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Q9BRA0

- LSMD1_HUMAN

UniProt

Q9BRA0 - LSMD1_HUMAN

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Protein

N-alpha-acetyltransferase 38, NatC auxiliary subunit

Gene
NAA38, LSMD1, MAK31, PFAAP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.1 Publication

GO - Biological processi

  1. negative regulation of apoptotic process Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ9BRA0.

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 38, NatC auxiliary subunit
Alternative name(s):
LSM domain-containing protein 1
Phosphonoformate immuno-associated protein 2
Gene namesi
Name:NAA38
Synonyms:LSMD1, MAK31, PFAAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:28212. NAA38.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. NatC complex Source: UniProtKB
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671503.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 125124N-alpha-acetyltransferase 38, NatC auxiliary subunitPRO_0000299155Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei22 – 221Phosphoserine1 Publication
Modified residuei25 – 251Phosphoserine1 Publication
Modified residuei29 – 291Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9BRA0.
PaxDbiQ9BRA0.
PRIDEiQ9BRA0.

PTM databases

PhosphoSiteiQ9BRA0.

Expressioni

Gene expression databases

ArrayExpressiQ9BRA0.
BgeeiQ9BRA0.
CleanExiHS_LSMD1.
GenevestigatoriQ9BRA0.

Organism-specific databases

HPAiHPA059189.

Interactioni

Subunit structurei

Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.1 Publication

Protein-protein interaction databases

BioGridi124042. 1 interaction.
IntActiQ9BRA0. 3 interactions.
STRINGi9606.ENSP00000332103.

Structurei

3D structure databases

ProteinModelPortaliQ9BRA0.
SMRiQ9BRA0. Positions 53-123.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili31 – 5626 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 254Poly-Ser

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG295890.
HOGENOMiHOG000048009.
HOVERGENiHBG107368.
OMAiANIAIFF.
OrthoDBiEOG7ZGX5G.
PhylomeDBiQ9BRA0.
TreeFamiTF323867.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BRA0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAGAGPTMLL REENGCCSRR QSSSSAGDSD GEREDSAAER ARQQLEALLN    50
KTMRIRMTDG RTLVGCFLCT DRDCNVILGS AQEFLKPSDS FSAGEPRVLG 100
LAMVPGHHIV SIEVQRESLT GPPYL 125
Length:125
Mass (Da):13,514
Last modified:June 1, 2001 - v1
Checksum:iDF6048668C06EFB5
GO
Isoform 2 (identifier: Q9BRA0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MAGAGPTMLLREENGCCSRRQSSSSAG → MAVAVGVRAA...RSERLLHPAQ

Show »
Length:173
Mass (Da):18,737
Checksum:i14C8CB00C0E31147
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 2 (identifier: Q9BRA0-2)
Natural varianti13 – 131L → P.
Corresponds to variant rs8522 [ dbSNP | Ensembl ].

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2727MAGAG…SSSAG → MAVAVGVRAAPVLGLARALV LGLRGSQAARWRGWGTAAPG SLWALCECPAGCRELWFRGR AAWAARSERLLHPAQ in isoform 2. VSP_027566Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF530060 mRNA. Translation: AAQ09944.1.
BC006407 mRNA. Translation: AAH06407.1.
BC033861 mRNA. Translation: AAH33861.1.
BC051846 mRNA. Translation: AAH51846.1.
BC059944 mRNA. Translation: AAH59944.1.
CCDSiCCDS11122.1. [Q9BRA0-2]
RefSeqiNP_115732.2. NM_032356.3. [Q9BRA0-2]
XP_005256880.1. XM_005256823.1. [Q9BRA0-1]
UniGeneiHs.565094.

Genome annotation databases

EnsembliENST00000333775; ENSP00000332103; ENSG00000183011. [Q9BRA0-2]
ENST00000335155; ENSP00000335611; ENSG00000183011. [Q9BRA0-1]
GeneIDi84316.
KEGGihsa:84316.
UCSCiuc002giz.3. human. [Q9BRA0-1]
uc002gja.3. human. [Q9BRA0-2]

Polymorphism databases

DMDMi74732854.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF530060 mRNA. Translation: AAQ09944.1 .
BC006407 mRNA. Translation: AAH06407.1 .
BC033861 mRNA. Translation: AAH33861.1 .
BC051846 mRNA. Translation: AAH51846.1 .
BC059944 mRNA. Translation: AAH59944.1 .
CCDSi CCDS11122.1. [Q9BRA0-2 ]
RefSeqi NP_115732.2. NM_032356.3. [Q9BRA0-2 ]
XP_005256880.1. XM_005256823.1. [Q9BRA0-1 ]
UniGenei Hs.565094.

3D structure databases

ProteinModelPortali Q9BRA0.
SMRi Q9BRA0. Positions 53-123.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124042. 1 interaction.
IntActi Q9BRA0. 3 interactions.
STRINGi 9606.ENSP00000332103.

PTM databases

PhosphoSitei Q9BRA0.

Polymorphism databases

DMDMi 74732854.

Proteomic databases

MaxQBi Q9BRA0.
PaxDbi Q9BRA0.
PRIDEi Q9BRA0.

Protocols and materials databases

DNASUi 84316.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000333775 ; ENSP00000332103 ; ENSG00000183011 . [Q9BRA0-2 ]
ENST00000335155 ; ENSP00000335611 ; ENSG00000183011 . [Q9BRA0-1 ]
GeneIDi 84316.
KEGGi hsa:84316.
UCSCi uc002giz.3. human. [Q9BRA0-1 ]
uc002gja.3. human. [Q9BRA0-2 ]

Organism-specific databases

CTDi 84316.
GeneCardsi GC17M007761.
H-InvDB HIX0013513.
HGNCi HGNC:28212. NAA38.
HPAi HPA059189.
neXtProti NX_Q9BRA0.
PharmGKBi PA142671503.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG295890.
HOGENOMi HOG000048009.
HOVERGENi HBG107368.
OMAi ANIAIFF.
OrthoDBi EOG7ZGX5G.
PhylomeDBi Q9BRA0.
TreeFami TF323867.

Enzyme and pathway databases

SignaLinki Q9BRA0.

Miscellaneous databases

ChiTaRSi LSMD1. human.
GenomeRNAii 84316.
NextBioi 74028.
PROi Q9BRA0.

Gene expression databases

ArrayExpressi Q9BRA0.
Bgeei Q9BRA0.
CleanExi HS_LSMD1.
Genevestigatori Q9BRA0.

Family and domain databases

InterProi IPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
[Graphical view ]
Pfami PF01423. LSM. 1 hit.
[Graphical view ]
SMARTi SM00651. Sm. 1 hit.
[Graphical view ]
SUPFAMi SSF50182. SSF50182. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Screening and cloning of a new immuno-associated gene regulated by phosphonoformate."
    Liu Y., Cheng J., Lu Y.
    Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Pancreas, Prostate and Uterus.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; SER-25 AND SER-29, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. "A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates."
    Polevoda B., Arnesen T., Sherman F.
    BMC Proc. 3:S2-S2(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.
  5. "Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization."
    Starheim K.K., Gromyko D., Evjenth R., Ryningen A., Varhaug J.E., Lillehaug J.R., Arnesen T.
    Mol. Cell. Biol. 29:3569-3581(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN NATC COMPLEX, SUBCELLULAR LOCATION.
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLSMD1_HUMAN
AccessioniPrimary (citable) accession number: Q9BRA0
Secondary accession number(s): Q8N4M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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