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Protein

Coronin-1B

Gene

CORO1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).By similarity1 Publication

GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • Arp2/3 complex binding Source: UniProtKB
  • cadherin binding Source: BHF-UCL
  • identical protein binding Source: UniProtKB

GO - Biological processi

  • actin cytoskeleton organization Source: CACAO
  • actin filament branching Source: UniProtKB
  • actin filament bundle assembly Source: UniProtKB
  • cell migration Source: UniProtKB
  • cellular response to platelet-derived growth factor stimulus Source: UniProtKB
  • endothelial cell chemotaxis Source: UniProtKB
  • negative regulation of Arp2/3 complex-mediated actin nucleation Source: UniProtKB
  • negative regulation of smooth muscle cell chemotaxis Source: UniProtKB
  • positive regulation of lamellipodium morphogenesis Source: UniProtKB
  • protein localization to cell leading edge Source: UniProtKB
  • regulation of Arp2/3 complex-mediated actin nucleation Source: UniProtKB
  • ruffle organization Source: UniProtKB
  • wound healing Source: UniProtKB

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

SignaLinkiQ9BR76.
SIGNORiQ9BR76.

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-1B
Alternative name(s):
Coronin-2
Gene namesi
Name:CORO1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000172725.13.
HGNCiHGNC:2253. CORO1B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2S → A: Stronger interaction with the Arp2/3 complex. Does not affect homo-oligomerization. Enhanced ruffling in response to phorbol 12-myristate 13-acetate (PMA) and increased speed in fibroblasts. 1 Publication1
Mutagenesisi2S → D: Weaker interaction with the Arp2/3 complex. Does not affect homo-oligomerization. Attenuated PMA-induced ruffling and slower speed in fibroblasts. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000172725.
PharmGKBiPA26769.

Polymorphism and mutation databases

BioMutaiCORO1B.
DMDMi21263481.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509221 – 489Coronin-1BAdd BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2Phosphoserine; by PKC1 Publication1

Post-translational modificationi

Phosphorylation by PKC on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts. Phosphorylation does not seem to affect subcellular location.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BR76.
MaxQBiQ9BR76.
PaxDbiQ9BR76.
PeptideAtlasiQ9BR76.
PRIDEiQ9BR76.

PTM databases

iPTMnetiQ9BR76.
PhosphoSitePlusiQ9BR76.
SwissPalmiQ9BR76.

Expressioni

Gene expression databases

BgeeiENSG00000172725.
CleanExiHS_CORO1B.
ExpressionAtlasiQ9BR76. baseline and differential.
GenevisibleiQ9BR76. HS.

Organism-specific databases

HPAiCAB017616.
HPA040113.
HPA070456.

Interactioni

Subunit structurei

Forms homooligomers, but does not form complexes with the other coronins. Interacts with Arp2/3 complex components, including ACTR2, ARPC1B and ARPC2. Binds actin (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • Arp2/3 complex binding Source: UniProtKB
  • cadherin binding Source: BHF-UCL
  • identical protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121425. 74 interactors.
DIPiDIP-33176N.
IntActiQ9BR76. 33 interactors.
MINTiMINT-5005556.
STRINGi9606.ENSP00000340211.

Structurei

3D structure databases

ProteinModelPortaliQ9BR76.
SMRiQ9BR76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 72WD 1Add BLAST55
Repeati73 – 122WD 2Add BLAST50
Repeati123 – 166WD 3Add BLAST44
Repeati167 – 210WD 4Add BLAST44
Repeati211 – 256WD 5Add BLAST46
Repeati257 – 296WD 6Add BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili449 – 474Sequence analysisAdd BLAST26

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0303. Eukaryota.
ENOG410XQAD. LUCA.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiQ9BR76.
KOiK13886.
OMAiLKNGYVP.
OrthoDBiEOG091G03H5.
PhylomeDBiQ9BR76.
TreeFamiTF314280.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiView protein in InterPro
IPR027340. Coro1b.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PANTHERiPTHR10856. PTHR10856. 1 hit.
PTHR10856:SF30. PTHR10856:SF30. 1 hit.
PfamiView protein in Pfam
PF08953. DUF1899. 1 hit.
PF00400. WD40. 3 hits.
SMARTiView protein in SMART
SM01166. DUF1899. 1 hit.
SM00320. WD40. 3 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BR76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFRKVVRQS KFRHVFGQPV KNDQCYEDIR VSRVTWDSTF CAVNPKFLAV
60 70 80 90 100
IVEASGGGAF LVLPLSKTGR IDKAYPTVCG HTGPVLDIDW CPHNDEVIAS
110 120 130 140 150
GSEDCTVMVW QIPENGLTSP LTEPVVVLEG HTKRVGIIAW HPTARNVLLS
160 170 180 190 200
AGCDNVVLIW NVGTAEELYR LDSLHPDLIY NVSWNHNGSL FCSACKDKSV
210 220 230 240 250
RIIDPRRGTL VAEREKAHEG ARPMRAIFLA DGKVFTTGFS RMSERQLALW
260 270 280 290 300
DPENLEEPMA LQELDSSNGA LLPFYDPDTS VVYVCGKGDS SIRYFEITEE
310 320 330 340 350
PPYIHFLNTF TSKEPQRGMG SMPKRGLEVS KCEIARFYKL HERKCEPIVM
360 370 380 390 400
TVPRKSDLFQ DDLYPDTAGP EAALEAEEWV SGRDADPILI SLREAYVPSK
410 420 430 440 450
QRDLKISRRN VLSDSRPAMA PGSSHLGAPA STTTAADATP SGSLARAGEA
460 470 480
GKLEEVMQEL RALRALVKEQ GDRICRLEEQ LGRMENGDA
Length:489
Mass (Da):54,235
Last modified:June 1, 2001 - v1
Checksum:iA6012FDA683ECB59
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035877411V → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs756117196Ensembl.1
Natural variantiVAR_053389476R → L. Corresponds to variant dbSNP:rs2286624Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315399 mRNA. Translation: BAG37792.1.
CH471076 Genomic DNA. Translation: EAW74623.1.
BC006449 mRNA. Translation: AAH06449.1.
CCDSiCCDS8164.1.
RefSeqiNP_001018080.1. NM_001018070.2.
NP_065174.1. NM_020441.2.
UniGeneiHs.6191.

Genome annotation databases

EnsembliENST00000341356; ENSP00000340211; ENSG00000172725.
ENST00000393893; ENSP00000377471; ENSG00000172725.
GeneIDi57175.
KEGGihsa:57175.
UCSCiuc001olk.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCOR1B_HUMAN
AccessioniPrimary (citable) accession number: Q9BR76
Secondary accession number(s): B2RD45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families