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Q9BQY4

- RHXF2_HUMAN

UniProt

Q9BQY4 - RHXF2_HUMAN

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Protein

Rhox homeobox family member 2

Gene
RHOXF2, PEPP2, THG1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi134 – 19360HomeoboxAdd
BLAST

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rhox homeobox family member 2
Alternative name(s):
Paired-like homeobox protein PEPP-2
Testis homeobox gene 1
Gene namesi
Name:RHOXF2
Synonyms:PEPP2, THG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:30011. RHOXF2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162401288.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Rhox homeobox family member 2PRO_0000049246Add
BLAST

Proteomic databases

MaxQBiQ9BQY4.
PaxDbiQ9BQY4.
PeptideAtlasiQ9BQY4.
PRIDEiQ9BQY4.

Expressioni

Tissue specificityi

Testis. Not detected in epididymis nor placenta.1 Publication

Gene expression databases

BgeeiQ9BQY4.
CleanExiHS_RHOXF2.
GenevestigatoriQ9BQY4.

Organism-specific databases

HPAiHPA003314.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CHAC1Q9BUX12EBI-372094,EBI-751127
DAZAP2Q150383EBI-372094,EBI-724310
EFEMP2O959672EBI-372094,EBI-743414
PLOD3O605682EBI-372094,EBI-741582

Protein-protein interaction databases

BioGridi124119. 43 interactions.
IntActiQ9BQY4. 32 interactions.
MINTiMINT-1435872.
STRINGi9606.ENSP00000360441.

Structurei

3D structure databases

ProteinModelPortaliQ9BQY4.
SMRiQ9BQY4. Positions 141-190.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi186 – 19510Nuclear localization signal By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi245 – 28642Pro-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG259605.
HOGENOMiHOG000154119.
HOVERGENiHBG094802.
InParanoidiQ9BQY4.
OMAiWGHSHSS.
OrthoDBiEOG7HF1KH.
PhylomeDBiQ9BQY4.
TreeFamiTF339348.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BQY4-1 [UniParc]FASTAAdd to Basket

« Hide

MEPPDQCSQY MTSLLSPAVD DEKELQDMNA MVLSLTEEVK EEEEDAQPEP    50
EQGTAAGEKL KSAGAQGGEE KDGGGEEKDG GGAGVPGHLW EGDLEGTSGS 100
DGNVEDSDQS EKEPGQQYSR PQGAVGGLEP GNAQQPNVHA FTPLQLQELE 150
RIFQREQFPS EFLRRRLARS MNVTELAVQI WFENRRAKWR RHQRALMARN 200
MLPFMAVGQP VMVTAAEAIT APLFISGMRD DYFWDHSHSS SLCFPMPPFP 250
PPSLPLPLML LPPMPPAGQA EFGPFPFVIV PSFTFPNV 288
Length:288
Mass (Da):31,692
Last modified:June 1, 2001 - v1
Checksum:i2B0E007064515808
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF317219 mRNA. Translation: AAL02160.1.
AL590526 mRNA. Translation: CAC36519.1.
AK058125 mRNA. Translation: BAB71675.1.
BC021719 mRNA. Translation: AAH21719.1.
CCDSiCCDS14594.1.
RefSeqiNP_115887.1. NM_032498.1.
UniGeneiHs.567620.

Genome annotation databases

EnsembliENST00000371388; ENSP00000360441; ENSG00000131721.
ENST00000595841; ENSP00000473010; ENSG00000268919.
GeneIDi84528.
KEGGihsa:84528.
UCSCiuc004esj.4. human.

Polymorphism databases

DMDMi37537987.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF317219 mRNA. Translation: AAL02160.1 .
AL590526 mRNA. Translation: CAC36519.1 .
AK058125 mRNA. Translation: BAB71675.1 .
BC021719 mRNA. Translation: AAH21719.1 .
CCDSi CCDS14594.1.
RefSeqi NP_115887.1. NM_032498.1.
UniGenei Hs.567620.

3D structure databases

ProteinModelPortali Q9BQY4.
SMRi Q9BQY4. Positions 141-190.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124119. 43 interactions.
IntActi Q9BQY4. 32 interactions.
MINTi MINT-1435872.
STRINGi 9606.ENSP00000360441.

Polymorphism databases

DMDMi 37537987.

Proteomic databases

MaxQBi Q9BQY4.
PaxDbi Q9BQY4.
PeptideAtlasi Q9BQY4.
PRIDEi Q9BQY4.

Protocols and materials databases

DNASUi 84528.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371388 ; ENSP00000360441 ; ENSG00000131721 .
ENST00000595841 ; ENSP00000473010 ; ENSG00000268919 .
GeneIDi 84528.
KEGGi hsa:84528.
UCSCi uc004esj.4. human.

Organism-specific databases

CTDi 84528.
GeneCardsi GC0XP119292.
H-InvDB HIX0056374.
HGNCi HGNC:30011. RHOXF2.
HPAi HPA003314.
MIMi 300447. gene.
neXtProti NX_Q9BQY4.
PharmGKBi PA162401288.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG259605.
HOGENOMi HOG000154119.
HOVERGENi HBG094802.
InParanoidi Q9BQY4.
OMAi WGHSHSS.
OrthoDBi EOG7HF1KH.
PhylomeDBi Q9BQY4.
TreeFami TF339348.

Miscellaneous databases

GenomeRNAii 84528.
NextBioi 74363.
PROi Q9BQY4.
SOURCEi Search...

Gene expression databases

Bgeei Q9BQY4.
CleanExi HS_RHOXF2.
Genevestigatori Q9BQY4.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel testis homeobox gene, THG1, as a potential testicular tumor suppressor gene."
    Yin Y., Jin Y., Levine A.J.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2, selectively expressed in the testis."
    Wayne C.M., MacLean J.A. II, Cornwall G., Wilkinson M.F.
    Gene 301:1-11(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiRHXF2_HUMAN
AccessioniPrimary (citable) accession number: Q9BQY4
Secondary accession number(s): Q9BR00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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