Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

N-alpha-acetyltransferase 38, NatC auxiliary subunit

Gene

NAA38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.1 Publication

GO - Biological processi

  • negative regulation of apoptotic process Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ9BRA0.

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 38, NatC auxiliary subunit
Alternative name(s):
LSM domain-containing protein 1
Phosphonoformate immuno-associated protein 2
Gene namesi
Name:NAA38
Synonyms:LSMD1, MAK31, PFAAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28212. NAA38.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • NatC complex Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671503.

Polymorphism and mutation databases

DMDMi74732854.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 125124N-alpha-acetyltransferase 38, NatC auxiliary subunitPRO_0000299155Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei22 – 221Phosphoserine1 Publication
Modified residuei25 – 251Phosphoserine1 Publication
Modified residuei29 – 291Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9BRA0.
PaxDbiQ9BRA0.
PRIDEiQ9BRA0.

PTM databases

PhosphoSiteiQ9BRA0.

Expressioni

Gene expression databases

BgeeiQ9BRA0.
CleanExiHS_LSMD1.
ExpressionAtlasiQ9BRA0. baseline and differential.
GenevisibleiQ9BRA0. HS.

Organism-specific databases

HPAiHPA059189.

Interactioni

Subunit structurei

Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
N4BP2L2Q928023EBI-9106509,EBI-2514973
PDE9AO760833EBI-9106509,EBI-742764
PRR20CP864793EBI-9106509,EBI-10172814

Protein-protein interaction databases

BioGridi124042. 4 interactions.
IntActiQ9BRA0. 7 interactions.
STRINGi9606.ENSP00000332103.

Structurei

3D structure databases

ProteinModelPortaliQ9BRA0.
SMRiQ9BRA0. Positions 53-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili31 – 5626Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 254Poly-Ser

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG295890.
GeneTreeiENSGT00390000018418.
HOGENOMiHOG000048009.
HOVERGENiHBG107368.
InParanoidiQ9BRA0.
OrthoDBiEOG7ZGX5G.
PhylomeDBiQ9BRA0.
TreeFamiTF323867.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BRA0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGAGPTMLL REENGCCSRR QSSSSAGDSD GEREDSAAER ARQQLEALLN
60 70 80 90 100
KTMRIRMTDG RTLVGCFLCT DRDCNVILGS AQEFLKPSDS FSAGEPRVLG
110 120
LAMVPGHHIV SIEVQRESLT GPPYL
Length:125
Mass (Da):13,514
Last modified:June 1, 2001 - v1
Checksum:iDF6048668C06EFB5
GO
Isoform 2 (identifier: Q9BRA0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MAGAGPTMLLREENGCCSRRQSSSSAG → MAVAVGVRAA...RSERLLHPAQ

Show »
Length:173
Mass (Da):18,737
Checksum:i14C8CB00C0E31147
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 2 (identifier: Q9BRA0-2)
Natural varianti13 – 131L → P.
Corresponds to variant rs8522 [ dbSNP | Ensembl ].

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2727MAGAG…SSSAG → MAVAVGVRAAPVLGLARALV LGLRGSQAARWRGWGTAAPG SLWALCECPAGCRELWFRGR AAWAARSERLLHPAQ in isoform 2. 1 PublicationVSP_027566Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF530060 mRNA. Translation: AAQ09944.1.
BC006407 mRNA. Translation: AAH06407.1.
BC033861 mRNA. Translation: AAH33861.1.
BC051846 mRNA. Translation: AAH51846.1.
BC059944 mRNA. Translation: AAH59944.1.
CCDSiCCDS11122.1. [Q9BRA0-2]
RefSeqiNP_115732.2. NM_032356.3. [Q9BRA0-2]
XP_005256880.1. XM_005256823.2. [Q9BRA0-1]
UniGeneiHs.565094.

Genome annotation databases

EnsembliENST00000333775; ENSP00000332103; ENSG00000183011. [Q9BRA0-2]
ENST00000575771; ENSP00000460172; ENSG00000183011. [Q9BRA0-1]
GeneIDi84316.
KEGGihsa:84316.
UCSCiuc002giz.3. human. [Q9BRA0-1]
uc002gja.3. human. [Q9BRA0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF530060 mRNA. Translation: AAQ09944.1.
BC006407 mRNA. Translation: AAH06407.1.
BC033861 mRNA. Translation: AAH33861.1.
BC051846 mRNA. Translation: AAH51846.1.
BC059944 mRNA. Translation: AAH59944.1.
CCDSiCCDS11122.1. [Q9BRA0-2]
RefSeqiNP_115732.2. NM_032356.3. [Q9BRA0-2]
XP_005256880.1. XM_005256823.2. [Q9BRA0-1]
UniGeneiHs.565094.

3D structure databases

ProteinModelPortaliQ9BRA0.
SMRiQ9BRA0. Positions 53-123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124042. 4 interactions.
IntActiQ9BRA0. 7 interactions.
STRINGi9606.ENSP00000332103.

PTM databases

PhosphoSiteiQ9BRA0.

Polymorphism and mutation databases

DMDMi74732854.

Proteomic databases

MaxQBiQ9BRA0.
PaxDbiQ9BRA0.
PRIDEiQ9BRA0.

Protocols and materials databases

DNASUi84316.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333775; ENSP00000332103; ENSG00000183011. [Q9BRA0-2]
ENST00000575771; ENSP00000460172; ENSG00000183011. [Q9BRA0-1]
GeneIDi84316.
KEGGihsa:84316.
UCSCiuc002giz.3. human. [Q9BRA0-1]
uc002gja.3. human. [Q9BRA0-2]

Organism-specific databases

CTDi84316.
GeneCardsiGC17M007763.
H-InvDBHIX0013513.
HGNCiHGNC:28212. NAA38.
HPAiHPA059189.
neXtProtiNX_Q9BRA0.
PharmGKBiPA142671503.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG295890.
GeneTreeiENSGT00390000018418.
HOGENOMiHOG000048009.
HOVERGENiHBG107368.
InParanoidiQ9BRA0.
OrthoDBiEOG7ZGX5G.
PhylomeDBiQ9BRA0.
TreeFamiTF323867.

Enzyme and pathway databases

SignaLinkiQ9BRA0.

Miscellaneous databases

ChiTaRSiNAA38. human.
GenomeRNAii84316.
NextBioi74028.
PROiQ9BRA0.

Gene expression databases

BgeeiQ9BRA0.
CleanExiHS_LSMD1.
ExpressionAtlasiQ9BRA0. baseline and differential.
GenevisibleiQ9BRA0. HS.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Screening and cloning of a new immuno-associated gene regulated by phosphonoformate."
    Liu Y., Cheng J., Lu Y.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Pancreas, Prostate and Uterus.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; SER-25 AND SER-29, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. "A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates."
    Polevoda B., Arnesen T., Sherman F.
    BMC Proc. 3:S2-S2(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.
  5. "Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization."
    Starheim K.K., Gromyko D., Evjenth R., Ryningen A., Varhaug J.E., Lillehaug J.R., Arnesen T.
    Mol. Cell. Biol. 29:3569-3581(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN NATC COMPLEX, SUBCELLULAR LOCATION.
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiLSMD1_HUMAN
AccessioniPrimary (citable) accession number: Q9BRA0
Secondary accession number(s): Q8N4M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.