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Q9BR26

- OCSTP_HUMAN

UniProt

Q9BR26 - OCSTP_HUMAN

Protein

Osteoclast stimulatory transmembrane protein

Gene

OCSTAMP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation By similarity.By similarity

    GO - Biological processi

    1. cellular response to estrogen stimulus Source: UniProtKB
    2. cellular response to tumor necrosis factor Source: UniProtKB
    3. multinuclear osteoclast differentiation Source: UniProtKB
    4. positive regulation of macrophage fusion Source: Ensembl
    5. positive regulation of osteoclast differentiation Source: UniProtKB
    6. positive regulation of osteoclast proliferation Source: UniProtKB

    Keywords - Biological processi

    Differentiation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Osteoclast stimulatory transmembrane protein
    Short name:
    OC-STAMP
    Gene namesi
    Name:OCSTAMP
    Synonyms:C20orf123
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:16116. OCSTAMP.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25664.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 566566Osteoclast stimulatory transmembrane proteinPRO_0000342121Add
    BLAST

    Proteomic databases

    PaxDbiQ9BR26.
    PRIDEiQ9BR26.

    PTM databases

    PhosphoSiteiQ9BR26.

    Expressioni

    Gene expression databases

    BgeeiQ9BR26.
    CleanExiHS_C20orf123.
    GenevestigatoriQ9BR26.

    Organism-specific databases

    HPAiHPA031116.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BR26.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5151CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini73 – 819ExtracellularSequence Analysis
    Topological domaini103 – 12826CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini150 – 22778ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini249 – 30456CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini326 – 39873ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini420 – 566147CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei52 – 7221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei228 – 24821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei305 – 32521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei399 – 41921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi59 – 635Poly-Ala

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42898.
    HOGENOMiHOG000112028.
    HOVERGENiHBG107776.
    InParanoidiQ9BR26.
    OMAiFIPFLFN.
    OrthoDBiEOG78M022.
    PhylomeDBiQ9BR26.
    TreeFamiTF332562.

    Family and domain databases

    InterProiIPR012858. DC_STAMP-like.
    [Graphical view]
    PfamiPF07782. DC_STAMP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BR26-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGHPGAAEQ LVKTGWRSWH LGFWKALAPL QAAWDAFSQP VPASCGQLLT    50
    QLLLCASLAA AAAGLVYHWL ASLLLYPPGP SAMVATVCGL LVFLSLGLVP 100
    PVRCLFALSV PTLGMEQGRR LLLSYSTATL AIAVVPNVLA NVGAAGQVLR 150
    CVTEGSLESL LNTTHQLHAA SRALGPTGQA GSRGLTFEAQ DNGSAFYLHM 200
    LRVTQQVLED FSGLESLARA AALGTQRVVT GLFMLGLLVE SAWYLHCYLT 250
    DLRFDNIYAT QQLTQRLAQA QATHLLAPPP TWLLQAAQLR LSQEELLSCL 300
    LRLGLLALLL VATAVAVATD HVAFLLAQAT VDWAQKLPTV PITLTVKYDV 350
    AYTVLGFIPF LFNQLAPESP FLSVHSSYQW ELRLTSARCP LLPARRPRAA 400
    APLAAGALQL LAGSTVLLEA YARRLRHAIA ASFFTAQEAR RVRHLHARLQ 450
    RRHDRHQGQQ LPLGDPSCVP TPRPACKPPA WIDYRLDALR TESSEGEGKE 500
    LWSCRDLSCN LGPVPPPCVT LGKSLHLSEP RFLHLHNDSI FTIDVTYFPR 550
    RDVVRMEGNT GHDRPG 566
    Length:566
    Mass (Da):61,579
    Last modified:July 1, 2008 - v2
    Checksum:i3F2F24D0137F859E
    GO

    Sequence cautioni

    The sequence AL935075 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti565 – 5651P → S.
    Corresponds to variant rs847079 [ dbSNP | Ensembl ].
    VAR_050919

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL034424 Genomic DNA. Translation: CAC36102.2.
    AL935075 mRNA. No translation available.
    AL935089 mRNA. No translation available.
    BX281477 mRNA. No translation available.
    CCDSiCCDS54468.1.
    RefSeqiNP_542452.1. NM_080721.2.
    UniGeneiHs.526636.

    Genome annotation databases

    EnsembliENST00000279028; ENSP00000279028; ENSG00000149635.
    GeneIDi128506.
    KEGGihsa:128506.
    UCSCiuc010zxu.2. human.

    Polymorphism databases

    DMDMi193806176.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL034424 Genomic DNA. Translation: CAC36102.2 .
    AL935075 mRNA. No translation available.
    AL935089 mRNA. No translation available.
    BX281477 mRNA. No translation available.
    CCDSi CCDS54468.1.
    RefSeqi NP_542452.1. NM_080721.2.
    UniGenei Hs.526636.

    3D structure databases

    ProteinModelPortali Q9BR26.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9BR26.

    Polymorphism databases

    DMDMi 193806176.

    Proteomic databases

    PaxDbi Q9BR26.
    PRIDEi Q9BR26.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000279028 ; ENSP00000279028 ; ENSG00000149635 .
    GeneIDi 128506.
    KEGGi hsa:128506.
    UCSCi uc010zxu.2. human.

    Organism-specific databases

    CTDi 128506.
    GeneCardsi GC20M045170.
    HGNCi HGNC:16116. OCSTAMP.
    HPAi HPA031116.
    neXtProti NX_Q9BR26.
    PharmGKBi PA25664.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42898.
    HOGENOMi HOG000112028.
    HOVERGENi HBG107776.
    InParanoidi Q9BR26.
    OMAi FIPFLFN.
    OrthoDBi EOG78M022.
    PhylomeDBi Q9BR26.
    TreeFami TF332562.

    Miscellaneous databases

    NextBioi 82378.
    PROi Q9BR26.

    Gene expression databases

    Bgeei Q9BR26.
    CleanExi HS_C20orf123.
    Genevestigatori Q9BR26.

    Family and domain databases

    InterProi IPR012858. DC_STAMP-like.
    [Graphical view ]
    Pfami PF07782. DC_STAMP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ashcroft K., Bethel G., Bye J.M., Howell G.R., Huckle E.J., Sheridan E.
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-472.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 454-566.

    Entry informationi

    Entry nameiOCSTP_HUMAN
    AccessioniPrimary (citable) accession number: Q9BR26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3