Q9BQT8 (ODC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial 2-oxodicarboxylate carrier

Alternative name(s):
Solute carrier family 25 member 21

Gene names

Name:	SLC25A21
Synonyms:	ODC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Tissue specificity	Ubiquitous. Ref.1
Sequence similarities	Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification] Contains 3 Solcar repeats.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular nitrogen compound metabolic process Traceable author statement. Source: Reactome lysine catabolic process Traceable author statement. Source: Reactome transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 299	299	Mitochondrial 2-oxodicarboxylate carrier		PRO_0000090644
Regions
	Transmembrane	17 – 37	21	Helical; Name=1; Potential
	Transmembrane	70 – 89	20	Helical; Name=2; Potential
	Transmembrane	113 – 133	21	Helical; Name=3; Potential
	Transmembrane	167 – 187	21	Helical; Name=4; Potential
	Transmembrane	205 – 225	21	Helical; Name=5; Potential
	Transmembrane	277 – 297	21	Helical; Name=6; Potential
	Repeat	11 – 100	90	Solcar 1
	Repeat	107 – 196	90	Solcar 2
	Repeat	205 – 294	90	Solcar 3
Natural variations
	Natural variant	299	1	W → C. Corresponds to variant rs17104991 [ dbSNP | Ensembl ].		VAR_050131

Sequences

	Sequence		Length	Mass (Da)
	Q9BQT8 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 69A259400328AE19	FASTA	299	33,303
	10 20 30 40 50 60 MSAKPEVSLV REASRQIVAG GSAGLVEICL MHPLDVVKTR FQIQRCATDP NSYKSLVDSF 70 80 90 100 110 120 RMIFQMEGLF GFYKGILPPI LAETPKRAVK FFTFEQYKKL LGYVSLSPAL TFAIAGLGSG 130 140 150 160 170 180 LTEAIVVNPF EVVKVGLQAN RNTFAEQPST VGYARQIIKK EGWGLQGLNK GLTATLGRHG 190 200 210 220 230 240 VFNMVYFGFY YNVKNMIPVN KDPILEFWRK FGIGLLSGTI ASVINIPFDV AKSRIQGPQP 250 260 270 280 290 VPGEIKYRTC FKTMATVYQE EGILALYKGL LPKIMRLGPG GAVMLLVYEY TYSWLQENW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution and chromosomal location." Fiermonte G., Dolce V., Palmieri L., Ventura M., Runswick M.J., Palmieri F., Walker J.E. J. Biol. Chem. 276:8225-8230(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ278148 mRNA. Translation: CAC27562.1. BC101521 mRNA. Translation: AAI01522.1. BC113365 mRNA. Translation: AAI13366.1.
IPI	IPI00012690.
RefSeq	NP_001164641.1. NM_001171170.1. NP_085134.1. NM_030631.3.
UniGene	Hs.730857.
3D structure databases
ProteinModelPortal	Q9BQT8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BQT8. 1 interaction.
STRING	9606.ENSP00000329452.
Protein family/group databases
TCDB	2.A.29.2.4. mitochondrial carrier (MC) family.
PTM databases
PhosphoSite	Q9BQT8.
Polymorphism databases
DMDM	20138852.
Proteomic databases
PaxDb	Q9BQT8.
PRIDE	Q9BQT8.
Protocols and materials databases
DNASU	89874.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000331299; ENSP00000329452; ENSG00000183032.
GeneID	89874.
KEGG	hsa:89874.
UCSC	uc001wtz.2. human.
Organism-specific databases
CTD	89874.
GeneCards	GC14M037148.
H-InvDB	HIX0037719.
HGNC	HGNC:14411. SLC25A21.
HPA	HPA000662.
MIM	607571. gene.
neXtProt	NX_Q9BQT8.
PharmGKB	PA37880.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG325140.
HOGENOM	HOG000168307.
HOVERGEN	HBG105598.
InParanoid	Q9BQT8.
KO	K15110.
OMA	IKYRTCF.
OrthoDB	EOG4X6C8S.
PhylomeDB	Q9BQT8.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	Q9BQT8.
Bgee	Q9BQT8.
CleanEx	HS_SLC25A21.
Genevestigator	Q9BQT8.
GermOnline	ENSG00000183032. Homo sapiens.
Family and domain databases
Gene3D	1.50.40.10. 1 hit.
InterPro	IPR002067. Mit_carrier. IPR018108. Mitochondrial_sb/sol_carrier. IPR023395. Mt_carrier_dom. [Graphical view]
Pfam	PF00153. Mito_carr. 3 hits. [Graphical view]
PRINTS	PR00926. MITOCARRIER.
SUPFAM	SSF103506. Mitoch_carrier. 1 hit.
PROSITE	PS50920. SOLCAR. 3 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	89874.
NextBio	76380.
SOURCE	Search...

Entry information

Entry name

ODC_HUMAN

Accession

Primary (citable) accession number: Q9BQT8
Secondary accession number(s): Q3MJ99

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.