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Protein

Serine/threonine-protein phosphatase CPPED1

Gene

CPPED1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.2 Publications

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.1 Publication

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Divalent metal cation 1By similarity1
Metal bindingi90Divalent metal cation 1By similarity1
Metal bindingi90Divalent metal cation 2By similarity1
Metal bindingi127Divalent metal cation 2By similarity1
Metal bindingi247Divalent metal cation 2By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase CPPED1 (EC:3.1.3.16)
Alternative name(s):
Calcineurin-like phosphoesterase domain-containing protein 1
Complete S-transactivated protein 1
Gene namesi
Name:CPPED1
Synonyms:CSTP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:25632. CPPED1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • extracellular exosome Source: UniProtKB
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi55313.
OpenTargetsiENSG00000103381.
PharmGKBiPA164718110.

Polymorphism and mutation databases

BioMutaiCPPED1.
DMDMi317373448.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003205561 – 314Serine/threonine-protein phosphatase CPPED1Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineCombined sources1
Modified residuei294PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BRF8.
MaxQBiQ9BRF8.
PaxDbiQ9BRF8.
PeptideAtlasiQ9BRF8.
PRIDEiQ9BRF8.

PTM databases

iPTMnetiQ9BRF8.
PhosphoSitePlusiQ9BRF8.

Expressioni

Tissue specificityi

Expressed in subcutaneous adipose tissue.1 Publication

Developmental stagei

Expression levels are slightly decreased in subcutaneous adipose tissue following weight loss. Expression levels may be not affected by preadipocyte differentiation.1 Publication

Inductioni

Transactivated by the large envelope protein of the hepatitis B virus (HBV).1 Publication

Gene expression databases

BgeeiENSG00000103381.
GenevisibleiQ9BRF8. HS.

Organism-specific databases

HPAiHPA040938.
HPA041970.

Interactioni

Protein-protein interaction databases

BioGridi120595. 5 interactors.
IntActiQ9BRF8. 1 interactor.
STRINGi9606.ENSP00000371193.

Structurei

3D structure databases

ProteinModelPortaliQ9BRF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni47 – 250CatalyticAdd BLAST204

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IP70. Eukaryota.
ENOG410ZI1D. LUCA.
GeneTreeiENSGT00390000008676.
HOGENOMiHOG000291782.
InParanoidiQ9BRF8.
OMAiGCQLGED.
OrthoDBiEOG091G0OHW.
PhylomeDBiQ9BRF8.
TreeFamiTF329406.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BRF8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAAEAGGVF HRARGRTLAA FPAEKESEWK GPFYFILGAD PQFGLIKAWS
60 70 80 90 100
TGDCDNGGDE WEQEIRLTEQ AVQAINKLNP KPKFFVLCGD LIHAMPGKPW
110 120 130 140 150
RTEQTEDLKR VLRAVDRAIP LVLVSGNHDI GNTPTAETVE EFCRTWGDDY
160 170 180 190 200
FSFWVGGVLF LVLNSQFYEN PSKCPSLKQA QDQWLDEQLS IARQRHCQHA
210 220 230 240 250
IVFQHIPLFL ESIDEDDDYY FNLSKSTRKK LADKFIHAGV KVVFSGHYHR
260 270 280 290 300
NAGGTYQNLD MVVSSAIGCQ LGRDPHGLRV VVVTAEKIVH RYYSLDELSE
310
KGIEDDLMDL IKKK
Length:314
Mass (Da):35,548
Last modified:January 11, 2011 - v3
Checksum:iD2DC770103053DA7
GO
Isoform 2 (identifier: Q9BRF8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-238: Missing.

Note: No experimental confirmation available.
Show »
Length:172
Mass (Da):19,036
Checksum:i63E35E20517FFCF7
GO
Isoform 3 (identifier: Q9BRF8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-122: GKPWRTEQTEDLKRVLRAVDRAIPLV → AGQRPPRAPSRGGHRRENCSPILQSR
     123-314: Missing.

Note: No experimental confirmation available.
Show »
Length:122
Mass (Da):13,462
Checksum:iA884324ECCA5FAF3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47K → R in CAE45887 (PubMed:17974005).Curated1
Sequence conflicti77K → E in BAA92034 (PubMed:14702039).Curated1
Sequence conflicti148D → Y in BAB14194 (PubMed:14702039).Curated1
Sequence conflicti230K → E in BAA92034 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03920419A → D.3 PublicationsCorresponds to variant rs3748976dbSNPEnsembl.1
Natural variantiVAR_03920586V → I.Corresponds to variant rs3748980dbSNPEnsembl.1
Natural variantiVAR_039206241K → R.Combined sources4 PublicationsCorresponds to variant rs1713480dbSNPEnsembl.1
Natural variantiVAR_039207290H → P.Corresponds to variant rs11645068dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03165897 – 238Missing in isoform 2. 1 PublicationAdd BLAST142
Alternative sequenceiVSP_05521897 – 122GKPWR…AIPLV → AGQRPPRAPSRGGHRRENCS PILQSR in isoform 3. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_055219123 – 314Missing in isoform 3. 1 PublicationAdd BLAST192

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY553877 mRNA. Translation: AAS64575.1.
AK002013 mRNA. Translation: BAA92034.1.
AK022710 mRNA. Translation: BAB14194.1.
AK298662 mRNA. Translation: BAG60830.1.
BX640805 mRNA. Translation: CAE45887.1.
AC010333 Genomic DNA. No translation available.
AC092324 Genomic DNA. No translation available.
AC109597 Genomic DNA. No translation available.
BC006289 mRNA. Translation: AAH06289.1.
CCDSiCCDS42119.1. [Q9BRF8-2]
CCDS42120.1. [Q9BRF8-1]
RefSeqiNP_001092925.1. NM_001099455.1. [Q9BRF8-2]
NP_060810.2. NM_018340.2. [Q9BRF8-1]
UniGeneiHs.460002.

Genome annotation databases

EnsembliENST00000261660; ENSP00000261660; ENSG00000103381. [Q9BRF8-3]
ENST00000381774; ENSP00000371193; ENSG00000103381. [Q9BRF8-1]
ENST00000433677; ENSP00000411127; ENSG00000103381. [Q9BRF8-2]
GeneIDi55313.
KEGGihsa:55313.
UCSCiuc002dca.5. human. [Q9BRF8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY553877 mRNA. Translation: AAS64575.1.
AK002013 mRNA. Translation: BAA92034.1.
AK022710 mRNA. Translation: BAB14194.1.
AK298662 mRNA. Translation: BAG60830.1.
BX640805 mRNA. Translation: CAE45887.1.
AC010333 Genomic DNA. No translation available.
AC092324 Genomic DNA. No translation available.
AC109597 Genomic DNA. No translation available.
BC006289 mRNA. Translation: AAH06289.1.
CCDSiCCDS42119.1. [Q9BRF8-2]
CCDS42120.1. [Q9BRF8-1]
RefSeqiNP_001092925.1. NM_001099455.1. [Q9BRF8-2]
NP_060810.2. NM_018340.2. [Q9BRF8-1]
UniGeneiHs.460002.

3D structure databases

ProteinModelPortaliQ9BRF8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120595. 5 interactors.
IntActiQ9BRF8. 1 interactor.
STRINGi9606.ENSP00000371193.

PTM databases

iPTMnetiQ9BRF8.
PhosphoSitePlusiQ9BRF8.

Polymorphism and mutation databases

BioMutaiCPPED1.
DMDMi317373448.

Proteomic databases

EPDiQ9BRF8.
MaxQBiQ9BRF8.
PaxDbiQ9BRF8.
PeptideAtlasiQ9BRF8.
PRIDEiQ9BRF8.

Protocols and materials databases

DNASUi55313.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261660; ENSP00000261660; ENSG00000103381. [Q9BRF8-3]
ENST00000381774; ENSP00000371193; ENSG00000103381. [Q9BRF8-1]
ENST00000433677; ENSP00000411127; ENSG00000103381. [Q9BRF8-2]
GeneIDi55313.
KEGGihsa:55313.
UCSCiuc002dca.5. human. [Q9BRF8-1]

Organism-specific databases

CTDi55313.
DisGeNETi55313.
GeneCardsiCPPED1.
H-InvDBHIX0012827.
HGNCiHGNC:25632. CPPED1.
HPAiHPA040938.
HPA041970.
MIMi615603. gene.
neXtProtiNX_Q9BRF8.
OpenTargetsiENSG00000103381.
PharmGKBiPA164718110.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IP70. Eukaryota.
ENOG410ZI1D. LUCA.
GeneTreeiENSGT00390000008676.
HOGENOMiHOG000291782.
InParanoidiQ9BRF8.
OMAiGCQLGED.
OrthoDBiEOG091G0OHW.
PhylomeDBiQ9BRF8.
TreeFamiTF329406.

Enzyme and pathway databases

ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

GenomeRNAii55313.
PROiQ9BRF8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103381.
GenevisibleiQ9BRF8. HS.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCPPED_HUMAN
AccessioniPrimary (citable) accession number: Q9BRF8
Secondary accession number(s): B4DQ68
, Q6MZY9, Q9H9M9, Q9NUT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.