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Protein

Uncharacterized protein C7orf50

Gene

C7orf50

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C7orf50
Gene namesi
Name:C7orf50
ORF Names:FP15621
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:22421. C7orf50.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162380546.

Polymorphism and mutation databases

BioMutaiC7orf50.
DMDMi74732893.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194Uncharacterized protein C7orf50PRO_0000309510Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231PhosphoserineCombined sources
Modified residuei59 – 591PhosphoserineCombined sources
Modified residuei97 – 971PhosphoserineCombined sources
Modified residuei175 – 1751PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BRJ6.
MaxQBiQ9BRJ6.
PaxDbiQ9BRJ6.
PeptideAtlasiQ9BRJ6.
PRIDEiQ9BRJ6.

PTM databases

iPTMnetiQ9BRJ6.
PhosphoSiteiQ9BRJ6.

Expressioni

Gene expression databases

BgeeiQ9BRJ6.
CleanExiHS_C7orf50.
ExpressionAtlasiQ9BRJ6. baseline and differential.
GenevisibleiQ9BRJ6. HS.

Organism-specific databases

HPAiHPA052281.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
THAP1Q9NVV93EBI-751612,EBI-741515

Protein-protein interaction databases

BioGridi124036. 26 interactions.
IntActiQ9BRJ6. 12 interactions.
MINTiMINT-5003494.
STRINGi9606.ENSP00000350011.

Structurei

3D structure databases

ProteinModelPortaliQ9BRJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4829. Eukaryota.
ENOG411268U. LUCA.
GeneTreeiENSGT00390000017838.
HOGENOMiHOG000111595.
HOVERGENiHBG107666.
InParanoidiQ9BRJ6.
OMAiNENRAAW.
OrthoDBiEOG77HDHD.
PhylomeDBiQ9BRJ6.
TreeFamiTF326634.

Family and domain databases

InterProiIPR019327. DUF2373.
[Graphical view]
PfamiPF10180. DUF2373. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BRJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKQKRKVPE VTEKKNKKLK KASAEGPLLG PEAAPSGEGA GSKGEAVLRP
60 70 80 90 100
GLDAEPELSP EEQRVLERKL KKERKKEERQ RLREAGLVAQ HPPARRSGAE
110 120 130 140 150
LALDYLCRWA QKHKNWRFQK TRQTWLLLHM YDSDKVPDEH FSTLLAYLEG
160 170 180 190
LQGRARELTV QKAEALMREL DEEGSDPPLP GRAQRIRQVL QLLS
Length:194
Mass (Da):22,083
Last modified:June 1, 2001 - v1
Checksum:iEDFF8B6A335416F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF495721 mRNA. Translation: AAQ06675.1.
BC006224 mRNA. Translation: AAH06224.1.
CCDSiCCDS5320.1.
RefSeqiNP_001127867.1. NM_001134395.1.
NP_001127868.1. NM_001134396.1.
NP_001305181.1. NM_001318252.1.
NP_115726.1. NM_032350.5.
UniGeneiHs.653258.
Hs.732316.

Genome annotation databases

EnsembliENST00000357429; ENSP00000350011; ENSG00000146540.
ENST00000397098; ENSP00000380286; ENSG00000146540.
ENST00000397100; ENSP00000380288; ENSG00000146540.
GeneIDi84310.
KEGGihsa:84310.
UCSCiuc003sju.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF495721 mRNA. Translation: AAQ06675.1.
BC006224 mRNA. Translation: AAH06224.1.
CCDSiCCDS5320.1.
RefSeqiNP_001127867.1. NM_001134395.1.
NP_001127868.1. NM_001134396.1.
NP_001305181.1. NM_001318252.1.
NP_115726.1. NM_032350.5.
UniGeneiHs.653258.
Hs.732316.

3D structure databases

ProteinModelPortaliQ9BRJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124036. 26 interactions.
IntActiQ9BRJ6. 12 interactions.
MINTiMINT-5003494.
STRINGi9606.ENSP00000350011.

PTM databases

iPTMnetiQ9BRJ6.
PhosphoSiteiQ9BRJ6.

Polymorphism and mutation databases

BioMutaiC7orf50.
DMDMi74732893.

Proteomic databases

EPDiQ9BRJ6.
MaxQBiQ9BRJ6.
PaxDbiQ9BRJ6.
PeptideAtlasiQ9BRJ6.
PRIDEiQ9BRJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357429; ENSP00000350011; ENSG00000146540.
ENST00000397098; ENSP00000380286; ENSG00000146540.
ENST00000397100; ENSP00000380288; ENSG00000146540.
GeneIDi84310.
KEGGihsa:84310.
UCSCiuc003sju.3. human.

Organism-specific databases

CTDi84310.
GeneCardsiC7orf50.
H-InvDBHIX0006412.
HGNCiHGNC:22421. C7orf50.
HPAiHPA052281.
neXtProtiNX_Q9BRJ6.
PharmGKBiPA162380546.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4829. Eukaryota.
ENOG411268U. LUCA.
GeneTreeiENSGT00390000017838.
HOGENOMiHOG000111595.
HOVERGENiHBG107666.
InParanoidiQ9BRJ6.
OMAiNENRAAW.
OrthoDBiEOG77HDHD.
PhylomeDBiQ9BRJ6.
TreeFamiTF326634.

Miscellaneous databases

ChiTaRSiC7orf50. human.
GenomeRNAii84310.
PROiQ9BRJ6.

Gene expression databases

BgeeiQ9BRJ6.
CleanExiHS_C7orf50.
ExpressionAtlasiQ9BRJ6. baseline and differential.
GenevisibleiQ9BRJ6. HS.

Family and domain databases

InterProiIPR019327. DUF2373.
[Graphical view]
PfamiPF10180. DUF2373. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23 AND SER-97, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59 AND SER-97, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59 AND SER-175, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59 AND SER-175, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.

Entry informationi

Entry nameiCG050_HUMAN
AccessioniPrimary (citable) accession number: Q9BRJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.