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Protein

Matrix-remodeling-associated protein 8

Gene

MXRA8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the maturation and maintenance of blood-brain barrier.By similarity

GO - Biological processi

  • establishment of glial blood-brain barrier Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix-remodeling-associated protein 8
Alternative name(s):
Limitrin
Gene namesi
Name:MXRA8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:7542. MXRA8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 341ExtracellularSequence analysisAdd BLAST322
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 442CytoplasmicSequence analysisAdd BLAST80

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162576.
PharmGKBiPA31343.

Polymorphism and mutation databases

DMDMi74761214.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000029866520 – 442Matrix-remodeling-associated protein 8Add BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 137PROSITE-ProRule annotation
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi186 ↔ 272PROSITE-ProRule annotation
Modified residuei228Phosphoserine; by FAM20C1 Publication1
Glycosylationi306N-linked (GlcNAc...)Sequence analysis1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei325 – 326CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9BRK3.
MaxQBiQ9BRK3.
PaxDbiQ9BRK3.
PeptideAtlasiQ9BRK3.
PRIDEiQ9BRK3.

PTM databases

iPTMnetiQ9BRK3.
PhosphoSitePlusiQ9BRK3.

Expressioni

Gene expression databases

BgeeiENSG00000162576.
CleanExiHS_MXRA8.
GenevisibleiQ9BRK3. HS.

Organism-specific databases

HPAiHPA053958.
HPA055780.

Interactioni

Protein-protein interaction databases

IntActiQ9BRK3. 6 interactors.
STRINGi9606.ENSP00000307887.

Structurei

3D structure databases

ProteinModelPortaliQ9BRK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 157Ig-like V-type 1Add BLAST129
Domaini160 – 288Ig-like V-type 2Add BLAST129

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi364 – 367Poly-Arg4

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJVY. Eukaryota.
ENOG41113W9. LUCA.
GeneTreeiENSGT00390000001509.
HOGENOMiHOG000065729.
HOVERGENiHBG058527.
InParanoidiQ9BRK3.
OMAiLLTCVNR.
OrthoDBiEOG091G09TD.
PhylomeDBiQ9BRK3.
TreeFamiTF332884.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00406. IGv. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BRK3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALPSRILLW KLVLLQSSAV LLHSGSSVPA AAGSSVVSES AVSWEAGARA
60 70 80 90 100
VLRCQSPRMV WTQDRLHDRQ RVLHWDLRGP GGGPARRLLD LYSAGEQRVY
110 120 130 140 150
EARDRGRLEL SASAFDDGNF SLLIRAVEET DAGLYTCNLH HHYCHLYESL
160 170 180 190 200
AVRLEVTDGP PATPAYWDGE KEVLAVARGA PALLTCVNRG HVWTDRHVEE
210 220 230 240 250
AQQVVHWDRQ PPGVPHDRAD RLLDLYASGE RRAYGPLFLR DRVAVGADAF
260 270 280 290 300
ERGDFSLRIE PLEVADEGTY SCHLHHHYCG LHERRVFHLT VAEPHAEPPP
310 320 330 340 350
RGSPGNGSSH SGAPGPDPTL ARGHNVINVI VPESRAHFFQ QLGYVLATLL
360 370 380 390 400
LFILLLVTVL LAARRRRGGY EYSDQKSGKS KGKDVNLAEF AVAAGDQMLY
410 420 430 440
RSEDIQLDYK NNILKERAEL AHSPLPAKYI DLDKGFRKEN CK
Length:442
Mass (Da):49,132
Last modified:June 1, 2001 - v1
Checksum:iB08F89D726222CA1
GO
Isoform 2 (identifier: Q9BRK3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     407-407: L → LASSPPT
     435-442: GFRKENCK → DPSGLCPLGA

Show »
Length:450
Mass (Da):49,620
Checksum:i93865CBB68AC1C04
GO
Isoform 3 (identifier: Q9BRK3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MALPSRILLWKLVLLQS → MIRCAATG

Note: No experimental confirmation available.
Show »
Length:433
Mass (Da):47,972
Checksum:iAFECF654C299D6D6
GO
Isoform 4 (identifier: Q9BRK3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-125: Missing.

Note: No experimental confirmation available.
Show »
Length:341
Mass (Da):38,070
Checksum:i788EDD861A10CCF5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti405I → V in BAB55010 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070893396D → N.1 PublicationCorresponds to variant rs150058708dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0545281 – 17MALPS…VLLQS → MIRCAATG in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_05452925 – 125Missing in isoform 4. 1 PublicationAdd BLAST101
Alternative sequenceiVSP_027448407L → LASSPPT in isoform 2. 1 Publication1
Alternative sequenceiVSP_027449435 – 442GFRKENCK → DPSGLCPLGA in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052096 mRNA. Translation: BAD05132.1.
AK027269 mRNA. Translation: BAB55010.1.
AK095966 mRNA. Translation: BAG53178.1.
AK293442 mRNA. Translation: BAG56945.1.
AL139287 Genomic DNA. Translation: CAI23188.1.
AL139287 Genomic DNA. Translation: CAI23189.1.
BC006213 mRNA. Translation: AAH06213.1.
BC017312 mRNA. Translation: AAH17312.1.
CCDSiCCDS24.1. [Q9BRK3-1]
CCDS59950.1. [Q9BRK3-4]
CCDS59951.1. [Q9BRK3-2]
CCDS59952.1. [Q9BRK3-3]
RefSeqiNP_001269511.1. NM_001282582.1. [Q9BRK3-1]
NP_001269512.1. NM_001282583.1. [Q9BRK3-3]
NP_001269513.1. NM_001282584.1. [Q9BRK3-4]
NP_001269514.1. NM_001282585.1. [Q9BRK3-2]
NP_115724.1. NM_032348.3. [Q9BRK3-1]
UniGeneiHs.515687.

Genome annotation databases

EnsembliENST00000309212; ENSP00000307887; ENSG00000162576. [Q9BRK3-1]
ENST00000342753; ENSP00000344998; ENSG00000162576. [Q9BRK3-4]
ENST00000445648; ENSP00000399229; ENSG00000162576. [Q9BRK3-2]
ENST00000477278; ENSP00000436135; ENSG00000162576. [Q9BRK3-3]
GeneIDi54587.
KEGGihsa:54587.
UCSCiuc001aew.5. human. [Q9BRK3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052096 mRNA. Translation: BAD05132.1.
AK027269 mRNA. Translation: BAB55010.1.
AK095966 mRNA. Translation: BAG53178.1.
AK293442 mRNA. Translation: BAG56945.1.
AL139287 Genomic DNA. Translation: CAI23188.1.
AL139287 Genomic DNA. Translation: CAI23189.1.
BC006213 mRNA. Translation: AAH06213.1.
BC017312 mRNA. Translation: AAH17312.1.
CCDSiCCDS24.1. [Q9BRK3-1]
CCDS59950.1. [Q9BRK3-4]
CCDS59951.1. [Q9BRK3-2]
CCDS59952.1. [Q9BRK3-3]
RefSeqiNP_001269511.1. NM_001282582.1. [Q9BRK3-1]
NP_001269512.1. NM_001282583.1. [Q9BRK3-3]
NP_001269513.1. NM_001282584.1. [Q9BRK3-4]
NP_001269514.1. NM_001282585.1. [Q9BRK3-2]
NP_115724.1. NM_032348.3. [Q9BRK3-1]
UniGeneiHs.515687.

3D structure databases

ProteinModelPortaliQ9BRK3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9BRK3. 6 interactors.
STRINGi9606.ENSP00000307887.

PTM databases

iPTMnetiQ9BRK3.
PhosphoSitePlusiQ9BRK3.

Polymorphism and mutation databases

DMDMi74761214.

Proteomic databases

EPDiQ9BRK3.
MaxQBiQ9BRK3.
PaxDbiQ9BRK3.
PeptideAtlasiQ9BRK3.
PRIDEiQ9BRK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309212; ENSP00000307887; ENSG00000162576. [Q9BRK3-1]
ENST00000342753; ENSP00000344998; ENSG00000162576. [Q9BRK3-4]
ENST00000445648; ENSP00000399229; ENSG00000162576. [Q9BRK3-2]
ENST00000477278; ENSP00000436135; ENSG00000162576. [Q9BRK3-3]
GeneIDi54587.
KEGGihsa:54587.
UCSCiuc001aew.5. human. [Q9BRK3-1]

Organism-specific databases

CTDi54587.
GeneCardsiMXRA8.
HGNCiHGNC:7542. MXRA8.
HPAiHPA053958.
HPA055780.
neXtProtiNX_Q9BRK3.
OpenTargetsiENSG00000162576.
PharmGKBiPA31343.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJVY. Eukaryota.
ENOG41113W9. LUCA.
GeneTreeiENSGT00390000001509.
HOGENOMiHOG000065729.
HOVERGENiHBG058527.
InParanoidiQ9BRK3.
OMAiLLTCVNR.
OrthoDBiEOG091G09TD.
PhylomeDBiQ9BRK3.
TreeFamiTF332884.

Miscellaneous databases

GenomeRNAii54587.
PROiQ9BRK3.

Gene expression databases

BgeeiENSG00000162576.
CleanExiHS_MXRA8.
GenevisibleiQ9BRK3. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00406. IGv. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMXRA8_HUMAN
AccessioniPrimary (citable) accession number: Q9BRK3
Secondary accession number(s): B3KTR6
, B4DE34, Q5TA39, Q96KC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.