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Protein

BUD13 homolog

Gene

BUD13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • mRNA export from nucleus Source: BHF-UCL
  • mRNA splicing, via spliceosome Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
BUD13 homolog
Gene namesi
Name:BUD13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28199. BUD13.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: HPA
  • RES complex Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi84811.
OpenTargetsiENSG00000137656.
PharmGKBiPA144596512.

Polymorphism and mutation databases

BioMutaiBUD13.
DMDMi74732865.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002876881 – 619BUD13 homologAdd BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28PhosphoserineCombined sources1
Cross-linki65Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei123PhosphothreonineBy similarity1
Modified residuei127PhosphoserineBy similarity1
Modified residuei135PhosphothreonineCombined sources1
Modified residuei139PhosphoserineBy similarity1
Modified residuei147PhosphothreonineCombined sources1
Modified residuei151PhosphoserineCombined sources1
Modified residuei159PhosphothreonineCombined sources1
Modified residuei163PhosphoserineCombined sources1
Modified residuei172PhosphoserineBy similarity1
Modified residuei175PhosphoserineBy similarity1
Modified residuei197PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei214PhosphoserineCombined sources1
Modified residuei222PhosphoserineCombined sources1
Modified residuei226PhosphoserineCombined sources1
Modified residuei235PhosphoserineCombined sources1
Modified residuei236PhosphoserineCombined sources1
Modified residuei240PhosphoserineCombined sources1
Modified residuei248PhosphoserineCombined sources1
Modified residuei258PhosphoserineCombined sources1
Modified residuei259PhosphoserineCombined sources1
Modified residuei271PhosphoserineCombined sources1
Modified residuei281PhosphoserineCombined sources1
Modified residuei325PhosphoserineCombined sources1
Modified residuei354PhosphoserineCombined sources1
Modified residuei357PhosphoserineBy similarity1
Modified residuei358PhosphoserineCombined sources1
Modified residuei391PhosphoserineCombined sources1
Modified residuei407PhosphoserineCombined sources1
Modified residuei494PhosphotyrosineCombined sources1
Modified residuei567PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9BRD0.
MaxQBiQ9BRD0.
PaxDbiQ9BRD0.
PeptideAtlasiQ9BRD0.
PRIDEiQ9BRD0.

PTM databases

iPTMnetiQ9BRD0.
PhosphoSitePlusiQ9BRD0.

Expressioni

Gene expression databases

BgeeiENSG00000137656.
CleanExiHS_BUD13.
ExpressionAtlasiQ9BRD0. baseline and differential.
GenevisibleiQ9BRD0. HS.

Organism-specific databases

HPAiHPA038340.
HPA038341.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GPKOWQ929179EBI-2561235,EBI-746309
RBMX2Q9Y3882EBI-2561235,EBI-7704044

Protein-protein interaction databases

BioGridi124272. 25 interactors.
IntActiQ9BRD0. 11 interactors.
MINTiMINT-4654852.
STRINGi9606.ENSP00000260210.

Structurei

3D structure databases

ProteinModelPortaliQ9BRD0.
SMRiQ9BRD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili433 – 520Sequence analysisAdd BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi129 – 268Arg-richAdd BLAST140

Sequence similaritiesi

Belongs to the CWC26 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2654. Eukaryota.
ENOG410XSEZ. LUCA.
GeneTreeiENSGT00390000014500.
HOGENOMiHOG000273883.
HOVERGENiHBG059757.
InParanoidiQ9BRD0.
KOiK13106.
OMAiPRRACHD.
OrthoDBiEOG091G0I85.
PhylomeDBiQ9BRD0.
TreeFamiTF315331.

Family and domain databases

InterProiIPR018609. Bud13.
[Graphical view]
PfamiPF09736. Bud13. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BRD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAPPLSKA EYLKRYLSGA DAGVDRGSES GRKRRKKRPK PGGAGGKGMR
60 70 80 90 100
IVDDDVSWTA ISTTKLEKEE EEDDGDLPVV AEFVDERPEE VKQMEAFRSS
110 120 130 140 150
AKWKLLGGHN EDLPSNRHFR HDTPDSSPRR VRHGTPDPSP RKDRHDTPDP
160 170 180 190 200
SPRRARHDTP DPSPLRGARH DSDTSPPRRI RHDSSDTSPP RRARHDSPDP
210 220 230 240 250
SPPRRPQHNS SGASPRRVRH DSPDPSPPRR ARHGSSDISS PRRVHNNSPD
260 270 280 290 300
TSRRTLGSSD TQQLRRARHD SPDLAPNVTY SLPRTKSGKA PERASSKTSP
310 320 330 340 350
HWKESGASHL SFPKNSKYEY DPDISPPRKK QAKSHFGDKK QLDSKGDCQK
360 370 380 390 400
ATDSDLSSPR HKQSPGHQDS DSDLSPPRNR PRHRSSDSDL SPPRRRQRTK
410 420 430 440 450
SSDSDLSPPR RSQPPGKKAA HMYSGAKTGL VLTDIQREQQ ELKEQDQETM
460 470 480 490 500
AFEAEFQYAE TVFRDKSGRK RNLKLERLEQ RRKAEKDSER DELYAQWGKG
510 520 530 540 550
LAQSRQQQQN VEDAMKEMQK PLARYIDDED LDRMLREQER EGDPMANFIK
560 570 580 590 600
KNKAKENKNK KVRPRYSGPA PPPNRFNIWP GYRWDGVDRS NGFEQKRFAR
610
LASKKAVEEL AYKWSVEDM
Length:619
Mass (Da):70,521
Last modified:June 1, 2001 - v1
Checksum:i98B7732B4AA158FF
GO
Isoform 2 (identifier: Q9BRD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     212-345: Missing.

Note: No experimental confirmation available.
Show »
Length:485
Mass (Da):55,567
Checksum:i2A27A53EB1A89CD9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032343120R → C.Corresponds to variant rs10488698dbSNPEnsembl.1
Natural variantiVAR_032344148P → L.Corresponds to variant rs11820589dbSNPEnsembl.1
Natural variantiVAR_032345242R → I.Corresponds to variant rs11216131dbSNPEnsembl.1
Natural variantiVAR_053908388S → C.Corresponds to variant rs35004487dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025590212 – 345Missing in isoform 2. 1 PublicationAdd BLAST134

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057832 mRNA. Translation: BAB71593.1.
AK289635 mRNA. Translation: BAF82324.1.
CH471065 Genomic DNA. Translation: EAW67265.1.
BC006350 mRNA. Translation: AAH06350.1.
CCDSiCCDS53712.1. [Q9BRD0-2]
CCDS8374.1. [Q9BRD0-1]
RefSeqiNP_001153208.1. NM_001159736.1. [Q9BRD0-2]
NP_116114.1. NM_032725.3. [Q9BRD0-1]
UniGeneiHs.437341.

Genome annotation databases

EnsembliENST00000260210; ENSP00000260210; ENSG00000137656. [Q9BRD0-1]
ENST00000375445; ENSP00000364594; ENSG00000137656. [Q9BRD0-2]
GeneIDi84811.
KEGGihsa:84811.
UCSCiuc001ppn.4. human. [Q9BRD0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057832 mRNA. Translation: BAB71593.1.
AK289635 mRNA. Translation: BAF82324.1.
CH471065 Genomic DNA. Translation: EAW67265.1.
BC006350 mRNA. Translation: AAH06350.1.
CCDSiCCDS53712.1. [Q9BRD0-2]
CCDS8374.1. [Q9BRD0-1]
RefSeqiNP_001153208.1. NM_001159736.1. [Q9BRD0-2]
NP_116114.1. NM_032725.3. [Q9BRD0-1]
UniGeneiHs.437341.

3D structure databases

ProteinModelPortaliQ9BRD0.
SMRiQ9BRD0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124272. 25 interactors.
IntActiQ9BRD0. 11 interactors.
MINTiMINT-4654852.
STRINGi9606.ENSP00000260210.

PTM databases

iPTMnetiQ9BRD0.
PhosphoSitePlusiQ9BRD0.

Polymorphism and mutation databases

BioMutaiBUD13.
DMDMi74732865.

Proteomic databases

EPDiQ9BRD0.
MaxQBiQ9BRD0.
PaxDbiQ9BRD0.
PeptideAtlasiQ9BRD0.
PRIDEiQ9BRD0.

Protocols and materials databases

DNASUi84811.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260210; ENSP00000260210; ENSG00000137656. [Q9BRD0-1]
ENST00000375445; ENSP00000364594; ENSG00000137656. [Q9BRD0-2]
GeneIDi84811.
KEGGihsa:84811.
UCSCiuc001ppn.4. human. [Q9BRD0-1]

Organism-specific databases

CTDi84811.
DisGeNETi84811.
GeneCardsiBUD13.
HGNCiHGNC:28199. BUD13.
HPAiHPA038340.
HPA038341.
neXtProtiNX_Q9BRD0.
OpenTargetsiENSG00000137656.
PharmGKBiPA144596512.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2654. Eukaryota.
ENOG410XSEZ. LUCA.
GeneTreeiENSGT00390000014500.
HOGENOMiHOG000273883.
HOVERGENiHBG059757.
InParanoidiQ9BRD0.
KOiK13106.
OMAiPRRACHD.
OrthoDBiEOG091G0I85.
PhylomeDBiQ9BRD0.
TreeFamiTF315331.

Miscellaneous databases

GenomeRNAii84811.
PROiQ9BRD0.

Gene expression databases

BgeeiENSG00000137656.
CleanExiHS_BUD13.
ExpressionAtlasiQ9BRD0. baseline and differential.
GenevisibleiQ9BRD0. HS.

Family and domain databases

InterProiIPR018609. Bud13.
[Graphical view]
PfamiPF09736. Bud13. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBUD13_HUMAN
AccessioniPrimary (citable) accession number: Q9BRD0
Secondary accession number(s): A8K0S0, Q96LS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.