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Protein

Zinc finger protein 559

Gene

ZNF559

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri91 – 113C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri119 – 141C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri147 – 179C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST33
Zinc fingeri185 – 207C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri241 – 263C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 319C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000090329-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 559
Gene namesi
Name:ZNF559
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28197. ZNF559.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84527.
OpenTargetsiENSG00000188321.
PharmGKBiPA134891126.

Polymorphism and mutation databases

BioMutaiZNF559.
DMDMi74762704.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476491 – 538Zinc finger protein 559Add BLAST538

Proteomic databases

EPDiQ9BR84.
MaxQBiQ9BR84.
PaxDbiQ9BR84.
PeptideAtlasiQ9BR84.
PRIDEiQ9BR84.

PTM databases

iPTMnetiQ9BR84.
PhosphoSitePlusiQ9BR84.

Expressioni

Gene expression databases

BgeeiENSG00000188321.
CleanExiHS_ZNF559.
ExpressionAtlasiQ9BR84. baseline and differential.
GenevisibleiQ9BR84. HS.

Organism-specific databases

HPAiHPA059632.
HPA065485.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-5P603703EBI-746605,EBI-10172150
KRTAP4-2Q9BYR53EBI-746605,EBI-10172511
MDFIQ997504EBI-746605,EBI-724076

Protein-protein interaction databases

BioGridi124118. 5 interactors.
IntActiQ9BR84. 3 interactors.
MINTiMINT-1479359.
STRINGi9606.ENSP00000377461.

Structurei

3D structure databases

ProteinModelPortaliQ9BR84.
SMRiQ9BR84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 89KRABPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri91 – 113C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri119 – 141C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri147 – 179C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST33
Zinc fingeri185 – 207C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri241 – 263C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri297 – 319C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri325 – 347C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri353 – 375C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri381 – 403C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri409 – 431C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri437 – 459C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri465 – 487C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri493 – 515C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9BR84.
KOiK09228.
PhylomeDBiQ9BR84.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BR84-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVAGWLTNYS QDSVTFEDVA VDFTQEEWTL LDQTQRNLYR DVMLENYKNL
60 70 80 90 100
VAVDWESHIN TKWSAPQQNF LQGKTSSVVE MERNHFGEEL FDFNQCEKAL
110 120 130 140 150
SEHSCLKTHR RTYFRKKTCE CNQCEKAFRK PSIFTLHKKT DIGEELPNCN
160 170 180 190 200
QCETAFSQHL HLVCKKTSQN LHLVCKKTHT QEKPYKCSDC EKGLPSSSHL
210 220 230 240 250
RECVRIYGGE RPYTHKEYVE TFSHSTALFV HMQTQDGEKF YECKACGKPF
260 270 280 290 300
TESSYLTQHL RTHSRVLPIE HKKFGKAFAF SPDLAKHIRL RTRGKHYVCN
310 320 330 340 350
ECGKEFTCFS KLNIHIRVHT GEKPYECNKC GKAFTDSSGL IKHRRTHTGE
360 370 380 390 400
KPYECKECGK AFANSSHLTV HMRTHTGEKP YQCKECGKAF INSSSFKSHM
410 420 430 440 450
QTHPGVKPYD CQQCGKAFIR SSFLIRHLRS HSAERPFECE ECGKAFRYSS
460 470 480 490 500
HLSQHKRIHT GERPYKCQKC GQAFSISSGL TVHMRTHTGE RPFECQECGK
510 520 530
AFTRSTYLIR HLRSHSVEKP YKECGQTFSN SSCLTECV
Length:538
Mass (Da):62,318
Last modified:June 1, 2001 - v1
Checksum:iC8BB5EB44B92034A
GO
Isoform 2 (identifier: Q9BR84-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-84: ERN → NSE
     85-538: Missing.

Note: No experimental confirmation available.
Show »
Length:84
Mass (Da):9,822
Checksum:i93DEFF7161C2685D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033576251T → N.Corresponds to variant rs16979670dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04703982 – 84ERN → NSE in isoform 2. 1 Publication3
Alternative sequenceiVSP_04704085 – 538Missing in isoform 2. 1 PublicationAdd BLAST454

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027700 mRNA. No translation available.
AC011451 Genomic DNA. No translation available.
BC006436 mRNA. Translation: AAH06436.1.
CCDSiCCDS12211.1. [Q9BR84-1]
CCDS59349.1. [Q9BR84-2]
RefSeqiNP_001189339.1. NM_001202410.1. [Q9BR84-2]
NP_001189341.1. NM_001202412.1. [Q9BR84-2]
NP_115886.1. NM_032497.2. [Q9BR84-1]
UniGeneiHs.172979.
Hs.744296.

Genome annotation databases

EnsembliENST00000317221; ENSP00000325393; ENSG00000188321. [Q9BR84-2]
ENST00000393883; ENSP00000377461; ENSG00000188321. [Q9BR84-1]
ENST00000585352; ENSP00000467048; ENSG00000188321. [Q9BR84-2]
ENST00000603380; ENSP00000474760; ENSG00000188321. [Q9BR84-1]
GeneIDi84527.
KEGGihsa:84527.
UCSCiuc002mlf.4. human. [Q9BR84-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027700 mRNA. No translation available.
AC011451 Genomic DNA. No translation available.
BC006436 mRNA. Translation: AAH06436.1.
CCDSiCCDS12211.1. [Q9BR84-1]
CCDS59349.1. [Q9BR84-2]
RefSeqiNP_001189339.1. NM_001202410.1. [Q9BR84-2]
NP_001189341.1. NM_001202412.1. [Q9BR84-2]
NP_115886.1. NM_032497.2. [Q9BR84-1]
UniGeneiHs.172979.
Hs.744296.

3D structure databases

ProteinModelPortaliQ9BR84.
SMRiQ9BR84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124118. 5 interactors.
IntActiQ9BR84. 3 interactors.
MINTiMINT-1479359.
STRINGi9606.ENSP00000377461.

PTM databases

iPTMnetiQ9BR84.
PhosphoSitePlusiQ9BR84.

Polymorphism and mutation databases

BioMutaiZNF559.
DMDMi74762704.

Proteomic databases

EPDiQ9BR84.
MaxQBiQ9BR84.
PaxDbiQ9BR84.
PeptideAtlasiQ9BR84.
PRIDEiQ9BR84.

Protocols and materials databases

DNASUi84527.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317221; ENSP00000325393; ENSG00000188321. [Q9BR84-2]
ENST00000393883; ENSP00000377461; ENSG00000188321. [Q9BR84-1]
ENST00000585352; ENSP00000467048; ENSG00000188321. [Q9BR84-2]
ENST00000603380; ENSP00000474760; ENSG00000188321. [Q9BR84-1]
GeneIDi84527.
KEGGihsa:84527.
UCSCiuc002mlf.4. human. [Q9BR84-1]

Organism-specific databases

CTDi84527.
DisGeNETi84527.
GeneCardsiZNF559.
HGNCiHGNC:28197. ZNF559.
HPAiHPA059632.
HPA065485.
neXtProtiNX_Q9BR84.
OpenTargetsiENSG00000188321.
PharmGKBiPA134891126.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063830.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9BR84.
KOiK09228.
PhylomeDBiQ9BR84.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000090329-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF559. human.
GenomeRNAii84527.
PROiQ9BR84.

Gene expression databases

BgeeiENSG00000188321.
CleanExiHS_ZNF559.
ExpressionAtlasiQ9BR84. baseline and differential.
GenevisibleiQ9BR84. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN559_HUMAN
AccessioniPrimary (citable) accession number: Q9BR84
Secondary accession number(s): K7EMG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.