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Protein

FYVE and coiled-coil domain-containing protein 1

Gene

FYCO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May mediate microtubule plus end-directed vesicle transport.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1173 – 1231FYVE-typePROSITE-ProRule annotationAdd BLAST59

GO - Molecular functioni

GO - Biological processi

  • plus-end-directed vesicle transport along microtubule Source: UniProtKB
  • positive regulation of autophagosome maturation Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163820-MONOMER.
SIGNORiQ9BQS8.

Names & Taxonomyi

Protein namesi
Recommended name:
FYVE and coiled-coil domain-containing protein 1
Alternative name(s):
Zinc finger FYVE domain-containing protein 7
Gene namesi
Name:FYCO1
Synonyms:ZFYVE7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:14673. FYCO1.

Subcellular locationi

  • Cytoplasmic vesicleautophagosome
  • Endosome
  • Lysosome

  • Note: Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes.

GO - Cellular componenti

  • autophagosome Source: UniProtKB
  • cytoplasmic vesicle Source: UniProtKB-KW
  • integral component of membrane Source: InterPro
  • intracellular membrane-bounded organelle Source: HPA
  • late endosome Source: UniProtKB
  • lysosome Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Lysosome

Pathology & Biotechi

Involvement in diseasei

Cataract 18 (CTRCT18)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. Pathogenic mutations in FYCO1 can affect intracellular transport of autophagocytic vesicles from the perinuclear area to the periphery, leading to an accumulation of large numbers of vesicles and hence loss of lens transparency (PubMed:21636066).1 Publication
Disease descriptionAn opacification of the crystalline lens of the eye becoming evident at birth or in infancy. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.
See also OMIM:610019
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0659741376L → P in CTRCT18. 1 PublicationCorresponds to variant rs387906965dbSNPEnsembl.1

Keywords - Diseasei

Cataract, Disease mutation

Organism-specific databases

DisGeNETi79443.
MalaCardsiFYCO1.
MIMi610019. phenotype.
OpenTargetsiENSG00000163820.
Orphaneti98991. Nuclear cataract.
PharmGKBiPA28453.

Polymorphism and mutation databases

BioMutaiFYCO1.
DMDMi322510128.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002458372 – 1478FYVE and coiled-coil domain-containing protein 1Add BLAST1477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei196PhosphoserineCombined sources1
Modified residuei342PhosphoserineCombined sources1
Modified residuei381PhosphothreonineBy similarity1
Modified residuei878PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9BQS8.
MaxQBiQ9BQS8.
PaxDbiQ9BQS8.
PeptideAtlasiQ9BQS8.
PRIDEiQ9BQS8.

PTM databases

iPTMnetiQ9BQS8.
PhosphoSitePlusiQ9BQS8.

Expressioni

Tissue specificityi

Expressed in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000163820.
CleanExiHS_FYCO1.
ExpressionAtlasiQ9BQS8. baseline and differential.
GenevisibleiQ9BQS8. HS.

Organism-specific databases

HPAiHPA035526.
HPA057966.

Interactioni

Subunit structurei

Can form homodimers. Interacts (via C-terminus) with MAP1LC3B. Interacts with RAB7A; the interaction with RAB7A induces FYCO1 recruitment to late endosomal/lysosomal compartments. Interacts with MAP1LC3B (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GABARAPO951662EBI-2869338,EBI-712001
GABARAPL1Q9H0R82EBI-2869338,EBI-746969
GABARAPL2P605202EBI-2869338,EBI-720116
KDM1AO603412EBI-2869338,EBI-710124
MAP1LC3BQ9GZQ87EBI-2869338,EBI-373144
MAP1LC3CQ9BXW42EBI-2869338,EBI-2603996
PRMT6Q96LA82EBI-2869338,EBI-912440

Protein-protein interaction databases

BioGridi122669. 48 interactors.
DIPiDIP-60600N.
IntActiQ9BQS8. 36 interactors.
MINTiMINT-8385159.
STRINGi9606.ENSP00000296137.

Structurei

Secondary structure

11478
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1276 – 1282Combined sources7
Helixi1285 – 1287Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CX3X-ray2.30E/F/G/H1273-1298[»]
5D94X-ray1.53B1276-1288[»]
ProteinModelPortaliQ9BQS8.
SMRiQ9BQS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 169RUNPROSITE-ProRule annotationAdd BLAST134
Domaini1337 – 1466GOLDPROSITE-ProRule annotationAdd BLAST130

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili4 – 33Sequence analysisAdd BLAST30
Coiled coili225 – 280Sequence analysisAdd BLAST56
Coiled coili394 – 555Sequence analysisAdd BLAST162
Coiled coili596 – 1151Sequence analysisAdd BLAST556

Sequence similaritiesi

Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 1 GOLD domain.PROSITE-ProRule annotation
Contains 1 RUN domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1173 – 1231FYVE-typePROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG1729. Eukaryota.
ENOG410XPJK. LUCA.
GeneTreeiENSGT00730000110715.
HOGENOMiHOG000168295.
HOVERGENiHBG063805.
InParanoidiQ9BQS8.
OMAiNNEALEG.
OrthoDBiEOG091G00LS.
PhylomeDBiQ9BQS8.
TreeFamiTF341788.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR009038. GOLD_dom.
IPR004012. Run_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF02759. RUN. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50866. GOLD. 1 hit.
PS50826. RUN. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BQS8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASTNAESQL QRIIRDLQDA VTELSKEFQE AGEPITDDST SLHKFSYKLE
60 70 80 90 100
YLLQFDQKEK ATLLGNKKDY WDYFCACLAK VKGANDGIRF VKSISELRTS
110 120 130 140 150
LGKGRAFIRY SLVHQRLADT LQQCFMNTKV TSDWYYARSP FLQPKLSSDI
160 170 180 190 200
VGQLYELTEV QFDLASRGFD LDAAWPTFAR RTLTTGSSAY LWKPPSRSSS
210 220 230 240 250
MSSLVSSYLQ TQEMVSNFDL NSPLNNEALE GFDEMRLELD QLEVREKQLR
260 270 280 290 300
ERMQQLDREN QELRAAVSQQ GEQLQTERER GRTAAEDNVR LTCLVAELQK
310 320 330 340 350
QWEVTQATQN TVKELQTCLQ GLELGAAEKE EDYHTALRRL ESMLQPLAQE
360 370 380 390 400
LEATRDSLDK KNQHLASFPG WLAMAQQKAD TASDTKGRQE PIPSDAAQEM
410 420 430 440 450
QELGEKLQAL ERERTKVEEV NRQQSAQLEQ LVKELQLKED ARASLERLVK
460 470 480 490 500
EMAPLQEELS GKGQEADQLW RRLQELLAHT SSWEEELAEL RREKKQQQEE
510 520 530 540 550
KELLEQEVRS LTRQLQFLET QLAQVSQHVS DLEEQKKQLI QDKDHLSQQV
560 570 580 590 600
GMLERLAGPP GPELPVAGEK NEALVPVNSS LQEAWGKPEE EQRGLQEAQL
610 620 630 640 650
DDTKVQEGSQ EEELRQANRE LEKELQNVVG RNQLLEGKLQ ALQADYQALQ
660 670 680 690 700
QRESAIQGSL ASLEAEQASI RHLGDQMEAS LLAVRKAKEA MKAQMAEKEA
710 720 730 740 750
ILQSKEGECQ QLREEVEQCQ QLAEARHREL RALESQCQQQ TQLIEVLTAE
760 770 780 790 800
KGQQGVGPPT DNEARELAAQ LALSQAQLEV HQGEVQRLQA QVVDLQAKMR
810 820 830 840 850
AALDDQDKVQ SQLSMAEAVL REHKTLVQQL KEQNEALNRA HVQELLQCSE
860 870 880 890 900
REGALQEERA DEAQQREEEL RALQEELSQA KCSSEEAQLE HAELQEQLHR
910 920 930 940 950
ANTDTAELGI QVCALTVEKE RVEEALACAV QELQDAKEAA SREREGLERQ
960 970 980 990 1000
VAGLQQEKES LQEKLKAAKA AAGSLPGLQA QLAQAEQRAQ SLQEAAHQEL
1010 1020 1030 1040 1050
NTLKFQLSAE IMDYQSRLKN AGEECKSLRG QLEEQGRQLQ AAEEAVEKLK
1060 1070 1080 1090 1100
ATQADMGEKL SCTSNHLAEC QAAMLRKDKE GAALREDLER TQKELEKATT
1110 1120 1130 1140 1150
KIQEYYNKLC QEVTNRERND QKMLADLDDL NRTKKYLEER LIELLRDKDA
1160 1170 1180 1190 1200
LWQKSDALEF QQKLSAEERW LGDTEANHCL DCKREFSWMV RRHHCRICGR
1210 1220 1230 1240 1250
IFCYYCCNNY VLSKHGGKKE RCCRACFQKL SEGPGSPDSS GSGTSQGEPS
1260 1270 1280 1290 1300
PALSPASPGP QATGGQGANT DYRPPDDAVF DIITDEELCQ IQESGSSLPE
1310 1320 1330 1340 1350
TPTETDSLDP NAAEQDTTST SLTPEDTEDM PVGQDSEICL LKSGELMIKV
1360 1370 1380 1390 1400
PLTVDEIASF GEGSRELFVR SSTYSLIPIT VAEAGLTISW VFSSDPKSIS
1410 1420 1430 1440 1450
FSVVFQEAED TPLDQCKVLI PTTRCNSHKE NIQGQLKVRT PGIYMLIFDN
1460 1470
TFSRFVSKKV FYHLTVDRPV IYDGSDFL
Length:1,478
Mass (Da):166,983
Last modified:February 8, 2011 - v3
Checksum:i11AB671A9F2B3D21
GO
Isoform 2 (identifier: Q9BQS8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     376-380: QQKAD → LHVGD
     381-1478: Missing.

Note: No experimental confirmation available.
Show »
Length:380
Mass (Da):43,482
Checksum:i141833AF14C25727
GO
Isoform 3 (identifier: Q9BQS8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     376-380: QQKAD → HLSE
     381-1478: Missing.

Note: No experimental confirmation available.
Show »
Length:379
Mass (Da):43,427
Checksum:i4B54D9D20257275F
GO
Isoform 4 (identifier: Q9BQS8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1315-1315: Q → QASVGASKGLGNLLCESSACR

Note: No experimental confirmation available.
Show »
Length:1,498
Mass (Da):168,888
Checksum:iBF5ABFEDF2712834
GO

Sequence cautioni

The sequence AAH07218 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14559 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB84991 differs from that shown. Reason: Frameshift at position 1402.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti155Y → C in CAD91151 (PubMed:17974005).Curated1
Sequence conflicti359D → G in CAD91151 (PubMed:17974005).Curated1
Sequence conflicti365L → S in BAB14559 (PubMed:14702039).Curated1
Sequence conflicti381T → S in CAC33883 (PubMed:11896456).Curated1
Sequence conflicti916T → I in CAD89924 (PubMed:17974005).Curated1
Sequence conflicti964K → E in CAD89924 (PubMed:17974005).Curated1
Sequence conflicti1382A → P in CAC33883 (PubMed:11896456).Curated1
Sequence conflicti1385G → A in CAC33883 (PubMed:11896456).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027006250R → Q.4 PublicationsCorresponds to variant rs4683158dbSNPEnsembl.1
Natural variantiVAR_027007282R → H.Corresponds to variant rs9875356dbSNPEnsembl.1
Natural variantiVAR_027008321G → A.4 PublicationsCorresponds to variant rs3733100dbSNPEnsembl.1
Natural variantiVAR_027009381T → M.Corresponds to variant rs3733101dbSNPEnsembl.1
Natural variantiVAR_056882447R → C.Corresponds to variant rs33910087dbSNPEnsembl.1
Natural variantiVAR_027010679A → V.1 PublicationCorresponds to variant rs3796375dbSNPEnsembl.1
Natural variantiVAR_056883994E → K.Corresponds to variant rs34801630dbSNPEnsembl.1
Natural variantiVAR_0270111001N → D.Corresponds to variant rs13059238dbSNPEnsembl.1
Natural variantiVAR_0659741376L → P in CTRCT18. 1 PublicationCorresponds to variant rs387906965dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019795376 – 380QQKAD → LHVGD in isoform 2. 1 Publication5
Alternative sequenceiVSP_019796376 – 380QQKAD → HLSE in isoform 3. 1 Publication5
Alternative sequenceiVSP_019797381 – 1478Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST1098
Alternative sequenceiVSP_0544771315Q → QASVGASKGLGNLLCESSAC R in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ292348 mRNA. Translation: CAC33883.1.
AL833308 mRNA. Translation: CAD89924.1.
AL832358 mRNA. Translation: CAD91151.1.
AC099782 Genomic DNA. No translation available.
BC007218 mRNA. Translation: AAH07218.1. Different initiation.
BC101468 mRNA. Translation: AAI01469.1.
BC101470 mRNA. Translation: AAI01471.1.
BC143368 mRNA. Translation: AAI43369.1.
AK023397 mRNA. Translation: BAB14559.1. Different initiation.
AK074165 mRNA. Translation: BAB84991.1. Frameshift.
CCDSiCCDS2734.1. [Q9BQS8-1]
RefSeqiNP_078789.2. NM_024513.3. [Q9BQS8-1]
XP_006713396.1. XM_006713333.3. [Q9BQS8-1]
XP_006713397.1. XM_006713334.3. [Q9BQS8-1]
XP_011532413.1. XM_011534111.2. [Q9BQS8-1]
UniGeneiHs.200227.
Hs.739775.

Genome annotation databases

EnsembliENST00000296137; ENSP00000296137; ENSG00000163820. [Q9BQS8-1]
ENST00000535325; ENSP00000441178; ENSG00000163820. [Q9BQS8-4]
GeneIDi79443.
KEGGihsa:79443.
UCSCiuc003cpb.6. human. [Q9BQS8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ292348 mRNA. Translation: CAC33883.1.
AL833308 mRNA. Translation: CAD89924.1.
AL832358 mRNA. Translation: CAD91151.1.
AC099782 Genomic DNA. No translation available.
BC007218 mRNA. Translation: AAH07218.1. Different initiation.
BC101468 mRNA. Translation: AAI01469.1.
BC101470 mRNA. Translation: AAI01471.1.
BC143368 mRNA. Translation: AAI43369.1.
AK023397 mRNA. Translation: BAB14559.1. Different initiation.
AK074165 mRNA. Translation: BAB84991.1. Frameshift.
CCDSiCCDS2734.1. [Q9BQS8-1]
RefSeqiNP_078789.2. NM_024513.3. [Q9BQS8-1]
XP_006713396.1. XM_006713333.3. [Q9BQS8-1]
XP_006713397.1. XM_006713334.3. [Q9BQS8-1]
XP_011532413.1. XM_011534111.2. [Q9BQS8-1]
UniGeneiHs.200227.
Hs.739775.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CX3X-ray2.30E/F/G/H1273-1298[»]
5D94X-ray1.53B1276-1288[»]
ProteinModelPortaliQ9BQS8.
SMRiQ9BQS8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122669. 48 interactors.
DIPiDIP-60600N.
IntActiQ9BQS8. 36 interactors.
MINTiMINT-8385159.
STRINGi9606.ENSP00000296137.

PTM databases

iPTMnetiQ9BQS8.
PhosphoSitePlusiQ9BQS8.

Polymorphism and mutation databases

BioMutaiFYCO1.
DMDMi322510128.

Proteomic databases

EPDiQ9BQS8.
MaxQBiQ9BQS8.
PaxDbiQ9BQS8.
PeptideAtlasiQ9BQS8.
PRIDEiQ9BQS8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296137; ENSP00000296137; ENSG00000163820. [Q9BQS8-1]
ENST00000535325; ENSP00000441178; ENSG00000163820. [Q9BQS8-4]
GeneIDi79443.
KEGGihsa:79443.
UCSCiuc003cpb.6. human. [Q9BQS8-1]

Organism-specific databases

CTDi79443.
DisGeNETi79443.
GeneCardsiFYCO1.
H-InvDBHIX0003244.
HGNCiHGNC:14673. FYCO1.
HPAiHPA035526.
HPA057966.
MalaCardsiFYCO1.
MIMi607182. gene.
610019. phenotype.
neXtProtiNX_Q9BQS8.
OpenTargetsiENSG00000163820.
Orphaneti98991. Nuclear cataract.
PharmGKBiPA28453.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1729. Eukaryota.
ENOG410XPJK. LUCA.
GeneTreeiENSGT00730000110715.
HOGENOMiHOG000168295.
HOVERGENiHBG063805.
InParanoidiQ9BQS8.
OMAiNNEALEG.
OrthoDBiEOG091G00LS.
PhylomeDBiQ9BQS8.
TreeFamiTF341788.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163820-MONOMER.
SIGNORiQ9BQS8.

Miscellaneous databases

ChiTaRSiFYCO1. human.
GenomeRNAii79443.
PROiQ9BQS8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163820.
CleanExiHS_FYCO1.
ExpressionAtlasiQ9BQS8. baseline and differential.
GenevisibleiQ9BQS8. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR009038. GOLD_dom.
IPR004012. Run_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF02759. RUN. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50866. GOLD. 1 hit.
PS50826. RUN. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFYCO1_HUMAN
AccessioniPrimary (citable) accession number: Q9BQS8
Secondary accession number(s): B7ZKT7
, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: February 8, 2011
Last modified: November 30, 2016
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.