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Protein

Thioredoxin domain-containing protein 17

Gene

TXNDC17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei43Nucleophile1 Publication1
Sitei44Contributes to redox potential value1 Publication1
Sitei45Contributes to redox potential value1 Publication1
Active sitei46Nucleophile1 Publication1

GO - Molecular functioni

  • peroxidase activity Source: UniProtKB
  • protein-disulfide reductase activity Source: UniProtKB

GO - Biological processi

  • tumor necrosis factor-mediated signaling pathway Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 17
Alternative name(s):
14 kDa thioredoxin-related protein
Short name:
TRP14
Protein 42-9-9
Thioredoxin-like protein 5
Gene namesi
Name:TXNDC17
Synonyms:TXNL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000129235.10
HGNCiHGNC:28218 TXNDC17
neXtProtiNX_Q9BRA2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi43C → S: Loss of peroxidase activity. 1 Publication1
Mutagenesisi46C → S: Loss of peroxidase activity. 1 Publication1

Organism-specific databases

DisGeNETi84817
OpenTargetsiENSG00000129235
PharmGKBiPA162407489

Polymorphism and mutation databases

BioMutaiTXNDC17
DMDMi74732856

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001200222 – 123Thioredoxin domain-containing protein 17Add BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Disulfide bondi43 ↔ 46Redox-active1 Publication

Post-translational modificationi

The oxidized protein is reduced by TRXR1.

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

EPDiQ9BRA2
MaxQBiQ9BRA2
PaxDbiQ9BRA2
PeptideAtlasiQ9BRA2
PRIDEiQ9BRA2
TopDownProteomicsiQ9BRA2

2D gel databases

REPRODUCTION-2DPAGEIPI00646689

PTM databases

iPTMnetiQ9BRA2
PhosphoSitePlusiQ9BRA2

Expressioni

Tissue specificityi

Ubiquitously expressed in cell lines.1 Publication

Gene expression databases

BgeeiENSG00000129235
CleanExiHS_TXNDC17
ExpressionAtlasiQ9BRA2 baseline and differential
GenevisibleiQ9BRA2 HS

Organism-specific databases

HPAiHPA022931

Interactioni

Subunit structurei

Interacts with TRXR1 and DYNLL1/DNCL1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124277, 32 interactors
IntActiQ9BRA2, 6 interactors
STRINGi9606.ENSP00000250101

Structurei

Secondary structure

1123
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 11Combined sources7
Helixi12 – 20Combined sources9
Turni21 – 24Combined sources4
Beta strandi25 – 32Combined sources8
Helixi44 – 56Combined sources13
Helixi57 – 59Combined sources3
Beta strandi64 – 70Combined sources7
Helixi74 – 78Combined sources5
Helixi83 – 88Combined sources6
Beta strandi92 – 98Combined sources7
Beta strandi104 – 106Combined sources3
Helixi107 – 111Combined sources5
Helixi113 – 121Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WOUX-ray1.80A1-123[»]
ProteinModelPortaliQ9BRA2
SMRiQ9BRA2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BRA2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 123ThioredoxinSequence analysisAdd BLAST83

Sequence similaritiesi

Belongs to the thioredoxin family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG3425 Eukaryota
ENOG4111Q2V LUCA
GeneTreeiENSGT00390000012195
HOGENOMiHOG000241811
HOVERGENiHBG079628
InParanoidiQ9BRA2
OMAiGESWCPY
OrthoDBiEOG091G0VBT
PhylomeDBiQ9BRA2
TreeFamiTF313854

Family and domain databases

InterProiView protein in InterPro
IPR010357 DUF953_thioredox
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR12452 PTHR12452, 1 hit
PfamiView protein in Pfam
PF06110 DUF953, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BRA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARYEEVSVS GFEEFHRAVE QHNGKTIFAY FTGSKDAGGK SWCPDCVQAE
60 70 80 90 100
PVVREGLKHI SEGCVFIYCQ VGEKPYWKDP NNDFRKNLKV TAVPTLLKYG
110 120
TPQKLVESEC LQANLVEMLF SED
Length:123
Mass (Da):13,941
Last modified:June 1, 2001 - v1
Checksum:i887ADB4704946B86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344101 mRNA Translation: CAC51435.1
AK291963 mRNA Translation: BAF84652.1
CH471108 Genomic DNA Translation: EAW90302.1
BC006405 mRNA Translation: AAH06405.1
CCDSiCCDS11077.1
RefSeqiNP_116120.1, NM_032731.3
UniGeneiHs.408236

Genome annotation databases

EnsembliENST00000250101; ENSP00000250101; ENSG00000129235
GeneIDi84817
KEGGihsa:84817
UCSCiuc002gdf.5 human

Similar proteinsi

Entry informationi

Entry nameiTXD17_HUMAN
AccessioniPrimary (citable) accession number: Q9BRA2
Secondary accession number(s): A8K7E8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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