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Protein

Osteoclast stimulatory transmembrane protein

Gene

OCSTAMP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149635-MONOMER.

Protein family/group databases

TCDBi1.N.1.1.1. the osteoclast fusion complex (ofc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Osteoclast stimulatory transmembrane protein
Short name:
OC-STAMP
Gene namesi
Name:OCSTAMP
Synonyms:C20orf123
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16116. OCSTAMP.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51CytoplasmicSequence analysisAdd BLAST51
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Topological domaini73 – 81ExtracellularSequence analysis9
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 128CytoplasmicSequence analysisAdd BLAST26
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Topological domaini150 – 227ExtracellularSequence analysisAdd BLAST78
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 304CytoplasmicSequence analysisAdd BLAST56
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Topological domaini326 – 398ExtracellularSequence analysisAdd BLAST73
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 566CytoplasmicSequence analysisAdd BLAST147

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000149635.
PharmGKBiPA25664.

Polymorphism and mutation databases

DMDMi193806176.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003421211 – 566Osteoclast stimulatory transmembrane proteinAdd BLAST566

Proteomic databases

PaxDbiQ9BR26.
PRIDEiQ9BR26.

PTM databases

PhosphoSitePlusiQ9BR26.

Expressioni

Gene expression databases

BgeeiENSG00000149635.
CleanExiHS_C20orf123.

Organism-specific databases

HPAiHPA031116.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000279028.

Structurei

3D structure databases

ProteinModelPortaliQ9BR26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi59 – 63Poly-Ala5

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INN5. Eukaryota.
ENOG4110TNU. LUCA.
GeneTreeiENSGT00530000064296.
HOGENOMiHOG000112028.
HOVERGENiHBG107776.
InParanoidiQ9BR26.
OMAiFIPFLFN.
OrthoDBiEOG091G0BT9.
PhylomeDBiQ9BR26.
TreeFamiTF332562.

Family and domain databases

InterProiIPR012858. DC_STAMP-like.
[Graphical view]
PfamiPF07782. DC_STAMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BR26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGHPGAAEQ LVKTGWRSWH LGFWKALAPL QAAWDAFSQP VPASCGQLLT
60 70 80 90 100
QLLLCASLAA AAAGLVYHWL ASLLLYPPGP SAMVATVCGL LVFLSLGLVP
110 120 130 140 150
PVRCLFALSV PTLGMEQGRR LLLSYSTATL AIAVVPNVLA NVGAAGQVLR
160 170 180 190 200
CVTEGSLESL LNTTHQLHAA SRALGPTGQA GSRGLTFEAQ DNGSAFYLHM
210 220 230 240 250
LRVTQQVLED FSGLESLARA AALGTQRVVT GLFMLGLLVE SAWYLHCYLT
260 270 280 290 300
DLRFDNIYAT QQLTQRLAQA QATHLLAPPP TWLLQAAQLR LSQEELLSCL
310 320 330 340 350
LRLGLLALLL VATAVAVATD HVAFLLAQAT VDWAQKLPTV PITLTVKYDV
360 370 380 390 400
AYTVLGFIPF LFNQLAPESP FLSVHSSYQW ELRLTSARCP LLPARRPRAA
410 420 430 440 450
APLAAGALQL LAGSTVLLEA YARRLRHAIA ASFFTAQEAR RVRHLHARLQ
460 470 480 490 500
RRHDRHQGQQ LPLGDPSCVP TPRPACKPPA WIDYRLDALR TESSEGEGKE
510 520 530 540 550
LWSCRDLSCN LGPVPPPCVT LGKSLHLSEP RFLHLHNDSI FTIDVTYFPR
560
RDVVRMEGNT GHDRPG
Length:566
Mass (Da):61,579
Last modified:July 1, 2008 - v2
Checksum:i3F2F24D0137F859E
GO

Sequence cautioni

The sequence AL935075 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050919565P → S.Corresponds to variant rs847079dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034424 Genomic DNA. Translation: CAC36102.2.
AL935075 mRNA. No translation available.
AL935089 mRNA. No translation available.
BX281477 mRNA. No translation available.
CCDSiCCDS54468.1.
RefSeqiNP_542452.1. NM_080721.2.
UniGeneiHs.526636.

Genome annotation databases

EnsembliENST00000279028; ENSP00000279028; ENSG00000149635.
GeneIDi128506.
KEGGihsa:128506.
UCSCiuc010zxu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL034424 Genomic DNA. Translation: CAC36102.2.
AL935075 mRNA. No translation available.
AL935089 mRNA. No translation available.
BX281477 mRNA. No translation available.
CCDSiCCDS54468.1.
RefSeqiNP_542452.1. NM_080721.2.
UniGeneiHs.526636.

3D structure databases

ProteinModelPortaliQ9BR26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000279028.

Protein family/group databases

TCDBi1.N.1.1.1. the osteoclast fusion complex (ofc) family.

PTM databases

PhosphoSitePlusiQ9BR26.

Polymorphism and mutation databases

DMDMi193806176.

Proteomic databases

PaxDbiQ9BR26.
PRIDEiQ9BR26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279028; ENSP00000279028; ENSG00000149635.
GeneIDi128506.
KEGGihsa:128506.
UCSCiuc010zxu.3. human.

Organism-specific databases

CTDi128506.
GeneCardsiOCSTAMP.
HGNCiHGNC:16116. OCSTAMP.
HPAiHPA031116.
neXtProtiNX_Q9BR26.
OpenTargetsiENSG00000149635.
PharmGKBiPA25664.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INN5. Eukaryota.
ENOG4110TNU. LUCA.
GeneTreeiENSGT00530000064296.
HOGENOMiHOG000112028.
HOVERGENiHBG107776.
InParanoidiQ9BR26.
OMAiFIPFLFN.
OrthoDBiEOG091G0BT9.
PhylomeDBiQ9BR26.
TreeFamiTF332562.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000149635-MONOMER.

Miscellaneous databases

GenomeRNAii128506.
PROiQ9BR26.

Gene expression databases

BgeeiENSG00000149635.
CleanExiHS_C20orf123.

Family and domain databases

InterProiIPR012858. DC_STAMP-like.
[Graphical view]
PfamiPF07782. DC_STAMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOCSTP_HUMAN
AccessioniPrimary (citable) accession number: Q9BR26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: November 30, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.