

BgeeiQ9BRK4.
CleanExiHS_LZTS2.
ExpressionAtlasiQ9BRK4. baseline and differential.
GenevisibleiQ9BRK4. HS.

Organism-specific databases

HPAiHPA044956.

Interactioni

Subunit structurei

Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.UniRule annotation2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
A8K9323EBI-741037,EBI-10174671
A8KAD63EBI-741037,EBI-10174974
P0C2064EBI-741037,EBI-9675596From a different organism.
Q95HA43EBI-741037,EBI-10236795
Q9H6F03EBI-741037,EBI-10307481
ABT1Q9ULW33EBI-741037,EBI-2602396
AENQ8WTP83EBI-741037,EBI-8637627
ANKRD36BP1Q96IX93EBI-741037,EBI-744859
AP1M1Q9BXS53EBI-741037,EBI-541426
ARHGAP32A7KAX93EBI-741037,EBI-308663
ARMC7Q9H6L43EBI-741037,EBI-742909
ATPAF2Q8N5M13EBI-741037,EBI-1166928
BAHD1Q8TBE04EBI-741037,EBI-742750
BEX2Q9BXY83EBI-741037,EBI-745073
BYSLQ138953EBI-741037,EBI-358049
C14orf105Q17R993EBI-741037,EBI-10238351
C19orf66Q9NUL53EBI-741037,EBI-10313866
C1orf109Q9NX043EBI-741037,EBI-8643161
C20orf195Q9BVV23EBI-741037,EBI-744935
C6orf165Q8IYR03EBI-741037,EBI-749051
C8orf33Q9H7E93EBI-741037,EBI-715389
CARD9Q9H2573EBI-741037,EBI-751319
CBX8Q9HC523EBI-741037,EBI-712912
CCNCP248633EBI-741037,EBI-395261
CCNG1P519593EBI-741037,EBI-3905829
CCNKO759093EBI-741037,EBI-739806
CDC23Q9UJX23EBI-741037,EBI-396137
CDK18Q070023EBI-741037,EBI-746238
CDKL3Q8IVW43EBI-741037,EBI-3919850
CEP57L1Q8IYX83EBI-741037,EBI-1104570
CEP57L1Q8IYX8-23EBI-741037,EBI-10181988
CHCHD3Q9NX633EBI-741037,EBI-743375
CLIP4Q8N3C73EBI-741037,EBI-5655540
CNNM3Q8NE013EBI-741037,EBI-741032
CNNM3Q8NE01-33EBI-741037,EBI-10269984
DCUN1D1Q96GG93EBI-741037,EBI-740086
DGCR6LQ9BY273EBI-741037,EBI-742953
DYRK1AQ136273EBI-741037,EBI-1053596
DYRK1BQ9Y4633EBI-741037,EBI-634187
DYRK2Q926303EBI-741037,EBI-749432
EHHADHQ084263EBI-741037,EBI-2339219
EIF3DO153713EBI-741037,EBI-353818
EIF4E2O605733EBI-741037,EBI-398610
FAM103A1Q9BTL33EBI-741037,EBI-744023
FAM107AO95990-33EBI-741037,EBI-10192902
FAM124BQ9H5Z63EBI-741037,EBI-741626
FAM161AQ3B8203EBI-741037,EBI-719941
FAM74A6Q5TZK33EBI-741037,EBI-10247271
FANCLQ9NW383EBI-741037,EBI-2339898
FBF1Q8TES7-63EBI-741037,EBI-10244131
FEM1CQ96JP03EBI-741037,EBI-2515330
FGF12P613283EBI-741037,EBI-6657662
FKBP6O753443EBI-741037,EBI-744771
FRG1Q143313EBI-741037,EBI-2515248
FRMD6Q96NE93EBI-741037,EBI-741729
GCC1Q96CN93EBI-741037,EBI-746252
GEMP550403EBI-741037,EBI-744104
GMCL1P1Q8NEA93EBI-741037,EBI-745707
GNL3LQ9NVN83EBI-741037,EBI-746682
GPATCH2LQ9NWQ43EBI-741037,EBI-5666657
GRB2P629933EBI-741037,EBI-401755
HM13Q8TCT93EBI-741037,EBI-347472
HOMER2Q9NSB83EBI-741037,EBI-2126733
HSPD1P108094EBI-741037,EBI-352528
KAT5Q929933EBI-741037,EBI-399080
KAZNQ674X73EBI-741037,EBI-949239
KIAA1683Q9H0B33EBI-741037,EBI-745878
KIFC3Q9BVG83EBI-741037,EBI-2125614
KPNA2Q6NVW73EBI-741037,EBI-9377406
LASP1Q148473EBI-741037,EBI-742828
LCKP062393EBI-741037,EBI-1348
LIN37Q96GY33EBI-741037,EBI-748884
LMO1P258003EBI-741037,EBI-8639312
LMO2P257913EBI-741037,EBI-739696
MAB21L3Q8N8X93EBI-741037,EBI-10268010
MAGEB4O154813EBI-741037,EBI-751857
MEMO1Q9Y3163EBI-741037,EBI-1104564
MORF4L1Q9UBU83EBI-741037,EBI-399246
MORF4L2Q150143EBI-741037,EBI-399257
MORN3Q6PF183EBI-741037,EBI-9675802
MOSP005403EBI-741037,EBI-1757866
MTA1Q133303EBI-741037,EBI-714236
NCBP2P522983EBI-741037,EBI-464729
NCK2O436393EBI-741037,EBI-713635
NEBLO760413EBI-741037,EBI-2880203
NEK6Q9HC983EBI-741037,EBI-740364
NIP7Q9Y2213EBI-741037,EBI-749003
OTUB2Q96DC93EBI-741037,EBI-746259
PKP4Q995693EBI-741037,EBI-726447
PLEKHN1Q494U13EBI-741037,EBI-10241513
POLDIP3Q8WUT13EBI-741037,EBI-10276663
POLR1CO151603EBI-741037,EBI-1055079
PPP1R18Q6NYC83EBI-741037,EBI-2557469
PQBP1O608283EBI-741037,EBI-713867
PRKAB2O437413EBI-741037,EBI-1053424
PSMA1P257863EBI-741037,EBI-359352
QARSP478973EBI-741037,EBI-347462
QARSP47897-23EBI-741037,EBI-10209725
RAC1P630003EBI-741037,EBI-413628
RAD51DO757713EBI-741037,EBI-1055693
RBM15Q96T373EBI-741037,EBI-2514922
RBM41Q96IZ53EBI-741037,EBI-740773
RCOR3Q9P2K33EBI-741037,EBI-743428
RHNO1Q9BSD33EBI-741037,EBI-9658624
RIN1Q136713EBI-741037,EBI-366017
RNF41Q9H4P43EBI-741037,EBI-2130266
RTP5Q14D333EBI-741037,EBI-10217913
RUNX1T1Q06455-43EBI-741037,EBI-10224192
SCNM1Q9BWG63EBI-741037,EBI-748391
SFRS2Q6NXQ03EBI-741037,EBI-10251550
SH2D4AQ9H7883EBI-741037,EBI-747035
SH3RF2Q08AM83EBI-741037,EBI-10225873
SLC15A3Q05CH43EBI-741037,EBI-10223741
SLC25A6P122363EBI-741037,EBI-356254
SLU7O953913EBI-741037,EBI-750559
SMIM3Q9BZL33EBI-741037,EBI-741850
SNW1Q135733EBI-741037,EBI-632715
SNX31Q8N9S93EBI-741037,EBI-9380649
SPATA2Q9UM823EBI-741037,EBI-744066
SPATA24Q86W543EBI-741037,EBI-3916986
SPATC1LQ9H0A93EBI-741037,EBI-372911
SPG7Q9UQ903EBI-741037,EBI-717201
STACQ8WUK83EBI-741037,EBI-10276615
SUPV3L1Q8IYB83EBI-741037,EBI-2876787
SUV39H1O434633EBI-741037,EBI-349968
taxP034105EBI-741037,EBI-9676218From a different organism.
TBC1D7Q9P0N93EBI-741037,EBI-3258000
TCEA2Q155603EBI-741037,EBI-710310
TCHPQ9BT923EBI-741037,EBI-740781
TEAD4D3DUQ63EBI-741037,EBI-10176734
THAP10Q9P2Z03EBI-741037,EBI-745404
THAP7Q9BT493EBI-741037,EBI-741350
TNIP3Q96KP63EBI-741037,EBI-2509913
TRIM29Q141344EBI-741037,EBI-702370
TRIM42A1L4B63EBI-741037,EBI-10172216
TSNAXQ995983EBI-741037,EBI-742638
TTC23Q5W5X93EBI-741037,EBI-6447954
TXNL4AP838763EBI-741037,EBI-746539
USF2Q158533EBI-741037,EBI-1055994
USP2O756043EBI-741037,EBI-743272
UTP14CQ08E774EBI-741037,EBI-10225961
WDYHV1Q96HA83EBI-741037,EBI-741158
WT1-ASQ062503EBI-741037,EBI-10223946
ZBTB25P242783EBI-741037,EBI-739899
ZGPATQ8N5A53EBI-741037,EBI-3439227
ZGPATQ8N5A5-23EBI-741037,EBI-10183064
ZKSCAN3Q9BRR03EBI-741037,EBI-1965777
ZMAT2Q96NC03EBI-741037,EBI-2682299
ZMYND19Q96E354EBI-741037,EBI-746595
ZNF20P170243EBI-741037,EBI-717634
ZNF250P15622-33EBI-741037,EBI-10177272
ZNF417Q8TAU33EBI-741037,EBI-740727
ZNF426Q9BUY53EBI-741037,EBI-743265
ZNF446Q96AF53EBI-741037,EBI-740232
ZNF490Q9ULM23EBI-741037,EBI-1105370
ZNF572Q7Z3I73EBI-741037,EBI-10257016
ZNF581Q9P0T44EBI-741037,EBI-745520

Protein-protein interaction databases

BioGridi124083. 262 interactions.
IntActiQ9BRK4. 194 interactions.
MINTiMINT-1199317.
STRINGi9606.ENSP00000359240.

Structurei

3D structure databases

ProteinModelPortaliQ9BRK4.
SMRiQ9BRK4. Positions 327-352, 405-438.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 332332Required for centrosomal localizationBy similarityAdd
BLAST
Regioni447 – 669223Sufficient for interaction with CTNNB1Add
BLAST
Regioni450 – 669220Sufficient for interaction with KATNB1 and for inhibition of katanin-mediated microtubule severingBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili328 – 649322UniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi631 – 64010Nuclear export signal

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi188 – 306119Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the LZTS2 family.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGJE. Eukaryota.
ENOG4111JZA. LUCA.
GeneTreeiENSGT00510000046769.
HOGENOMiHOG000230889.
HOVERGENiHBG052381.
InParanoidiQ9BRK4.
OMAiEPAPCIC.
OrthoDBiEOG7F7W8K.
PhylomeDBiQ9BRK4.
TreeFamiTF331420.

Family and domain databases

HAMAPiMF_03026. LZTS2.
InterProiIPR028597. LZTS2.
[Graphical view]
PANTHERiPTHR19354:SF4. PTHR19354:SF4. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BRK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIVQTLPVP LEPAPEAATA PQAPVMGSVS SLISGRPCPG GPAPPRHHGP
60 70 80 90 100
PGPTFFRQQD GLLRGGYEAQ EPLCPAVPPR KAVPVTSFTY INEDFRTESP
110 120 130 140 150
PSPSSDVEDA REQRAHNAHL RGPPPKLIPV SGKLEKNMEK ILIRPTAFKP
160 170 180 190 200
VLPKPRGAPS LPSFMGPRAT GLSGSQGSLT QLFGGPASSS SSSSSSSAAD
210 220 230 240 250
KPLAFSGWAS GCPSGTLSDS GRNSLSSLPT YSTGGAEPTT SSPGGHLPSH
260 270 280 290 300
GSGRGALPGP ARGVPTGPSH SDSGRSSSSK STGSLGGRVA GGLLGSGTRA
310 320 330 340 350
SPDSSSCGER SPPPPPPPPS DEALLHCVLE GKLRDREAEL QQLRDSLDEN
360 370 380 390 400
EATMCQAYEE RQRHWQRERE ALREDCAAQA QRAQRAQQLL QLQVFQLQQE
410 420 430 440 450
KRQLQDDFAQ LLQEREQLER RCATLEREQR ELGPRLEETK WEVCQKSGEI
460 470 480 490 500
SLLKQQLKES QAELVQKGSE LVALRVALRE ARATLRVSEG RARGLQEAAR
510 520 530 540 550
ARELELEACS QELQRHRQEA EQLREKAGQL DAEAAGLREP PVPPATADPF
560 570 580 590 600
LLAESDEAKV QRAAAGVGGS LRAQVERLRV ELQRERRRGE EQRDSFEGER
610 620 630 640 650
LAWQAEKEQV IRYQKQLQHN YIQMYRRNRQ LEQELQQLSL ELEARELADL
660
GLAEQAPCIC LEEITATEI
Length:669
Mass (Da):72,759
Last modified:March 1, 2004 - v2
Checksum:i1274FD9A36A217E6
GO

Sequence cautioni

The sequence BAB47442.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti289 – 2891V → L in AAH58938 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti121 – 1211R → H in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036364
Natural varianti291 – 2911G → R in a breast cancer sample; somatic mutation. 1 Publication
VAR_036365
Natural varianti299 – 2991R → W.
Corresponds to variant rs2275381 [ dbSNP | Ensembl ].
VAR_018277

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058716 mRNA. Translation: BAB47442.1. Different initiation.
AL133215 Genomic DNA. Translation: CAI10929.1.
CH471066 Genomic DNA. Translation: EAW49790.1.
CH471066 Genomic DNA. Translation: EAW49791.1.
CH471066 Genomic DNA. Translation: EAW49792.1.
BC006212 mRNA. Translation: AAH06212.2.
BC058938 mRNA. Translation: AAH58938.1.
AY029201 mRNA. Translation: AAK31577.1.
AL834338 mRNA. Translation: CAD39005.1.
CCDSiCCDS7507.1.
RefSeqiNP_001305028.1. NM_001318099.1.
NP_001305029.1. NM_001318100.1.
NP_001305030.1. NM_001318101.1.
NP_115805.1. NM_032429.3.
XP_005270279.1. XM_005270222.3.
UniGeneiHs.523221.
Hs.734981.

Genome annotation databases

EnsembliENST00000370220; ENSP00000359240; ENSG00000107816.
ENST00000370223; ENSP00000359243; ENSG00000107816.
GeneIDi84445.
KEGGihsa:84445.
UCSCiuc001ksj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058716 mRNA. Translation: BAB47442.1. Different initiation.
AL133215 Genomic DNA. Translation: CAI10929.1.
CH471066 Genomic DNA. Translation: EAW49790.1.
CH471066 Genomic DNA. Translation: EAW49791.1.
CH471066 Genomic DNA. Translation: EAW49792.1.
BC006212 mRNA. Translation: AAH06212.2.
BC058938 mRNA. Translation: AAH58938.1.
AY029201 mRNA. Translation: AAK31577.1.
AL834338 mRNA. Translation: CAD39005.1.
CCDSiCCDS7507.1.
RefSeqiNP_001305028.1. NM_001318099.1.
NP_001305029.1. NM_001318100.1.
NP_001305030.1. NM_001318101.1.
NP_115805.1. NM_032429.3.
XP_005270279.1. XM_005270222.3.
UniGeneiHs.523221.
Hs.734981.

3D structure databases

ProteinModelPortaliQ9BRK4.
SMRiQ9BRK4. Positions 327-352, 405-438.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124083. 262 interactions.
IntActiQ9BRK4. 194 interactions.
MINTiMINT-1199317.
STRINGi9606.ENSP00000359240.

PTM databases

iPTMnetiQ9BRK4.
PhosphoSiteiQ9BRK4.

Polymorphism and mutation databases

BioMutaiLZTS2.
DMDMi46396501.

Proteomic databases

EPDiQ9BRK4.
MaxQBiQ9BRK4.
PaxDbiQ9BRK4.
PRIDEiQ9BRK4.

Protocols and materials databases

DNASUi84445.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370220; ENSP00000359240; ENSG00000107816.
ENST00000370223; ENSP00000359243; ENSG00000107816.
GeneIDi84445.
KEGGihsa:84445.
UCSCiuc001ksj.4. human.

Organism-specific databases

CTDi84445.
GeneCardsiLZTS2.
HGNCiHGNC:29381. LZTS2.
HPAiHPA044956.
MIMi610454. gene.
neXtProtiNX_Q9BRK4.
PharmGKBiPA134944540.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGJE. Eukaryota.
ENOG4111JZA. LUCA.
GeneTreeiENSGT00510000046769.
HOGENOMiHOG000230889.
HOVERGENiHBG052381.
InParanoidiQ9BRK4.
OMAiEPAPCIC.
OrthoDBiEOG7F7W8K.
PhylomeDBiQ9BRK4.
TreeFamiTF331420.

Miscellaneous databases

ChiTaRSiLZTS2. human.
GenomeRNAii84445.
NextBioi74209.
PROiQ9BRK4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BRK4.
CleanExiHS_LZTS2.
ExpressionAtlasiQ9BRK4. baseline and differential.
GenevisibleiQ9BRK4. HS.

Family and domain databases

HAMAPiMF_03026. LZTS2.
InterProiIPR028597. LZTS2.
[Graphical view]
PANTHERiPTHR19354:SF4. PTHR19354:SF4. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Uterus.
  5. "LAPSER1: a novel candidate tumor suppressor gene from 10q24.3."
    Cabeza-Arvelaiz Y., Thompson T.C., Sepulveda J.L., Chinault A.C.
    Oncogene 20:6707-6717(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-669, ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Tissue: Prostate.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 139-669.
    Tissue: Amygdala.
  7. "LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin."
    Thyssen G., Li T.-H., Lehmann L., Zhuo M., Sharma M., Sun Z.
    Mol. Cell. Biol. 26:8857-8867(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CTNNB1, SUBCELLULAR LOCATION, NUCLEAR EXPORT SIGNAL, MUTAGENESIS OF LEU-638 AND LEU-640.
  8. "LAPSER1 is a putative cytokinetic tumor suppressor that shows the same centrosome and midbody subcellular localization pattern as p80 katanin."
    Sudo H., Maru Y.
    FASEB J. 21:2086-2100(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GAMMA-TUBULIN; KIF23 AND KATNB1, SUBCELLULAR LOCATION.
  9. "Crossregulation of beta-catenin/Tcf pathway by NF-kappaB is mediated by lzts2 in human adipose tissue-derived mesenchymal stem cells."
    Cho H.H., Joo H.J., Song J.S., Bae Y.C., Jung J.S.
    Biochim. Biophys. Acta 1783:419-428(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  10. "LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing."
    Sudo H., Maru Y.
    Hum. Mol. Genet. 17:2524-2540(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-121 AND ARG-291.

Entry informationi

Entry nameiLZTS2_HUMAN
AccessioniPrimary (citable) accession number: Q9BRK4
Secondary accession number(s): B1AL14
, D3DR72, Q8N3I0, Q96J79, Q96JL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2004
Last modified: May 11, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.