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Q9BRJ2

- RM45_HUMAN

UniProt

Q9BRJ2 - RM45_HUMAN

Protein

39S ribosomal protein L45, mitochondrial

Gene

MRPL45

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (04 Apr 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L45, mitochondrial
    Short name:
    L45mt
    Short name:
    MRP-L45
    Gene namesi
    Name:MRPL45
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:16651. MRPL45.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: HPA
    2. ribosome Source: UniProtKB-KW

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 30639S ribosomal protein L45, mitochondrialPRO_0000030563
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    MaxQBiQ9BRJ2.
    PaxDbiQ9BRJ2.
    PRIDEiQ9BRJ2.

    PTM databases

    PhosphoSiteiQ9BRJ2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BRJ2.
    BgeeiQ9BRJ2.
    CleanExiHS_MRPL45.
    GenevestigatoriQ9BRJ2.

    Organism-specific databases

    HPAiHPA023373.
    HPA023385.

    Interactioni

    Protein-protein interaction databases

    BioGridi124037. 26 interactions.
    DIPiDIP-53786N.
    IntActiQ9BRJ2. 4 interactions.
    STRINGi9606.ENSP00000308901.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BRJ2.
    SMRiQ9BRJ2. Positions 104-264.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L45 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG276760.
    HOVERGENiHBG044506.
    InParanoidiQ9BRJ2.
    KOiK17426.
    OMAiIVPAWAP.
    PhylomeDBiQ9BRJ2.
    TreeFamiTF105825.

    Family and domain databases

    InterProiIPR007379. Tim44-like_dom.
    [Graphical view]
    PfamiPF04280. Tim44. 1 hit.
    [Graphical view]
    SMARTiSM00978. Tim44. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9BRJ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAPIPQGFS CLSRFLGWWF RQPVLVTQSA AIVPVRTKKR FTPPIYQPKF    50
    KTEKEFMQHA RKAGLVIPPE KSDRSIHLAC TAGIFDAYVP PEGDARISSL 100
    SKEGLIERTE RMKKTMASQV SIRRIKDYDA NFKIKDFPEK AKDIFIEAHL 150
    CLNNSDHDRL HTLVTEHCFP DMTWDIKYKT VRWSFVESLE PSHVVQVRCS 200
    SMMNQGNVYG QITVRMHTRQ TLAIYDRFGR LMYGQEDVPK DVLEYVVFEK 250
    QLTNPYGSWR MHTKIVPPWA PPKQPILKTV MIPGPQLKPE EEYEEAQGEA 300
    QKPQLA 306
    Length:306
    Mass (Da):35,351
    Last modified:April 4, 2003 - v2
    Checksum:iC00CC379D337910A
    GO

    Sequence cautioni

    The sequence BC006235 differs from that shown. Reason: Frameshift at position 40.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti139 – 1391E → G in BAD18730. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti298 – 2981G → V.
    Corresponds to variant rs34749623 [ dbSNP | Ensembl ].
    VAR_061810

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK172741 mRNA. Translation: BAD18730.1.
    BC006235 mRNA. No translation available.
    BC130382 mRNA. Translation: AAI30383.1.
    BC130384 mRNA. Translation: AAI30385.1.
    CCDSiCCDS11326.1.
    UniGeneiHs.537279.
    Hs.744110.

    Genome annotation databases

    KEGGihsa:84311.
    UCSCiuc002hpy.3. human.

    Polymorphism databases

    DMDMi29611869.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK172741 mRNA. Translation: BAD18730.1 .
    BC006235 mRNA. No translation available.
    BC130382 mRNA. Translation: AAI30383.1 .
    BC130384 mRNA. Translation: AAI30385.1 .
    CCDSi CCDS11326.1.
    UniGenei Hs.537279.
    Hs.744110.

    3D structure databases

    ProteinModelPortali Q9BRJ2.
    SMRi Q9BRJ2. Positions 104-264.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124037. 26 interactions.
    DIPi DIP-53786N.
    IntActi Q9BRJ2. 4 interactions.
    STRINGi 9606.ENSP00000308901.

    PTM databases

    PhosphoSitei Q9BRJ2.

    Polymorphism databases

    DMDMi 29611869.

    Proteomic databases

    MaxQBi Q9BRJ2.
    PaxDbi Q9BRJ2.
    PRIDEi Q9BRJ2.

    Protocols and materials databases

    DNASUi 84311.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    KEGGi hsa:84311.
    UCSCi uc002hpy.3. human.

    Organism-specific databases

    CTDi 84311.
    GeneCardsi GC17P036363.
    H-InvDB HIX0013754.
    HIX0039493.
    HGNCi HGNC:16651. MRPL45.
    HPAi HPA023373.
    HPA023385.
    MIMi 611850. gene.
    neXtProti NX_Q9BRJ2.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG276760.
    HOVERGENi HBG044506.
    InParanoidi Q9BRJ2.
    KOi K17426.
    OMAi IVPAWAP.
    PhylomeDBi Q9BRJ2.
    TreeFami TF105825.

    Miscellaneous databases

    ChiTaRSi MRPL45. human.
    GenomeRNAii 84311.
    NextBioi 74004.
    PROi Q9BRJ2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BRJ2.
    Bgeei Q9BRJ2.
    CleanExi HS_MRPL45.
    Genevestigatori Q9BRJ2.

    Family and domain databases

    InterProi IPR007379. Tim44-like_dom.
    [Graphical view ]
    Pfami PF04280. Tim44. 1 hit.
    [Graphical view ]
    SMARTi SM00978. Tim44. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Adipose tissue.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Ovary.
    3. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
      Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
      J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM45_HUMAN
    AccessioniPrimary (citable) accession number: Q9BRJ2
    Secondary accession number(s): A1L436, Q6ZMJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2003
    Last sequence update: April 4, 2003
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3