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Q9BQY4 (RHXF2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rhox homeobox family member 2
Alternative name(s):
Paired-like homeobox protein PEPP-2
Testis homeobox gene 1
Gene names
Name:RHOXF2
Synonyms:PEPP2, THG1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Nucleus By similarity.

Tissue specificity

Testis. Not detected in epididymis nor placenta. Ref.4

Sequence similarities

Belongs to the paired-like homeobox family. PEPP subfamily.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Rhox homeobox family member 2
PRO_0000049246

Regions

DNA binding134 – 19360Homeobox
Motif186 – 19510Nuclear localization signal By similarity
Compositional bias245 – 28642Pro-rich

Sequences

Sequence LengthMass (Da)Tools
Q9BQY4 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 2B0E007064515808

FASTA28831,692
        10         20         30         40         50         60 
MEPPDQCSQY MTSLLSPAVD DEKELQDMNA MVLSLTEEVK EEEEDAQPEP EQGTAAGEKL 

        70         80         90        100        110        120 
KSAGAQGGEE KDGGGEEKDG GGAGVPGHLW EGDLEGTSGS DGNVEDSDQS EKEPGQQYSR 

       130        140        150        160        170        180 
PQGAVGGLEP GNAQQPNVHA FTPLQLQELE RIFQREQFPS EFLRRRLARS MNVTELAVQI 

       190        200        210        220        230        240 
WFENRRAKWR RHQRALMARN MLPFMAVGQP VMVTAAEAIT APLFISGMRD DYFWDHSHSS 

       250        260        270        280 
SLCFPMPPFP PPSLPLPLML LPPMPPAGQA EFGPFPFVIV PSFTFPNV 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a novel testis homeobox gene, THG1, as a potential testicular tumor suppressor gene."
Yin Y., Jin Y., Levine A.J.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2, selectively expressed in the testis."
Wayne C.M., MacLean J.A. II, Cornwall G., Wilkinson M.F.
Gene 301:1-11(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF317219 mRNA. Translation: AAL02160.1.
AL590526 mRNA. Translation: CAC36519.1.
AK058125 mRNA. Translation: BAB71675.1.
BC021719 mRNA. Translation: AAH21719.1.
RefSeqNP_115887.1. NM_032498.1.
UniGeneHs.567620.

3D structure databases

ProteinModelPortalQ9BQY4.
SMRQ9BQY4. Positions 141-190.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124119. 43 interactions.
IntActQ9BQY4. 32 interactions.
MINTMINT-1435872.
STRING9606.ENSP00000360441.

Polymorphism databases

DMDM37537987.

Proteomic databases

PaxDbQ9BQY4.
PeptideAtlasQ9BQY4.
PRIDEQ9BQY4.

Protocols and materials databases

DNASU84528.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000371388; ENSP00000360441; ENSG00000131721.
ENST00000595841; ENSP00000473010; ENSG00000268919.
GeneID84528.
KEGGhsa:84528.
UCSCuc004esj.4. human.

Organism-specific databases

CTD84528.
GeneCardsGC0XP119292.
H-InvDBHIX0056374.
HGNCHGNC:30011. RHOXF2.
HPAHPA003314.
MIM300447. gene.
neXtProtNX_Q9BQY4.
PharmGKBPA162401288.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG259605.
HOGENOMHOG000154119.
HOVERGENHBG094802.
InParanoidQ9BQY4.
OMAWGHSHSS.
OrthoDBEOG7HF1KH.
PhylomeDBQ9BQY4.
TreeFamTF339348.

Gene expression databases

BgeeQ9BQY4.
CleanExHS_RHOXF2.
GenevestigatorQ9BQY4.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi84528.
NextBio74363.
PROQ9BQY4.
SOURCESearch...

Entry information

Entry nameRHXF2_HUMAN
AccessionPrimary (citable) accession number: Q9BQY4
Secondary accession number(s): Q9BR00
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM