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Protein

Dysbindin domain-containing protein 2

Gene

DBNDD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro).1 Publication

GO - Biological processi

  • negative regulation of protein kinase activity Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Dysbindin domain-containing protein 2
Alternative name(s):
Casein kinase-1 binding protein
Short name:
CK1BP
HSMNP1
Gene namesi
Name:DBNDD2
Synonyms:C20orf35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15881. DBNDD2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25749.

Polymorphism and mutation databases

BioMutaiDBNDD2.
DMDMi327478587.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Dysbindin domain-containing protein 2PRO_0000191003Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei217 – 2171PhosphoserineBy similarity
Modified residuei218 – 2181PhosphoserineBy similarity
Modified residuei237 – 2371PhosphothreonineBy similarity
Modified residuei242 – 2421PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9BQY9.
PRIDEiQ9BQY9.

PTM databases

PhosphoSiteiQ9BQY9.

Expressioni

Tissue specificityi

Detected in brain.1 Publication

Gene expression databases

BgeeiQ9BQY9.
CleanExiHS_DBNDD2.
ExpressionAtlasiQ9BQY9. baseline and differential.
GenevisibleiQ9BQY9. HS.

Organism-specific databases

HPAiHPA043991.

Interactioni

Subunit structurei

Monomer. Interacts with CSNK1D and CSNK1E.1 Publication

Protein-protein interaction databases

BioGridi120963. 5 interactions.
IntActiQ9BQY9. 2 interactions.
MINTiMINT-1476709.
STRINGi9606.ENSP00000361795.

Structurei

3D structure databases

ProteinModelPortaliQ9BQY9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi33 – 386Poly-Pro
Compositional biasi214 – 2229Poly-Ser
Compositional biasi244 – 2474Poly-Glu

Sequence similaritiesi

Belongs to the dysbindin family.Curated

Phylogenomic databases

eggNOGiENOG410IZAY. Eukaryota.
ENOG4111ACH. LUCA.
GeneTreeiENSGT00390000010667.
HOGENOMiHOG000112170.
InParanoidiQ9BQY9.
OMAiMESWALA.
OrthoDBiEOG72VH6B.
PhylomeDBiQ9BQY9.
TreeFamiTF332997.

Family and domain databases

InterProiIPR007531. Dysbindin.
[Graphical view]
PANTHERiPTHR16294. PTHR16294. 1 hit.
PfamiPF04440. Dysbindin. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BQY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAGNFLTAL EVPVAALAGA ASDRRASCER VSPPPPLPHF RLPPLPRSRL
60 70 80 90 100
PGPVSRPEPG APLLGCWLQW GAPSPGPLCL LFRLCSCTCF APLPAGADMD
110 120 130 140 150
PNPRAALERQ QLRLRERQKF FEDILQPETE FVFPLSHLHL ESQRPPIGSI
160 170 180 190 200
SSMEVNVDTL EQVELIDLGD PDAADVFLPC EDPPPTPQSS GMDNHLEELS
210 220 230 240 250
LPVPTSDRTT SRTSSSSSSD SSTNLHSPNP SDDGADTPLA QSDEEEERGD

GGAEPGACS
Length:259
Mass (Da):27,671
Last modified:April 5, 2011 - v3
Checksum:iDA1F062426867A2C
GO
Isoform 2 (identifier: Q9BQY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: Missing.

Show »
Length:161
Mass (Da):17,525
Checksum:i6840B7093720567B
GO
Isoform 3 (identifier: Q9BQY9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: Missing.
     193-210: DNHLEELSLPVPTSDRTT → PLCFGDFSASQPEPDVRL
     211-259: Missing.

Show »
Length:112
Mass (Da):12,614
Checksum:iBB2C19A23C184395
GO
Isoform 4 (identifier: Q9BQY9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MGAGNFLTAL...PLPRSRLPGP → MESWALAVFP...GRGKRSPRAE

Show »
Length:263
Mass (Da):28,785
Checksum:iB14539919D137982
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431P → GTR in AAF67656 (PubMed:10931946).Curated
Sequence conflicti162 – 1621Q → H in BAA91235 (PubMed:14702039).Curated
Sequence conflicti192 – 1921M → V in AAF67656 (PubMed:10931946).Curated
Sequence conflicti192 – 1921M → V in AAM77463 (PubMed:16305340).Curated
Sequence conflicti192 – 1921M → V in BAA91235 (PubMed:14702039).Curated
Sequence conflicti192 – 1921M → V in EAW75854 (Ref. 6) Curated
Sequence conflicti192 – 1921M → V in EAW75848 (Ref. 6) Curated
Sequence conflicti192 – 1921M → V in AAH12818 (PubMed:15489334).Curated
Sequence conflicti192 – 1921M → V in AAH01105 (PubMed:15489334).Curated
Sequence conflicti204 – 2041P → A in AAF67656 (PubMed:10931946).Curated
Sequence conflicti249 – 2491G → D in BAA91235 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9898Missing in isoform 2 and isoform 3. 3 PublicationsVSP_007753Add
BLAST
Alternative sequencei1 – 5353MGAGN…RLPGP → MESWALAVFPEYRVSLLWCL ELASPLWSLGQAPPLHETWF VGHTWFQGRGKRSPRAE in isoform 4. CuratedVSP_046691Add
BLAST
Alternative sequencei193 – 21018DNHLE…SDRTT → PLCFGDFSASQPEPDVRL in isoform 3. 1 PublicationVSP_040767Add
BLAST
Alternative sequencei211 – 25949Missing in isoform 3. 1 PublicationVSP_040768Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220191 mRNA. Translation: AAF67656.1.
AY113697 mRNA. Translation: AAM77463.1.
AK000531 mRNA. Translation: BAA91235.1.
AJ276469 mRNA. Translation: CAB83042.1.
AL021578 Genomic DNA. Translation: CAI21087.1.
AL021578 Genomic DNA. Translation: CAC18108.1.
AL021578 Genomic DNA. Translation: CAC18109.1.
CH471077 Genomic DNA. Translation: EAW75848.1.
CH471077 Genomic DNA. Translation: EAW75854.1.
AL591565 mRNA. Translation: CAC39141.1.
BC001105 mRNA. Translation: AAH01105.1.
BC012818 mRNA. Translation: AAH12818.1.
BG703352 mRNA. No translation available.
CCDSiCCDS42880.1. [Q9BQY9-2]
CCDS42881.1. [Q9BQY9-3]
CCDS56193.1. [Q9BQY9-1]
CCDS56194.1. [Q9BQY9-4]
RefSeqiNP_001041686.1. NM_001048221.2. [Q9BQY9-2]
NP_001041687.1. NM_001048222.2. [Q9BQY9-3]
NP_001041688.1. NM_001048223.2. [Q9BQY9-2]
NP_001041689.1. NM_001048224.2. [Q9BQY9-3]
NP_001041690.2. NM_001048225.2. [Q9BQY9-4]
NP_001184068.1. NM_001197139.1. [Q9BQY9-2]
NP_001184069.1. NM_001197140.1. [Q9BQY9-2]
NP_060948.3. NM_018478.3. [Q9BQY9-1]
UniGeneiHs.730643.

Genome annotation databases

EnsembliENST00000357275; ENSP00000349822; ENSG00000244274. [Q9BQY9-2]
ENST00000360981; ENSP00000354250; ENSG00000244274. [Q9BQY9-2]
ENST00000372710; ENSP00000361795; ENSG00000244274. [Q9BQY9-4]
ENST00000372712; ENSP00000361797; ENSG00000244274. [Q9BQY9-2]
ENST00000372717; ENSP00000361802; ENSG00000244274. [Q9BQY9-3]
ENST00000372720; ENSP00000361805; ENSG00000244274. [Q9BQY9-1]
ENST00000372722; ENSP00000361807; ENSG00000244274. [Q9BQY9-3]
ENST00000372723; ENSP00000361808; ENSG00000244274. [Q9BQY9-2]
GeneIDi55861.
KEGGihsa:55861.
UCSCiuc002xnz.4. human. [Q9BQY9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220191 mRNA. Translation: AAF67656.1.
AY113697 mRNA. Translation: AAM77463.1.
AK000531 mRNA. Translation: BAA91235.1.
AJ276469 mRNA. Translation: CAB83042.1.
AL021578 Genomic DNA. Translation: CAI21087.1.
AL021578 Genomic DNA. Translation: CAC18108.1.
AL021578 Genomic DNA. Translation: CAC18109.1.
CH471077 Genomic DNA. Translation: EAW75848.1.
CH471077 Genomic DNA. Translation: EAW75854.1.
AL591565 mRNA. Translation: CAC39141.1.
BC001105 mRNA. Translation: AAH01105.1.
BC012818 mRNA. Translation: AAH12818.1.
BG703352 mRNA. No translation available.
CCDSiCCDS42880.1. [Q9BQY9-2]
CCDS42881.1. [Q9BQY9-3]
CCDS56193.1. [Q9BQY9-1]
CCDS56194.1. [Q9BQY9-4]
RefSeqiNP_001041686.1. NM_001048221.2. [Q9BQY9-2]
NP_001041687.1. NM_001048222.2. [Q9BQY9-3]
NP_001041688.1. NM_001048223.2. [Q9BQY9-2]
NP_001041689.1. NM_001048224.2. [Q9BQY9-3]
NP_001041690.2. NM_001048225.2. [Q9BQY9-4]
NP_001184068.1. NM_001197139.1. [Q9BQY9-2]
NP_001184069.1. NM_001197140.1. [Q9BQY9-2]
NP_060948.3. NM_018478.3. [Q9BQY9-1]
UniGeneiHs.730643.

3D structure databases

ProteinModelPortaliQ9BQY9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120963. 5 interactions.
IntActiQ9BQY9. 2 interactions.
MINTiMINT-1476709.
STRINGi9606.ENSP00000361795.

PTM databases

PhosphoSiteiQ9BQY9.

Polymorphism and mutation databases

BioMutaiDBNDD2.
DMDMi327478587.

Proteomic databases

PaxDbiQ9BQY9.
PRIDEiQ9BQY9.

Protocols and materials databases

DNASUi55861.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357275; ENSP00000349822; ENSG00000244274. [Q9BQY9-2]
ENST00000360981; ENSP00000354250; ENSG00000244274. [Q9BQY9-2]
ENST00000372710; ENSP00000361795; ENSG00000244274. [Q9BQY9-4]
ENST00000372712; ENSP00000361797; ENSG00000244274. [Q9BQY9-2]
ENST00000372717; ENSP00000361802; ENSG00000244274. [Q9BQY9-3]
ENST00000372720; ENSP00000361805; ENSG00000244274. [Q9BQY9-1]
ENST00000372722; ENSP00000361807; ENSG00000244274. [Q9BQY9-3]
ENST00000372723; ENSP00000361808; ENSG00000244274. [Q9BQY9-2]
GeneIDi55861.
KEGGihsa:55861.
UCSCiuc002xnz.4. human. [Q9BQY9-1]

Organism-specific databases

CTDi55861.
GeneCardsiDBNDD2.
H-InvDBHIX0015858.
HIX0019509.
HGNCiHGNC:15881. DBNDD2.
HPAiHPA043991.
MIMi611453. gene.
neXtProtiNX_Q9BQY9.
PharmGKBiPA25749.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZAY. Eukaryota.
ENOG4111ACH. LUCA.
GeneTreeiENSGT00390000010667.
HOGENOMiHOG000112170.
InParanoidiQ9BQY9.
OMAiMESWALA.
OrthoDBiEOG72VH6B.
PhylomeDBiQ9BQY9.
TreeFamiTF332997.

Miscellaneous databases

GeneWikiiDBNDD2.
GenomeRNAii55861.
NextBioi61155.
PROiQ9BQY9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BQY9.
CleanExiHS_DBNDD2.
ExpressionAtlasiQ9BQY9. baseline and differential.
GenevisibleiQ9BQY9. HS.

Family and domain databases

InterProiIPR007531. Dysbindin.
[Graphical view]
PANTHERiPTHR16294. PTHR16294. 1 hit.
PfamiPF04440. Dysbindin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hypothalamus.
  2. "The human orthologue of a novel apoptosis response gene induced during rat myelomonocytic stem cell apoptosis maps to 20q13.12."
    Lucas T., Pratscher B., Fink D., Wolschek M., Samorapoompichit P., Schofer C., Pehamberger H., Muller M., Sorensen P., Jansen B.
    Stem Cells Dev. 14:556-563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
  4. "Full-length sequencing of some human and murine muscular transcripts (Telethon Italy project B41)."
    Frigimelica E., Lanfranchi G.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Skeletal muscle.
  5. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  8. "Dysbindin structural homologue CK1BP is an isoform-selective binding partner of human casein kinase-1."
    Yin H., Laguna K.A., Li G., Kuret J.
    Biochemistry 45:5297-5308(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INTERACTION WITH CSNK1D AND CSNK1E, TISSUE SPECIFICITY.

Entry informationi

Entry nameiDBND2_HUMAN
AccessioniPrimary (citable) accession number: Q9BQY9
Secondary accession number(s): Q331S6
, Q5QPV4, Q5QPV6, Q9BQZ0, Q9BVL1, Q9H1F6, Q9NWZ0, Q9NY07, Q9NZ31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: April 5, 2011
Last modified: May 11, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.