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Protein

Transcription factor COE4

Gene

EBF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional factor which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri152 – 17120C5-typeSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor COE4
Alternative name(s):
Early B-cell factor 4
Short name:
EBF-4
Olf-1/EBF-like 4
Short name:
O/E-4
Short name:
OE-4
Gene namesi
Name:EBF4
Synonyms:COE4, KIAA1442
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:29278. EBF4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162384262.

Polymorphism and mutation databases

DMDMi152031576.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 602602Transcription factor COE4PRO_0000107835Add
BLAST

Proteomic databases

MaxQBiQ9BQW3.
PaxDbiQ9BQW3.
PeptideAtlasiQ9BQW3.
PRIDEiQ9BQW3.
TopDownProteomicsiQ9BQW3-1. [Q9BQW3-1]

PTM databases

iPTMnetiQ9BQW3.
PhosphoSiteiQ9BQW3.

Expressioni

Gene expression databases

BgeeiENSG00000088881.
CleanExiHS_EBF4.
ExpressionAtlasiQ9BQW3. baseline and differential.

Organism-specific databases

HPAiCAB034061.
CAB034065.

Interactioni

Subunit structurei

Forms either a homodimer or a heterodimer with a related family member.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei164 – 1641Interaction with DNABy similarity
Sitei173 – 1731Interaction with DNABy similarity

Protein-protein interaction databases

BioGridi121644. 3 interactions.
IntActiQ9BQW3. 1 interaction.
STRINGi9606.ENSP00000370022.

Structurei

3D structure databases

ProteinModelPortaliQ9BQW3.
SMRiQ9BQW3. Positions 37-387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini256 – 33883IPT/TIGAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni64 – 674Interaction with DNABy similarity
Regioni198 – 2058Interaction with DNABy similarity
Regioni237 – 2404Interaction with DNABy similarity

Sequence similaritiesi

Belongs to the COE family.Curated
Contains 1 IPT/TIG domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri152 – 17120C5-typeSequence analysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3836. Eukaryota.
ENOG410XQ9Z. LUCA.
GeneTreeiENSGT00390000014051.
HOGENOMiHOG000092311.
HOVERGENiHBG005108.
InParanoidiQ9BQW3.
KOiK09103.
PhylomeDBiQ9BQW3.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR032200. COE_DBD.
IPR032201. COE_HLH.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR003523. Transcription_factor_COE.
IPR018350. Transcription_factor_COE_CS.
[Graphical view]
PANTHERiPTHR10747. PTHR10747. 1 hit.
PfamiPF16422. COE1_DBD. 1 hit.
PF16423. COE1_HLH. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS01345. COE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q9BQW3-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFPAQDALPR SGLNLKEEPL LPAGLGSVRS WMQGAGILDA STAAQSGVGL
60 70 80 90 100
ARAHFEKQPP SNLRKSNFFH FVLAMYDRQG QPVEVERTAF IDFVEKDREP
110 120 130 140 150
GAEKTNNGIH YRLRLVYNNG LRTEQDLYVR LIDSMSKQAI IYEGQDKNPE
160 170 180 190 200
MCRVLLTHEI MCSRCCDRKS CGNRNETPSD PVIIDRFFLK FFLKCNQNCL
210 220 230 240 250
KNAGNPRDMR RFQVVVSTTV SVDGHVLAVS DNMFVHNNSK HGRRARRLDP
260 270 280 290 300
SEAATPCIKA ISPGEGWTTG GATVIVIGDN FFDGLQVVFG NVLVWSELIT
310 320 330 340 350
PHAIRVQTPP RHIPGVVEVT LSYKSKQFCK GCPGRFVYTA LNEPTIDYGF
360 370 380 390 400
QRLQKVIPRH PGDPERLPKE VLLKRAADLA EALYGVPGSN QELLLKRAAD
410 420 430 440 450
VAEALYSTPR APGPLAPLAP SHPHPAVVGI NAFSSPLAIA VGDATPGPEP
460 470 480 490 500
GYARSCSSAS PRGFAPSPGS QQSGYGGGLG AGLGGYGAPG VAGLGVPGSP
510 520 530 540 550
SFLNGSTATS PFAIMPSSPP LAAASSMSLP AAAPTTSVFS FSPVNMISAV
560 570 580 590 600
KQRSAFAPVL RPPSSPPQAC PRAHGEGLPD QSFEDSDKFH SPARGLQGLA

YS
Length:602
Mass (Da):64,473
Last modified:July 10, 2007 - v2
Checksum:iEA340606A71094C1
GO
Isoform 1 (identifier: Q9BQW3-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MFPAQ → MARARGQAPG...SAPAASASRM
     514-602: IMPSSPPLAA...ARGLQGLAYS → KERLRPRAAPPKLPTPGLPQSPRRGASRPVF

Note: No experimental confirmation available.
Show »
Length:642
Mass (Da):68,232
Checksum:i18C0BE24442AFA76
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti425 – 4251P → S in BAA92680 (PubMed:10718198).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 55MFPAQ → MARARGQAPGSGGRRRPRRG GAGTGPRGESAGLLLLLLQV LPPGATAGPGRRGTRGAGGG GVCWPGAAPAFPRDARLLLL LPPLPPLSPPPPSSAPAASA SRM in isoform 1. 1 PublicationVSP_026469
Alternative sequencei514 – 60289IMPSS…GLAYS → KERLRPRAAPPKLPTPGLPQ SPRRGASRPVF in isoform 1. 1 PublicationVSP_026470Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035460 Genomic DNA. Translation: CAB82244.1.
AB037863 mRNA. Translation: BAA92680.1.
RefSeqiNP_001103984.1. NM_001110514.1.
UniGeneiHs.471955.

Genome annotation databases

EnsembliENST00000609451; ENSP00000477023; ENSG00000088881. [Q9BQW3-2]
GeneIDi57593.
KEGGihsa:57593.
UCSCiuc061vby.1. human. [Q9BQW3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035460 Genomic DNA. Translation: CAB82244.1.
AB037863 mRNA. Translation: BAA92680.1.
RefSeqiNP_001103984.1. NM_001110514.1.
UniGeneiHs.471955.

3D structure databases

ProteinModelPortaliQ9BQW3.
SMRiQ9BQW3. Positions 37-387.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121644. 3 interactions.
IntActiQ9BQW3. 1 interaction.
STRINGi9606.ENSP00000370022.

PTM databases

iPTMnetiQ9BQW3.
PhosphoSiteiQ9BQW3.

Polymorphism and mutation databases

DMDMi152031576.

Proteomic databases

MaxQBiQ9BQW3.
PaxDbiQ9BQW3.
PeptideAtlasiQ9BQW3.
PRIDEiQ9BQW3.
TopDownProteomicsiQ9BQW3-1. [Q9BQW3-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000609451; ENSP00000477023; ENSG00000088881. [Q9BQW3-2]
GeneIDi57593.
KEGGihsa:57593.
UCSCiuc061vby.1. human. [Q9BQW3-2]

Organism-specific databases

CTDi57593.
GeneCardsiEBF4.
HGNCiHGNC:29278. EBF4.
HPAiCAB034061.
CAB034065.
MIMi609935. gene.
neXtProtiNX_Q9BQW3.
PharmGKBiPA162384262.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3836. Eukaryota.
ENOG410XQ9Z. LUCA.
GeneTreeiENSGT00390000014051.
HOGENOMiHOG000092311.
HOVERGENiHBG005108.
InParanoidiQ9BQW3.
KOiK09103.
PhylomeDBiQ9BQW3.

Miscellaneous databases

ChiTaRSiEBF4. human.
GenomeRNAii57593.
PROiQ9BQW3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000088881.
CleanExiHS_EBF4.
ExpressionAtlasiQ9BQW3. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR032200. COE_DBD.
IPR032201. COE_HLH.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR003523. Transcription_factor_COE.
IPR018350. Transcription_factor_COE_CS.
[Graphical view]
PANTHERiPTHR10747. PTHR10747. 1 hit.
PfamiPF16422. COE1_DBD. 1 hit.
PF16423. COE1_HLH. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS01345. COE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOE4_HUMAN
AccessioniPrimary (citable) accession number: Q9BQW3
Secondary accession number(s): Q1MTP7
, Q5JY53, Q9NUB6, Q9P2A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: July 10, 2007
Last modified: September 7, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.