Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9BQY4

- RHXF2_HUMAN

UniProt

Q9BQY4 - RHXF2_HUMAN

Protein

Rhox homeobox family member 2

Gene

RHOXF2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi134 – 19360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rhox homeobox family member 2
    Alternative name(s):
    Paired-like homeobox protein PEPP-2
    Testis homeobox gene 1
    Gene namesi
    Name:RHOXF2
    Synonyms:PEPP2, THG1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:30011. RHOXF2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162401288.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Rhox homeobox family member 2PRO_0000049246Add
    BLAST

    Proteomic databases

    MaxQBiQ9BQY4.
    PaxDbiQ9BQY4.
    PeptideAtlasiQ9BQY4.
    PRIDEiQ9BQY4.

    Expressioni

    Tissue specificityi

    Testis. Not detected in epididymis nor placenta.1 Publication

    Gene expression databases

    BgeeiQ9BQY4.
    CleanExiHS_RHOXF2.
    GenevestigatoriQ9BQY4.

    Organism-specific databases

    HPAiHPA003314.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CHAC1Q9BUX12EBI-372094,EBI-751127
    DAZAP2Q150383EBI-372094,EBI-724310
    EFEMP2O959672EBI-372094,EBI-743414
    PLOD3O605682EBI-372094,EBI-741582

    Protein-protein interaction databases

    BioGridi124119. 43 interactions.
    IntActiQ9BQY4. 32 interactions.
    MINTiMINT-1435872.
    STRINGi9606.ENSP00000360441.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BQY4.
    SMRiQ9BQY4. Positions 141-190.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi186 – 19510Nuclear localization signalBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi245 – 28642Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG259605.
    HOGENOMiHOG000154119.
    HOVERGENiHBG094802.
    InParanoidiQ9BQY4.
    OMAiWGHSHSS.
    OrthoDBiEOG7HF1KH.
    PhylomeDBiQ9BQY4.
    TreeFamiTF339348.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BQY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPPDQCSQY MTSLLSPAVD DEKELQDMNA MVLSLTEEVK EEEEDAQPEP    50
    EQGTAAGEKL KSAGAQGGEE KDGGGEEKDG GGAGVPGHLW EGDLEGTSGS 100
    DGNVEDSDQS EKEPGQQYSR PQGAVGGLEP GNAQQPNVHA FTPLQLQELE 150
    RIFQREQFPS EFLRRRLARS MNVTELAVQI WFENRRAKWR RHQRALMARN 200
    MLPFMAVGQP VMVTAAEAIT APLFISGMRD DYFWDHSHSS SLCFPMPPFP 250
    PPSLPLPLML LPPMPPAGQA EFGPFPFVIV PSFTFPNV 288
    Length:288
    Mass (Da):31,692
    Last modified:June 1, 2001 - v1
    Checksum:i2B0E007064515808
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF317219 mRNA. Translation: AAL02160.1.
    AL590526 mRNA. Translation: CAC36519.1.
    AK058125 mRNA. Translation: BAB71675.1.
    BC021719 mRNA. Translation: AAH21719.1.
    CCDSiCCDS14594.1.
    RefSeqiNP_115887.1. NM_032498.1.
    UniGeneiHs.567620.

    Genome annotation databases

    EnsembliENST00000371388; ENSP00000360441; ENSG00000131721.
    GeneIDi84528.
    KEGGihsa:84528.
    UCSCiuc004esj.4. human.

    Polymorphism databases

    DMDMi37537987.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF317219 mRNA. Translation: AAL02160.1 .
    AL590526 mRNA. Translation: CAC36519.1 .
    AK058125 mRNA. Translation: BAB71675.1 .
    BC021719 mRNA. Translation: AAH21719.1 .
    CCDSi CCDS14594.1.
    RefSeqi NP_115887.1. NM_032498.1.
    UniGenei Hs.567620.

    3D structure databases

    ProteinModelPortali Q9BQY4.
    SMRi Q9BQY4. Positions 141-190.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124119. 43 interactions.
    IntActi Q9BQY4. 32 interactions.
    MINTi MINT-1435872.
    STRINGi 9606.ENSP00000360441.

    Polymorphism databases

    DMDMi 37537987.

    Proteomic databases

    MaxQBi Q9BQY4.
    PaxDbi Q9BQY4.
    PeptideAtlasi Q9BQY4.
    PRIDEi Q9BQY4.

    Protocols and materials databases

    DNASUi 84528.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371388 ; ENSP00000360441 ; ENSG00000131721 .
    GeneIDi 84528.
    KEGGi hsa:84528.
    UCSCi uc004esj.4. human.

    Organism-specific databases

    CTDi 84528.
    GeneCardsi GC0XP119292.
    H-InvDB HIX0056374.
    HGNCi HGNC:30011. RHOXF2.
    HPAi HPA003314.
    MIMi 300447. gene.
    neXtProti NX_Q9BQY4.
    PharmGKBi PA162401288.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG259605.
    HOGENOMi HOG000154119.
    HOVERGENi HBG094802.
    InParanoidi Q9BQY4.
    OMAi WGHSHSS.
    OrthoDBi EOG7HF1KH.
    PhylomeDBi Q9BQY4.
    TreeFami TF339348.

    Miscellaneous databases

    GenomeRNAii 84528.
    NextBioi 74363.
    PROi Q9BQY4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9BQY4.
    CleanExi HS_RHOXF2.
    Genevestigatori Q9BQY4.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a novel testis homeobox gene, THG1, as a potential testicular tumor suppressor gene."
      Yin Y., Jin Y., Levine A.J.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2, selectively expressed in the testis."
      Wayne C.M., MacLean J.A. II, Cornwall G., Wilkinson M.F.
      Gene 301:1-11(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiRHXF2_HUMAN
    AccessioniPrimary (citable) accession number: Q9BQY4
    Secondary accession number(s): Q9BR00
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3