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Q9BQT8

- ODC_HUMAN

UniProt

Q9BQT8 - ODC_HUMAN

Protein

Mitochondrial 2-oxodicarboxylate carrier

Gene

SLC25A21

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.

    GO - Biological processi

    1. cellular nitrogen compound metabolic process Source: Reactome
    2. lysine catabolic process Source: Reactome
    3. small molecule metabolic process Source: Reactome
    4. transmembrane transport Source: InterPro

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_1298. Lysine catabolism.

    Protein family/group databases

    TCDBi2.A.29.2.4. the mitochondrial carrier (mc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial 2-oxodicarboxylate carrier
    Alternative name(s):
    Solute carrier family 25 member 21
    Gene namesi
    Name:SLC25A21
    Synonyms:ODC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:14411. SLC25A21.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37880.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Mitochondrial 2-oxodicarboxylate carrierPRO_0000090644Add
    BLAST

    Proteomic databases

    MaxQBiQ9BQT8.
    PaxDbiQ9BQT8.
    PRIDEiQ9BQT8.

    PTM databases

    PhosphoSiteiQ9BQT8.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiQ9BQT8.
    BgeeiQ9BQT8.
    CleanExiHS_SLC25A21.
    GenevestigatoriQ9BQT8.

    Organism-specific databases

    HPAiHPA000662.

    Interactioni

    Protein-protein interaction databases

    BioGridi124629. 1 interaction.
    IntActiQ9BQT8. 1 interaction.
    STRINGi9606.ENSP00000329452.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BQT8.
    SMRiQ9BQT8. Positions 15-289.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei70 – 8920Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei205 – 22521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati11 – 10090Solcar 1Add
    BLAST
    Repeati107 – 19690Solcar 2Add
    BLAST
    Repeati205 – 29490Solcar 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG325140.
    HOGENOMiHOG000168307.
    HOVERGENiHBG105598.
    InParanoidiQ9BQT8.
    KOiK15110.
    OMAiWTYPALV.
    OrthoDBiEOG74N5H8.
    PhylomeDBiQ9BQT8.
    TreeFamiTF314035.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00926. MITOCARRIER.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BQT8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSAKPEVSLV REASRQIVAG GSAGLVEICL MHPLDVVKTR FQIQRCATDP    50
    NSYKSLVDSF RMIFQMEGLF GFYKGILPPI LAETPKRAVK FFTFEQYKKL 100
    LGYVSLSPAL TFAIAGLGSG LTEAIVVNPF EVVKVGLQAN RNTFAEQPST 150
    VGYARQIIKK EGWGLQGLNK GLTATLGRHG VFNMVYFGFY YNVKNMIPVN 200
    KDPILEFWRK FGIGLLSGTI ASVINIPFDV AKSRIQGPQP VPGEIKYRTC 250
    FKTMATVYQE EGILALYKGL LPKIMRLGPG GAVMLLVYEY TYSWLQENW 299
    Length:299
    Mass (Da):33,303
    Last modified:June 1, 2001 - v1
    Checksum:i69A259400328AE19
    GO
    Isoform 2 (identifier: Q9BQT8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         299-299: Missing.

    Show »
    Length:298
    Mass (Da):33,117
    Checksum:i0259400328AE1911
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti299 – 2991W → C.
    Corresponds to variant rs17104991 [ dbSNP | Ensembl ].
    VAR_050131

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei299 – 2991Missing in isoform 2. 1 PublicationVSP_046690

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ278148 mRNA. Translation: CAC27562.1.
    AK289575 mRNA. Translation: BAF82264.1.
    AL079303 Genomic DNA. No translation available.
    AL079304 Genomic DNA. No translation available.
    AL121775 Genomic DNA. No translation available.
    AL162464 Genomic DNA. No translation available.
    BC101521 mRNA. Translation: AAI01522.1.
    BC113365 mRNA. Translation: AAI13366.1.
    CCDSiCCDS55913.1. [Q9BQT8-2]
    CCDS9663.1. [Q9BQT8-1]
    RefSeqiNP_001164641.1. NM_001171170.1. [Q9BQT8-2]
    NP_085134.1. NM_030631.3. [Q9BQT8-1]
    UniGeneiHs.730857.

    Genome annotation databases

    EnsembliENST00000331299; ENSP00000329452; ENSG00000183032. [Q9BQT8-1]
    ENST00000555449; ENSP00000451873; ENSG00000183032. [Q9BQT8-2]
    GeneIDi89874.
    KEGGihsa:89874.
    UCSCiuc001wtz.2. human. [Q9BQT8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ278148 mRNA. Translation: CAC27562.1 .
    AK289575 mRNA. Translation: BAF82264.1 .
    AL079303 Genomic DNA. No translation available.
    AL079304 Genomic DNA. No translation available.
    AL121775 Genomic DNA. No translation available.
    AL162464 Genomic DNA. No translation available.
    BC101521 mRNA. Translation: AAI01522.1 .
    BC113365 mRNA. Translation: AAI13366.1 .
    CCDSi CCDS55913.1. [Q9BQT8-2 ]
    CCDS9663.1. [Q9BQT8-1 ]
    RefSeqi NP_001164641.1. NM_001171170.1. [Q9BQT8-2 ]
    NP_085134.1. NM_030631.3. [Q9BQT8-1 ]
    UniGenei Hs.730857.

    3D structure databases

    ProteinModelPortali Q9BQT8.
    SMRi Q9BQT8. Positions 15-289.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124629. 1 interaction.
    IntActi Q9BQT8. 1 interaction.
    STRINGi 9606.ENSP00000329452.

    Protein family/group databases

    TCDBi 2.A.29.2.4. the mitochondrial carrier (mc) family.

    PTM databases

    PhosphoSitei Q9BQT8.

    Proteomic databases

    MaxQBi Q9BQT8.
    PaxDbi Q9BQT8.
    PRIDEi Q9BQT8.

    Protocols and materials databases

    DNASUi 89874.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000331299 ; ENSP00000329452 ; ENSG00000183032 . [Q9BQT8-1 ]
    ENST00000555449 ; ENSP00000451873 ; ENSG00000183032 . [Q9BQT8-2 ]
    GeneIDi 89874.
    KEGGi hsa:89874.
    UCSCi uc001wtz.2. human. [Q9BQT8-1 ]

    Organism-specific databases

    CTDi 89874.
    GeneCardsi GC14M037148.
    H-InvDB HIX0037719.
    HGNCi HGNC:14411. SLC25A21.
    HPAi HPA000662.
    MIMi 607571. gene.
    neXtProti NX_Q9BQT8.
    PharmGKBi PA37880.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG325140.
    HOGENOMi HOG000168307.
    HOVERGENi HBG105598.
    InParanoidi Q9BQT8.
    KOi K15110.
    OMAi WTYPALV.
    OrthoDBi EOG74N5H8.
    PhylomeDBi Q9BQT8.
    TreeFami TF314035.

    Enzyme and pathway databases

    Reactomei REACT_1298. Lysine catabolism.

    Miscellaneous databases

    GeneWikii SLC25A21.
    GenomeRNAii 89874.
    NextBioi 76380.
    PROi Q9BQT8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BQT8.
    Bgeei Q9BQT8.
    CleanExi HS_SLC25A21.
    Genevestigatori Q9BQT8.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00926. MITOCARRIER.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution and chromosomal location."
      Fiermonte G., Dolce V., Palmieri L., Ventura M., Runswick M.J., Palmieri F., Walker J.E.
      J. Biol. Chem. 276:8225-8230(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, TISSUE SPECIFICITY.
      Tissue: Liver.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Cerebellum.
    3. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiODC_HUMAN
    AccessioniPrimary (citable) accession number: Q9BQT8
    Secondary accession number(s): A8K0L0, G3V4L5, Q3MJ99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3