Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Osteoclast stimulatory transmembrane protein

Gene

OCSTAMP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Osteoclast stimulatory transmembrane protein
Short name:
OC-STAMP
Gene namesi
Name:OCSTAMP
Synonyms:C20orf123
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16116. OCSTAMP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence AnalysisAdd
BLAST
Topological domaini73 – 819ExtracellularSequence Analysis
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Topological domaini103 – 12826CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei129 – 14921HelicalSequence AnalysisAdd
BLAST
Topological domaini150 – 22778ExtracellularSequence AnalysisAdd
BLAST
Transmembranei228 – 24821HelicalSequence AnalysisAdd
BLAST
Topological domaini249 – 30456CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence AnalysisAdd
BLAST
Topological domaini326 – 39873ExtracellularSequence AnalysisAdd
BLAST
Transmembranei399 – 41921HelicalSequence AnalysisAdd
BLAST
Topological domaini420 – 566147CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25664.

Polymorphism and mutation databases

DMDMi193806176.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Osteoclast stimulatory transmembrane proteinPRO_0000342121Add
BLAST

Proteomic databases

PaxDbiQ9BR26.
PRIDEiQ9BR26.

PTM databases

PhosphoSiteiQ9BR26.

Expressioni

Gene expression databases

BgeeiQ9BR26.
CleanExiHS_C20orf123.

Organism-specific databases

HPAiHPA031116.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000279028.

Structurei

3D structure databases

ProteinModelPortaliQ9BR26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi59 – 635Poly-Ala

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42898.
GeneTreeiENSGT00530000064296.
HOGENOMiHOG000112028.
HOVERGENiHBG107776.
InParanoidiQ9BR26.
OMAiFIPFLFN.
OrthoDBiEOG78M022.
PhylomeDBiQ9BR26.
TreeFamiTF332562.

Family and domain databases

InterProiIPR012858. DC_STAMP-like.
[Graphical view]
PfamiPF07782. DC_STAMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BR26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGHPGAAEQ LVKTGWRSWH LGFWKALAPL QAAWDAFSQP VPASCGQLLT
60 70 80 90 100
QLLLCASLAA AAAGLVYHWL ASLLLYPPGP SAMVATVCGL LVFLSLGLVP
110 120 130 140 150
PVRCLFALSV PTLGMEQGRR LLLSYSTATL AIAVVPNVLA NVGAAGQVLR
160 170 180 190 200
CVTEGSLESL LNTTHQLHAA SRALGPTGQA GSRGLTFEAQ DNGSAFYLHM
210 220 230 240 250
LRVTQQVLED FSGLESLARA AALGTQRVVT GLFMLGLLVE SAWYLHCYLT
260 270 280 290 300
DLRFDNIYAT QQLTQRLAQA QATHLLAPPP TWLLQAAQLR LSQEELLSCL
310 320 330 340 350
LRLGLLALLL VATAVAVATD HVAFLLAQAT VDWAQKLPTV PITLTVKYDV
360 370 380 390 400
AYTVLGFIPF LFNQLAPESP FLSVHSSYQW ELRLTSARCP LLPARRPRAA
410 420 430 440 450
APLAAGALQL LAGSTVLLEA YARRLRHAIA ASFFTAQEAR RVRHLHARLQ
460 470 480 490 500
RRHDRHQGQQ LPLGDPSCVP TPRPACKPPA WIDYRLDALR TESSEGEGKE
510 520 530 540 550
LWSCRDLSCN LGPVPPPCVT LGKSLHLSEP RFLHLHNDSI FTIDVTYFPR
560
RDVVRMEGNT GHDRPG
Length:566
Mass (Da):61,579
Last modified:July 1, 2008 - v2
Checksum:i3F2F24D0137F859E
GO

Sequence cautioni

The sequence AL935075 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti565 – 5651P → S.
Corresponds to variant rs847079 [ dbSNP | Ensembl ].
VAR_050919

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034424 Genomic DNA. Translation: CAC36102.2.
AL935075 mRNA. No translation available.
AL935089 mRNA. No translation available.
BX281477 mRNA. No translation available.
CCDSiCCDS54468.1.
RefSeqiNP_542452.1. NM_080721.2.
UniGeneiHs.526636.

Genome annotation databases

EnsembliENST00000279028; ENSP00000279028; ENSG00000149635.
GeneIDi128506.
KEGGihsa:128506.
UCSCiuc010zxu.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034424 Genomic DNA. Translation: CAC36102.2.
AL935075 mRNA. No translation available.
AL935089 mRNA. No translation available.
BX281477 mRNA. No translation available.
CCDSiCCDS54468.1.
RefSeqiNP_542452.1. NM_080721.2.
UniGeneiHs.526636.

3D structure databases

ProteinModelPortaliQ9BR26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000279028.

PTM databases

PhosphoSiteiQ9BR26.

Polymorphism and mutation databases

DMDMi193806176.

Proteomic databases

PaxDbiQ9BR26.
PRIDEiQ9BR26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279028; ENSP00000279028; ENSG00000149635.
GeneIDi128506.
KEGGihsa:128506.
UCSCiuc010zxu.2. human.

Organism-specific databases

CTDi128506.
GeneCardsiGC20M045170.
HGNCiHGNC:16116. OCSTAMP.
HPAiHPA031116.
neXtProtiNX_Q9BR26.
PharmGKBiPA25664.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG42898.
GeneTreeiENSGT00530000064296.
HOGENOMiHOG000112028.
HOVERGENiHBG107776.
InParanoidiQ9BR26.
OMAiFIPFLFN.
OrthoDBiEOG78M022.
PhylomeDBiQ9BR26.
TreeFamiTF332562.

Miscellaneous databases

GenomeRNAii128506.
NextBioi82378.
PROiQ9BR26.

Gene expression databases

BgeeiQ9BR26.
CleanExiHS_C20orf123.

Family and domain databases

InterProiIPR012858. DC_STAMP-like.
[Graphical view]
PfamiPF07782. DC_STAMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ashcroft K., Bethel G., Bye J.M., Howell G.R., Huckle E.J., Sheridan E.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-472.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 454-566.

Entry informationi

Entry nameiOCSTP_HUMAN
AccessioniPrimary (citable) accession number: Q9BR26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: June 24, 2015
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.