Q9BQW3 (COE4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor COE4

Alternative name(s):
Early B-cell factor 4
Short name=EBF-4
Olf-1/EBF-like 4
Short name=O/E-4
Short name=OE-4

Gene names

Name:	EBF4
Synonyms:	COE4, KIAA1442

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	602 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcriptional factor which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' By similarity.
Subunit structure	Forms either a homodimer or a heterodimer with a related family member By similarity.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the COE family. Contains 1 IPT/TIG domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 2 (identifier: Q9BQW3-2)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q9BQW3-1)

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MFPAQ → MARARGQAPG...SAPAASASRM
     514-602: IMPSSPPLAA...ARGLQGLAYS → KERLRPRAAPPKLPTPGLPQSPRRGASRPVF

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 602	602	Transcription factor COE4		PRO_0000107835
Regions
	Domain	256 – 338	83	IPT/TIG
	Zinc finger	152 – 171	20	C5-type Potential
	Region	64 – 67	4	Interaction with DNA By similarity
	Region	198 – 205	8	Interaction with DNA By similarity
	Region	237 – 240	4	Interaction with DNA By similarity
Sites
	Site	164	1	Interaction with DNA By similarity
	Site	173	1	Interaction with DNA By similarity
Natural variations
	Alternative sequence	1 – 5	5	MFPAQ → MARARGQAPGSGGRRRPRRG GAGTGPRGESAGLLLLLLQV LPPGATAGPGRRGTRGAGGG GVCWPGAAPAFPRDARLLLL LPPLPPLSPPPPSSAPAASA SRM in isoform 1.		VSP_026469
	Alternative sequence	514 – 602	89	IMPSS…GLAYS → KERLRPRAAPPKLPTPGLPQ SPRRGASRPVF in isoform 1.		VSP_026470
Experimental info
	Sequence conflict	425	1	P → S in BAA92680. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 [UniParc]. Last modified July 10, 2007. Version 2. Checksum: EA340606A71094C1	FASTA	602	64,473
	10 20 30 40 50 60 MFPAQDALPR SGLNLKEEPL LPAGLGSVRS WMQGAGILDA STAAQSGVGL ARAHFEKQPP 70 80 90 100 110 120 SNLRKSNFFH FVLAMYDRQG QPVEVERTAF IDFVEKDREP GAEKTNNGIH YRLRLVYNNG 130 140 150 160 170 180 LRTEQDLYVR LIDSMSKQAI IYEGQDKNPE MCRVLLTHEI MCSRCCDRKS CGNRNETPSD 190 200 210 220 230 240 PVIIDRFFLK FFLKCNQNCL KNAGNPRDMR RFQVVVSTTV SVDGHVLAVS DNMFVHNNSK 250 260 270 280 290 300 HGRRARRLDP SEAATPCIKA ISPGEGWTTG GATVIVIGDN FFDGLQVVFG NVLVWSELIT 310 320 330 340 350 360 PHAIRVQTPP RHIPGVVEVT LSYKSKQFCK GCPGRFVYTA LNEPTIDYGF QRLQKVIPRH 370 380 390 400 410 420 PGDPERLPKE VLLKRAADLA EALYGVPGSN QELLLKRAAD VAEALYSTPR APGPLAPLAP 430 440 450 460 470 480 SHPHPAVVGI NAFSSPLAIA VGDATPGPEP GYARSCSSAS PRGFAPSPGS QQSGYGGGLG 490 500 510 520 530 540 AGLGGYGAPG VAGLGVPGSP SFLNGSTATS PFAIMPSSPP LAAASSMSLP AAAPTTSVFS 550 560 570 580 590 600 FSPVNMISAV KQRSAFAPVL RPPSSPPQAC PRAHGEGLPD QSFEDSDKFH SPARGLQGLA YS
	Isoform 1 [UniParc]. Checksum: 18C0BE24442AFA76	FASTA	642	68,232
	10 20 30 40 50 60 MARARGQAPG SGGRRRPRRG GAGTGPRGES AGLLLLLLQV LPPGATAGPG RRGTRGAGGG 70 80 90 100 110 120 GVCWPGAAPA FPRDARLLLL LPPLPPLSPP PPSSAPAASA SRMDALPRSG LNLKEEPLLP 130 140 150 160 170 180 AGLGSVRSWM QGAGILDAST AAQSGVGLAR AHFEKQPPSN LRKSNFFHFV LAMYDRQGQP 190 200 210 220 230 240 VEVERTAFID FVEKDREPGA EKTNNGIHYR LRLVYNNGLR TEQDLYVRLI DSMSKQAIIY 250 260 270 280 290 300 EGQDKNPEMC RVLLTHEIMC SRCCDRKSCG NRNETPSDPV IIDRFFLKFF LKCNQNCLKN 310 320 330 340 350 360 AGNPRDMRRF QVVVSTTVSV DGHVLAVSDN MFVHNNSKHG RRARRLDPSE AATPCIKAIS 370 380 390 400 410 420 PGEGWTTGGA TVIVIGDNFF DGLQVVFGNV LVWSELITPH AIRVQTPPRH IPGVVEVTLS 430 440 450 460 470 480 YKSKQFCKGC PGRFVYTALN EPTIDYGFQR LQKVIPRHPG DPERLPKEVL LKRAADLAEA 490 500 510 520 530 540 LYGVPGSNQE LLLKRAADVA EALYSTPRAP GPLAPLAPSH PHPAVVGINA FSSPLAIAVG 550 560 570 580 590 600 DATPGPEPGY ARSCSSASPR GFAPSPGSQQ SGYGGGLGAG LGGYGAPGVA GLGVPGSPSF 610 620 630 640 LNGSTATSPF AKERLRPRAA PPKLPTPGLP QSPRRGASRP VF

References

[1]

"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed: 10718198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-602 (ISOFORM 1). Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL035460 Genomic DNA. Translation: CAB82244.1. AB037863 mRNA. Translation: BAA92680.1.
IPI	IPI00215773. IPI00853002.
RefSeq	NP_001103984.1. NM_001110514.1.
UniGene	Hs.471955.
3D structure databases
ProteinModelPortal	Q9BQW3.
SMR	Q9BQW3. Positions 37-387.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9BQW3.
Polymorphism databases
DMDM	152031576.
Proteomic databases
PRIDE	Q9BQW3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000342725; ENSP00000345030; ENSG00000088881.
GeneID	57593.
KEGG	hsa:57593.
NMPDR	fig|9606.3.peg.19739.
UCSC	uc002wgt.2. human.
Organism-specific databases
CTD	57593.
GeneCards	GC20P002673.
HGNC	HGNC:29278. EBF4.
MIM	609935. gene.
neXtProt	NX_Q9BQW3.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG04415.
GeneTree	ENSGT00390000014051.
HOVERGEN	HBG005108.
InParanoid	Q9BQW3.
OMA	QACPRTH.
Gene expression databases
ArrayExpress	Q9BQW3.
Bgee	Q9BQW3.
CleanEx	HS_EBF4.
Genevestigator	Q9BQW3.
Family and domain databases
InterPro	IPR011598. HLH_DNA-bd. IPR013783. Ig-like_fold. IPR014756. Ig_E-set. IPR002909. IPT_TIG_rcpt. IPR003523. Transcription_factor_COE. IPR018350. Transcription_factor_COE_CS. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
KO	K09103.
PANTHER	PTHR10747. TF_COE. 1 hit.
Pfam	PF01833. TIG. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. SM00429. IPT. 1 hit. [Graphical view]
SUPFAM	SSF81296. Ig_E-set. 1 hit.
PROSITE	PS01345. COE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	64186.
SOURCE	Search...

Entry information

Entry name

COE4_HUMAN

Accession

Primary (citable) accession number: Q9BQW3
Secondary accession number(s): Q1MTP7 , Q5JY53, Q9NUB6, Q9P2A6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	July 10, 2007
Last modified:	January 25, 2012
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.