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Q9BRG2

- SH23A_HUMAN

UniProt

Q9BRG2 - SH23A_HUMAN

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Protein

SH2 domain-containing protein 3A

Gene
SH2D3A, NSP1, UNQ175/PRO201
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in JNK activation.

GO - Molecular functioni

  1. guanyl-nucleotide exchange factor activity Source: InterPro
  2. SH3/SH2 adaptor activity Source: ProtInc

GO - Biological processi

  1. JNK cascade Source: ProtInc
  2. positive regulation of signal transduction Source: GOC
  3. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ9BRG2.

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing protein 3A
Alternative name(s):
Novel SH2-containing protein 1
Gene namesi
Name:SH2D3A
Synonyms:NSP1
ORF Names:UNQ175/PRO201
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:16885. SH2D3A.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi95 – 951Y → F: Loss of phosphorylation. 1 Publication
Mutagenesisi231 – 2311Y → F: Weak phosphorylation. 1 Publication

Organism-specific databases

PharmGKBiPA38192.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576SH2 domain-containing protein 3APRO_0000233132Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei123 – 1231Phosphoserine2 Publications
Modified residuei125 – 1251Phosphoserine2 Publications
Modified residuei147 – 1471Phosphoserine1 Publication
Modified residuei180 – 1801Phosphoserine2 Publications

Post-translational modificationi

Phosphorylated on tyrosine.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9BRG2.
PaxDbiQ9BRG2.
PRIDEiQ9BRG2.

PTM databases

PhosphoSiteiQ9BRG2.

Expressioni

Tissue specificityi

Weakly expressed in placenta, fetal kidney, fetal lung, adult pancreas, adult kidney and adult lung.1 Publication

Gene expression databases

ArrayExpressiQ9BRG2.
BgeeiQ9BRG2.
CleanExiHS_SH2D3A.
GenevestigatoriQ9BRG2.

Organism-specific databases

HPAiHPA035722.

Interactioni

Subunit structurei

Interacts with BCAR1.1 Publication

Protein-protein interaction databases

BioGridi115356. 7 interactions.
IntActiQ9BRG2. 4 interactions.
MINTiMINT-1498531.
STRINGi9606.ENSP00000245908.

Structurei

3D structure databases

ProteinModelPortaliQ9BRG2.
SMRiQ9BRG2. Positions 15-97.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 114100SH2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi259 – 2679Poly-Glu

Sequence similaritiesi

Contains 1 SH2 domain.

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG148579.
HOGENOMiHOG000231595.
HOVERGENiHBG053174.
InParanoidiQ9BRG2.
OMAiGCSGPLE.
OrthoDBiEOG7J9VPN.
PhylomeDBiQ9BRG2.
TreeFamiTF323756.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
IPR000980. SH2.
[Graphical view]
PfamiPF00617. RasGEF. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BRG2-1 [UniParc]FASTAAdd to Basket

« Hide

MQVPQDGEDL AGQPWYHGLL SRQKAEALLQ QNGDFLVRAS GSRGGNPVIS    50
CRWRGSALHF EVFRVALRPR PGRPTALFQL EDEQFPSIPA LVHSYMTGRR 100
PLSQATGAVV SRPVTWQGPL RRSFSEDTLM DGPARIEPLR ARKWSNSQPA 150
DLAHMGRSRE DPAGMEASTM PISALPRTSS DPVLLKAPAP LGTVADSLRA 200
SDGQLQAKAP TKPPRTPSFE LPDASERPPT YCELVPRVPS VQGTSPSQSC 250
PEPEAPWWEA EEDEEEENRC FTRPQAEISF CPHDAPSCLL GPQNRPLEPQ 300
VLHTLRGLFL EHHPGSTALH LLLVDCQATG LLGVTRDQRG NMGVSSGLEL 350
LTLPHGHHLR LELLERHQTL ALAGALAVLG CSGPLEERAA ALRGLVELAL 400
ALRPGAAGDL PGLAAVMGAL LMPQVSRLEH TWRQLRRSHT EAALAFEQEL 450
KPLMRALDEG AGPCDPGEVA LPHVAPMVRL LEGEEVAGPL DESCERLLRT 500
LHGARHMVRD APKFRKVAAQ RLRGFRPNPE LREALTTGFV RRLLWGSRGA 550
GAPRAERFEK FQRVLGVLSQ RLEPDR 576
Length:576
Mass (Da):63,093
Last modified:June 1, 2001 - v1
Checksum:i2909F7632B61F18D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti32 – 321N → D.2 Publications
Corresponds to variant rs7258236 [ dbSNP | Ensembl ].
VAR_026054
Natural varianti223 – 2231D → G.
Corresponds to variant rs12608960 [ dbSNP | Ensembl ].
VAR_051349
Natural varianti265 – 2651E → G in a breast cancer sample; somatic mutation. 1 Publication
VAR_035989

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF124249 mRNA. Translation: AAD28244.1.
AY358406 mRNA. Translation: AAQ88772.1.
AK292781 mRNA. Translation: BAF85470.1.
CH471139 Genomic DNA. Translation: EAW69059.1.
BC006281 mRNA. Translation: AAH06281.1.
CCDSiCCDS12173.1.
RefSeqiNP_005481.2. NM_005490.2.
UniGeneiHs.439645.

Genome annotation databases

EnsembliENST00000245908; ENSP00000245908; ENSG00000125731.
GeneIDi10045.
KEGGihsa:10045.
UCSCiuc002mft.3. human.

Polymorphism databases

DMDMi74732879.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF124249 mRNA. Translation: AAD28244.1 .
AY358406 mRNA. Translation: AAQ88772.1 .
AK292781 mRNA. Translation: BAF85470.1 .
CH471139 Genomic DNA. Translation: EAW69059.1 .
BC006281 mRNA. Translation: AAH06281.1 .
CCDSi CCDS12173.1.
RefSeqi NP_005481.2. NM_005490.2.
UniGenei Hs.439645.

3D structure databases

ProteinModelPortali Q9BRG2.
SMRi Q9BRG2. Positions 15-97.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115356. 7 interactions.
IntActi Q9BRG2. 4 interactions.
MINTi MINT-1498531.
STRINGi 9606.ENSP00000245908.

PTM databases

PhosphoSitei Q9BRG2.

Polymorphism databases

DMDMi 74732879.

Proteomic databases

MaxQBi Q9BRG2.
PaxDbi Q9BRG2.
PRIDEi Q9BRG2.

Protocols and materials databases

DNASUi 10045.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000245908 ; ENSP00000245908 ; ENSG00000125731 .
GeneIDi 10045.
KEGGi hsa:10045.
UCSCi uc002mft.3. human.

Organism-specific databases

CTDi 10045.
GeneCardsi GC19M006752.
HGNCi HGNC:16885. SH2D3A.
HPAi HPA035722.
MIMi 604721. gene.
neXtProti NX_Q9BRG2.
PharmGKBi PA38192.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148579.
HOGENOMi HOG000231595.
HOVERGENi HBG053174.
InParanoidi Q9BRG2.
OMAi GCSGPLE.
OrthoDBi EOG7J9VPN.
PhylomeDBi Q9BRG2.
TreeFami TF323756.

Enzyme and pathway databases

SignaLinki Q9BRG2.

Miscellaneous databases

GeneWikii SH2D3A.
GenomeRNAii 10045.
NextBioi 37943.
PROi Q9BRG2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BRG2.
Bgeei Q9BRG2.
CleanExi HS_SH2D3A.
Genevestigatori Q9BRG2.

Family and domain databases

Gene3Di 1.10.840.10. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
IPR000980. SH2.
[Graphical view ]
Pfami PF00617. RasGEF. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
SMARTi SM00252. SH2. 1 hit.
[Graphical view ]
SUPFAMi SSF48366. SSF48366. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway."
    Lu Y., Brush J., Stewart T.A.
    J. Biol. Chem. 274:10047-10052(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, PHOSPHORYLATION, INTERACTION WITH BCAR1, MUTAGENESIS OF TYR-95 AND TYR-231, VARIANT ASP-32.
    Tissue: Fetal kidney.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-32.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-123; SER-125 AND SER-180, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-123, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-125; SER-147 AND SER-180, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-265.

Entry informationi

Entry nameiSH23A_HUMAN
AccessioniPrimary (citable) accession number: Q9BRG2
Secondary accession number(s): A8K9R6, Q9Y2X4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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