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Protein

Mitochondrial 2-oxodicarboxylate carrier

Gene

SLC25A21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_1298. Lysine catabolism.

Protein family/group databases

TCDBi2.A.29.2.4. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial 2-oxodicarboxylate carrier
Alternative name(s):
Solute carrier family 25 member 21
Gene namesi
Name:SLC25A21
Synonyms:ODC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:14411. SLC25A21.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei70 – 8920Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei113 – 13321Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei167 – 18721Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei205 – 22521Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37880.

Polymorphism and mutation databases

BioMutaiSLC25A21.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Mitochondrial 2-oxodicarboxylate carrierPRO_0000090644Add
BLAST

Proteomic databases

MaxQBiQ9BQT8.
PaxDbiQ9BQT8.
PRIDEiQ9BQT8.

PTM databases

PhosphoSiteiQ9BQT8.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiQ9BQT8.
CleanExiHS_SLC25A21.
ExpressionAtlasiQ9BQT8. baseline and differential.
GenevisibleiQ9BQT8. HS.

Organism-specific databases

HPAiHPA000662.

Interactioni

Protein-protein interaction databases

BioGridi124629. 5 interactions.
IntActiQ9BQT8. 1 interaction.
STRINGi9606.ENSP00000329452.

Structurei

3D structure databases

ProteinModelPortaliQ9BQT8.
SMRiQ9BQT8. Positions 15-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 10090Solcar 1Add
BLAST
Repeati107 – 19690Solcar 2Add
BLAST
Repeati205 – 29490Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG325140.
GeneTreeiENSGT00730000111119.
HOGENOMiHOG000168307.
HOVERGENiHBG105598.
InParanoidiQ9BQT8.
KOiK15110.
OMAiIYFGFYF.
OrthoDBiEOG74N5H8.
PhylomeDBiQ9BQT8.
TreeFamiTF314035.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BQT8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAKPEVSLV REASRQIVAG GSAGLVEICL MHPLDVVKTR FQIQRCATDP
60 70 80 90 100
NSYKSLVDSF RMIFQMEGLF GFYKGILPPI LAETPKRAVK FFTFEQYKKL
110 120 130 140 150
LGYVSLSPAL TFAIAGLGSG LTEAIVVNPF EVVKVGLQAN RNTFAEQPST
160 170 180 190 200
VGYARQIIKK EGWGLQGLNK GLTATLGRHG VFNMVYFGFY YNVKNMIPVN
210 220 230 240 250
KDPILEFWRK FGIGLLSGTI ASVINIPFDV AKSRIQGPQP VPGEIKYRTC
260 270 280 290
FKTMATVYQE EGILALYKGL LPKIMRLGPG GAVMLLVYEY TYSWLQENW
Length:299
Mass (Da):33,303
Last modified:June 1, 2001 - v1
Checksum:i69A259400328AE19
GO
Isoform 2 (identifier: Q9BQT8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     299-299: Missing.

Show »
Length:298
Mass (Da):33,117
Checksum:i0259400328AE1911
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti299 – 2991W → C.
Corresponds to variant rs17104991 [ dbSNP | Ensembl ].
VAR_050131

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei299 – 2991Missing in isoform 2. 1 PublicationVSP_046690

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278148 mRNA. Translation: CAC27562.1.
AK289575 mRNA. Translation: BAF82264.1.
AL079303 Genomic DNA. No translation available.
AL079304 Genomic DNA. No translation available.
AL121775 Genomic DNA. No translation available.
AL162464 Genomic DNA. No translation available.
BC101521 mRNA. Translation: AAI01522.1.
BC113365 mRNA. Translation: AAI13366.1.
CCDSiCCDS55913.1. [Q9BQT8-2]
CCDS9663.1. [Q9BQT8-1]
RefSeqiNP_001164641.1. NM_001171170.1. [Q9BQT8-2]
NP_085134.1. NM_030631.3. [Q9BQT8-1]
UniGeneiHs.730857.

Genome annotation databases

EnsembliENST00000331299; ENSP00000329452; ENSG00000183032.
ENST00000555449; ENSP00000451873; ENSG00000183032. [Q9BQT8-2]
GeneIDi89874.
KEGGihsa:89874.
UCSCiuc001wtz.2. human. [Q9BQT8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278148 mRNA. Translation: CAC27562.1.
AK289575 mRNA. Translation: BAF82264.1.
AL079303 Genomic DNA. No translation available.
AL079304 Genomic DNA. No translation available.
AL121775 Genomic DNA. No translation available.
AL162464 Genomic DNA. No translation available.
BC101521 mRNA. Translation: AAI01522.1.
BC113365 mRNA. Translation: AAI13366.1.
CCDSiCCDS55913.1. [Q9BQT8-2]
CCDS9663.1. [Q9BQT8-1]
RefSeqiNP_001164641.1. NM_001171170.1. [Q9BQT8-2]
NP_085134.1. NM_030631.3. [Q9BQT8-1]
UniGeneiHs.730857.

3D structure databases

ProteinModelPortaliQ9BQT8.
SMRiQ9BQT8. Positions 15-289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124629. 5 interactions.
IntActiQ9BQT8. 1 interaction.
STRINGi9606.ENSP00000329452.

Protein family/group databases

TCDBi2.A.29.2.4. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSiteiQ9BQT8.

Polymorphism and mutation databases

BioMutaiSLC25A21.

Proteomic databases

MaxQBiQ9BQT8.
PaxDbiQ9BQT8.
PRIDEiQ9BQT8.

Protocols and materials databases

DNASUi89874.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331299; ENSP00000329452; ENSG00000183032.
ENST00000555449; ENSP00000451873; ENSG00000183032. [Q9BQT8-2]
GeneIDi89874.
KEGGihsa:89874.
UCSCiuc001wtz.2. human. [Q9BQT8-1]

Organism-specific databases

CTDi89874.
GeneCardsiGC14M037148.
H-InvDBHIX0037719.
HGNCiHGNC:14411. SLC25A21.
HPAiHPA000662.
MIMi607571. gene.
neXtProtiNX_Q9BQT8.
PharmGKBiPA37880.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG325140.
GeneTreeiENSGT00730000111119.
HOGENOMiHOG000168307.
HOVERGENiHBG105598.
InParanoidiQ9BQT8.
KOiK15110.
OMAiIYFGFYF.
OrthoDBiEOG74N5H8.
PhylomeDBiQ9BQT8.
TreeFamiTF314035.

Enzyme and pathway databases

ReactomeiREACT_1298. Lysine catabolism.

Miscellaneous databases

GeneWikiiSLC25A21.
GenomeRNAii89874.
NextBioi76380.
PROiQ9BQT8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BQT8.
CleanExiHS_SLC25A21.
ExpressionAtlasiQ9BQT8. baseline and differential.
GenevisibleiQ9BQT8. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution and chromosomal location."
    Fiermonte G., Dolce V., Palmieri L., Ventura M., Runswick M.J., Palmieri F., Walker J.E.
    J. Biol. Chem. 276:8225-8230(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHARACTERIZATION, TISSUE SPECIFICITY.
    Tissue: Liver.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiODC_HUMAN
AccessioniPrimary (citable) accession number: Q9BQT8
Secondary accession number(s): A8K0L0, G3V4L5, Q3MJ99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: July 22, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.