ID   Q9BQU1_HUMAN            Unreviewed;        31 AA.
AC   Q9BQU1;
DT   01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2001, sequence version 1.
DT   27-MAR-2024, entry version 135.
DE   SubName: Full=6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase {ECO:0000313|EMBL:CAC34794.1};
DE            EC=2.7.1.105 {ECO:0000313|EMBL:CAC34794.1};
DE   SubName: Full=6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 {ECO:0000313|Ensembl:ENSP00000404995.1};
DE   Flags: Fragment;
GN   Name=PFKFB3 {ECO:0000313|EMBL:CAC34794.1,
GN   ECO:0000313|Ensembl:ENSP00000404995.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CAC34794.1};
RN   [1] {ECO:0000313|EMBL:CAC34794.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Caucasian {ECO:0000313|EMBL:CAC34794.1};
RC   TISSUE=Brain {ECO:0000313|EMBL:CAC34794.1};
RX   PubMed=11245921; DOI=10.1016/S0169-328X(01)00014-6;
RA   Kessler R., Eschrich K.;
RT   "Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-
RT   bisphosphatase in human brain.";
RL   Brain Res. Mol. Brain Res. 87:190-195(2001).
RN   [2] {ECO:0000313|Ensembl:ENSP00000404995.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [3] {ECO:0000313|Ensembl:ENSP00000404995.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
RN   [4] {ECO:0000313|EMBL:CAC34794.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Caucasian {ECO:0000313|EMBL:CAC34794.1};
RC   TISSUE=Brain {ECO:0000313|EMBL:CAC34794.1};
RA   Kessler R., Eschrich K.;
RT   "Alternative splicing of ubiquitous 6-phosphofructo-2-kinase/ fructose-2,6-
RT   bisphosphatase in human brain.";
RL   FEBS Lett. 0:0-0(0).
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DR   EMBL; AL157395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL359960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJ272440; CAC34794.1; -; mRNA.
DR   ProteomicsDB; 78724; -.
DR   Antibodypedia; 10861; 411 antibodies from 38 providers.
DR   Ensembl; ENST00000441697.1; ENSP00000404995.1; ENSG00000170525.21.
DR   UCSC; uc057rne.1; human.
DR   HGNC; HGNC:8874; PFKFB3.
DR   VEuPathDB; HostDB:ENSG00000170525; -.
DR   GeneTree; ENSGT00950000182835; -.
DR   HOGENOM; CLU_3401174_0_0_1; -.
DR   ChiTaRS; PFKFB3; human.
DR   Proteomes; UP000005640; Chromosome 10.
DR   Bgee; ENSG00000170525; Expressed in pancreatic ductal cell and 194 other cell types or tissues.
DR   GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:UniProtKB-EC.
PE   2: Evidence at transcript level;
KW   Kinase {ECO:0000313|EMBL:CAC34794.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transferase {ECO:0000313|EMBL:CAC34794.1}.
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..31
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CAC34794.1"
SQ   SEQUENCE   31 AA;  3565 MW;  38D7A145E9FF6E25 CRC64;
     IYLNVESVCT HRERSENMKG SRSSADSSRK H
//