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Q9BQS8

- FYCO1_HUMAN

UniProt

Q9BQS8 - FYCO1_HUMAN

Protein

FYVE and coiled-coil domain-containing protein 1

Gene

FYCO1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 3 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    May mediate microtubule plus end-directed vesicle transport.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1173 – 123159FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. plus-end-directed vesicle transport along microtubule Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FYVE and coiled-coil domain-containing protein 1
    Alternative name(s):
    Zinc finger FYVE domain-containing protein 7
    Gene namesi
    Name:FYCO1
    Synonyms:ZFYVE7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:14673. FYCO1.

    Subcellular locationi

    Cytoplasmic vesicleautophagosome. Endosome. Lysosome
    Note: Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes.

    GO - Cellular componenti

    1. autophagic vacuole Source: UniProtKB
    2. cytoplasmic vesicle Source: UniProtKB-KW
    3. integral component of membrane Source: InterPro
    4. late endosome Source: UniProtKB
    5. lysosome Source: UniProtKB
    6. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endosome, Lysosome

    Pathology & Biotechi

    Involvement in diseasei

    Cataract 18 (CTRCT18) [MIM:610019]: An opacification of the crystalline lens of the eye becoming evident at birth or in infancy. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry. Pathogenic mutations in FYCO1 can affect intracellular transport of autophagocytic vesicles from the perinuclear area to the periphery, leading to an accumulation of large numbers of vesicles and hence loss of lens transparency (PubMed:21636066).1 Publication
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1376 – 13761L → P in CTRCT18. 1 Publication
    VAR_065974

    Keywords - Diseasei

    Cataract, Disease mutation

    Organism-specific databases

    MIMi610019. phenotype.
    Orphaneti98991. Nuclear cataract.
    PharmGKBiPA28453.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 14781477FYVE and coiled-coil domain-containing protein 1PRO_0000245837Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine3 Publications
    Modified residuei381 – 3811PhosphothreonineBy similarity
    Modified residuei878 – 8781Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9BQS8.
    PaxDbiQ9BQS8.
    PRIDEiQ9BQS8.

    PTM databases

    PhosphoSiteiQ9BQS8.

    Expressioni

    Tissue specificityi

    Expressed in heart and skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiQ9BQS8.
    BgeeiQ9BQS8.
    CleanExiHS_FYCO1.
    GenevestigatoriQ9BQS8.

    Organism-specific databases

    HPAiHPA035526.

    Interactioni

    Subunit structurei

    Can form homodimers. Interacts (via C-terminus) with MAP1LC3B. Interacts with RAB7A; the interaction with RAB7A induces FYCO1 recruitment to late endosomal/lysosomal compartments. Interacts with MAP1LC3B By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GABARAPO951662EBI-2869338,EBI-712001
    GABARAPL1Q9H0R82EBI-2869338,EBI-746969
    GABARAPL2P605202EBI-2869338,EBI-720116
    KDM1AO603412EBI-2869338,EBI-710124
    MAP1LC3BQ9GZQ87EBI-2869338,EBI-373144
    MAP1LC3CQ9BXW42EBI-2869338,EBI-2603996
    PRMT6Q96LA82EBI-2869338,EBI-912440

    Protein-protein interaction databases

    BioGridi122669. 23 interactions.
    DIPiDIP-60600N.
    IntActiQ9BQS8. 27 interactions.
    MINTiMINT-8385159.
    STRINGi9606.ENSP00000296137.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BQS8.
    SMRiQ9BQS8. Positions 32-173, 1137-1230, 1385-1469.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 169134RUNPROSITE-ProRule annotationAdd
    BLAST
    Domaini1337 – 1466130GOLDPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili4 – 3330Sequence AnalysisAdd
    BLAST
    Coiled coili225 – 28056Sequence AnalysisAdd
    BLAST
    Coiled coili394 – 555162Sequence AnalysisAdd
    BLAST
    Coiled coili596 – 1151556Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
    Contains 1 GOLD domain.PROSITE-ProRule annotation
    Contains 1 RUN domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1173 – 123159FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG262828.
    HOVERGENiHBG063805.
    InParanoidiQ9BQS8.
    OrthoDBiEOG7Z0JVJ.
    PhylomeDBiQ9BQS8.
    TreeFamiTF341788.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR009038. GOLD.
    IPR004012. Run.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF01363. FYVE. 1 hit.
    PF02759. RUN. 1 hit.
    [Graphical view]
    SMARTiSM00064. FYVE. 1 hit.
    [Graphical view]
    SUPFAMiSSF101576. SSF101576. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEiPS50866. GOLD. 1 hit.
    PS50826. RUN. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BQS8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASTNAESQL QRIIRDLQDA VTELSKEFQE AGEPITDDST SLHKFSYKLE     50
    YLLQFDQKEK ATLLGNKKDY WDYFCACLAK VKGANDGIRF VKSISELRTS 100
    LGKGRAFIRY SLVHQRLADT LQQCFMNTKV TSDWYYARSP FLQPKLSSDI 150
    VGQLYELTEV QFDLASRGFD LDAAWPTFAR RTLTTGSSAY LWKPPSRSSS 200
    MSSLVSSYLQ TQEMVSNFDL NSPLNNEALE GFDEMRLELD QLEVREKQLR 250
    ERMQQLDREN QELRAAVSQQ GEQLQTERER GRTAAEDNVR LTCLVAELQK 300
    QWEVTQATQN TVKELQTCLQ GLELGAAEKE EDYHTALRRL ESMLQPLAQE 350
    LEATRDSLDK KNQHLASFPG WLAMAQQKAD TASDTKGRQE PIPSDAAQEM 400
    QELGEKLQAL ERERTKVEEV NRQQSAQLEQ LVKELQLKED ARASLERLVK 450
    EMAPLQEELS GKGQEADQLW RRLQELLAHT SSWEEELAEL RREKKQQQEE 500
    KELLEQEVRS LTRQLQFLET QLAQVSQHVS DLEEQKKQLI QDKDHLSQQV 550
    GMLERLAGPP GPELPVAGEK NEALVPVNSS LQEAWGKPEE EQRGLQEAQL 600
    DDTKVQEGSQ EEELRQANRE LEKELQNVVG RNQLLEGKLQ ALQADYQALQ 650
    QRESAIQGSL ASLEAEQASI RHLGDQMEAS LLAVRKAKEA MKAQMAEKEA 700
    ILQSKEGECQ QLREEVEQCQ QLAEARHREL RALESQCQQQ TQLIEVLTAE 750
    KGQQGVGPPT DNEARELAAQ LALSQAQLEV HQGEVQRLQA QVVDLQAKMR 800
    AALDDQDKVQ SQLSMAEAVL REHKTLVQQL KEQNEALNRA HVQELLQCSE 850
    REGALQEERA DEAQQREEEL RALQEELSQA KCSSEEAQLE HAELQEQLHR 900
    ANTDTAELGI QVCALTVEKE RVEEALACAV QELQDAKEAA SREREGLERQ 950
    VAGLQQEKES LQEKLKAAKA AAGSLPGLQA QLAQAEQRAQ SLQEAAHQEL 1000
    NTLKFQLSAE IMDYQSRLKN AGEECKSLRG QLEEQGRQLQ AAEEAVEKLK 1050
    ATQADMGEKL SCTSNHLAEC QAAMLRKDKE GAALREDLER TQKELEKATT 1100
    KIQEYYNKLC QEVTNRERND QKMLADLDDL NRTKKYLEER LIELLRDKDA 1150
    LWQKSDALEF QQKLSAEERW LGDTEANHCL DCKREFSWMV RRHHCRICGR 1200
    IFCYYCCNNY VLSKHGGKKE RCCRACFQKL SEGPGSPDSS GSGTSQGEPS 1250
    PALSPASPGP QATGGQGANT DYRPPDDAVF DIITDEELCQ IQESGSSLPE 1300
    TPTETDSLDP NAAEQDTTST SLTPEDTEDM PVGQDSEICL LKSGELMIKV 1350
    PLTVDEIASF GEGSRELFVR SSTYSLIPIT VAEAGLTISW VFSSDPKSIS 1400
    FSVVFQEAED TPLDQCKVLI PTTRCNSHKE NIQGQLKVRT PGIYMLIFDN 1450
    TFSRFVSKKV FYHLTVDRPV IYDGSDFL 1478
    Length:1,478
    Mass (Da):166,983
    Last modified:February 8, 2011 - v3
    Checksum:i11AB671A9F2B3D21
    GO
    Isoform 2 (identifier: Q9BQS8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         376-380: QQKAD → LHVGD
         381-1478: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:380
    Mass (Da):43,482
    Checksum:i141833AF14C25727
    GO
    Isoform 3 (identifier: Q9BQS8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         376-380: QQKAD → HLSE
         381-1478: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:379
    Mass (Da):43,427
    Checksum:i4B54D9D20257275F
    GO
    Isoform 4 (identifier: Q9BQS8-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1315-1315: Q → QASVGASKGLGNLLCESSACR

    Note: No experimental confirmation available.

    Show »
    Length:1,498
    Mass (Da):168,888
    Checksum:iBF5ABFEDF2712834
    GO

    Sequence cautioni

    The sequence BAB84991.1 differs from that shown. Reason: Frameshift at position 1402.
    The sequence AAH07218.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB14559.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti155 – 1551Y → C in CAD91151. (PubMed:17974005)Curated
    Sequence conflicti359 – 3591D → G in CAD91151. (PubMed:17974005)Curated
    Sequence conflicti365 – 3651L → S in BAB14559. (PubMed:14702039)Curated
    Sequence conflicti381 – 3811T → S in CAC33883. (PubMed:11896456)Curated
    Sequence conflicti916 – 9161T → I in CAD89924. (PubMed:17974005)Curated
    Sequence conflicti964 – 9641K → E in CAD89924. (PubMed:17974005)Curated
    Sequence conflicti1382 – 13821A → P in CAC33883. (PubMed:11896456)Curated
    Sequence conflicti1385 – 13851G → A in CAC33883. (PubMed:11896456)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti250 – 2501R → Q.4 Publications
    Corresponds to variant rs4683158 [ dbSNP | Ensembl ].
    VAR_027006
    Natural varianti282 – 2821R → H.
    Corresponds to variant rs9875356 [ dbSNP | Ensembl ].
    VAR_027007
    Natural varianti321 – 3211G → A.4 Publications
    Corresponds to variant rs3733100 [ dbSNP | Ensembl ].
    VAR_027008
    Natural varianti381 – 3811T → M.
    Corresponds to variant rs3733101 [ dbSNP | Ensembl ].
    VAR_027009
    Natural varianti447 – 4471R → C.
    Corresponds to variant rs33910087 [ dbSNP | Ensembl ].
    VAR_056882
    Natural varianti679 – 6791A → V.1 Publication
    Corresponds to variant rs3796375 [ dbSNP | Ensembl ].
    VAR_027010
    Natural varianti994 – 9941E → K.
    Corresponds to variant rs34801630 [ dbSNP | Ensembl ].
    VAR_056883
    Natural varianti1001 – 10011N → D.
    Corresponds to variant rs13059238 [ dbSNP | Ensembl ].
    VAR_027011
    Natural varianti1376 – 13761L → P in CTRCT18. 1 Publication
    VAR_065974

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei376 – 3805QQKAD → LHVGD in isoform 2. 1 PublicationVSP_019795
    Alternative sequencei376 – 3805QQKAD → HLSE in isoform 3. 1 PublicationVSP_019796
    Alternative sequencei381 – 14781098Missing in isoform 2 and isoform 3. 2 PublicationsVSP_019797Add
    BLAST
    Alternative sequencei1315 – 13151Q → QASVGASKGLGNLLCESSAC R in isoform 4. 1 PublicationVSP_054477

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ292348 mRNA. Translation: CAC33883.1.
    AL833308 mRNA. Translation: CAD89924.1.
    AL832358 mRNA. Translation: CAD91151.1.
    AC099782 Genomic DNA. No translation available.
    BC007218 mRNA. Translation: AAH07218.1. Different initiation.
    BC101468 mRNA. Translation: AAI01469.1.
    BC101470 mRNA. Translation: AAI01471.1.
    BC143368 mRNA. Translation: AAI43369.1.
    AK023397 mRNA. Translation: BAB14559.1. Different initiation.
    AK074165 mRNA. Translation: BAB84991.1. Frameshift.
    CCDSiCCDS2734.1. [Q9BQS8-1]
    RefSeqiNP_078789.2. NM_024513.3. [Q9BQS8-1]
    XP_006713396.1. XM_006713333.1. [Q9BQS8-1]
    XP_006713397.1. XM_006713334.1. [Q9BQS8-1]
    XP_006713398.1. XM_006713335.1. [Q9BQS8-1]
    UniGeneiHs.200227.
    Hs.739775.

    Genome annotation databases

    EnsembliENST00000296137; ENSP00000296137; ENSG00000163820. [Q9BQS8-1]
    ENST00000535325; ENSP00000441178; ENSG00000163820. [Q9BQS8-4]
    GeneIDi79443.
    KEGGihsa:79443.
    UCSCiuc003cpb.5. human. [Q9BQS8-1]

    Polymorphism databases

    DMDMi322510128.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ292348 mRNA. Translation: CAC33883.1 .
    AL833308 mRNA. Translation: CAD89924.1 .
    AL832358 mRNA. Translation: CAD91151.1 .
    AC099782 Genomic DNA. No translation available.
    BC007218 mRNA. Translation: AAH07218.1 . Different initiation.
    BC101468 mRNA. Translation: AAI01469.1 .
    BC101470 mRNA. Translation: AAI01471.1 .
    BC143368 mRNA. Translation: AAI43369.1 .
    AK023397 mRNA. Translation: BAB14559.1 . Different initiation.
    AK074165 mRNA. Translation: BAB84991.1 . Frameshift.
    CCDSi CCDS2734.1. [Q9BQS8-1 ]
    RefSeqi NP_078789.2. NM_024513.3. [Q9BQS8-1 ]
    XP_006713396.1. XM_006713333.1. [Q9BQS8-1 ]
    XP_006713397.1. XM_006713334.1. [Q9BQS8-1 ]
    XP_006713398.1. XM_006713335.1. [Q9BQS8-1 ]
    UniGenei Hs.200227.
    Hs.739775.

    3D structure databases

    ProteinModelPortali Q9BQS8.
    SMRi Q9BQS8. Positions 32-173, 1137-1230, 1385-1469.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122669. 23 interactions.
    DIPi DIP-60600N.
    IntActi Q9BQS8. 27 interactions.
    MINTi MINT-8385159.
    STRINGi 9606.ENSP00000296137.

    PTM databases

    PhosphoSitei Q9BQS8.

    Polymorphism databases

    DMDMi 322510128.

    Proteomic databases

    MaxQBi Q9BQS8.
    PaxDbi Q9BQS8.
    PRIDEi Q9BQS8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296137 ; ENSP00000296137 ; ENSG00000163820 . [Q9BQS8-1 ]
    ENST00000535325 ; ENSP00000441178 ; ENSG00000163820 . [Q9BQS8-4 ]
    GeneIDi 79443.
    KEGGi hsa:79443.
    UCSCi uc003cpb.5. human. [Q9BQS8-1 ]

    Organism-specific databases

    CTDi 79443.
    GeneCardsi GC03M045934.
    H-InvDB HIX0003244.
    HGNCi HGNC:14673. FYCO1.
    HPAi HPA035526.
    MIMi 607182. gene.
    610019. phenotype.
    neXtProti NX_Q9BQS8.
    Orphaneti 98991. Nuclear cataract.
    PharmGKBi PA28453.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG262828.
    HOVERGENi HBG063805.
    InParanoidi Q9BQS8.
    OrthoDBi EOG7Z0JVJ.
    PhylomeDBi Q9BQS8.
    TreeFami TF341788.

    Miscellaneous databases

    ChiTaRSi FYCO1. human.
    GenomeRNAii 79443.
    NextBioi 35481191.
    PROi Q9BQS8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BQS8.
    Bgeei Q9BQS8.
    CleanExi HS_FYCO1.
    Genevestigatori Q9BQS8.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR009038. GOLD.
    IPR004012. Run.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF01363. FYVE. 1 hit.
    PF02759. RUN. 1 hit.
    [Graphical view ]
    SMARTi SM00064. FYVE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101576. SSF101576. 1 hit.
    SSF57903. SSF57903. 1 hit.
    PROSITEi PS50866. GOLD. 1 hit.
    PS50826. RUN. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional map of the common eliminated region 1 (C3CER1) in 3p21.3."
      Kiss H., Yang Y., Kiss C., Andersson K., Klein G., Imreh S., Dumanski J.P.
      Eur. J. Hum. Genet. 10:52-61(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS GLN-250 AND ALA-321.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLN-250; ALA-321 AND VAL-679.
      Tissue: Skeletal muscle.
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 41-1478 (ISOFORM 2), VARIANTS GLN-250 AND ALA-321.
      Tissue: Heart, Lung and Skin.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 56-1478 (ISOFORM 3), VARIANTS GLN-250 AND ALA-321.
      Tissue: Ovary.
    6. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
      Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1213-1478 (ISOFORM 1).
      Tissue: Spleen.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-878, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    9. "FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport."
      Pankiv S., Alemu E.A., Brech A., Bruun J.A., Lamark T., Overvatn A., Bjorkoy G., Johansen T.
      J. Cell Biol. 188:253-269(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH MAP1LC3B AND RAB7A.
    10. Cited for: SUBCELLULAR LOCATION, VARIANT CTRCT18 PRO-1376.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites."
      Tang Z., Lin M.G., Stowe T.R., Chen S., Zhu M., Stearns T., Franco B., Zhong Q.
      Nature 502:254-257(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MAP1LC3B.

    Entry informationi

    Entry nameiFYCO1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BQS8
    Secondary accession number(s): B7ZKT7
    , Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 107 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3