Q9BQS8 (FYCO1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FYVE and coiled-coil domain-containing protein 1

Alternative name(s):
Zinc finger FYVE domain-containing protein 7

Gene names

Name:	FYCO1
Synonyms:	ZFYVE7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1478 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May mediate microtubule plus end-directed vesicle transport. Ref.8
Subunit structure	Can form homodimers. Interacts (via C-terminus) with MAP1LC3B. Interacts with RAB7A; the interaction with RAB7A induces FYCO1 recruitment to late endosomal/lysosomal compartments. Ref.8
Subcellular location	Cytoplasmic vesicle › autophagosome. Endosome. Lysosome. Note: Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes. Ref.8 Ref.9
Tissue specificity	Expressed in heart and skeletal muscle. Ref.1
Involvement in disease	Cataract, congenital, autosomal recessive 2 (CATC2) [MIM:610019]: An opacification of the crystalline lens of the eye becoming evident at birth or in infancy. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Note: The disease is caused by mutations affecting the gene represented in this entry. Pathogenic mutations in FYCO1 can affect intracellular transport of autophagocytic vesicles from the perinuclear area to the periphery, leading to an accumulation of large numbers of vesicles and hence loss of lens transparency (Ref.9). Ref.9
Sequence similarities	Contains 1 FYVE-type zinc finger. Contains 1 GOLD domain. Contains 1 RUN domain.
Sequence caution	The sequence AAH07218.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB14559.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB84991.1 differs from that shown. Reason: Frameshift at position 1402.

Ontologies

Keywords
Cellular component	Cytoplasmic vesicle Endosome Lysosome
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Cataract Disease mutation
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	plus-end-directed vesicle transport along microtubule Inferred from mutant phenotype Ref.8. Source: UniProtKB
Cellular_component	autophagic vacuole Inferred from direct assay Ref.8. Source: UniProtKB cytoplasmic vesicle Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: InterPro late endosome Inferred from direct assay Ref.8. Source: UniProtKB lysosome Inferred from direct assay Ref.8. Source: UniProtKB
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GABARAP	O95166	2	EBI-2869338,EBI-712001
GABARAPL1	Q9H0R8	2	EBI-2869338,EBI-746969
GABARAPL2	P60520	2	EBI-2869338,EBI-720116
MAP1LC3B	Q9GZQ8	7	EBI-2869338,EBI-373144
MAP1LC3C	Q9BXW4	2	EBI-2869338,EBI-2603996

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BQS8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BQS8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     376-380: QQKAD → LHVGD
     381-1478: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9BQS8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     376-380: QQKAD → HLSE
     381-1478: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1478	1478	FYVE and coiled-coil domain-containing protein 1		PRO_0000245837
Regions
	Domain	36 – 169	134	RUN
	Domain	1337 – 1466	130	GOLD
	Zinc finger	1173 – 1231	59	FYVE-type
	Coiled coil	4 – 33	30	Potential
	Coiled coil	225 – 280	56	Potential
	Coiled coil	394 – 555	162	Potential
	Coiled coil	596 – 1151	556	Potential
Amino acid modifications
	Modified residue	381	1	Phosphothreonine By similarity
	Modified residue	878	1	Phosphoserine Ref.7
Natural variations
	Alternative sequence	376 – 380	5	QQKAD → LHVGD in isoform 2.		VSP_019795
	Alternative sequence	376 – 380	5	QQKAD → HLSE in isoform 3.		VSP_019796
	Alternative sequence	381 – 1478	1098	Missing in isoform 2 and isoform 3.		VSP_019797
	Natural variant	250	1	R → Q. Ref.1 Ref.2 Ref.4 Ref.5 Corresponds to variant rs4683158 [ dbSNP | Ensembl ].		VAR_027006
	Natural variant	282	1	R → H. Corresponds to variant rs9875356 [ dbSNP | Ensembl ].		VAR_027007
	Natural variant	321	1	G → A. Ref.1 Ref.2 Ref.4 Ref.5 Corresponds to variant rs3733100 [ dbSNP | Ensembl ].		VAR_027008
	Natural variant	381	1	T → M. Corresponds to variant rs3733101 [ dbSNP | Ensembl ].		VAR_027009
	Natural variant	447	1	R → C. Corresponds to variant rs33910087 [ dbSNP | Ensembl ].		VAR_056882
	Natural variant	679	1	A → V. Ref.2 Corresponds to variant rs3796375 [ dbSNP | Ensembl ].		VAR_027010
	Natural variant	994	1	E → K. Corresponds to variant rs34801630 [ dbSNP | Ensembl ].		VAR_056883
	Natural variant	1001	1	N → D. Corresponds to variant rs13059238 [ dbSNP | Ensembl ].		VAR_027011
	Natural variant	1376	1	L → P in CATC2. Ref.9		VAR_065974
Experimental info
	Sequence conflict	155	1	Y → C in CAD91151. Ref.2
	Sequence conflict	359	1	D → G in CAD91151. Ref.2
	Sequence conflict	365	1	L → S in BAB14559. Ref.5
	Sequence conflict	381	1	T → S in CAC33883. Ref.1
	Sequence conflict	916	1	T → I in CAD89924. Ref.2
	Sequence conflict	964	1	K → E in CAD89924. Ref.2
	Sequence conflict	1382	1	A → P in CAC33883. Ref.1
	Sequence conflict	1385	1	G → A in CAC33883. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 8, 2011. Version 3. Checksum: 11AB671A9F2B3D21	FASTA	1,478	166,983
	10 20 30 40 50 60 MASTNAESQL QRIIRDLQDA VTELSKEFQE AGEPITDDST SLHKFSYKLE YLLQFDQKEK 70 80 90 100 110 120 ATLLGNKKDY WDYFCACLAK VKGANDGIRF VKSISELRTS LGKGRAFIRY SLVHQRLADT 130 140 150 160 170 180 LQQCFMNTKV TSDWYYARSP FLQPKLSSDI VGQLYELTEV QFDLASRGFD LDAAWPTFAR 190 200 210 220 230 240 RTLTTGSSAY LWKPPSRSSS MSSLVSSYLQ TQEMVSNFDL NSPLNNEALE GFDEMRLELD 250 260 270 280 290 300 QLEVREKQLR ERMQQLDREN QELRAAVSQQ GEQLQTERER GRTAAEDNVR LTCLVAELQK 310 320 330 340 350 360 QWEVTQATQN TVKELQTCLQ GLELGAAEKE EDYHTALRRL ESMLQPLAQE LEATRDSLDK 370 380 390 400 410 420 KNQHLASFPG WLAMAQQKAD TASDTKGRQE PIPSDAAQEM QELGEKLQAL ERERTKVEEV 430 440 450 460 470 480 NRQQSAQLEQ LVKELQLKED ARASLERLVK EMAPLQEELS GKGQEADQLW RRLQELLAHT 490 500 510 520 530 540 SSWEEELAEL RREKKQQQEE KELLEQEVRS LTRQLQFLET QLAQVSQHVS DLEEQKKQLI 550 560 570 580 590 600 QDKDHLSQQV GMLERLAGPP GPELPVAGEK NEALVPVNSS LQEAWGKPEE EQRGLQEAQL 610 620 630 640 650 660 DDTKVQEGSQ EEELRQANRE LEKELQNVVG RNQLLEGKLQ ALQADYQALQ QRESAIQGSL 670 680 690 700 710 720 ASLEAEQASI RHLGDQMEAS LLAVRKAKEA MKAQMAEKEA ILQSKEGECQ QLREEVEQCQ 730 740 750 760 770 780 QLAEARHREL RALESQCQQQ TQLIEVLTAE KGQQGVGPPT DNEARELAAQ LALSQAQLEV 790 800 810 820 830 840 HQGEVQRLQA QVVDLQAKMR AALDDQDKVQ SQLSMAEAVL REHKTLVQQL KEQNEALNRA 850 860 870 880 890 900 HVQELLQCSE REGALQEERA DEAQQREEEL RALQEELSQA KCSSEEAQLE HAELQEQLHR 910 920 930 940 950 960 ANTDTAELGI QVCALTVEKE RVEEALACAV QELQDAKEAA SREREGLERQ VAGLQQEKES 970 980 990 1000 1010 1020 LQEKLKAAKA AAGSLPGLQA QLAQAEQRAQ SLQEAAHQEL NTLKFQLSAE IMDYQSRLKN 1030 1040 1050 1060 1070 1080 AGEECKSLRG QLEEQGRQLQ AAEEAVEKLK ATQADMGEKL SCTSNHLAEC QAAMLRKDKE 1090 1100 1110 1120 1130 1140 GAALREDLER TQKELEKATT KIQEYYNKLC QEVTNRERND QKMLADLDDL NRTKKYLEER 1150 1160 1170 1180 1190 1200 LIELLRDKDA LWQKSDALEF QQKLSAEERW LGDTEANHCL DCKREFSWMV RRHHCRICGR 1210 1220 1230 1240 1250 1260 IFCYYCCNNY VLSKHGGKKE RCCRACFQKL SEGPGSPDSS GSGTSQGEPS PALSPASPGP 1270 1280 1290 1300 1310 1320 QATGGQGANT DYRPPDDAVF DIITDEELCQ IQESGSSLPE TPTETDSLDP NAAEQDTTST 1330 1340 1350 1360 1370 1380 SLTPEDTEDM PVGQDSEICL LKSGELMIKV PLTVDEIASF GEGSRELFVR SSTYSLIPIT 1390 1400 1410 1420 1430 1440 VAEAGLTISW VFSSDPKSIS FSVVFQEAED TPLDQCKVLI PTTRCNSHKE NIQGQLKVRT 1450 1460 1470 PGIYMLIFDN TFSRFVSKKV FYHLTVDRPV IYDGSDFL
	Isoform 2 [UniParc]. Checksum: 141833AF14C25727	FASTA	380	43,482
	10 20 30 40 50 60 MASTNAESQL QRIIRDLQDA VTELSKEFQE AGEPITDDST SLHKFSYKLE YLLQFDQKEK 70 80 90 100 110 120 ATLLGNKKDY WDYFCACLAK VKGANDGIRF VKSISELRTS LGKGRAFIRY SLVHQRLADT 130 140 150 160 170 180 LQQCFMNTKV TSDWYYARSP FLQPKLSSDI VGQLYELTEV QFDLASRGFD LDAAWPTFAR 190 200 210 220 230 240 RTLTTGSSAY LWKPPSRSSS MSSLVSSYLQ TQEMVSNFDL NSPLNNEALE GFDEMRLELD 250 260 270 280 290 300 QLEVREKQLR ERMQQLDREN QELRAAVSQQ GEQLQTERER GRTAAEDNVR LTCLVAELQK 310 320 330 340 350 360 QWEVTQATQN TVKELQTCLQ GLELGAAEKE EDYHTALRRL ESMLQPLAQE LEATRDSLDK 370 380 KNQHLASFPG WLAMALHVGD
	Isoform 3 [UniParc]. Checksum: 4B54D9D20257275F	FASTA	379	43,427
	10 20 30 40 50 60 MASTNAESQL QRIIRDLQDA VTELSKEFQE AGEPITDDST SLHKFSYKLE YLLQFDQKEK 70 80 90 100 110 120 ATLLGNKKDY WDYFCACLAK VKGANDGIRF VKSISELRTS LGKGRAFIRY SLVHQRLADT 130 140 150 160 170 180 LQQCFMNTKV TSDWYYARSP FLQPKLSSDI VGQLYELTEV QFDLASRGFD LDAAWPTFAR 190 200 210 220 230 240 RTLTTGSSAY LWKPPSRSSS MSSLVSSYLQ TQEMVSNFDL NSPLNNEALE GFDEMRLELD 250 260 270 280 290 300 QLEVREKQLR ERMQQLDREN QELRAAVSQQ GEQLQTERER GRTAAEDNVR LTCLVAELQK 310 320 330 340 350 360 QWEVTQATQN TVKELQTCLQ GLELGAAEKE EDYHTALRRL ESMLQPLAQE LEATRDSLDK 370 KNQHLASFPG WLAMAHLSE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional map of the common eliminated region 1 (C3CER1) in 3p21.3." Kiss H., Yang Y., Kiss C., Andersson K., Klein G., Imreh S., Dumanski J.P. Eur. J. Hum. Genet. 10:52-61(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS GLN-250 AND ALA-321.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLN-250; ALA-321 AND VAL-679. Tissue: Skeletal muscle.
[3]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 41-1478 (ISOFORM 2), VARIANTS GLN-250 AND ALA-321. Tissue: Heart, Lung and Skin.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 56-1478 (ISOFORM 3), VARIANTS GLN-250 AND ALA-321. Tissue: Ovary.
[6]	"The nucleotide sequence of a long cDNA clone isolated from human spleen." Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1213-1478 (ISOFORM 1). Tissue: Spleen.
[7]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-878, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[8]	"FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport." Pankiv S., Alemu E.A., Brech A., Bruun J.A., Lamark T., Overvatn A., Bjorkoy G., Johansen T. J. Cell Biol. 188:253-269(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH MAP1LC3B AND RAB7A.
[9]	"Mutations in FYCO1 cause autosomal-recessive congenital cataracts." Chen J., Ma Z., Jiao X., Fariss R., Kantorow W.L., Kantorow M., Pras E., Frydman M., Pras E., Riazuddin S., Riazuddin S.A., Hejtmancik J.F. Am. J. Hum. Genet. 88:827-838(2011) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, VARIANT CATC2 PRO-1376.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ292348 mRNA. Translation: CAC33883.1. AL833308 mRNA. Translation: CAD89924.1. AL832358 mRNA. Translation: CAD91151.1. AC099782 Genomic DNA. No translation available. BC007218 mRNA. Translation: AAH07218.1. Different initiation. BC101468 mRNA. Translation: AAI01469.1. BC101470 mRNA. Translation: AAI01471.1. AK023397 mRNA. Translation: BAB14559.1. Different initiation. AK074165 mRNA. Translation: BAB84991.1. Frameshift.
IPI	IPI00001580. IPI00760582. IPI00760784.
RefSeq	NP_078789.2. NM_024513.3.
UniGene	Hs.739775. Hs.741405.
3D structure databases
ProteinModelPortal	Q9BQS8.
SMR	Q9BQS8. Positions 32-173, 1137-1230, 1385-1469.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BQS8. 24 interactions.
STRING	9606.ENSP00000296137.
PTM databases
PhosphoSite	Q9BQS8.
Polymorphism databases
DMDM	110278986.
Proteomic databases
PaxDb	Q9BQS8.
PRIDE	Q9BQS8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000296137; ENSP00000296137; ENSG00000163820.
GeneID	79443.
KEGG	hsa:79443.
UCSC	uc003cpb.4. human.
Organism-specific databases
CTD	79443.
GeneCards	GC03M045934.
H-InvDB	HIX0003244.
HGNC	HGNC:14673. FYCO1.
HPA	HPA035526.
MIM	607182. gene. 610019. phenotype.
neXtProt	NX_Q9BQS8.
Orphanet	98991. Nuclear cataract.
PharmGKB	PA28453.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG262828.
HOVERGEN	HBG063805.
InParanoid	Q9BQS8.
OrthoDB	EOG4SN1MW.
PhylomeDB	Q9BQS8.
Gene expression databases
ArrayExpress	Q9BQS8.
Bgee	Q9BQS8.
CleanEx	HS_FYCO1.
Genevestigator	Q9BQS8.
GermOnline	ENSG00000163820. Homo sapiens.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR009038. GOLD. IPR004012. Run. IPR000306. Znf_FYVE. IPR017455. Znf_FYVE-rel. IPR011011. Znf_FYVE_PHD. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Pfam	PF01363. FYVE. 1 hit. PF02759. RUN. 1 hit. [Graphical view]
SMART	SM00064. FYVE. 1 hit. [Graphical view]
SUPFAM	SSF57903. FYVE_PHD_ZnF. 1 hit. SSF101576. GOLD. 1 hit.
PROSITE	PS50866. GOLD. 1 hit. PS50826. RUN. 1 hit. PS50178. ZF_FYVE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FYCO1. human.
GenomeRNAi	79443.
NextBio	68403.
SOURCE	Search...

Entry information

Entry name

FYCO1_HUMAN

Accession

Primary (citable) accession number: Q9BQS8
Secondary accession number(s): Q3MJE6 , Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	February 8, 2011
Last modified:	May 1, 2013
This is version 94 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.