ID   REEP2_HUMAN    STANDARD;      PRT;   252 AA.
AC   Q9BRK0; Q53EM8; Q9NYF2;
DT   24-JAN-2006 (Rel. 49, Created)
DT   24-JAN-2006 (Rel. 49, Last sequence update)
DT   24-JAN-2006 (Rel. 49, Last annotation update)
DE   Receptor expression-enhancing protein 2.
GN   Name=REEP2; Synonyms=C5orf19, SGC32445;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=15550249; DOI=10.1016/j.cell.2004.11.021;
RA   Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.;
RT   "RTP family members induce functional expression of mammalian odorant
RT   receptors.";
RL   Cell 119:679-691(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain;
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Lung;
RX   MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA   Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA   Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 8-252 (ISOFORM 2), AND TISSUE
RP   SPECIFICITY.
RX   MEDLINE=21100896; PubMed=11161817; DOI=10.1006/geno.2000.6414;
RA   Lai F., Godley L.A., Joslin J., Fernald A.A., Liu J., Espinosa R. III,
RA   Zhao N., Pamintuan L., Till B.G., Larson R.A., Qian Z., Le Beau M.M.;
RT   "Transcript map and comparative analysis of the 1.5-Mb commonly
RT   deleted segment of human 5q31 in malignant myeloid diseases with a
RT   del(5q).";
RL   Genomics 71:235-245(2001).
CC   -!- FUNCTION: May enhance the cell surface expression of odorant
CC       receptors (By similarity).
CC   -!- SUBUNIT: Interacts with odorant receptor proteins (By similarity).
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9BRK0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9BRK0-2; Sequence=VSP_016633;
CC   -!- TISSUE SPECIFICITY: Detected in brain, heart and skeletal muscle,
CC       and at low levels in placenta, kidney and pancreas.
CC   -!- SIMILARITY: Belongs to the DP1 family.
CC   -!- CAUTION: Ref.4 sequence differs from that shown due to a
CC       frameshift in position 171.
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DR   EMBL; AY562240; AAT70685.1; -; mRNA.
DR   EMBL; AK223611; BAD97331.1; -; mRNA.
DR   EMBL; BC006218; AAH06218.2; -; mRNA.
DR   EMBL; AF251041; AAF63767.1; ALT_FRAME; mRNA.
DR   Ensembl; ENSG00000132563; Homo sapiens.
DR   HGNC; HGNC:17975; C5orf19.
DR   MIM; 609347; -.
DR   InterPro; IPR004345; TB2_DP1_HVA22.
DR   Pfam; PF03134; TB2_DP1_HVA22; 1.
KW   Alternative splicing; Membrane; Transmembrane.
FT   TRANSMEM      1     21       Potential.
FT   TRANSMEM     35     55       Potential.
FT   VARSPLIC    139    139       K -> KGQ (in isoform 2).
FT                                /FTId=VSP_016633.
SQ   SEQUENCE   252 AA;  28261 MW;  C2A4DD7F35E7F9C5 CRC64;
     MVSWIISRLV VLIFGTLYPA YSSYKAVKTK NVKEYVKWMM YWIVFAFFTT AETLTDIVLS
     WFPFYFELKI AFVIWLLSPY TKGSSVLYRK FVHPTLSNKE KEIDEYITQA RDKSYETMMR
     VGKRGLNLAA NAAVTAAAKG VLSEKLRSFS MQDLTLIRDE DALPLQRPDG RLRPSPGSLL
     DTIEDLGDDP ALSLRSSTNP ADSRTEASED DMGDKAPKRA KPIKKAPKAE PLASKTLKTR
     PKKKTSGGGD SA
//