Q9BRJ2 (RM45_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
39S ribosomal protein L45, mitochondrial
Short name=L45mt
Short name=MRP-L45

Gene names

Name:

MRPL45

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the ribosomal protein L45 family.
Sequence caution	The sequence BC006235 differs from that shown. Reason: Frameshift at position 40.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Polymorphism
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular protein transport Inferred from electronic annotation. Source: InterPro translation Non-traceable author statement. Source: UniProtKB
Cellular_component	mitochondrial inner membrane presequence translocase complex Inferred from electronic annotation. Source: InterPro mitochondrion Non-traceable author statement. Source: UniProtKB ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	P-P-bond-hydrolysis-driven protein transmembrane transporter activity Inferred from electronic annotation. Source: InterPro structural constituent of ribosome Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 306		39S ribosomal protein L45, mitochondrial		PRO_0000030563
Natural variations
	Natural variant	298	1	G → V. Corresponds to variant rs34749623 [ dbSNP | Ensembl ].		VAR_061810
Experimental info
	Sequence conflict	139	1	E → G in BAD18730. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9BRJ2 [UniParc]. Last modified April 4, 2003. Version 2. Checksum: C00CC379D337910A	FASTA	306	35,351
	10 20 30 40 50 60 MAAPIPQGFS CLSRFLGWWF RQPVLVTQSA AIVPVRTKKR FTPPIYQPKF KTEKEFMQHA 70 80 90 100 110 120 RKAGLVIPPE KSDRSIHLAC TAGIFDAYVP PEGDARISSL SKEGLIERTE RMKKTMASQV 130 140 150 160 170 180 SIRRIKDYDA NFKIKDFPEK AKDIFIEAHL CLNNSDHDRL HTLVTEHCFP DMTWDIKYKT 190 200 210 220 230 240 VRWSFVESLE PSHVVQVRCS SMMNQGNVYG QITVRMHTRQ TLAIYDRFGR LMYGQEDVPK 250 260 270 280 290 300 DVLEYVVFEK QLTNPYGSWR MHTKIVPPWA PPKQPILKTV MIPGPQLKPE EEYEEAQGEA QKPQLA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adipose tissue.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Ovary.
[3]	"The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present." Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L. J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK172741 mRNA. Translation: BAD18730.1. BC006235 mRNA. No translation available. BC130382 mRNA. Translation: AAI30383.1. BC130384 mRNA. Translation: AAI30385.1.
IPI	IPI00790292.
RefSeq	NP_115727.4. NM_032351.4.
UniGene	Hs.537279. Hs.731941.
3D structure databases
ProteinModelPortal	Q9BRJ2.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-53786N.
IntAct	Q9BRJ2. 4 interactions.
STRING	9606.ENSP00000308901.
PTM databases
PhosphoSite	Q9BRJ2.
Polymorphism databases
DMDM	29611869.
Proteomic databases
PaxDb	Q9BRJ2.
PRIDE	Q9BRJ2.
Protocols and materials databases
DNASU	84311.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000312513; ENSP00000308901; ENSG00000174100. ENST00000570192; ENSP00000454228; ENSG00000259980.
GeneID	84311.
KEGG	hsa:84311.
UCSC	uc002hpy.3. human.
Organism-specific databases
CTD	84311.
GeneCards	GC17P036363.
H-InvDB	HIX0013754. HIX0039493.
HGNC	HGNC:16651. MRPL45.
HPA	HPA023373. HPA023385.
MIM	611850. gene.
neXtProt	NX_Q9BRJ2.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG276760.
HOVERGEN	HBG044506.
InParanoid	Q9BRJ2.
OMA	HCFPDMV.
OrthoDB	EOG4HHP2V.
Gene expression databases
Bgee	Q9BRJ2.
CleanEx	HS_MRPL45.
Genevestigator	Q9BRJ2.
GermOnline	ENSG00000174100. Homo sapiens.
Family and domain databases
InterPro	IPR007379. Tim44-related/Ribosome_L45. [Graphical view]
Pfam	PF04280. Tim44. 1 hit. [Graphical view]
SMART	SM00978. Tim44. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MRPL45. human.
GenomeRNAi	84311.
NextBio	74004.
SOURCE	Search...

Entry information

Entry name

RM45_HUMAN

Accession

Primary (citable) accession number: Q9BRJ2
Secondary accession number(s): A1L436, Q6ZMJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2003
Last sequence update:	April 4, 2003
Last modified:	April 3, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.