Q9BR10 (SPT25_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Spermatogenesis-associated protein 25

Alternative name(s):
Testis-specific gene 23 protein

Gene names

Name:	SPATA25
Synonyms:	C20orf165, TSG23

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in spermatogenesis.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Tissue specificity	Expressed predominantly in testis (at protein level). Expression is lower in patients with obstructive azoospermia than in fertile controls and is not detected in patients with non-obstructive azoospermia.
Developmental stage	60-fold stronger expression found in adult than fetal testis. Detected in spermatocytes and round spermatids of the seminiferous tubule.
Sequence similarities	Belongs to the SPATA25 family.

Ontologies

Keywords
Biological process	Differentiation Spermatogenesis
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Spermatogenesis-associated protein 25		PRO_0000079478
Regions
	Transmembrane	152 – 172	21	Helical; Potential
Natural variations
	Natural variant	94	1	P → L. Corresponds to variant rs3827040 [ dbSNP | Ensembl ].		VAR_015146

Sequences

	Sequence		Length	Mass (Da)
	Q9BR10 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 938556AB1005C218	FASTA	227	23,834
	10 20 30 40 50 60 MSYFRTPQTH PGPLPSGQGG AASPGLSLGL CSPVEPVVVA SGGTGPLSQK AEQVAPAAQA 70 80 90 100 110 120 WGPALAMPQA RGCPGGTSWE TLRKEYSRNC HKFPHVRQLE SLGWDNGYSR SRAPDLGGPS 130 140 150 160 170 180 RPRPLMLCGL SPRVLPVPSE AVGKEASSQP DICILTLAMM IAGIPTVPVP GVREEDLIWA 190 200 210 220 AQAFMMAHPE PEGAVEGARW EQAHAHTASG KMPLVRSKRG QPPGSCL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Developmental expression pattern of a novel gene, TSG23/Tsg23, suggests a role in spermatogenesis." Zhou Y., Qin D., Tang A., Zhou D., Qin J., Yan B., Diao R., Jiang Z., Cai Z., Gui Y. Mol. Hum. Reprod. 15:223-230(2009) [PubMed: 19240080] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL008726 Genomic DNA. Translation: CAC36017.1. BC039607 mRNA. Translation: AAH39607.1.
IPI	IPI00028648.
RefSeq	NP_542175.1. NM_080608.3.
UniGene	Hs.128235.
3D structure databases
ProteinModelPortal	Q9BR10.
ModBase	Search...
Polymorphism databases
DMDM	27805437.
Proteomic databases
PRIDE	Q9BR10.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372519; ENSP00000361597; ENSG00000149634.
GeneID	128497.
KEGG	hsa:128497.
UCSC	uc002xqf.1. human.
Organism-specific databases
CTD	128497.
GeneCards	GC20M044515.
HGNC	HGNC:16158. SPATA25.
HPA	CAB034457.
neXtProt	NX_Q9BR10.
PharmGKB	PA25707.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06376.
GeneTree	ENSGT00390000018626.
HOGENOM	HBG126076.
HOVERGEN	HBG051206.
InParanoid	Q9BR10.
OMA	QPPGSCL.
OrthoDB	EOG4X97JB.
PhylomeDB	Q9BR10.
Gene expression databases
ArrayExpress	Q9BR10.
Bgee	Q9BR10.
CleanEx	HS_C20orf165.
Genevestigator	Q9BR10.
GermOnline	ENSG00000149634. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	82372.

Entry information

Entry name

SPT25_HUMAN

Accession

Primary (citable) accession number: Q9BR10

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 17, 2003
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.