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Q9BR26

- OCSTP_HUMAN

UniProt

Q9BR26 - OCSTP_HUMAN

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Protein
Osteoclast stimulatory transmembrane protein
Gene
OCSTAMP, C20orf123
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation By similarity.

GO - Biological processi

  1. cellular response to estrogen stimulus Source: UniProtKB
  2. cellular response to tumor necrosis factor Source: UniProtKB
  3. multinuclear osteoclast differentiation Source: UniProtKB
  4. positive regulation of macrophage fusion Source: Ensembl
  5. positive regulation of osteoclast differentiation Source: UniProtKB
  6. positive regulation of osteoclast proliferation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Osteoclast stimulatory transmembrane protein
Short name:
OC-STAMP
Gene namesi
Name:OCSTAMP
Synonyms:C20orf123
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:16116. OCSTAMP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei52 – 7221Helical; Reviewed prediction
Add
BLAST
Topological domaini73 – 819Extracellular Reviewed prediction
Transmembranei82 – 10221Helical; Reviewed prediction
Add
BLAST
Topological domaini103 – 12826Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei129 – 14921Helical; Reviewed prediction
Add
BLAST
Topological domaini150 – 22778Extracellular Reviewed prediction
Add
BLAST
Transmembranei228 – 24821Helical; Reviewed prediction
Add
BLAST
Topological domaini249 – 30456Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei305 – 32521Helical; Reviewed prediction
Add
BLAST
Topological domaini326 – 39873Extracellular Reviewed prediction
Add
BLAST
Transmembranei399 – 41921Helical; Reviewed prediction
Add
BLAST
Topological domaini420 – 566147Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25664.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Osteoclast stimulatory transmembrane protein
PRO_0000342121Add
BLAST

Proteomic databases

PaxDbiQ9BR26.
PRIDEiQ9BR26.

PTM databases

PhosphoSiteiQ9BR26.

Expressioni

Gene expression databases

BgeeiQ9BR26.
CleanExiHS_C20orf123.
GenevestigatoriQ9BR26.

Organism-specific databases

HPAiHPA031116.

Structurei

3D structure databases

ProteinModelPortaliQ9BR26.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi59 – 635Poly-Ala

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42898.
HOGENOMiHOG000112028.
HOVERGENiHBG107776.
InParanoidiQ9BR26.
OMAiFIPFLFN.
OrthoDBiEOG78M022.
PhylomeDBiQ9BR26.
TreeFamiTF332562.

Family and domain databases

InterProiIPR012858. DC_STAMP-like.
[Graphical view]
PfamiPF07782. DC_STAMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BR26-1 [UniParc]FASTAAdd to Basket

« Hide

MPGHPGAAEQ LVKTGWRSWH LGFWKALAPL QAAWDAFSQP VPASCGQLLT    50
QLLLCASLAA AAAGLVYHWL ASLLLYPPGP SAMVATVCGL LVFLSLGLVP 100
PVRCLFALSV PTLGMEQGRR LLLSYSTATL AIAVVPNVLA NVGAAGQVLR 150
CVTEGSLESL LNTTHQLHAA SRALGPTGQA GSRGLTFEAQ DNGSAFYLHM 200
LRVTQQVLED FSGLESLARA AALGTQRVVT GLFMLGLLVE SAWYLHCYLT 250
DLRFDNIYAT QQLTQRLAQA QATHLLAPPP TWLLQAAQLR LSQEELLSCL 300
LRLGLLALLL VATAVAVATD HVAFLLAQAT VDWAQKLPTV PITLTVKYDV 350
AYTVLGFIPF LFNQLAPESP FLSVHSSYQW ELRLTSARCP LLPARRPRAA 400
APLAAGALQL LAGSTVLLEA YARRLRHAIA ASFFTAQEAR RVRHLHARLQ 450
RRHDRHQGQQ LPLGDPSCVP TPRPACKPPA WIDYRLDALR TESSEGEGKE 500
LWSCRDLSCN LGPVPPPCVT LGKSLHLSEP RFLHLHNDSI FTIDVTYFPR 550
RDVVRMEGNT GHDRPG 566
Length:566
Mass (Da):61,579
Last modified:July 1, 2008 - v2
Checksum:i3F2F24D0137F859E
GO

Sequence cautioni

The sequence AL935075 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti565 – 5651P → S.
Corresponds to variant rs847079 [ dbSNP | Ensembl ].
VAR_050919

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL034424 Genomic DNA. Translation: CAC36102.2.
AL935075 mRNA. No translation available.
AL935089 mRNA. No translation available.
BX281477 mRNA. No translation available.
CCDSiCCDS54468.1.
RefSeqiNP_542452.1. NM_080721.2.
UniGeneiHs.526636.

Genome annotation databases

EnsembliENST00000279028; ENSP00000279028; ENSG00000149635.
GeneIDi128506.
KEGGihsa:128506.
UCSCiuc010zxu.2. human.

Polymorphism databases

DMDMi193806176.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL034424 Genomic DNA. Translation: CAC36102.2 .
AL935075 mRNA. No translation available.
AL935089 mRNA. No translation available.
BX281477 mRNA. No translation available.
CCDSi CCDS54468.1.
RefSeqi NP_542452.1. NM_080721.2.
UniGenei Hs.526636.

3D structure databases

ProteinModelPortali Q9BR26.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9BR26.

Polymorphism databases

DMDMi 193806176.

Proteomic databases

PaxDbi Q9BR26.
PRIDEi Q9BR26.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000279028 ; ENSP00000279028 ; ENSG00000149635 .
GeneIDi 128506.
KEGGi hsa:128506.
UCSCi uc010zxu.2. human.

Organism-specific databases

CTDi 128506.
GeneCardsi GC20M045170.
HGNCi HGNC:16116. OCSTAMP.
HPAi HPA031116.
neXtProti NX_Q9BR26.
PharmGKBi PA25664.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42898.
HOGENOMi HOG000112028.
HOVERGENi HBG107776.
InParanoidi Q9BR26.
OMAi FIPFLFN.
OrthoDBi EOG78M022.
PhylomeDBi Q9BR26.
TreeFami TF332562.

Miscellaneous databases

NextBioi 82378.
PROi Q9BR26.

Gene expression databases

Bgeei Q9BR26.
CleanExi HS_C20orf123.
Genevestigatori Q9BR26.

Family and domain databases

InterProi IPR012858. DC_STAMP-like.
[Graphical view ]
Pfami PF07782. DC_STAMP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ashcroft K., Bethel G., Bye J.M., Howell G.R., Huckle E.J., Sheridan E.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-472.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 454-566.

Entry informationi

Entry nameiOCSTP_HUMAN
AccessioniPrimary (citable) accession number: Q9BR26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: July 9, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

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