ID   REEP2_HUMAN             Reviewed;         252 AA.
AC   Q9BRK0; Q53EM8; Q9NYF2;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 2.
DT   10-JUL-2007, entry version 35.
DE   Receptor expression-enhancing protein 2.
GN   Name=REEP2; Synonyms=C5orf19, SGC32445;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=15550249; DOI=10.1016/j.cell.2004.11.021;
RA   Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.;
RT   "RTP family members induce functional expression of mammalian odorant
RT   receptors.";
RL   Cell 119:679-691(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain;
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 8-252 (ISOFORM 2), AND TISSUE
RP   SPECIFICITY.
RX   MEDLINE=21100896; PubMed=11161817; DOI=10.1006/geno.2000.6414;
RA   Lai F., Godley L.A., Joslin J., Fernald A.A., Liu J., Espinosa R. III,
RA   Zhao N., Pamintuan L., Till B.G., Larson R.A., Qian Z., Le Beau M.M.;
RT   "Transcript map and comparative analysis of the 1.5-Mb commonly
RT   deleted segment of human 5q31 in malignant myeloid diseases with a
RT   del(5q).";
RL   Genomics 71:235-245(2001).
CC   -!- FUNCTION: May enhance the cell surface expression of odorant
CC       receptors (By similarity).
CC   -!- SUBUNIT: Interacts with odorant receptor proteins (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (By
CC       similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9BRK0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9BRK0-2; Sequence=VSP_016633;
CC   -!- TISSUE SPECIFICITY: Detected in brain, heart and skeletal muscle,
CC       and at low levels in placenta, kidney and pancreas.
CC   -!- SIMILARITY: Belongs to the DP1 family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF63767.1; Type=Frameshift; Positions=171;
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DR   EMBL; AY562240; AAT70685.1; -; mRNA.
DR   EMBL; AK223611; BAD97331.1; -; mRNA.
DR   EMBL; BC006218; AAH06218.2; -; mRNA.
DR   EMBL; AF251041; AAF63767.1; ALT_FRAME; mRNA.
DR   UniGene; Hs.416090; -.
DR   Ensembl; ENSG00000132563; Homo sapiens.
DR   HGNC; HGNC:17975; REEP2.
DR   MIM; 609347; gene.
DR   ArrayExpress; Q9BRK0; -.
DR   GermOnline; ENSG00000132563; Homo sapiens.
DR   RZPD-ProtExp; IOH40596; -.
DR   RZPD-ProtExp; V0882; -.
DR   InterPro; IPR004345; TB2_DP1_HVA22.
DR   PANTHER; PTHR12300; TB2_DP1_HVA22; 1.
DR   Pfam; PF03134; TB2_DP1_HVA22; 1.
KW   Alternative splicing; Membrane; Transmembrane.
FT   CHAIN         1    252       Receptor expression-enhancing protein 2.
FT                                /FTId=PRO_0000101823.
FT   TRANSMEM      1     21       Potential.
FT   TRANSMEM     35     55       Potential.
FT   VAR_SEQ     139    139       K -> KGQ (in isoform 2).
FT                                /FTId=VSP_016633.
SQ   SEQUENCE   252 AA;  28261 MW;  C2A4DD7F35E7F9C5 CRC64;
     MVSWIISRLV VLIFGTLYPA YSSYKAVKTK NVKEYVKWMM YWIVFAFFTT AETLTDIVLS
     WFPFYFELKI AFVIWLLSPY TKGSSVLYRK FVHPTLSNKE KEIDEYITQA RDKSYETMMR
     VGKRGLNLAA NAAVTAAAKG VLSEKLRSFS MQDLTLIRDE DALPLQRPDG RLRPSPGSLL
     DTIEDLGDDP ALSLRSSTNP ADSRTEASED DMGDKAPKRA KPIKKAPKAE PLASKTLKTR
     PKKKTSGGGD SA
//