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Protein

Zinc finger protein 251

Gene

ZNF251

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri209 – 23123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri237 – 25923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri461 – 48323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri489 – 51123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri566 – 58823C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri594 – 61623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri622 – 64423C2H2-type 14; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 251
Gene namesi
Name:ZNF251
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:13045. ZNF251.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37623.

Polymorphism and mutation databases

BioMutaiZNF251.
DMDMi317373550.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 671671Zinc finger protein 251PRO_0000047485Add
BLAST

Proteomic databases

EPDiQ9BRH9.
MaxQBiQ9BRH9.
PaxDbiQ9BRH9.
PeptideAtlasiQ9BRH9.
PRIDEiQ9BRH9.

PTM databases

iPTMnetiQ9BRH9.
PhosphoSiteiQ9BRH9.

Expressioni

Gene expression databases

BgeeiQ9BRH9.
CleanExiHS_ZNF251.
ExpressionAtlasiQ9BRH9. baseline and differential.
GenevisibleiQ9BRH9. HS.

Organism-specific databases

HPAiHPA018290.

Interactioni

Protein-protein interaction databases

BioGridi124784. 6 interactions.
IntActiQ9BRH9. 3 interactions.
MINTiMINT-1200327.
STRINGi9606.ENSP00000292562.

Structurei

3D structure databases

ProteinModelPortaliQ9BRH9.
SMRiQ9BRH9. Positions 183-649.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 8672KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri209 – 23123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri237 – 25923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri461 – 48323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri489 – 51123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri566 – 58823C2H2-type 12; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri594 – 61623C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri622 – 64423C2H2-type 14; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129726.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9BRH9.
KOiK09228.
OMAiRCGRAFT.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9BRH9.
TreeFamiTF350822.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BRH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATFQLPGH QEMPLTFQDV AVYFSQAEGR QLGPQQRALY RDVMLENYGN
60 70 80 90 100
VASLGFPVPK PELISQLEQG KELWVLNLLG AEEPDILKSC QKDSEVGTKK
110 120 130 140 150
ELSILNQKFS EEVKTPEFVS RRLLRDNAQA AEFREAWGRE GKLKERVGNS
160 170 180 190 200
AGQSLNKPNI HKRVLTEATV GRERSLGERT QECSAFDRNL NLDQNVVRLQ
210 220 230 240 250
RNKTGERVFK CDICSKTFKY NSDLSRHQRS HTGEKPYECG RCGRAFTHSS
260 270 280 290 300
NLVLHHHIHT GNKPFKCDEC GKTFGLNSHL RLHRRIHTGE KPFGCGECGK
310 320 330 340 350
AFSRSSTLIQ HRIIHTGEKP YKCNECGRGF SQSPQLTQHQ RIHTGEKPHE
360 370 380 390 400
CSHCGKAFSR SSSLIQHERI HTGEKPHKCN QCGKAFSQSS SLFLHHRVHT
410 420 430 440 450
GEKPYVCNEC GRAFGFNSHL TEHVRIHTGE KPYVCNECGK AFRRSSTLVQ
460 470 480 490 500
HRRVHTGEKP YQCVECGKAF SQSSQLTLHQ RVHTGEKPYD CGDCGKAFSR
510 520 530 540 550
RSTLIQHQKV HSGETRKCRK HGPAFVHGSS LTADGQIPTG EKHGRAFNHG
560 570 580 590 600
ANLILRWTVH TGEKSFGCNE YGKAFSPTSR PTEDQIMHAG EKPYKCQECG
610 620 630 640 650
NAFSGKSTLI QHQVTHTGQK PCHCSVYGKA FSQSSQLTPP QQTRVGEKPA
660 670
LNDGSKRYFI HIKKIFQERH F
Length:671
Mass (Da):75,763
Last modified:January 11, 2011 - v4
Checksum:iBDD04357D9D7825F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti204 – 2041T → A in AK000435 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000435 mRNA. No translation available.
AF186192 Genomic DNA. No translation available.
BC006258 mRNA. Translation: AAH06258.2.
BC112137 mRNA. Translation: AAI12138.1.
CCDSiCCDS47944.1.
RefSeqiNP_612376.1. NM_138367.1.
UniGeneiHs.534516.

Genome annotation databases

EnsembliENST00000292562; ENSP00000292562; ENSG00000198169.
ENST00000612318; ENSP00000477765; ENSG00000278062.
GeneIDi90987.
KEGGihsa:90987.
UCSCiuc003zdv.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000435 mRNA. No translation available.
AF186192 Genomic DNA. No translation available.
BC006258 mRNA. Translation: AAH06258.2.
BC112137 mRNA. Translation: AAI12138.1.
CCDSiCCDS47944.1.
RefSeqiNP_612376.1. NM_138367.1.
UniGeneiHs.534516.

3D structure databases

ProteinModelPortaliQ9BRH9.
SMRiQ9BRH9. Positions 183-649.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124784. 6 interactions.
IntActiQ9BRH9. 3 interactions.
MINTiMINT-1200327.
STRINGi9606.ENSP00000292562.

PTM databases

iPTMnetiQ9BRH9.
PhosphoSiteiQ9BRH9.

Polymorphism and mutation databases

BioMutaiZNF251.
DMDMi317373550.

Proteomic databases

EPDiQ9BRH9.
MaxQBiQ9BRH9.
PaxDbiQ9BRH9.
PeptideAtlasiQ9BRH9.
PRIDEiQ9BRH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292562; ENSP00000292562; ENSG00000198169.
ENST00000612318; ENSP00000477765; ENSG00000278062.
GeneIDi90987.
KEGGihsa:90987.
UCSCiuc003zdv.5. human.

Organism-specific databases

CTDi90987.
GeneCardsiZNF251.
HGNCiHGNC:13045. ZNF251.
HPAiHPA018290.
neXtProtiNX_Q9BRH9.
PharmGKBiPA37623.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129726.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9BRH9.
KOiK09228.
OMAiRCGRAFT.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9BRH9.
TreeFamiTF350822.

Miscellaneous databases

ChiTaRSiZNF251. human.
GenomeRNAii90987.
PROiQ9BRH9.

Gene expression databases

BgeeiQ9BRH9.
CleanExiHS_ZNF251.
ExpressionAtlasiQ9BRH9. baseline and differential.
GenevisibleiQ9BRH9. HS.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 379-671.
    Tissue: Brain and Ovary.

Entry informationi

Entry nameiZN251_HUMAN
AccessioniPrimary (citable) accession number: Q9BRH9
Secondary accession number(s): Q2M219
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: January 11, 2011
Last modified: July 6, 2016
This is version 124 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.