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Q9BRA0 (LSMD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-alpha-acetyltransferase 38, NatC auxiliary subunit
Alternative name(s):
LSM domain-containing protein 1
Phosphonoformate immuno-associated protein 2
Gene names
Name:NAA38
Synonyms:LSMD1, MAK31, PFAAP2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length125 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Ref.5

Subunit structure

Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30. Ref.5

Subcellular location

Cytoplasm. Nucleus Ref.5.

Sequence similarities

Belongs to the snRNP Sm proteins family.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of apoptotic process

Inferred from mutant phenotype Ref.5. Source: UniProtKB

   Cellular_componentNatC complex

Inferred from direct assay Ref.5. Source: UniProtKB

cytoplasm

Inferred from direct assay Ref.5. Source: UniProtKB

nucleus

Inferred from direct assay Ref.5. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BRA0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BRA0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MAGAGPTMLLREENGCCSRRQSSSSAG → MAVAVGVRAA...RSERLLHPAQ

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.6
Chain2 – 125124N-alpha-acetyltransferase 38, NatC auxiliary subunit
PRO_0000299155

Regions

Coiled coil31 – 5626 Potential
Compositional bias22 – 254Poly-Ser

Amino acid modifications

Modified residue21N-acetylalanine Ref.6
Modified residue221Phosphoserine Ref.3
Modified residue251Phosphoserine Ref.3
Modified residue291Phosphoserine Ref.3

Natural variations

Alternative sequence1 – 2727MAGAG…SSSAG → MAVAVGVRAAPVLGLARALV LGLRGSQAARWRGWGTAAPG SLWALCECPAGCRELWFRGR AAWAARSERLLHPAQ in isoform 2.
VSP_027566
Isoform 2:
Natural variant131L → P.
Corresponds to variant rs8522 [ dbSNP | Ensembl ].

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: DF6048668C06EFB5

FASTA12513,514
        10         20         30         40         50         60 
MAGAGPTMLL REENGCCSRR QSSSSAGDSD GEREDSAAER ARQQLEALLN KTMRIRMTDG 

        70         80         90        100        110        120 
RTLVGCFLCT DRDCNVILGS AQEFLKPSDS FSAGEPRVLG LAMVPGHHIV SIEVQRESLT 


GPPYL 

« Hide

Isoform 2 [UniParc].

Checksum: 14C8CB00C0E31147
Show »

FASTA17318,737

References

« Hide 'large scale' references
[1]"Screening and cloning of a new immuno-associated gene regulated by phosphonoformate."
Liu Y., Cheng J., Lu Y.
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Pancreas, Prostate and Uterus.
[3]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; SER-25 AND SER-29, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[4]"A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates."
Polevoda B., Arnesen T., Sherman F.
BMC Proc. 3:S2-S2(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE.
[5]"Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization."
Starheim K.K., Gromyko D., Evjenth R., Ryningen A., Varhaug J.E., Lillehaug J.R., Arnesen T.
Mol. Cell. Biol. 29:3569-3581(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN NATC COMPLEX, SUBCELLULAR LOCATION.
[6]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF530060 mRNA. Translation: AAQ09944.1.
BC006407 mRNA. Translation: AAH06407.1.
BC033861 mRNA. Translation: AAH33861.1.
BC051846 mRNA. Translation: AAH51846.1.
BC059944 mRNA. Translation: AAH59944.1.
CCDSCCDS11122.1. [Q9BRA0-2]
RefSeqNP_115732.2. NM_032356.3. [Q9BRA0-2]
XP_005256880.1. XM_005256823.1. [Q9BRA0-1]
UniGeneHs.565094.

3D structure databases

ProteinModelPortalQ9BRA0.
SMRQ9BRA0. Positions 53-123.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124042. 1 interaction.
IntActQ9BRA0. 3 interactions.
STRING9606.ENSP00000332103.

PTM databases

PhosphoSiteQ9BRA0.

Polymorphism databases

DMDM74732854.

Proteomic databases

MaxQBQ9BRA0.
PaxDbQ9BRA0.
PRIDEQ9BRA0.

Protocols and materials databases

DNASU84316.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000333775; ENSP00000332103; ENSG00000183011. [Q9BRA0-2]
ENST00000335155; ENSP00000335611; ENSG00000183011. [Q9BRA0-1]
GeneID84316.
KEGGhsa:84316.
UCSCuc002giz.3. human. [Q9BRA0-1]
uc002gja.3. human. [Q9BRA0-2]

Organism-specific databases

CTD84316.
GeneCardsGC17M007761.
H-InvDBHIX0013513.
HGNCHGNC:28212. NAA38.
HPAHPA059189.
neXtProtNX_Q9BRA0.
PharmGKBPA142671503.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG295890.
HOGENOMHOG000048009.
HOVERGENHBG107368.
OMAANIAIFF.
OrthoDBEOG7ZGX5G.
PhylomeDBQ9BRA0.
TreeFamTF323867.

Enzyme and pathway databases

SignaLinkQ9BRA0.

Gene expression databases

ArrayExpressQ9BRA0.
BgeeQ9BRA0.
CleanExHS_LSMD1.
GenevestigatorQ9BRA0.

Family and domain databases

InterProIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
[Graphical view]
PfamPF01423. LSM. 1 hit.
[Graphical view]
SMARTSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMSSF50182. SSF50182. 1 hit.
ProtoNetSearch...

Other

ChiTaRSLSMD1. human.
GenomeRNAi84316.
NextBio74028.
PROQ9BRA0.

Entry information

Entry nameLSMD1_HUMAN
AccessionPrimary (citable) accession number: Q9BRA0
Secondary accession number(s): Q8N4M0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM