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Protein

Coronin-1B

Gene

CORO1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity).By similarity1 Publication

GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • Arp2/3 complex binding Source: UniProtKB
  • cadherin binding Source: BHF-UCL
  • identical protein binding Source: UniProtKB

GO - Biological processi

  • actin cytoskeleton organization Source: CACAO
  • actin filament branching Source: UniProtKB
  • actin filament bundle assembly Source: UniProtKB
  • cell migration Source: UniProtKB
  • cellular response to platelet-derived growth factor stimulus Source: UniProtKB
  • endothelial cell chemotaxis Source: UniProtKB
  • negative regulation of Arp2/3 complex-mediated actin nucleation Source: UniProtKB
  • negative regulation of smooth muscle cell chemotaxis Source: UniProtKB
  • positive regulation of lamellipodium morphogenesis Source: UniProtKB
  • protein localization to cell leading edge Source: UniProtKB
  • regulation of Arp2/3 complex-mediated actin nucleation Source: UniProtKB
  • ruffle organization Source: UniProtKB
  • wound healing Source: UniProtKB

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

SignaLinkiQ9BR76
SIGNORiQ9BR76

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-1B
Alternative name(s):
Coronin-2
Gene namesi
Name:CORO1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000172725.13
HGNCiHGNC:2253 CORO1B
MIMi609849 gene
neXtProtiNX_Q9BR76

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2S → A: Stronger interaction with the Arp2/3 complex. Does not affect homo-oligomerization. Enhanced ruffling in response to phorbol 12-myristate 13-acetate (PMA) and increased speed in fibroblasts. 1 Publication1
Mutagenesisi2S → D: Weaker interaction with the Arp2/3 complex. Does not affect homo-oligomerization. Attenuated PMA-induced ruffling and slower speed in fibroblasts. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000172725
PharmGKBiPA26769

Polymorphism and mutation databases

BioMutaiCORO1B
DMDMi21263481

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509221 – 489Coronin-1BAdd BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2Phosphoserine; by PKC1 Publication1

Post-translational modificationi

Phosphorylation by PKC on Ser-2 regulates the interaction with the Arp2/3 complex and cell motility in fibroblasts. Phosphorylation does not seem to affect subcellular location.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BR76
MaxQBiQ9BR76
PaxDbiQ9BR76
PeptideAtlasiQ9BR76
PRIDEiQ9BR76

PTM databases

iPTMnetiQ9BR76
PhosphoSitePlusiQ9BR76
SwissPalmiQ9BR76

Expressioni

Gene expression databases

BgeeiENSG00000172725
CleanExiHS_CORO1B
ExpressionAtlasiQ9BR76 baseline and differential
GenevisibleiQ9BR76 HS

Organism-specific databases

HPAiCAB017616
HPA040113
HPA070456

Interactioni

Subunit structurei

Forms homooligomers, but does not form complexes with the other coronins. Interacts with Arp2/3 complex components, including ACTR2, ARPC1B and ARPC2. Binds actin (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • actin filament binding Source: UniProtKB
  • cadherin binding Source: BHF-UCL
  • identical protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121425, 76 interactors
DIPiDIP-33176N
IntActiQ9BR76, 35 interactors
STRINGi9606.ENSP00000340211

Structurei

3D structure databases

ProteinModelPortaliQ9BR76
SMRiQ9BR76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 72WD 1Add BLAST55
Repeati73 – 122WD 2Add BLAST50
Repeati123 – 166WD 3Add BLAST44
Repeati167 – 210WD 4Add BLAST44
Repeati211 – 256WD 5Add BLAST46
Repeati257 – 296WD 6Add BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili449 – 474Sequence analysisAdd BLAST26

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0303 Eukaryota
ENOG410XQAD LUCA
GeneTreeiENSGT00760000119195
HOGENOMiHOG000166356
HOVERGENiHBG059978
InParanoidiQ9BR76
KOiK13886
OMAiLKNGYVP
OrthoDBiEOG091G03H5
PhylomeDBiQ9BR76
TreeFamiTF314280

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR027340 Coro1b
IPR015505 Coronin
IPR015048 DUF1899
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR10856 PTHR10856, 1 hit
PTHR10856:SF24 PTHR10856:SF24, 1 hit
PfamiView protein in Pfam
PF08953 DUF1899, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM01166 DUF1899, 1 hit
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BR76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFRKVVRQS KFRHVFGQPV KNDQCYEDIR VSRVTWDSTF CAVNPKFLAV
60 70 80 90 100
IVEASGGGAF LVLPLSKTGR IDKAYPTVCG HTGPVLDIDW CPHNDEVIAS
110 120 130 140 150
GSEDCTVMVW QIPENGLTSP LTEPVVVLEG HTKRVGIIAW HPTARNVLLS
160 170 180 190 200
AGCDNVVLIW NVGTAEELYR LDSLHPDLIY NVSWNHNGSL FCSACKDKSV
210 220 230 240 250
RIIDPRRGTL VAEREKAHEG ARPMRAIFLA DGKVFTTGFS RMSERQLALW
260 270 280 290 300
DPENLEEPMA LQELDSSNGA LLPFYDPDTS VVYVCGKGDS SIRYFEITEE
310 320 330 340 350
PPYIHFLNTF TSKEPQRGMG SMPKRGLEVS KCEIARFYKL HERKCEPIVM
360 370 380 390 400
TVPRKSDLFQ DDLYPDTAGP EAALEAEEWV SGRDADPILI SLREAYVPSK
410 420 430 440 450
QRDLKISRRN VLSDSRPAMA PGSSHLGAPA STTTAADATP SGSLARAGEA
460 470 480
GKLEEVMQEL RALRALVKEQ GDRICRLEEQ LGRMENGDA
Length:489
Mass (Da):54,235
Last modified:June 1, 2001 - v1
Checksum:iA6012FDA683ECB59
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035877411V → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs756117196Ensembl.1
Natural variantiVAR_053389476R → L. Corresponds to variant dbSNP:rs2286624Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315399 mRNA Translation: BAG37792.1
CH471076 Genomic DNA Translation: EAW74623.1
BC006449 mRNA Translation: AAH06449.1
CCDSiCCDS8164.1
RefSeqiNP_001018080.1, NM_001018070.2
NP_065174.1, NM_020441.2
UniGeneiHs.6191

Genome annotation databases

EnsembliENST00000341356; ENSP00000340211; ENSG00000172725
ENST00000393893; ENSP00000377471; ENSG00000172725
GeneIDi57175
KEGGihsa:57175
UCSCiuc001olk.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCOR1B_HUMAN
AccessioniPrimary (citable) accession number: Q9BR76
Secondary accession number(s): B2RD45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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Main funding by: National Institutes of Health