Q9BRA0 (LSMD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
LSM domain-containing protein 1

Alternative name(s):
Phosphonoformate immuno-associated protein 2

Gene names

Name:	LSMD1
Synonyms:	MAK31, PFAAP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues. Ref.4
Subunit structure	Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, LSMD1 and NAA30. Ref.4
Subcellular location	Cytoplasm. Nucleus Ref.4.
Sequence similarities	Belongs to the snRNP Sm proteins family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BRA0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BRA0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MAGAGPTMLLREENGCCSRRQSSSSAG → MAVAVGVRAA...RSERLLHPAQ

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 125	125	LSM domain-containing protein 1		PRO_0000299155
Regions
	Coiled coil	31 – 56	26	Potential
	Compositional bias	22 – 25	4	Poly-Ser
Amino acid modifications
	Modified residue	22	1	Phosphoserine Ref.3
	Modified residue	25	1	Phosphoserine Ref.3
	Modified residue	29	1	Phosphoserine Ref.3
Natural variations
	Alternative sequence	1 – 27	27	MAGAG…SSSAG → MAVAVGVRAAPVLGLARALV LGLRGSQAARWRGWGTAAPG SLWALCECPAGCRELWFRGR AAWAARSERLLHPAQ in isoform 2.		VSP_027566
Isoform 2:
	Natural variant	13	1	L → P. Corresponds to variant rs8522 [ dbSNP | Ensembl ].

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: DF6048668C06EFB5	FASTA	125	13,514
	10 20 30 40 50 60 MAGAGPTMLL REENGCCSRR QSSSSAGDSD GEREDSAAER ARQQLEALLN KTMRIRMTDG 70 80 90 100 110 120 RTLVGCFLCT DRDCNVILGS AQEFLKPSDS FSAGEPRVLG LAMVPGHHIV SIEVQRESLT GPPYL
	Isoform 2 [UniParc]. Checksum: 14C8CB00C0E31147	FASTA	173	18,737
	10 20 30 40 50 60 MAVAVGVRAA PVLGLARALV LGLRGSQAAR WRGWGTAAPG SLWALCECPA GCRELWFRGR 70 80 90 100 110 120 AAWAARSERL LHPAQDSDGE REDSAAERAR QQLEALLNKT MRIRMTDGRT LVGCFLCTDR 130 140 150 160 170 DCNVILGSAQ EFLKPSDSFS AGEPRVLGLA MVPGHHIVSI EVQRESLTGP PYL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Screening and cloning of a new immuno-associated gene regulated by phosphonoformate." Liu Y., Cheng J., Lu Y. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Pancreas, Prostate and Uterus.
[3]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; SER-25 AND SER-29, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[4]	"Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization." Starheim K.K., Gromyko D., Evjenth R., Ryningen A., Varhaug J.E., Lillehaug J.R., Arnesen T. Mol. Cell. Biol. 29:3569-3581(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, IDENTIFICATION IN NATC COMPLEX, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF530060 mRNA. Translation: AAQ09944.1. BC006407 mRNA. Translation: AAH06407.1. BC033861 mRNA. Translation: AAH33861.1. BC051846 mRNA. Translation: AAH51846.1. BC059944 mRNA. Translation: AAH59944.1.
IPI	IPI00304922. IPI00384274.
RefSeq	NP_115732.2. NM_032356.3.
UniGene	Hs.565094.
3D structure databases
ProteinModelPortal	Q9BRA0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000332103.
PTM databases
PhosphoSite	Q9BRA0.
Polymorphism databases
DMDM	74732854.
Proteomic databases
PaxDb	Q9BRA0.
PRIDE	Q9BRA0.
Protocols and materials databases
DNASU	84316.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000333775; ENSP00000332103; ENSG00000183011. ENST00000335155; ENSP00000335611; ENSG00000183011.
GeneID	84316.
KEGG	hsa:84316.
UCSC	uc002giz.3. human. uc002gja.3. human.
Organism-specific databases
CTD	84316.
GeneCards	GC17M007761.
H-InvDB	HIX0013513.
HGNC	HGNC:28212. LSMD1.
neXtProt	NX_Q9BRA0.
PharmGKB	PA142671503.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG295890.
HOGENOM	HOG000048009.
HOVERGEN	HBG107368.
OMA	ENGPSTH.
OrthoDB	EOG4DFPPW.
Enzyme and pathway databases
SignaLink	Q9BRA0.
Gene expression databases
ArrayExpress	Q9BRA0.
Bgee	Q9BRA0.
CleanEx	HS_LSMD1.
Genevestigator	Q9BRA0.
Family and domain databases
InterPro	IPR010920. LSM_dom. IPR001163. Ribonucl_LSM. IPR006649. Ribonucl_LSM_euk/arc. [Graphical view]
Pfam	PF01423. LSM. 1 hit. [Graphical view]
SMART	SM00651. Sm. 1 hit. [Graphical view]
SUPFAM	SSF50182. Sm_like_riboprot. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	LSMD1. human.
GenomeRNAi	84316.
NextBio	74028.

Entry information

Entry name

LSMD1_HUMAN

Accession

Primary (citable) accession number: Q9BRA0
Secondary accession number(s): Q8N4M0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	June 1, 2001
Last modified:	May 29, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.