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Q9BRJ2 (RM45_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
39S ribosomal protein L45, mitochondrial

Short name=L45mt
Short name=MRP-L45
Gene names
Name:MRPL45
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Mitochondrion.

Sequence similarities

Belongs to the ribosomal protein L45 family.

Sequence caution

The sequence BC006235 differs from that shown. Reason: Frameshift at position 40.

Ontologies

Keywords
   Cellular componentMitochondrion
   Coding sequence diversityPolymorphism
   DomainTransit peptide
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentmitochondrion

Inferred from direct assay. Source: HPA

ribosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 30639S ribosomal protein L45, mitochondrialPRO_0000030563

Natural variations

Natural variant2981G → V.
Corresponds to variant rs34749623 [ dbSNP | Ensembl ].
VAR_061810

Experimental info

Sequence conflict1391E → G in BAD18730. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9BRJ2 [UniParc].

Last modified April 4, 2003. Version 2.
Checksum: C00CC379D337910A

FASTA30635,351
        10         20         30         40         50         60 
MAAPIPQGFS CLSRFLGWWF RQPVLVTQSA AIVPVRTKKR FTPPIYQPKF KTEKEFMQHA 

        70         80         90        100        110        120 
RKAGLVIPPE KSDRSIHLAC TAGIFDAYVP PEGDARISSL SKEGLIERTE RMKKTMASQV 

       130        140        150        160        170        180 
SIRRIKDYDA NFKIKDFPEK AKDIFIEAHL CLNNSDHDRL HTLVTEHCFP DMTWDIKYKT 

       190        200        210        220        230        240 
VRWSFVESLE PSHVVQVRCS SMMNQGNVYG QITVRMHTRQ TLAIYDRFGR LMYGQEDVPK 

       250        260        270        280        290        300 
DVLEYVVFEK QLTNPYGSWR MHTKIVPPWA PPKQPILKTV MIPGPQLKPE EEYEEAQGEA 


QKPQLA 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Adipose tissue.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Ovary.
[3]"The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK172741 mRNA. Translation: BAD18730.1.
BC006235 mRNA. No translation available.
BC130382 mRNA. Translation: AAI30383.1.
BC130384 mRNA. Translation: AAI30385.1.
RefSeqNP_001265208.1. NM_001278279.1.
NP_115727.4. NM_032351.4.
UniGeneHs.537279.
Hs.744110.

3D structure databases

ProteinModelPortalQ9BRJ2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124037. 26 interactions.
DIPDIP-53786N.
IntActQ9BRJ2. 4 interactions.
STRING9606.ENSP00000308901.

PTM databases

PhosphoSiteQ9BRJ2.

Polymorphism databases

DMDM29611869.

Proteomic databases

PaxDbQ9BRJ2.
PRIDEQ9BRJ2.

Protocols and materials databases

DNASU84311.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000312513; ENSP00000308901; ENSG00000174100.
ENST00000570192; ENSP00000454228; ENSG00000259980.
GeneID84311.
KEGGhsa:84311.
UCSCuc002hpy.3. human.

Organism-specific databases

CTD84311.
GeneCardsGC17P036363.
H-InvDBHIX0013754.
HIX0039493.
HGNCHGNC:16651. MRPL45.
HPAHPA023373.
HPA023385.
MIM611850. gene.
neXtProtNX_Q9BRJ2.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG276760.
HOVERGENHBG044506.
InParanoidQ9BRJ2.
KOK17426.
OMAERHLVNP.
PhylomeDBQ9BRJ2.
TreeFamTF105825.

Gene expression databases

ArrayExpressQ9BRJ2.
BgeeQ9BRJ2.
CleanExHS_MRPL45.
GenevestigatorQ9BRJ2.

Family and domain databases

InterProIPR007379. Tim44-like_dom.
[Graphical view]
PfamPF04280. Tim44. 1 hit.
[Graphical view]
SMARTSM00978. Tim44. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMRPL45. human.
GenomeRNAi84311.
NextBio74004.
PROQ9BRJ2.
SOURCESearch...

Entry information

Entry nameRM45_HUMAN
AccessionPrimary (citable) accession number: Q9BRJ2
Secondary accession number(s): A1L436, Q6ZMJ5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: April 4, 2003
Last modified: April 16, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM