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Q9BQT8

- ODC_HUMAN

UniProt

Q9BQT8 - ODC_HUMAN

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Protein

Mitochondrial 2-oxodicarboxylate carrier

Gene

SLC25A21

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.

GO - Biological processi

  1. cellular nitrogen compound metabolic process Source: Reactome
  2. lysine catabolic process Source: Reactome
  3. small molecule metabolic process Source: Reactome
  4. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_1298. Lysine catabolism.

Protein family/group databases

TCDBi2.A.29.2.4. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 2-oxodicarboxylate carrier
Alternative name(s):
Solute carrier family 25 member 21
Gene namesi
Name:SLC25A21
Synonyms:ODC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:14411. SLC25A21.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei70 – 8920Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei167 – 18721Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei205 – 22521Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37880.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Mitochondrial 2-oxodicarboxylate carrierPRO_0000090644Add
BLAST

Proteomic databases

MaxQBiQ9BQT8.
PaxDbiQ9BQT8.
PRIDEiQ9BQT8.

PTM databases

PhosphoSiteiQ9BQT8.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiQ9BQT8.
CleanExiHS_SLC25A21.
GenevestigatoriQ9BQT8.

Organism-specific databases

HPAiHPA000662.

Interactioni

Protein-protein interaction databases

BioGridi124629. 5 interactions.
IntActiQ9BQT8. 1 interaction.
STRINGi9606.ENSP00000329452.

Structurei

3D structure databases

ProteinModelPortaliQ9BQT8.
SMRiQ9BQT8. Positions 15-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 10090Solcar 1Add
BLAST
Repeati107 – 19690Solcar 2Add
BLAST
Repeati205 – 29490Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG325140.
GeneTreeiENSGT00730000111119.
HOGENOMiHOG000168307.
HOVERGENiHBG105598.
InParanoidiQ9BQT8.
KOiK15110.
OMAiWTYPALV.
OrthoDBiEOG74N5H8.
PhylomeDBiQ9BQT8.
TreeFamiTF314035.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BQT8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAKPEVSLV REASRQIVAG GSAGLVEICL MHPLDVVKTR FQIQRCATDP
60 70 80 90 100
NSYKSLVDSF RMIFQMEGLF GFYKGILPPI LAETPKRAVK FFTFEQYKKL
110 120 130 140 150
LGYVSLSPAL TFAIAGLGSG LTEAIVVNPF EVVKVGLQAN RNTFAEQPST
160 170 180 190 200
VGYARQIIKK EGWGLQGLNK GLTATLGRHG VFNMVYFGFY YNVKNMIPVN
210 220 230 240 250
KDPILEFWRK FGIGLLSGTI ASVINIPFDV AKSRIQGPQP VPGEIKYRTC
260 270 280 290
FKTMATVYQE EGILALYKGL LPKIMRLGPG GAVMLLVYEY TYSWLQENW
Length:299
Mass (Da):33,303
Last modified:June 1, 2001 - v1
Checksum:i69A259400328AE19
GO
Isoform 2 (identifier: Q9BQT8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     299-299: Missing.

Show »
Length:298
Mass (Da):33,117
Checksum:i0259400328AE1911
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti299 – 2991W → C.
Corresponds to variant rs17104991 [ dbSNP | Ensembl ].
VAR_050131

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei299 – 2991Missing in isoform 2. 1 PublicationVSP_046690

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278148 mRNA. Translation: CAC27562.1.
AK289575 mRNA. Translation: BAF82264.1.
AL079303 Genomic DNA. No translation available.
AL079304 Genomic DNA. No translation available.
AL121775 Genomic DNA. No translation available.
AL162464 Genomic DNA. No translation available.
BC101521 mRNA. Translation: AAI01522.1.
BC113365 mRNA. Translation: AAI13366.1.
CCDSiCCDS55913.1. [Q9BQT8-2]
CCDS9663.1. [Q9BQT8-1]
RefSeqiNP_001164641.1. NM_001171170.1. [Q9BQT8-2]
NP_085134.1. NM_030631.3. [Q9BQT8-1]
UniGeneiHs.730857.

Genome annotation databases

EnsembliENST00000331299; ENSP00000329452; ENSG00000183032. [Q9BQT8-1]
ENST00000555449; ENSP00000451873; ENSG00000183032. [Q9BQT8-2]
GeneIDi89874.
KEGGihsa:89874.
UCSCiuc001wtz.2. human. [Q9BQT8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278148 mRNA. Translation: CAC27562.1 .
AK289575 mRNA. Translation: BAF82264.1 .
AL079303 Genomic DNA. No translation available.
AL079304 Genomic DNA. No translation available.
AL121775 Genomic DNA. No translation available.
AL162464 Genomic DNA. No translation available.
BC101521 mRNA. Translation: AAI01522.1 .
BC113365 mRNA. Translation: AAI13366.1 .
CCDSi CCDS55913.1. [Q9BQT8-2 ]
CCDS9663.1. [Q9BQT8-1 ]
RefSeqi NP_001164641.1. NM_001171170.1. [Q9BQT8-2 ]
NP_085134.1. NM_030631.3. [Q9BQT8-1 ]
UniGenei Hs.730857.

3D structure databases

ProteinModelPortali Q9BQT8.
SMRi Q9BQT8. Positions 15-289.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124629. 5 interactions.
IntActi Q9BQT8. 1 interaction.
STRINGi 9606.ENSP00000329452.

Protein family/group databases

TCDBi 2.A.29.2.4. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSitei Q9BQT8.

Proteomic databases

MaxQBi Q9BQT8.
PaxDbi Q9BQT8.
PRIDEi Q9BQT8.

Protocols and materials databases

DNASUi 89874.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000331299 ; ENSP00000329452 ; ENSG00000183032 . [Q9BQT8-1 ]
ENST00000555449 ; ENSP00000451873 ; ENSG00000183032 . [Q9BQT8-2 ]
GeneIDi 89874.
KEGGi hsa:89874.
UCSCi uc001wtz.2. human. [Q9BQT8-1 ]

Organism-specific databases

CTDi 89874.
GeneCardsi GC14M037148.
H-InvDB HIX0037719.
HGNCi HGNC:14411. SLC25A21.
HPAi HPA000662.
MIMi 607571. gene.
neXtProti NX_Q9BQT8.
PharmGKBi PA37880.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG325140.
GeneTreei ENSGT00730000111119.
HOGENOMi HOG000168307.
HOVERGENi HBG105598.
InParanoidi Q9BQT8.
KOi K15110.
OMAi WTYPALV.
OrthoDBi EOG74N5H8.
PhylomeDBi Q9BQT8.
TreeFami TF314035.

Enzyme and pathway databases

Reactomei REACT_1298. Lysine catabolism.

Miscellaneous databases

GeneWikii SLC25A21.
GenomeRNAii 89874.
NextBioi 76380.
PROi Q9BQT8.
SOURCEi Search...

Gene expression databases

Bgeei Q9BQT8.
CleanExi HS_SLC25A21.
Genevestigatori Q9BQT8.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
PRINTSi PR00926. MITOCARRIER.
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution and chromosomal location."
    Fiermonte G., Dolce V., Palmieri L., Ventura M., Runswick M.J., Palmieri F., Walker J.E.
    J. Biol. Chem. 276:8225-8230(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, TISSUE SPECIFICITY.
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiODC_HUMAN
AccessioniPrimary (citable) accession number: Q9BQT8
Secondary accession number(s): A8K0L0, G3V4L5, Q3MJ99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3