Q9BR26 (OCSTP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Osteoclast stimulatory transmembrane protein
Short name=OC-STAMP

Gene names

Name:	OCSTAMP
Synonyms:	C20orf123

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	566 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence caution	The sequence AL935075 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Differentiation
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to estrogen stimulus Inferred from sequence or structural similarity. Source: UniProtKB cellular response to tumor necrosis factor Inferred from sequence or structural similarity. Source: UniProtKB multinuclear osteoclast differentiation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of osteoclast differentiation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of osteoclast proliferation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 566	566	Osteoclast stimulatory transmembrane protein		PRO_0000342121
Regions
	Topological domain	1 – 51	51	Cytoplasmic Potential
	Transmembrane	52 – 72	21	Helical; Potential
	Topological domain	73 – 81	9	Extracellular Potential
	Transmembrane	82 – 102	21	Helical; Potential
	Topological domain	103 – 128	26	Cytoplasmic Potential
	Transmembrane	129 – 149	21	Helical; Potential
	Topological domain	150 – 227	78	Extracellular Potential
	Transmembrane	228 – 248	21	Helical; Potential
	Topological domain	249 – 304	56	Cytoplasmic Potential
	Transmembrane	305 – 325	21	Helical; Potential
	Topological domain	326 – 398	73	Extracellular Potential
	Transmembrane	399 – 419	21	Helical; Potential
	Topological domain	420 – 566	147	Cytoplasmic Potential
	Compositional bias	59 – 63	5	Poly-Ala
Natural variations
	Natural variant	565	1	P → S. Corresponds to variant rs847079 [ dbSNP | Ensembl ].		VAR_050919

Sequences

	Sequence		Length	Mass (Da)
	Q9BR26 [UniParc]. Last modified July 1, 2008. Version 2. Checksum: 3F2F24D0137F859E	FASTA	566	61,579
	10 20 30 40 50 60 MPGHPGAAEQ LVKTGWRSWH LGFWKALAPL QAAWDAFSQP VPASCGQLLT QLLLCASLAA 70 80 90 100 110 120 AAAGLVYHWL ASLLLYPPGP SAMVATVCGL LVFLSLGLVP PVRCLFALSV PTLGMEQGRR 130 140 150 160 170 180 LLLSYSTATL AIAVVPNVLA NVGAAGQVLR CVTEGSLESL LNTTHQLHAA SRALGPTGQA 190 200 210 220 230 240 GSRGLTFEAQ DNGSAFYLHM LRVTQQVLED FSGLESLARA AALGTQRVVT GLFMLGLLVE 250 260 270 280 290 300 SAWYLHCYLT DLRFDNIYAT QQLTQRLAQA QATHLLAPPP TWLLQAAQLR LSQEELLSCL 310 320 330 340 350 360 LRLGLLALLL VATAVAVATD HVAFLLAQAT VDWAQKLPTV PITLTVKYDV AYTVLGFIPF 370 380 390 400 410 420 LFNQLAPESP FLSVHSSYQW ELRLTSARCP LLPARRPRAA APLAAGALQL LAGSTVLLEA 430 440 450 460 470 480 YARRLRHAIA ASFFTAQEAR RVRHLHARLQ RRHDRHQGQQ LPLGDPSCVP TPRPACKPPA 490 500 510 520 530 540 WIDYRLDALR TESSEGEGKE LWSCRDLSCN LGPVPPPCVT LGKSLHLSEP RFLHLHNDSI 550 560 FTIDVTYFPR RDVVRMEGNT GHDRPG

References

[1]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ashcroft K., Bethel G., Bye J.M., Howell G.R., Huckle E.J., Sheridan E. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-472.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 454-566.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL034424 Genomic DNA. Translation: CAC36102.2. AL935075 mRNA. No translation available. AL935089 mRNA. No translation available. BX281477 mRNA. No translation available.
IPI	IPI00552151.
RefSeq	NP_542452.1. NM_080721.2.
UniGene	Hs.526636.
3D structure databases
ProteinModelPortal	Q9BR26.
ModBase	Search...
PTM databases
PhosphoSite	Q9BR26.
Polymorphism databases
DMDM	193806176.
Proteomic databases
PaxDb	Q9BR26.
PRIDE	Q9BR26.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000279028; ENSP00000279028; ENSG00000149635.
GeneID	128506.
KEGG	hsa:128506.
UCSC	uc010zxu.1. human.
Organism-specific databases
CTD	128506.
GeneCards	GC20M045170.
HGNC	HGNC:16116. OCSTAMP.
HPA	HPA031116.
neXtProt	NX_Q9BR26.
PharmGKB	PA25664.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG42898.
HOGENOM	HOG000112028.
HOVERGEN	HBG107776.
InParanoid	Q9BR26.
OMA	FIPFLFN.
OrthoDB	EOG4PC9SP.
Gene expression databases
Bgee	Q9BR26.
CleanEx	HS_C20orf123.
Genevestigator	Q9BR26.
Family and domain databases
InterPro	IPR012858. DC_STAMP-like. [Graphical view]
Pfam	PF07782. DC_STAMP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	82378.

Entry information

Entry name

OCSTP_HUMAN

Accession

Primary (citable) accession number: Q9BR26

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	April 3, 2013
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.