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Protein

Dysbindin domain-containing protein 2

Gene

DBNDD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro).1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Dysbindin domain-containing protein 2
Alternative name(s):
Casein kinase-1 binding protein
Short name:
CK1BP
HSMNP1
Gene namesi
Name:DBNDD2
Synonyms:C20orf35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000244274.7
HGNCiHGNC:15881 DBNDD2
MIMi611453 gene
neXtProtiNX_Q9BQY9

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi55861
OpenTargetsiENSG00000244274
PharmGKBiPA25749

Polymorphism and mutation databases

BioMutaiDBNDD2
DMDMi327478587

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910031 – 259Dysbindin domain-containing protein 2Add BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei217PhosphoserineBy similarity1
Modified residuei218PhosphoserineBy similarity1
Modified residuei237PhosphothreonineBy similarity1
Modified residuei242PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9BQY9
PeptideAtlasiQ9BQY9
PRIDEiQ9BQY9
ProteomicsDBi78730
78731 [Q9BQY9-2]
78732 [Q9BQY9-3]

PTM databases

iPTMnetiQ9BQY9
PhosphoSitePlusiQ9BQY9

Expressioni

Tissue specificityi

Detected in brain.1 Publication

Gene expression databases

BgeeiENSG00000244274
CleanExiHS_DBNDD2
ExpressionAtlasiQ9BQY9 baseline and differential
GenevisibleiQ9BQY9 HS

Organism-specific databases

HPAiHPA043991

Interactioni

Subunit structurei

Monomer. Interacts with CSNK1D and CSNK1E.1 Publication

Protein-protein interaction databases

BioGridi120963, 7 interactors
IntActiQ9BQY9, 2 interactors
MINTiQ9BQY9

Structurei

3D structure databases

ProteinModelPortaliQ9BQY9
SMRiQ9BQY9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 38Poly-Pro6
Compositional biasi214 – 222Poly-Ser9
Compositional biasi244 – 247Poly-Glu4

Sequence similaritiesi

Belongs to the dysbindin family.Curated

Phylogenomic databases

eggNOGiENOG410IZAY Eukaryota
ENOG4111ACH LUCA
GeneTreeiENSGT00390000010667
HOGENOMiHOG000112170
InParanoidiQ9BQY9
OMAiQTSGVDD
OrthoDBiEOG091G0ZXL
PhylomeDBiQ9BQY9
TreeFamiTF332997

Family and domain databases

InterProiView protein in InterPro
IPR007531 Dysbindin
PANTHERiPTHR16294 PTHR16294, 1 hit
PfamiView protein in Pfam
PF04440 Dysbindin, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BQY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAGNFLTAL EVPVAALAGA ASDRRASCER VSPPPPLPHF RLPPLPRSRL
60 70 80 90 100
PGPVSRPEPG APLLGCWLQW GAPSPGPLCL LFRLCSCTCF APLPAGADMD
110 120 130 140 150
PNPRAALERQ QLRLRERQKF FEDILQPETE FVFPLSHLHL ESQRPPIGSI
160 170 180 190 200
SSMEVNVDTL EQVELIDLGD PDAADVFLPC EDPPPTPQSS GMDNHLEELS
210 220 230 240 250
LPVPTSDRTT SRTSSSSSSD SSTNLHSPNP SDDGADTPLA QSDEEEERGD

GGAEPGACS
Length:259
Mass (Da):27,671
Last modified:April 5, 2011 - v3
Checksum:iDA1F062426867A2C
GO
Isoform 2 (identifier: Q9BQY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: Missing.

Show »
Length:161
Mass (Da):17,525
Checksum:i6840B7093720567B
GO
Isoform 3 (identifier: Q9BQY9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: Missing.
     193-210: DNHLEELSLPVPTSDRTT → PLCFGDFSASQPEPDVRL
     211-259: Missing.

Show »
Length:112
Mass (Da):12,614
Checksum:iBB2C19A23C184395
GO
Isoform 4 (identifier: Q9BQY9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MGAGNFLTAL...PLPRSRLPGP → MESWALAVFP...GRGKRSPRAE

Show »
Length:263
Mass (Da):28,785
Checksum:iB14539919D137982
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43P → GTR in AAF67656 (PubMed:10931946).Curated1
Sequence conflicti162Q → H in BAA91235 (PubMed:14702039).Curated1
Sequence conflicti192M → V in AAF67656 (PubMed:10931946).Curated1
Sequence conflicti192M → V in AAM77463 (PubMed:16305340).Curated1
Sequence conflicti192M → V in BAA91235 (PubMed:14702039).Curated1
Sequence conflicti192M → V in EAW75854 (Ref. 6) Curated1
Sequence conflicti192M → V in EAW75848 (Ref. 6) Curated1
Sequence conflicti192M → V in AAH12818 (PubMed:15489334).Curated1
Sequence conflicti192M → V in AAH01105 (PubMed:15489334).Curated1
Sequence conflicti204P → A in AAF67656 (PubMed:10931946).Curated1
Sequence conflicti249G → D in BAA91235 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0077531 – 98Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST98
Alternative sequenceiVSP_0466911 – 53MGAGN…RLPGP → MESWALAVFPEYRVSLLWCL ELASPLWSLGQAPPLHETWF VGHTWFQGRGKRSPRAE in isoform 4. CuratedAdd BLAST53
Alternative sequenceiVSP_040767193 – 210DNHLE…SDRTT → PLCFGDFSASQPEPDVRL in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_040768211 – 259Missing in isoform 3. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220191 mRNA Translation: AAF67656.1
AY113697 mRNA Translation: AAM77463.1
AK000531 mRNA Translation: BAA91235.1
AJ276469 mRNA Translation: CAB83042.1
AL021578 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75848.1
CH471077 Genomic DNA Translation: EAW75854.1
AL591565 mRNA Translation: CAC39141.1
BC001105 mRNA Translation: AAH01105.1
BC012818 mRNA Translation: AAH12818.1
BG703352 mRNA No translation available.
CCDSiCCDS42880.1 [Q9BQY9-2]
CCDS42881.1 [Q9BQY9-3]
CCDS56193.1 [Q9BQY9-1]
CCDS56194.1 [Q9BQY9-4]
RefSeqiNP_001041686.1, NM_001048221.2 [Q9BQY9-2]
NP_001041687.1, NM_001048222.2 [Q9BQY9-3]
NP_001041688.1, NM_001048223.2 [Q9BQY9-2]
NP_001041689.1, NM_001048224.2 [Q9BQY9-3]
NP_001041690.2, NM_001048225.2 [Q9BQY9-4]
NP_001184068.1, NM_001197139.1 [Q9BQY9-2]
NP_001184069.1, NM_001197140.1 [Q9BQY9-2]
NP_060948.3, NM_018478.3 [Q9BQY9-1]
UniGeneiHs.730643

Genome annotation databases

EnsembliENST00000357275; ENSP00000349822; ENSG00000244274 [Q9BQY9-2]
ENST00000360981; ENSP00000354250; ENSG00000244274 [Q9BQY9-2]
ENST00000372710; ENSP00000361795; ENSG00000244274 [Q9BQY9-4]
ENST00000372712; ENSP00000361797; ENSG00000244274 [Q9BQY9-2]
ENST00000372717; ENSP00000361802; ENSG00000244274 [Q9BQY9-3]
ENST00000372720; ENSP00000361805; ENSG00000244274 [Q9BQY9-1]
ENST00000372722; ENSP00000361807; ENSG00000244274 [Q9BQY9-3]
ENST00000372723; ENSP00000361808; ENSG00000244274 [Q9BQY9-2]
GeneIDi55861
KEGGihsa:55861
UCSCiuc002xnz.4 human [Q9BQY9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDBND2_HUMAN
AccessioniPrimary (citable) accession number: Q9BQY9
Secondary accession number(s): Q331S6
, Q5QPV4, Q5QPV6, Q9BQZ0, Q9BVL1, Q9H1F6, Q9NWZ0, Q9NY07, Q9NZ31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: April 5, 2011
Last modified: June 20, 2018
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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