Q9BQY4 (RHXF2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rhox homeobox family member 2

Alternative name(s):
Paired-like homeobox protein PEPP-2
Testis homeobox gene 1

Gene names

Name:	RHOXF2
Synonyms:	PEPP2, THG1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Nucleus By similarity.
Tissue specificity	Testis. Not detected in epididymis nor placenta. Ref.4
Sequence similarities	Belongs to the paired-like homeobox family. PEPP subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CHAC1	Q9BUX1	2	EBI-372094,EBI-751127
DAZAP2	Q15038	3	EBI-372094,EBI-724310
EFEMP2	O95967	2	EBI-372094,EBI-743414
PLOD3	O60568	2	EBI-372094,EBI-741582

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Rhox homeobox family member 2		PRO_0000049246
Regions
	DNA binding	134 – 193	60	Homeobox
	Motif	186 – 195	10	Nuclear localization signal By similarity
	Compositional bias	245 – 286	42	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	Q9BQY4 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 2B0E007064515808	FASTA	288	31,692
	10 20 30 40 50 60 MEPPDQCSQY MTSLLSPAVD DEKELQDMNA MVLSLTEEVK EEEEDAQPEP EQGTAAGEKL 70 80 90 100 110 120 KSAGAQGGEE KDGGGEEKDG GGAGVPGHLW EGDLEGTSGS DGNVEDSDQS EKEPGQQYSR 130 140 150 160 170 180 PQGAVGGLEP GNAQQPNVHA FTPLQLQELE RIFQREQFPS EFLRRRLARS MNVTELAVQI 190 200 210 220 230 240 WFENRRAKWR RHQRALMARN MLPFMAVGQP VMVTAAEAIT APLFISGMRD DYFWDHSHSS 250 260 270 280 SLCFPMPPFP PPSLPLPLML LPPMPPAGQA EFGPFPFVIV PSFTFPNV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a novel testis homeobox gene, THG1, as a potential testicular tumor suppressor gene." Yin Y., Jin Y., Levine A.J. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2, selectively expressed in the testis." Wayne C.M., MacLean J.A. II, Cornwall G., Wilkinson M.F. Gene 301:1-11(2002) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF317219 mRNA. Translation: AAL02160.1. AL590526 mRNA. Translation: CAC36519.1. AK058125 mRNA. Translation: BAB71675.1. BC021719 mRNA. Translation: AAH21719.1.
IPI	IPI00032523.
RefSeq	NP_115887.1. NM_032498.1.
UniGene	Hs.567620.
3D structure databases
ProteinModelPortal	Q9BQY4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BQY4. 32 interactions.
MINT	MINT-1435872.
STRING	9606.ENSP00000360441.
Polymorphism databases
DMDM	37537987.
Proteomic databases
PaxDb	Q9BQY4.
PeptideAtlas	Q9BQY4.
PRIDE	Q9BQY4.
Protocols and materials databases
DNASU	84528.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371388; ENSP00000360441; ENSG00000131721. ENST00000595841; ENSP00000473010; ENSG00000268919.
GeneID	84528.
KEGG	hsa:84528.
UCSC	uc004esj.4. human.
Organism-specific databases
CTD	84528.
GeneCards	GC0XP119292.
H-InvDB	HIX0056374.
HGNC	HGNC:30011. RHOXF2.
HPA	HPA003314.
MIM	300447. gene.
neXtProt	NX_Q9BQY4.
PharmGKB	PA162401288.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG259605.
HOGENOM	HOG000154119.
HOVERGEN	HBG094802.
InParanoid	Q9BQY4.
OMA	WGHSHSS.
OrthoDB	EOG4Q84ZH.
Gene expression databases
Bgee	Q9BQY4.
CleanEx	HS_RHOXF2.
Genevestigator	Q9BQY4.
GermOnline	ENSG00000131721. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	84528.
NextBio	74363.
SOURCE	Search...

Entry information

Entry name

RHXF2_HUMAN

Accession

Primary (citable) accession number: Q9BQY4
Secondary accession number(s): Q9BR00

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2003
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.