ID OCSTP_HUMAN Reviewed; 566 AA. AC Q9BR26; DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-2008, sequence version 2. DT 27-MAR-2024, entry version 122. DE RecName: Full=Osteoclast stimulatory transmembrane protein; DE Short=OC-STAMP; GN Name=OCSTAMP; Synonyms=C20orf123; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11780052; DOI=10.1038/414865a; RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 20."; RL Nature 414:865-871(2001). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-472. RA Ashcroft K., Bethel G., Bye J.M., Howell G.R., Huckle E.J., Sheridan E.; RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 454-566. RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Probable cell surface receptor that plays a role in cellular CC fusion and cell differentiation. Cooperates with DCSTAMP in modulating CC cell-cell fusion in both osteoclasts and foreign body giant cells CC (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast CC differentiation and may play a role in the multinucleated osteoclast CC maturation (By similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AL935075; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL034424; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL935075; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; AL935089; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; BX281477; -; NOT_ANNOTATED_CDS; mRNA. DR CCDS; CCDS54468.1; -. DR RefSeq; NP_542452.1; NM_080721.2. DR AlphaFoldDB; Q9BR26; -. DR STRING; 9606.ENSP00000279028; -. DR TCDB; 1.N.1.1.1; the osteoclast fusion complex (ofc) family. DR PhosphoSitePlus; Q9BR26; -. DR BioMuta; OCSTAMP; -. DR DMDM; 193806176; -. DR PaxDb; 9606-ENSP00000279028; -. DR ProteomicsDB; 78739; -. DR Antibodypedia; 28113; 23 antibodies from 10 providers. DR DNASU; 128506; -. DR Ensembl; ENST00000279028.3; ENSP00000279028.2; ENSG00000149635.3. DR GeneID; 128506; -. DR KEGG; hsa:128506; -. DR MANE-Select; ENST00000279028.3; ENSP00000279028.2; NM_080721.3; NP_542452.1. DR UCSC; uc010zxu.3; human. DR AGR; HGNC:16116; -. DR GeneCards; OCSTAMP; -. DR HGNC; HGNC:16116; OCSTAMP. DR HPA; ENSG00000149635; Not detected. DR MIM; 620432; gene. DR neXtProt; NX_Q9BR26; -. DR OpenTargets; ENSG00000149635; -. DR PharmGKB; PA25664; -. DR VEuPathDB; HostDB:ENSG00000149635; -. DR eggNOG; ENOG502QWNK; Eukaryota. DR GeneTree; ENSGT00940000153269; -. DR HOGENOM; CLU_045128_0_0_1; -. DR InParanoid; Q9BR26; -. DR OMA; ARCVFSM; -. DR OrthoDB; 4641300at2759; -. DR PhylomeDB; Q9BR26; -. DR TreeFam; TF332562; -. DR PathwayCommons; Q9BR26; -. DR SignaLink; Q9BR26; -. DR BioGRID-ORCS; 128506; 17 hits in 1141 CRISPR screens. DR GenomeRNAi; 128506; -. DR Pharos; Q9BR26; Tdark. DR PRO; PR:Q9BR26; -. DR Proteomes; UP000005640; Chromosome 20. DR RNAct; Q9BR26; Protein. DR Bgee; ENSG00000149635; Expressed in adult mammalian kidney and 3 other cell types or tissues. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0071391; P:cellular response to estrogen stimulus; ISS:UniProtKB. DR GO; GO:0071356; P:cellular response to tumor necrosis factor; ISS:UniProtKB. DR GO; GO:0072674; P:multinuclear osteoclast differentiation; ISS:UniProtKB. DR GO; GO:0034241; P:positive regulation of macrophage fusion; IEA:Ensembl. DR GO; GO:0045672; P:positive regulation of osteoclast differentiation; ISS:UniProtKB. DR GO; GO:0090290; P:positive regulation of osteoclast proliferation; ISS:UniProtKB. DR InterPro; IPR012858; DC_STAMP-like. DR PANTHER; PTHR21041; DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN; 1. DR PANTHER; PTHR21041:SF3; OSTEOCLAST STIMULATORY TRANSMEMBRANE PROTEIN; 1. DR Pfam; PF07782; DC_STAMP; 1. PE 2: Evidence at transcript level; KW Differentiation; Membrane; Reference proteome; Transmembrane; KW Transmembrane helix. FT CHAIN 1..566 FT /note="Osteoclast stimulatory transmembrane protein" FT /id="PRO_0000342121" FT TOPO_DOM 1..51 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 52..72 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 73..81 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 82..102 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 103..128 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 129..149 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 150..227 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 228..248 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 249..304 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 305..325 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 326..398 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 399..419 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 420..566 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT VARIANT 565 FT /note="P -> S (in dbSNP:rs847079)" FT /id="VAR_050919" SQ SEQUENCE 566 AA; 61579 MW; 3F2F24D0137F859E CRC64; MPGHPGAAEQ LVKTGWRSWH LGFWKALAPL QAAWDAFSQP VPASCGQLLT QLLLCASLAA AAAGLVYHWL ASLLLYPPGP SAMVATVCGL LVFLSLGLVP PVRCLFALSV PTLGMEQGRR LLLSYSTATL AIAVVPNVLA NVGAAGQVLR CVTEGSLESL LNTTHQLHAA SRALGPTGQA GSRGLTFEAQ DNGSAFYLHM LRVTQQVLED FSGLESLARA AALGTQRVVT GLFMLGLLVE SAWYLHCYLT DLRFDNIYAT QQLTQRLAQA QATHLLAPPP TWLLQAAQLR LSQEELLSCL LRLGLLALLL VATAVAVATD HVAFLLAQAT VDWAQKLPTV PITLTVKYDV AYTVLGFIPF LFNQLAPESP FLSVHSSYQW ELRLTSARCP LLPARRPRAA APLAAGALQL LAGSTVLLEA YARRLRHAIA ASFFTAQEAR RVRHLHARLQ RRHDRHQGQQ LPLGDPSCVP TPRPACKPPA WIDYRLDALR TESSEGEGKE LWSCRDLSCN LGPVPPPCVT LGKSLHLSEP RFLHLHNDSI FTIDVTYFPR RDVVRMEGNT GHDRPG //