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Protein

N-alpha-acetyltransferase 38, NatC auxiliary subunit

Gene

NAA38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.1 Publication

GO - Biological processi

  • negative regulation of apoptotic process Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-33018-MONOMER.
ReactomeiR-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.
SignaLinkiQ9BRA0.

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 38, NatC auxiliary subunit
Alternative name(s):
LSM domain-containing protein 1
Phosphonoformate immuno-associated protein 2
Gene namesi
Name:NAA38
Synonyms:LSMD1, MAK31, PFAAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28212. NAA38.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • NatC complex Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183011.
PharmGKBiPA142671503.

Polymorphism and mutation databases

DMDMi74732854.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002991552 – 125N-alpha-acetyltransferase 38, NatC auxiliary subunitAdd BLAST124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Modified residuei25PhosphoserineCombined sources1
Modified residuei29PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BRA0.
MaxQBiQ9BRA0.
PaxDbiQ9BRA0.
PeptideAtlasiQ9BRA0.
PRIDEiQ9BRA0.

PTM databases

iPTMnetiQ9BRA0.
PhosphoSitePlusiQ9BRA0.

Expressioni

Gene expression databases

BgeeiENSG00000183011.
CleanExiHS_LSMD1.
ExpressionAtlasiQ9BRA0. baseline and differential.
GenevisibleiQ9BRA0. HS.

Organism-specific databases

HPAiHPA059189.

Interactioni

Subunit structurei

Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
N4BP2L2Q928023EBI-9106509,EBI-2514973
PDE9AO760833EBI-9106509,EBI-742764
PRR20CP864793EBI-9106509,EBI-10172814

Protein-protein interaction databases

BioGridi124042. 15 interactors.
IntActiQ9BRA0. 7 interactors.
STRINGi9606.ENSP00000332103.

Structurei

3D structure databases

ProteinModelPortaliQ9BRA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili31 – 56Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 25Poly-Ser4

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IRT4. Eukaryota.
ENOG4111XHR. LUCA.
GeneTreeiENSGT00390000018418.
HOGENOMiHOG000048009.
HOVERGENiHBG107368.
InParanoidiQ9BRA0.
KOiK20824.
OrthoDBiEOG091G146E.
PhylomeDBiQ9BRA0.
TreeFamiTF323867.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BRA0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGAGPTMLL REENGCCSRR QSSSSAGDSD GEREDSAAER ARQQLEALLN
60 70 80 90 100
KTMRIRMTDG RTLVGCFLCT DRDCNVILGS AQEFLKPSDS FSAGEPRVLG
110 120
LAMVPGHHIV SIEVQRESLT GPPYL
Length:125
Mass (Da):13,514
Last modified:June 1, 2001 - v1
Checksum:iDF6048668C06EFB5
GO
Isoform 2 (identifier: Q9BRA0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MAGAGPTMLLREENGCCSRRQSSSSAG → MAVAVGVRAA...RSERLLHPAQ

Show »
Length:173
Mass (Da):18,737
Checksum:i14C8CB00C0E31147
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q9BRA0-2)
Natural varianti13L → P.Corresponds to variant rs8522dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0275661 – 27MAGAG…SSSAG → MAVAVGVRAAPVLGLARALV LGLRGSQAARWRGWGTAAPG SLWALCECPAGCRELWFRGR AAWAARSERLLHPAQ in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF530060 mRNA. Translation: AAQ09944.1.
BC006407 mRNA. Translation: AAH06407.1.
BC033861 mRNA. Translation: AAH33861.1.
BC051846 mRNA. Translation: AAH51846.1.
BC059944 mRNA. Translation: AAH59944.1.
CCDSiCCDS11122.1. [Q9BRA0-2]
CCDS82060.1. [Q9BRA0-1]
RefSeqiNP_001307854.1. NM_001320925.2. [Q9BRA0-1]
NP_115732.2. NM_032356.5. [Q9BRA0-2]
UniGeneiHs.565094.

Genome annotation databases

EnsembliENST00000333775; ENSP00000332103; ENSG00000183011. [Q9BRA0-2]
ENST00000575771; ENSP00000460172; ENSG00000183011. [Q9BRA0-1]
GeneIDi84316.
KEGGihsa:84316.
UCSCiuc002giz.4. human. [Q9BRA0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF530060 mRNA. Translation: AAQ09944.1.
BC006407 mRNA. Translation: AAH06407.1.
BC033861 mRNA. Translation: AAH33861.1.
BC051846 mRNA. Translation: AAH51846.1.
BC059944 mRNA. Translation: AAH59944.1.
CCDSiCCDS11122.1. [Q9BRA0-2]
CCDS82060.1. [Q9BRA0-1]
RefSeqiNP_001307854.1. NM_001320925.2. [Q9BRA0-1]
NP_115732.2. NM_032356.5. [Q9BRA0-2]
UniGeneiHs.565094.

3D structure databases

ProteinModelPortaliQ9BRA0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124042. 15 interactors.
IntActiQ9BRA0. 7 interactors.
STRINGi9606.ENSP00000332103.

PTM databases

iPTMnetiQ9BRA0.
PhosphoSitePlusiQ9BRA0.

Polymorphism and mutation databases

DMDMi74732854.

Proteomic databases

EPDiQ9BRA0.
MaxQBiQ9BRA0.
PaxDbiQ9BRA0.
PeptideAtlasiQ9BRA0.
PRIDEiQ9BRA0.

Protocols and materials databases

DNASUi84316.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333775; ENSP00000332103; ENSG00000183011. [Q9BRA0-2]
ENST00000575771; ENSP00000460172; ENSG00000183011. [Q9BRA0-1]
GeneIDi84316.
KEGGihsa:84316.
UCSCiuc002giz.4. human. [Q9BRA0-1]

Organism-specific databases

CTDi84316.
GeneCardsiNAA38.
H-InvDBHIX0013513.
HGNCiHGNC:28212. NAA38.
HPAiHPA059189.
neXtProtiNX_Q9BRA0.
OpenTargetsiENSG00000183011.
PharmGKBiPA142671503.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRT4. Eukaryota.
ENOG4111XHR. LUCA.
GeneTreeiENSGT00390000018418.
HOGENOMiHOG000048009.
HOVERGENiHBG107368.
InParanoidiQ9BRA0.
KOiK20824.
OrthoDBiEOG091G146E.
PhylomeDBiQ9BRA0.
TreeFamiTF323867.

Enzyme and pathway databases

BioCyciZFISH:G66-33018-MONOMER.
ReactomeiR-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.
SignaLinkiQ9BRA0.

Miscellaneous databases

ChiTaRSiNAA38. human.
GenomeRNAii84316.
PROiQ9BRA0.

Gene expression databases

BgeeiENSG00000183011.
CleanExiHS_LSMD1.
ExpressionAtlasiQ9BRA0. baseline and differential.
GenevisibleiQ9BRA0. HS.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLSMD1_HUMAN
AccessioniPrimary (citable) accession number: Q9BRA0
Secondary accession number(s): Q8N4M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.