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Q9BRA0

- LSMD1_HUMAN

UniProt

Q9BRA0 - LSMD1_HUMAN

Protein

N-alpha-acetyltransferase 38, NatC auxiliary subunit

Gene

NAA38

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.1 Publication

    GO - Biological processi

    1. negative regulation of apoptotic process Source: UniProtKB

    Enzyme and pathway databases

    SignaLinkiQ9BRA0.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-alpha-acetyltransferase 38, NatC auxiliary subunit
    Alternative name(s):
    LSM domain-containing protein 1
    Phosphonoformate immuno-associated protein 2
    Gene namesi
    Name:NAA38
    Synonyms:LSMD1, MAK31, PFAAP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:28212. NAA38.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. NatC complex Source: UniProtKB
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671503.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 125124N-alpha-acetyltransferase 38, NatC auxiliary subunitPRO_0000299155Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei22 – 221Phosphoserine1 Publication
    Modified residuei25 – 251Phosphoserine1 Publication
    Modified residuei29 – 291Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9BRA0.
    PaxDbiQ9BRA0.
    PRIDEiQ9BRA0.

    PTM databases

    PhosphoSiteiQ9BRA0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BRA0.
    BgeeiQ9BRA0.
    CleanExiHS_LSMD1.
    GenevestigatoriQ9BRA0.

    Organism-specific databases

    HPAiHPA059189.

    Interactioni

    Subunit structurei

    Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.1 Publication

    Protein-protein interaction databases

    BioGridi124042. 1 interaction.
    IntActiQ9BRA0. 3 interactions.
    STRINGi9606.ENSP00000332103.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BRA0.
    SMRiQ9BRA0. Positions 53-123.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili31 – 5626Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi22 – 254Poly-Ser

    Sequence similaritiesi

    Belongs to the snRNP Sm proteins family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG295890.
    HOGENOMiHOG000048009.
    HOVERGENiHBG107368.
    OMAiANIAIFF.
    OrthoDBiEOG7ZGX5G.
    PhylomeDBiQ9BRA0.
    TreeFamiTF323867.

    Family and domain databases

    InterProiIPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    [Graphical view]
    PfamiPF01423. LSM. 1 hit.
    [Graphical view]
    SMARTiSM00651. Sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF50182. SSF50182. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BRA0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGAGPTMLL REENGCCSRR QSSSSAGDSD GEREDSAAER ARQQLEALLN    50
    KTMRIRMTDG RTLVGCFLCT DRDCNVILGS AQEFLKPSDS FSAGEPRVLG 100
    LAMVPGHHIV SIEVQRESLT GPPYL 125
    Length:125
    Mass (Da):13,514
    Last modified:June 1, 2001 - v1
    Checksum:iDF6048668C06EFB5
    GO
    Isoform 2 (identifier: Q9BRA0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-27: MAGAGPTMLLREENGCCSRRQSSSSAG → MAVAVGVRAA...RSERLLHPAQ

    Show »
    Length:173
    Mass (Da):18,737
    Checksum:i14C8CB00C0E31147
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Isoform 2 (identifier: Q9BRA0-2)
    Natural varianti13 – 131L → P.
    Corresponds to variant rs8522 [ dbSNP | Ensembl ].

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2727MAGAG…SSSAG → MAVAVGVRAAPVLGLARALV LGLRGSQAARWRGWGTAAPG SLWALCECPAGCRELWFRGR AAWAARSERLLHPAQ in isoform 2. 1 PublicationVSP_027566Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF530060 mRNA. Translation: AAQ09944.1.
    BC006407 mRNA. Translation: AAH06407.1.
    BC033861 mRNA. Translation: AAH33861.1.
    BC051846 mRNA. Translation: AAH51846.1.
    BC059944 mRNA. Translation: AAH59944.1.
    CCDSiCCDS11122.1. [Q9BRA0-2]
    RefSeqiNP_115732.2. NM_032356.3. [Q9BRA0-2]
    XP_005256880.1. XM_005256823.1. [Q9BRA0-1]
    UniGeneiHs.565094.

    Genome annotation databases

    EnsembliENST00000333775; ENSP00000332103; ENSG00000183011. [Q9BRA0-2]
    GeneIDi84316.
    KEGGihsa:84316.
    UCSCiuc002giz.3. human. [Q9BRA0-1]
    uc002gja.3. human. [Q9BRA0-2]

    Polymorphism databases

    DMDMi74732854.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF530060 mRNA. Translation: AAQ09944.1 .
    BC006407 mRNA. Translation: AAH06407.1 .
    BC033861 mRNA. Translation: AAH33861.1 .
    BC051846 mRNA. Translation: AAH51846.1 .
    BC059944 mRNA. Translation: AAH59944.1 .
    CCDSi CCDS11122.1. [Q9BRA0-2 ]
    RefSeqi NP_115732.2. NM_032356.3. [Q9BRA0-2 ]
    XP_005256880.1. XM_005256823.1. [Q9BRA0-1 ]
    UniGenei Hs.565094.

    3D structure databases

    ProteinModelPortali Q9BRA0.
    SMRi Q9BRA0. Positions 53-123.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124042. 1 interaction.
    IntActi Q9BRA0. 3 interactions.
    STRINGi 9606.ENSP00000332103.

    PTM databases

    PhosphoSitei Q9BRA0.

    Polymorphism databases

    DMDMi 74732854.

    Proteomic databases

    MaxQBi Q9BRA0.
    PaxDbi Q9BRA0.
    PRIDEi Q9BRA0.

    Protocols and materials databases

    DNASUi 84316.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000333775 ; ENSP00000332103 ; ENSG00000183011 . [Q9BRA0-2 ]
    GeneIDi 84316.
    KEGGi hsa:84316.
    UCSCi uc002giz.3. human. [Q9BRA0-1 ]
    uc002gja.3. human. [Q9BRA0-2 ]

    Organism-specific databases

    CTDi 84316.
    GeneCardsi GC17M007761.
    H-InvDB HIX0013513.
    HGNCi HGNC:28212. NAA38.
    HPAi HPA059189.
    neXtProti NX_Q9BRA0.
    PharmGKBi PA142671503.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG295890.
    HOGENOMi HOG000048009.
    HOVERGENi HBG107368.
    OMAi ANIAIFF.
    OrthoDBi EOG7ZGX5G.
    PhylomeDBi Q9BRA0.
    TreeFami TF323867.

    Enzyme and pathway databases

    SignaLinki Q9BRA0.

    Miscellaneous databases

    ChiTaRSi LSMD1. human.
    GenomeRNAii 84316.
    NextBioi 74028.
    PROi Q9BRA0.

    Gene expression databases

    ArrayExpressi Q9BRA0.
    Bgeei Q9BRA0.
    CleanExi HS_LSMD1.
    Genevestigatori Q9BRA0.

    Family and domain databases

    InterProi IPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    [Graphical view ]
    Pfami PF01423. LSM. 1 hit.
    [Graphical view ]
    SMARTi SM00651. Sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50182. SSF50182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Screening and cloning of a new immuno-associated gene regulated by phosphonoformate."
      Liu Y., Cheng J., Lu Y.
      Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Pancreas, Prostate and Uterus.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; SER-25 AND SER-29, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    4. "A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates."
      Polevoda B., Arnesen T., Sherman F.
      BMC Proc. 3:S2-S2(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.
    5. "Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization."
      Starheim K.K., Gromyko D., Evjenth R., Ryningen A., Varhaug J.E., Lillehaug J.R., Arnesen T.
      Mol. Cell. Biol. 29:3569-3581(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN NATC COMPLEX, SUBCELLULAR LOCATION.
    6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiLSMD1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BRA0
    Secondary accession number(s): Q8N4M0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3