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Protein

Rhox homeobox family member 2

Gene

RHOXF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi134 – 19360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Rhox homeobox family member 2
Alternative name(s):
Paired-like homeobox protein PEPP-2
Testis homeobox gene 1
Gene namesi
Name:RHOXF2
Synonyms:PEPP2, THG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:30011. RHOXF2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162401288.

Polymorphism and mutation databases

BioMutaiRHOXF2.
DMDMi37537987.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Rhox homeobox family member 2PRO_0000049246Add
BLAST

Proteomic databases

MaxQBiQ9BQY4.
PaxDbiQ9BQY4.
PeptideAtlasiQ9BQY4.
PRIDEiQ9BQY4.

Expressioni

Tissue specificityi

Testis. Not detected in epididymis nor placenta.1 Publication

Gene expression databases

BgeeiQ9BQY4.
CleanExiHS_RHOXF2.
GenevisibleiQ9BQY4. HS.

Organism-specific databases

HPAiCAB020794.
HPA003314.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081173EBI-372094,EBI-717810
ARID5AC9J1Q03EBI-372094,EBI-10176351
CHAC1Q9BUX12EBI-372094,EBI-751127
CRYBA1P058133EBI-372094,EBI-7043337
DAB1O755533EBI-372094,EBI-7875264
DAZAP2Q150386EBI-372094,EBI-724310
EFEMP2O959672EBI-372094,EBI-743414
FAM46CQ5VWP23EBI-372094,EBI-741787
HNRNPLLQ8WVV93EBI-372094,EBI-535849
KRTAP19-5Q3LI723EBI-372094,EBI-1048945
KRTAP19-7Q3SYF93EBI-372094,EBI-10241353
LASP1Q148473EBI-372094,EBI-742828
MAGED1Q9Y5V33EBI-372094,EBI-716006
PLOD3O605682EBI-372094,EBI-741582
RBPMSQ930626EBI-372094,EBI-740322
SUMO1P631653EBI-372094,EBI-80140
TMCC2Q7Z6C63EBI-372094,EBI-10177480
TRIP13Q156455EBI-372094,EBI-358993
VAC14Q08AM63EBI-372094,EBI-2107455
ZBTB32A0A0C4DGF13EBI-372094,EBI-10188476

Protein-protein interaction databases

BioGridi124119. 57 interactions.
IntActiQ9BQY4. 46 interactions.
MINTiMINT-1435872.
STRINGi9606.ENSP00000360441.

Structurei

3D structure databases

ProteinModelPortaliQ9BQY4.
SMRiQ9BQY4. Positions 141-190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi186 – 19510Nuclear localization signalBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi245 – 28642Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG259605.
GeneTreeiENSGT00770000120623.
HOGENOMiHOG000154119.
HOVERGENiHBG094802.
InParanoidiQ9BQY4.
OMAiMRDGYFW.
OrthoDBiEOG7HF1KH.
PhylomeDBiQ9BQY4.
TreeFamiTF339348.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BQY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPPDQCSQY MTSLLSPAVD DEKELQDMNA MVLSLTEEVK EEEEDAQPEP
60 70 80 90 100
EQGTAAGEKL KSAGAQGGEE KDGGGEEKDG GGAGVPGHLW EGDLEGTSGS
110 120 130 140 150
DGNVEDSDQS EKEPGQQYSR PQGAVGGLEP GNAQQPNVHA FTPLQLQELE
160 170 180 190 200
RIFQREQFPS EFLRRRLARS MNVTELAVQI WFENRRAKWR RHQRALMARN
210 220 230 240 250
MLPFMAVGQP VMVTAAEAIT APLFISGMRD DYFWDHSHSS SLCFPMPPFP
260 270 280
PPSLPLPLML LPPMPPAGQA EFGPFPFVIV PSFTFPNV
Length:288
Mass (Da):31,692
Last modified:June 1, 2001 - v1
Checksum:i2B0E007064515808
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317219 mRNA. Translation: AAL02160.1.
AL590526 mRNA. Translation: CAC36519.1.
AK058125 mRNA. Translation: BAB71675.1.
BC021719 mRNA. Translation: AAH21719.1.
CCDSiCCDS14594.1.
RefSeqiNP_115887.1. NM_032498.1.
UniGeneiHs.567620.

Genome annotation databases

EnsembliENST00000371388; ENSP00000360441; ENSG00000131721.
GeneIDi84528.
KEGGihsa:84528.
UCSCiuc004esj.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317219 mRNA. Translation: AAL02160.1.
AL590526 mRNA. Translation: CAC36519.1.
AK058125 mRNA. Translation: BAB71675.1.
BC021719 mRNA. Translation: AAH21719.1.
CCDSiCCDS14594.1.
RefSeqiNP_115887.1. NM_032498.1.
UniGeneiHs.567620.

3D structure databases

ProteinModelPortaliQ9BQY4.
SMRiQ9BQY4. Positions 141-190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124119. 57 interactions.
IntActiQ9BQY4. 46 interactions.
MINTiMINT-1435872.
STRINGi9606.ENSP00000360441.

Polymorphism and mutation databases

BioMutaiRHOXF2.
DMDMi37537987.

Proteomic databases

MaxQBiQ9BQY4.
PaxDbiQ9BQY4.
PeptideAtlasiQ9BQY4.
PRIDEiQ9BQY4.

Protocols and materials databases

DNASUi84528.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371388; ENSP00000360441; ENSG00000131721.
GeneIDi84528.
KEGGihsa:84528.
UCSCiuc004esj.4. human.

Organism-specific databases

CTDi84528.
GeneCardsiGC0XP119292.
H-InvDBHIX0056374.
HGNCiHGNC:30011. RHOXF2.
HPAiCAB020794.
HPA003314.
MIMi300447. gene.
neXtProtiNX_Q9BQY4.
PharmGKBiPA162401288.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG259605.
GeneTreeiENSGT00770000120623.
HOGENOMiHOG000154119.
HOVERGENiHBG094802.
InParanoidiQ9BQY4.
OMAiMRDGYFW.
OrthoDBiEOG7HF1KH.
PhylomeDBiQ9BQY4.
TreeFamiTF339348.

Miscellaneous databases

GenomeRNAii84528.
NextBioi74363.
PROiQ9BQY4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BQY4.
CleanExiHS_RHOXF2.
GenevisibleiQ9BQY4. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel testis homeobox gene, THG1, as a potential testicular tumor suppressor gene."
    Yin Y., Jin Y., Levine A.J.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2, selectively expressed in the testis."
    Wayne C.M., MacLean J.A. II, Cornwall G., Wilkinson M.F.
    Gene 301:1-11(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiRHXF2_HUMAN
AccessioniPrimary (citable) accession number: Q9BQY4
Secondary accession number(s): Q9BR00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2001
Last modified: July 22, 2015
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.