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Protein

Acyl-CoA-binding domain-containing protein 6

Gene

ACBD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95Acyl-CoABy similarity1
Binding sitei114Acyl-CoABy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135847-MONOMER.
ReactomeiR-HSA-75105. Fatty Acyl-CoA Biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding domain-containing protein 6
Gene namesi
Name:ACBD6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:23339. ACBD6.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi84320.
OpenTargetsiENSG00000230124.
PharmGKBiPA134925459.

Polymorphism and mutation databases

BioMutaiACBD6.
DMDMi74762703.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002328791 – 282Acyl-CoA-binding domain-containing protein 6Add BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei106PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BR61.
MaxQBiQ9BR61.
PaxDbiQ9BR61.
PeptideAtlasiQ9BR61.
PRIDEiQ9BR61.

PTM databases

iPTMnetiQ9BR61.
PhosphoSitePlusiQ9BR61.

Expressioni

Tissue specificityi

Detected in placenta and spleen (at protein level). Detected in placenta, umbilical cord blood, CD34-positive hematopoietic progenitor cells and bone marrow.1 Publication

Gene expression databases

BgeeiENSG00000135847.
CleanExiHS_ACBD6.
ExpressionAtlasiQ9BR61. baseline and differential.
GenevisibleiQ9BR61. HS.

Organism-specific databases

HPAiHPA028179.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi124046. 3 interactors.
IntActiQ9BR61. 5 interactors.
STRINGi9606.ENSP00000356567.

Structurei

Secondary structure

1282
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi43 – 53Combined sources11
Turni57 – 59Combined sources3
Helixi62 – 76Combined sources15
Helixi90 – 100Combined sources11
Helixi107 – 121Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2COPNMR-A42-137[»]
ProteinModelPortaliQ9BR61.
SMRiQ9BR61.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BR61.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 127ACBPROSITE-ProRule annotationAdd BLAST86
Repeati191 – 220ANK 1Add BLAST30
Repeati224 – 253ANK 2Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni69 – 73Acyl-CoA bindingBy similarity5

Sequence similaritiesi

Contains 1 ACB (acyl-CoA-binding) domain.PROSITE-ProRule annotation
Contains 2 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
GeneTreeiENSGT00820000127112.
HOGENOMiHOG000241133.
HOVERGENiHBG080775.
InParanoidiQ9BR61.
OMAiPGWNPQS.
OrthoDBiEOG091G0NXJ.
PhylomeDBiQ9BR61.
TreeFamiTF329102.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
1.25.40.20. 1 hit.
InterProiIPR000582. Acyl-CoA-binding_protein.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR00689. ACOABINDINGP.
PR01415. ANKYRIN.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF47027. SSF47027. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS51228. ACB_2. 1 hit.
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BR61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSFLPAGA ITGDSGGELS SGDDSGEVEF PHSPEIEETS CLAELFEKAA
60 70 80 90 100
AHLQGLIQVA SREQLLYLYA RYKQVKVGNC NTPKPSFFDF EGKQKWEAWK
110 120 130 140 150
ALGDSSPSQA MQEYIAVVKK LDPGWNPQIP EKKGKEANTG FGGPVISSLY
160 170 180 190 200
HEETIREEDK NIFDYCRENN IDHITKAIKS KNVDVNVKDE EGRALLHWAC
210 220 230 240 250
DRGHKELVTV LLQHRADINC QDNEGQTALH YASACEFLDI VELLLQSGAD
260 270 280
PTLRDQDGCL PEEVTGCKTV SLVLQRHTTG KA
Length:282
Mass (Da):31,151
Last modified:June 1, 2001 - v1
Checksum:i0EA01CFDB5C5ECB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445469, AL139141, AL358354 Genomic DNA. Translation: CAH71747.1.
AL139141, AL358354, AL445469 Genomic DNA. Translation: CAI19365.1.
AL358354, AL139141, AL445469 Genomic DNA. Translation: CAI15093.1.
BC006505 mRNA. Translation: AAH06505.1.
CCDSiCCDS1339.1.
RefSeqiNP_115736.1. NM_032360.3.
UniGeneiHs.200051.

Genome annotation databases

EnsembliENST00000367595; ENSP00000356567; ENSG00000230124.
GeneIDi84320.
KEGGihsa:84320.
UCSCiuc001gog.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445469, AL139141, AL358354 Genomic DNA. Translation: CAH71747.1.
AL139141, AL358354, AL445469 Genomic DNA. Translation: CAI19365.1.
AL358354, AL139141, AL445469 Genomic DNA. Translation: CAI15093.1.
BC006505 mRNA. Translation: AAH06505.1.
CCDSiCCDS1339.1.
RefSeqiNP_115736.1. NM_032360.3.
UniGeneiHs.200051.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2COPNMR-A42-137[»]
ProteinModelPortaliQ9BR61.
SMRiQ9BR61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124046. 3 interactors.
IntActiQ9BR61. 5 interactors.
STRINGi9606.ENSP00000356567.

PTM databases

iPTMnetiQ9BR61.
PhosphoSitePlusiQ9BR61.

Polymorphism and mutation databases

BioMutaiACBD6.
DMDMi74762703.

Proteomic databases

EPDiQ9BR61.
MaxQBiQ9BR61.
PaxDbiQ9BR61.
PeptideAtlasiQ9BR61.
PRIDEiQ9BR61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367595; ENSP00000356567; ENSG00000230124.
GeneIDi84320.
KEGGihsa:84320.
UCSCiuc001gog.4. human.

Organism-specific databases

CTDi84320.
DisGeNETi84320.
GeneCardsiACBD6.
LHX4-AS1.
HGNCiHGNC:23339. ACBD6.
HPAiHPA028179.
MIMi616352. gene.
neXtProtiNX_Q9BR61.
OpenTargetsiENSG00000230124.
PharmGKBiPA134925459.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
GeneTreeiENSGT00820000127112.
HOGENOMiHOG000241133.
HOVERGENiHBG080775.
InParanoidiQ9BR61.
OMAiPGWNPQS.
OrthoDBiEOG091G0NXJ.
PhylomeDBiQ9BR61.
TreeFamiTF329102.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135847-MONOMER.
ReactomeiR-HSA-75105. Fatty Acyl-CoA Biosynthesis.

Miscellaneous databases

ChiTaRSiACBD6. human.
EvolutionaryTraceiQ9BR61.
GenomeRNAii84320.
PROiQ9BR61.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135847.
CleanExiHS_ACBD6.
ExpressionAtlasiQ9BR61. baseline and differential.
GenevisibleiQ9BR61. HS.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
1.25.40.20. 1 hit.
InterProiIPR000582. Acyl-CoA-binding_protein.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR00689. ACOABINDINGP.
PR01415. ANKYRIN.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF47027. SSF47027. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS51228. ACB_2. 1 hit.
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACBD6_HUMAN
AccessioniPrimary (citable) accession number: Q9BR61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.