Reviewed, UniProtKB/Swiss-Prot Q9BR61 (ACBD6_HUMAN)

Names and origin

Protein names

Recommended name:
    Acyl-CoA-binding domain-containing protein 6

Gene names

Name:

ACBD6

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids. Ref.3
Subunit structure	Monomer. Ref.3
Subcellular location	Cytoplasm Ref.3.
Tissue specificity	Detected in placenta and spleen (at protein level). Detected in placenta, umbilical cord blood, CD34-positive hematopoietic progenitor cells and bone marrow. Ref.3
Sequence similarities	Contains 1 ACB (acyl-CoA-binding) domain. Contains 2 ANK repeats.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	ANK repeat Repeat
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acyl-CoA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 282

282

Acyl-CoA-binding domain-containing protein 6

PRO_0000232879

Regions

Domain

42 – 127

86

ACB

Repeat

191 – 220

30

ANK 1

Repeat

224 – 253

30

ANK 2

Amino acid modifications

Modified residue

69

1

Phosphotyrosine By similarity

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

282

Helix Strand Turn

Details...

Helix

43 – 53

11

Turn

57 – 59

3

Helix

62 – 76

15

Helix

90 – 100

11

Helix

107 – 121

15

Sequences

	Sequence		Length	Mass (Da)
	Q9BR61-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 0EA01CFDB5C5ECB2	FASTA	282	31,151
	10 20 30 40 50 60 MASSFLPAGA ITGDSGGELS SGDDSGEVEF PHSPEIEETS CLAELFEKAA AHLQGLIQVA 70 80 90 100 110 120 SREQLLYLYA RYKQVKVGNC NTPKPSFFDF EGKQKWEAWK ALGDSSPSQA MQEYIAVVKK 130 140 150 160 170 180 LDPGWNPQIP EKKGKEANTG FGGPVISSLY HEETIREEDK NIFDYCRENN IDHITKAIKS 190 200 210 220 230 240 KNVDVNVKDE EGRALLHWAC DRGHKELVTV LLQHRADINC QDNEGQTALH YASACEFLDI 250 260 270 280 VELLLQSGAD PTLRDQDGCL PEEVTGCKTV SLVLQRHTTG KA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[3]	"Characterization of an acyl-coenzyme A binding protein predominantly expressed in human primitive progenitor cells." Soupene E., Serikov V., Kuypers F.A. J. Lipid Res. 49:1103-1112(2008) [PubMed: 18268358] [Abstract] Cited for: FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[4]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[5]	"Solution structure of RSGI RUH-040, an ACBP domain from human cDNA." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 42-137.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AL445469, AL139141, AL358354 Genomic DNA. Translation: CAH71747.1.
AL139141, AL358354, AL445469 Genomic DNA. Translation: CAI19365.1.
AL358354, AL139141, AL445469 Genomic DNA. Translation: CAI15093.1.
BC006505 mRNA. Translation: AAH06505.1.

IPI

IPI00031680.

RefSeq

NP_115736.1.

UniGene

Hs.200051

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2COP	NMR	-	A	42-137	[»]

ModBase

Search...

PTM databases

PhosphoSite

Q9BR61.

Proteomic databases

PRIDE

Q9BR61.

Genome annotation databases

Ensembl

ENST00000367595; ENSP00000356567; ENSG00000135847; Homo sapiens. [Genome view]

GeneID

84320.

KEGG

hsa:84320.

UCSC

uc001gog.1. human.

Organism-specific databases

CTD

84320.

GeneCards

GC01M178523.

HGNC

HGNC:23339. ACBD6.

PharmGKB

PA134925459.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

HBG596574.

HOVERGEN

Q9BR61.

InParanoid

Q9BR61.

OMA

WNPQSPE.

OrthoDB

EOG9X9B3D.

Gene expression databases

ArrayExpress

Q9BR61.

Bgee

Q9BR61.

CleanEx

HS_ACBD6.

Genevestigator

Q9BR61.

GermOnline

ENSG00000135847. Homo sapiens.

Family and domain databases

InterPro

IPR000582. Acyl-CoA-binding_protein.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR014352. FERM/acyl-CoA_bd_prot_3-hlx.
[Graphical view]

Gene3D

G3DSA:1.20.80.10. ACBP. 1 hit.
G3DSA:1.25.40.20. ANK. 1 hit.

Pfam

PF00887. ACBP. 1 hit.
PF00023. Ank. 2 hits.
[Graphical view]

PRINTS

PR00689. ACOABINDINGP.

SMART

SM00248. ANK. 2 hits.
[Graphical view]

PROSITE

PS00880. ACB_1. False negative.
PS51228. ACB_2. 1 hit.
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

74044.

Entry information

Entry name

ACBD6_HUMAN

Accession

Primary (citable) accession number: Q9BR61

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 18, 2006
Last sequence update:	June 1, 2001
Last modified:	December 15, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.