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Protein

Mesoderm posterior protein 1

Gene

MESP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Notch signaling pathway, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mesoderm posterior protein 1
Alternative name(s):
Class C basic helix-loop-helix protein 5
Short name:
bHLHc5
Gene namesi
Name:MESP1
Synonyms:BHLHC5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:29658. MESP1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671468.

Polymorphism and mutation databases

BioMutaiMESP1.
DMDMi74732894.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Mesoderm posterior protein 1PRO_0000304404Add
BLAST

Proteomic databases

PaxDbiQ9BRJ9.
PRIDEiQ9BRJ9.

PTM databases

iPTMnetiQ9BRJ9.

Expressioni

Gene expression databases

BgeeiQ9BRJ9.
CleanExiHS_MESP1.
GenevisibleiQ9BRJ9. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000300057.

Structurei

3D structure databases

ProteinModelPortaliQ9BRJ9.
SMRiQ9BRJ9. Positions 94-137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 13655bHLHPROSITE-ProRule annotationAdd
BLAST
Repeati182 – 183211 Publication
Repeati184 – 185221 Publication

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni182 – 18542 X 2 AA tandem repeats of G-Q

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi163 – 1675CPLCP

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00530000063712.
HOGENOMiHOG000113566.
HOVERGENiHBG094949.
InParanoidiQ9BRJ9.
KOiK09076.
OMAiPLSESWM.
OrthoDBiEOG79PJQZ.
PhylomeDBiQ9BRJ9.
TreeFamiTF325707.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BRJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQPLCPPLS ESWMLSAAWG PTRRPPPSDK DCGRSLVSSP DSWGSTPADS
60 70 80 90 100
PVASPARPGT LRDPRAPSVG RRGARSSRLG SGQRQSASER EKLRMRTLAR
110 120 130 140 150
ALHELRRFLP PSVAPAGQSL TKIETLRLAI RYIGHLSAVL GLSEESLQRR
160 170 180 190 200
CRQRGDAGSP RGCPLCPDDC PAQMQTRTQA EGQGQGRGLG LVSAVRAGAS
210 220 230 240 250
WGSPPACPGA RAAPEPRDPP ALFAEAACPE GQAMEPSPPS PLLPGDVLAL
260
LETWMPLSPL EWLPEEPK
Length:268
Mass (Da):28,501
Last modified:June 1, 2001 - v1
Checksum:i50508D4AF6EA7CE2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti223 – 2231F → L in CAB93425 (Ref. 2) Curated
Sequence conflicti223 – 2231F → L in CAB93426 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531A → P.
Corresponds to variant rs6496598 [ dbSNP | Ensembl ].
VAR_035021

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC006219 mRNA. Translation: AAH06219.1.
AL357533 mRNA. Translation: CAB93425.1.
AL357534 mRNA. Translation: CAB93426.1.
CCDSiCCDS10355.1.
RefSeqiNP_061140.1. NM_018670.3.
UniGeneiHs.447531.

Genome annotation databases

EnsembliENST00000300057; ENSP00000300057; ENSG00000166823.
GeneIDi55897.
KEGGihsa:55897.
UCSCiuc002bol.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC006219 mRNA. Translation: AAH06219.1.
AL357533 mRNA. Translation: CAB93425.1.
AL357534 mRNA. Translation: CAB93426.1.
CCDSiCCDS10355.1.
RefSeqiNP_061140.1. NM_018670.3.
UniGeneiHs.447531.

3D structure databases

ProteinModelPortaliQ9BRJ9.
SMRiQ9BRJ9. Positions 94-137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000300057.

PTM databases

iPTMnetiQ9BRJ9.

Polymorphism and mutation databases

BioMutaiMESP1.
DMDMi74732894.

Proteomic databases

PaxDbiQ9BRJ9.
PRIDEiQ9BRJ9.

Protocols and materials databases

DNASUi55897.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300057; ENSP00000300057; ENSG00000166823.
GeneIDi55897.
KEGGihsa:55897.
UCSCiuc002bol.4. human.

Organism-specific databases

CTDi55897.
GeneCardsiMESP1.
HGNCiHGNC:29658. MESP1.
MIMi608689. gene.
neXtProtiNX_Q9BRJ9.
PharmGKBiPA142671468.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00530000063712.
HOGENOMiHOG000113566.
HOVERGENiHBG094949.
InParanoidiQ9BRJ9.
KOiK09076.
OMAiPLSESWM.
OrthoDBiEOG79PJQZ.
PhylomeDBiQ9BRJ9.
TreeFamiTF325707.

Miscellaneous databases

GenomeRNAii55897.
PROiQ9BRJ9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BRJ9.
CleanExiHS_MESP1.
GenevisibleiQ9BRJ9. HS.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  2. The European IMAGE consortium
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 124-268.
  3. Cited for: REPEATS.

Entry informationi

Entry nameiMESP1_HUMAN
AccessioniPrimary (citable) accession number: Q9BRJ9
Secondary accession number(s): Q9NSF1, Q9NSF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The N- and C-terminal domains are separated by a 2-repeat G-Q region.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.