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Protein

39S ribosomal protein L45, mitochondrial

Gene

MRPL45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L45, mitochondrial
Short name:
L45mt
Short name:
MRP-L45
Gene namesi
Name:MRPL45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:16651. MRPL45.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial large ribosomal subunit Source: UniProtKB
  • mitochondrion Source: GO_Central

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000277936.

Polymorphism and mutation databases

BioMutaiMRPL45.
DMDMi29611869.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030563? – 30639S ribosomal protein L45, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ9BRJ2.
MaxQBiQ9BRJ2.
PaxDbiQ9BRJ2.
PeptideAtlasiQ9BRJ2.
PRIDEiQ9BRJ2.

PTM databases

iPTMnetiQ9BRJ2.
PhosphoSitePlusiQ9BRJ2.
SwissPalmiQ9BRJ2.

Expressioni

Gene expression databases

BgeeiENSG00000174100.
CleanExiHS_MRPL45.

Organism-specific databases

HPAiHPA023373.
HPA023385.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIM23P364063EBI-2514313,EBI-740098

Protein-protein interaction databases

DIPiDIP-53786N.
IntActiQ9BRJ2. 21 interactors.
STRINGi9606.ENSP00000308901.

Structurei

Secondary structure

1306
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi118 – 129Combined sources12
Beta strandi134 – 136Combined sources3
Helixi137 – 154Combined sources18
Helixi157 – 160Combined sources4
Helixi168 – 173Combined sources6
Beta strandi174 – 181Combined sources8
Beta strandi184 – 188Combined sources5
Beta strandi193 – 198Combined sources6
Beta strandi209 – 221Combined sources13
Beta strandi227 – 229Combined sources3
Beta strandi240 – 251Combined sources12
Beta strandi260 – 264Combined sources5
Beta strandi280 – 282Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40d1-306[»]
3J9Melectron microscopy3.50d1-306[»]
ProteinModelPortaliQ9BRJ2.
SMRiQ9BRJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L45 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4599. Eukaryota.
ENOG411019B. LUCA.
HOVERGENiHBG044506.
InParanoidiQ9BRJ2.
OMAiWNEETIF.
OrthoDBiEOG090A09N1.
PhylomeDBiQ9BRJ2.
TreeFamiTF105825.

Family and domain databases

InterProiView protein in InterPro
IPR032710. NTF2-like_dom.
IPR007379. Tim44-like_dom.
PfamiView protein in Pfam
PF04280. Tim44. 1 hit.
SMARTiView protein in SMART
SM00978. Tim44. 1 hit.
SUPFAMiSSF54427. SSF54427. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BRJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPIPQGFS CLSRFLGWWF RQPVLVTQSA AIVPVRTKKR FTPPIYQPKF
60 70 80 90 100
KTEKEFMQHA RKAGLVIPPE KSDRSIHLAC TAGIFDAYVP PEGDARISSL
110 120 130 140 150
SKEGLIERTE RMKKTMASQV SIRRIKDYDA NFKIKDFPEK AKDIFIEAHL
160 170 180 190 200
CLNNSDHDRL HTLVTEHCFP DMTWDIKYKT VRWSFVESLE PSHVVQVRCS
210 220 230 240 250
SMMNQGNVYG QITVRMHTRQ TLAIYDRFGR LMYGQEDVPK DVLEYVVFEK
260 270 280 290 300
QLTNPYGSWR MHTKIVPPWA PPKQPILKTV MIPGPQLKPE EEYEEAQGEA

QKPQLA
Length:306
Mass (Da):35,351
Last modified:April 4, 2003 - v2
Checksum:iC00CC379D337910A
GO

Sequence cautioni

The sequence BC006235 differs from that shown. Reason: Frameshift at position 40.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti139E → G in BAD18730 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061810298G → V. Corresponds to variant dbSNP:rs34749623Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172741 mRNA. Translation: BAD18730.1.
BC006235 mRNA. No translation available.
BC130382 mRNA. Translation: AAI30383.1.
BC130384 mRNA. Translation: AAI30385.1.
CCDSiCCDS11326.1.
UniGeneiHs.537279.
Hs.744110.

Genome annotation databases

EnsembliENST00000621878; ENSP00000483030; ENSG00000277936.
UCSCiuc032gks.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172741 mRNA. Translation: BAD18730.1.
BC006235 mRNA. No translation available.
BC130382 mRNA. Translation: AAI30383.1.
BC130384 mRNA. Translation: AAI30385.1.
CCDSiCCDS11326.1.
UniGeneiHs.537279.
Hs.744110.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40d1-306[»]
3J9Melectron microscopy3.50d1-306[»]
ProteinModelPortaliQ9BRJ2.
SMRiQ9BRJ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-53786N.
IntActiQ9BRJ2. 21 interactors.
STRINGi9606.ENSP00000308901.

PTM databases

iPTMnetiQ9BRJ2.
PhosphoSitePlusiQ9BRJ2.
SwissPalmiQ9BRJ2.

Polymorphism and mutation databases

BioMutaiMRPL45.
DMDMi29611869.

Proteomic databases

EPDiQ9BRJ2.
MaxQBiQ9BRJ2.
PaxDbiQ9BRJ2.
PeptideAtlasiQ9BRJ2.
PRIDEiQ9BRJ2.

Protocols and materials databases

DNASUi84311.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000621878; ENSP00000483030; ENSG00000277936.
UCSCiuc032gks.2. human.

Organism-specific databases

GeneCardsiMRPL45.
H-InvDBHIX0013754.
HIX0039493.
HGNCiHGNC:16651. MRPL45.
HPAiHPA023373.
HPA023385.
MIMi611850. gene.
neXtProtiNX_Q9BRJ2.
OpenTargetsiENSG00000277936.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4599. Eukaryota.
ENOG411019B. LUCA.
HOVERGENiHBG044506.
InParanoidiQ9BRJ2.
OMAiWNEETIF.
OrthoDBiEOG090A09N1.
PhylomeDBiQ9BRJ2.
TreeFamiTF105825.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPL45. human.
PROiQ9BRJ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174100.
CleanExiHS_MRPL45.

Family and domain databases

InterProiView protein in InterPro
IPR032710. NTF2-like_dom.
IPR007379. Tim44-like_dom.
PfamiView protein in Pfam
PF04280. Tim44. 1 hit.
SMARTiView protein in SMART
SM00978. Tim44. 1 hit.
SUPFAMiSSF54427. SSF54427. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRM45_HUMAN
AccessioniPrimary (citable) accession number: Q9BRJ2
Secondary accession number(s): A1L436, Q6ZMJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: April 4, 2003
Last modified: February 15, 2017
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.