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Q9BR26 (OCSTP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Osteoclast stimulatory transmembrane protein

Short name=OC-STAMP
Gene names
Name:OCSTAMP
Synonyms:C20orf123
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length566 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence caution

The sequence AL935075 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 566566Osteoclast stimulatory transmembrane protein
PRO_0000342121

Regions

Topological domain1 – 5151Cytoplasmic Potential
Transmembrane52 – 7221Helical; Potential
Topological domain73 – 819Extracellular Potential
Transmembrane82 – 10221Helical; Potential
Topological domain103 – 12826Cytoplasmic Potential
Transmembrane129 – 14921Helical; Potential
Topological domain150 – 22778Extracellular Potential
Transmembrane228 – 24821Helical; Potential
Topological domain249 – 30456Cytoplasmic Potential
Transmembrane305 – 32521Helical; Potential
Topological domain326 – 39873Extracellular Potential
Transmembrane399 – 41921Helical; Potential
Topological domain420 – 566147Cytoplasmic Potential
Compositional bias59 – 635Poly-Ala

Natural variations

Natural variant5651P → S.
Corresponds to variant rs847079 [ dbSNP | Ensembl ].
VAR_050919

Sequences

Sequence LengthMass (Da)Tools
Q9BR26 [UniParc].

Last modified July 1, 2008. Version 2.
Checksum: 3F2F24D0137F859E

FASTA56661,579
        10         20         30         40         50         60 
MPGHPGAAEQ LVKTGWRSWH LGFWKALAPL QAAWDAFSQP VPASCGQLLT QLLLCASLAA 

        70         80         90        100        110        120 
AAAGLVYHWL ASLLLYPPGP SAMVATVCGL LVFLSLGLVP PVRCLFALSV PTLGMEQGRR 

       130        140        150        160        170        180 
LLLSYSTATL AIAVVPNVLA NVGAAGQVLR CVTEGSLESL LNTTHQLHAA SRALGPTGQA 

       190        200        210        220        230        240 
GSRGLTFEAQ DNGSAFYLHM LRVTQQVLED FSGLESLARA AALGTQRVVT GLFMLGLLVE 

       250        260        270        280        290        300 
SAWYLHCYLT DLRFDNIYAT QQLTQRLAQA QATHLLAPPP TWLLQAAQLR LSQEELLSCL 

       310        320        330        340        350        360 
LRLGLLALLL VATAVAVATD HVAFLLAQAT VDWAQKLPTV PITLTVKYDV AYTVLGFIPF 

       370        380        390        400        410        420 
LFNQLAPESP FLSVHSSYQW ELRLTSARCP LLPARRPRAA APLAAGALQL LAGSTVLLEA 

       430        440        450        460        470        480 
YARRLRHAIA ASFFTAQEAR RVRHLHARLQ RRHDRHQGQQ LPLGDPSCVP TPRPACKPPA 

       490        500        510        520        530        540 
WIDYRLDALR TESSEGEGKE LWSCRDLSCN LGPVPPPCVT LGKSLHLSEP RFLHLHNDSI 

       550        560 
FTIDVTYFPR RDVVRMEGNT GHDRPG 

« Hide

References

[1]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Ashcroft K., Bethel G., Bye J.M., Howell G.R., Huckle E.J., Sheridan E.
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-472.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 454-566.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL034424 Genomic DNA. Translation: CAC36102.2.
AL935075 mRNA. No translation available.
AL935089 mRNA. No translation available.
BX281477 mRNA. No translation available.
RefSeqNP_542452.1. NM_080721.2.
UniGeneHs.526636.

3D structure databases

ProteinModelPortalQ9BR26.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9BR26.

Polymorphism databases

DMDM193806176.

Proteomic databases

PaxDbQ9BR26.
PRIDEQ9BR26.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000279028; ENSP00000279028; ENSG00000149635.
GeneID128506.
KEGGhsa:128506.
UCSCuc010zxu.2. human.

Organism-specific databases

CTD128506.
GeneCardsGC20M045170.
HGNCHGNC:16116. OCSTAMP.
HPAHPA031116.
neXtProtNX_Q9BR26.
PharmGKBPA25664.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42898.
HOGENOMHOG000112028.
HOVERGENHBG107776.
InParanoidQ9BR26.
OMAFIPFLFN.
OrthoDBEOG78M022.
PhylomeDBQ9BR26.
TreeFamTF332562.

Gene expression databases

BgeeQ9BR26.
CleanExHS_C20orf123.
GenevestigatorQ9BR26.

Family and domain databases

InterProIPR012858. DC_STAMP-like.
[Graphical view]
PfamPF07782. DC_STAMP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio82378.
PROQ9BR26.

Entry information

Entry nameOCSTP_HUMAN
AccessionPrimary (citable) accession number: Q9BR26
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: April 16, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM