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Q9BRK0 (REEP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Receptor expression-enhancing protein 2
Gene names
Name:REEP2
Synonyms:C5orf19, SGC32445
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May enhance the cell surface expression of odorant receptors By similarity.

Subunit structure

Interacts with odorant receptor proteins By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Detected in brain, heart and skeletal muscle, and at low levels in placenta, kidney and pancreas. Ref.4

Sequence similarities

Belongs to the DP1 family.

Sequence caution

The sequence AAF63767.1 differs from that shown. Reason: Frameshift at position 171.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BRK0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BRK0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     139-139: K → KGQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 252252Receptor expression-enhancing protein 2
PRO_0000101823

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane35 – 5521Helical; Potential

Natural variations

Alternative sequence1391K → KGQ in isoform 2.
VSP_016633

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2004. Version 2.
Checksum: C2A4DD7F35E7F9C5

FASTA25228,261
        10         20         30         40         50         60 
MVSWIISRLV VLIFGTLYPA YSSYKAVKTK NVKEYVKWMM YWIVFAFFTT AETLTDIVLS 

        70         80         90        100        110        120 
WFPFYFELKI AFVIWLLSPY TKGSSVLYRK FVHPTLSNKE KEIDEYITQA RDKSYETMMR 

       130        140        150        160        170        180 
VGKRGLNLAA NAAVTAAAKG VLSEKLRSFS MQDLTLIRDE DALPLQRPDG RLRPSPGSLL 

       190        200        210        220        230        240 
DTIEDLGDDP ALSLRSSTNP ADSRTEASED DMGDKAPKRA KPIKKAPKAE PLASKTLKTR 

       250 
PKKKTSGGGD SA 

« Hide

Isoform 2 [UniParc].

Checksum: D19FC26DC93101F7
Show »

FASTA25428,446

References

« Hide 'large scale' references
[1]"RTP family members induce functional expression of mammalian odorant receptors."
Saito H., Kubota M., Roberts R.W., Chi Q., Matsunami H.
Cell 119:679-691(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lung.
[4]"Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q)."
Lai F., Godley L.A., Joslin J., Fernald A.A., Liu J., Espinosa R. III, Zhao N., Pamintuan L., Till B.G., Larson R.A., Qian Z., Le Beau M.M.
Genomics 71:235-245(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-252 (ISOFORM 2), TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY562240 mRNA. Translation: AAT70685.1.
AK223611 mRNA. Translation: BAD97331.1.
BC006218 mRNA. Translation: AAH06218.2.
AF251041 mRNA. Translation: AAF63767.1. Frameshift.
RefSeqNP_001258732.1. NM_001271803.1.
NP_057690.2. NM_016606.3.
UniGeneHs.416090.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119459. 1 interaction.
STRING9606.ENSP00000254901.

PTM databases

PhosphoSiteQ9BRK0.

Polymorphism databases

DMDM74732895.

Proteomic databases

PaxDbQ9BRK0.
PRIDEQ9BRK0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000254901; ENSP00000254901; ENSG00000132563. [Q9BRK0-1]
ENST00000378339; ENSP00000367590; ENSG00000132563. [Q9BRK0-2]
GeneID51308.
KEGGhsa:51308.
UCSCuc003lcz.4. human. [Q9BRK0-1]

Organism-specific databases

CTD51308.
GeneCardsGC05P137774.
H-InvDBHIX0121063.
HGNCHGNC:17975. REEP2.
HPAHPA031813.
MIM609347. gene.
neXtProtNX_Q9BRK0.
PharmGKBPA134920985.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5052.
HOGENOMHOG000007472.
HOVERGENHBG056861.
KOK17338.
OMASEDDMGD.
OrthoDBEOG71RXJX.
PhylomeDBQ9BRK0.
TreeFamTF314177.

Gene expression databases

ArrayExpressQ9BRK0.
BgeeQ9BRK0.
CleanExHS_REEP2.
GenevestigatorQ9BRK0.

Family and domain databases

InterProIPR004345. TB2_DP1_HVA22.
[Graphical view]
PANTHERPTHR12300. PTHR12300. 1 hit.
PfamPF03134. TB2_DP1_HVA22. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiREEP2.
GenomeRNAi51308.
NextBio54633.
PROQ9BRK0.
SOURCESearch...

Entry information

Entry nameREEP2_HUMAN
AccessionPrimary (citable) accession number: Q9BRK0
Secondary accession number(s): Q53EM8, Q9NYF2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2004
Last modified: March 19, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM