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Q9BQS8

- FYCO1_HUMAN

UniProt

Q9BQS8 - FYCO1_HUMAN

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Protein

FYVE and coiled-coil domain-containing protein 1

Gene

FYCO1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May mediate microtubule plus end-directed vesicle transport.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1173 – 123159FYVE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. plus-end-directed vesicle transport along microtubule Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
FYVE and coiled-coil domain-containing protein 1
Alternative name(s):
Zinc finger FYVE domain-containing protein 7
Gene namesi
Name:FYCO1
Synonyms:ZFYVE7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:14673. FYCO1.

Subcellular locationi

Cytoplasmic vesicleautophagosome. Endosome. Lysosome
Note: Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes.

GO - Cellular componenti

  1. autophagic vacuole Source: UniProtKB
  2. cytoplasmic vesicle Source: UniProtKB-KW
  3. integral component of membrane Source: InterPro
  4. late endosome Source: UniProtKB
  5. lysosome Source: UniProtKB
  6. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Lysosome

Pathology & Biotechi

Involvement in diseasei

Cataract 18 (CTRCT18) [MIM:610019]: An opacification of the crystalline lens of the eye becoming evident at birth or in infancy. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry. Pathogenic mutations in FYCO1 can affect intracellular transport of autophagocytic vesicles from the perinuclear area to the periphery, leading to an accumulation of large numbers of vesicles and hence loss of lens transparency (PubMed:21636066).1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1376 – 13761L → P in CTRCT18. 1 Publication
VAR_065974

Keywords - Diseasei

Cataract, Disease mutation

Organism-specific databases

MIMi610019. phenotype.
Orphaneti98991. Nuclear cataract.
PharmGKBiPA28453.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 14781477FYVE and coiled-coil domain-containing protein 1PRO_0000245837Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine3 Publications
Modified residuei381 – 3811PhosphothreonineBy similarity
Modified residuei878 – 8781Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9BQS8.
PaxDbiQ9BQS8.
PRIDEiQ9BQS8.

PTM databases

PhosphoSiteiQ9BQS8.

Expressioni

Tissue specificityi

Expressed in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9BQS8.
CleanExiHS_FYCO1.
ExpressionAtlasiQ9BQS8. baseline and differential.
GenevestigatoriQ9BQS8.

Organism-specific databases

HPAiHPA035526.

Interactioni

Subunit structurei

Can form homodimers. Interacts (via C-terminus) with MAP1LC3B. Interacts with RAB7A; the interaction with RAB7A induces FYCO1 recruitment to late endosomal/lysosomal compartments. Interacts with MAP1LC3B (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GABARAPO951662EBI-2869338,EBI-712001
GABARAPL1Q9H0R82EBI-2869338,EBI-746969
GABARAPL2P605202EBI-2869338,EBI-720116
KDM1AO603412EBI-2869338,EBI-710124
MAP1LC3BQ9GZQ87EBI-2869338,EBI-373144
MAP1LC3CQ9BXW42EBI-2869338,EBI-2603996
PRMT6Q96LA82EBI-2869338,EBI-912440

Protein-protein interaction databases

BioGridi122669. 36 interactions.
DIPiDIP-60600N.
IntActiQ9BQS8. 27 interactions.
MINTiMINT-8385159.
STRINGi9606.ENSP00000296137.

Structurei

3D structure databases

ProteinModelPortaliQ9BQS8.
SMRiQ9BQS8. Positions 32-173, 1137-1230, 1385-1469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 169134RUNPROSITE-ProRule annotationAdd
BLAST
Domaini1337 – 1466130GOLDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili4 – 3330Sequence AnalysisAdd
BLAST
Coiled coili225 – 28056Sequence AnalysisAdd
BLAST
Coiled coili394 – 555162Sequence AnalysisAdd
BLAST
Coiled coili596 – 1151556Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 1 GOLD domain.PROSITE-ProRule annotation
Contains 1 RUN domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1173 – 123159FYVE-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG262828.
GeneTreeiENSGT00730000110715.
HOVERGENiHBG063805.
InParanoidiQ9BQS8.
OrthoDBiEOG7Z0JVJ.
PhylomeDBiQ9BQS8.
TreeFamiTF341788.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR009038. GOLD.
IPR004012. Run.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF02759. RUN. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50866. GOLD. 1 hit.
PS50826. RUN. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BQS8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASTNAESQL QRIIRDLQDA VTELSKEFQE AGEPITDDST SLHKFSYKLE
60 70 80 90 100
YLLQFDQKEK ATLLGNKKDY WDYFCACLAK VKGANDGIRF VKSISELRTS
110 120 130 140 150
LGKGRAFIRY SLVHQRLADT LQQCFMNTKV TSDWYYARSP FLQPKLSSDI
160 170 180 190 200
VGQLYELTEV QFDLASRGFD LDAAWPTFAR RTLTTGSSAY LWKPPSRSSS
210 220 230 240 250
MSSLVSSYLQ TQEMVSNFDL NSPLNNEALE GFDEMRLELD QLEVREKQLR
260 270 280 290 300
ERMQQLDREN QELRAAVSQQ GEQLQTERER GRTAAEDNVR LTCLVAELQK
310 320 330 340 350
QWEVTQATQN TVKELQTCLQ GLELGAAEKE EDYHTALRRL ESMLQPLAQE
360 370 380 390 400
LEATRDSLDK KNQHLASFPG WLAMAQQKAD TASDTKGRQE PIPSDAAQEM
410 420 430 440 450
QELGEKLQAL ERERTKVEEV NRQQSAQLEQ LVKELQLKED ARASLERLVK
460 470 480 490 500
EMAPLQEELS GKGQEADQLW RRLQELLAHT SSWEEELAEL RREKKQQQEE
510 520 530 540 550
KELLEQEVRS LTRQLQFLET QLAQVSQHVS DLEEQKKQLI QDKDHLSQQV
560 570 580 590 600
GMLERLAGPP GPELPVAGEK NEALVPVNSS LQEAWGKPEE EQRGLQEAQL
610 620 630 640 650
DDTKVQEGSQ EEELRQANRE LEKELQNVVG RNQLLEGKLQ ALQADYQALQ
660 670 680 690 700
QRESAIQGSL ASLEAEQASI RHLGDQMEAS LLAVRKAKEA MKAQMAEKEA
710 720 730 740 750
ILQSKEGECQ QLREEVEQCQ QLAEARHREL RALESQCQQQ TQLIEVLTAE
760 770 780 790 800
KGQQGVGPPT DNEARELAAQ LALSQAQLEV HQGEVQRLQA QVVDLQAKMR
810 820 830 840 850
AALDDQDKVQ SQLSMAEAVL REHKTLVQQL KEQNEALNRA HVQELLQCSE
860 870 880 890 900
REGALQEERA DEAQQREEEL RALQEELSQA KCSSEEAQLE HAELQEQLHR
910 920 930 940 950
ANTDTAELGI QVCALTVEKE RVEEALACAV QELQDAKEAA SREREGLERQ
960 970 980 990 1000
VAGLQQEKES LQEKLKAAKA AAGSLPGLQA QLAQAEQRAQ SLQEAAHQEL
1010 1020 1030 1040 1050
NTLKFQLSAE IMDYQSRLKN AGEECKSLRG QLEEQGRQLQ AAEEAVEKLK
1060 1070 1080 1090 1100
ATQADMGEKL SCTSNHLAEC QAAMLRKDKE GAALREDLER TQKELEKATT
1110 1120 1130 1140 1150
KIQEYYNKLC QEVTNRERND QKMLADLDDL NRTKKYLEER LIELLRDKDA
1160 1170 1180 1190 1200
LWQKSDALEF QQKLSAEERW LGDTEANHCL DCKREFSWMV RRHHCRICGR
1210 1220 1230 1240 1250
IFCYYCCNNY VLSKHGGKKE RCCRACFQKL SEGPGSPDSS GSGTSQGEPS
1260 1270 1280 1290 1300
PALSPASPGP QATGGQGANT DYRPPDDAVF DIITDEELCQ IQESGSSLPE
1310 1320 1330 1340 1350
TPTETDSLDP NAAEQDTTST SLTPEDTEDM PVGQDSEICL LKSGELMIKV
1360 1370 1380 1390 1400
PLTVDEIASF GEGSRELFVR SSTYSLIPIT VAEAGLTISW VFSSDPKSIS
1410 1420 1430 1440 1450
FSVVFQEAED TPLDQCKVLI PTTRCNSHKE NIQGQLKVRT PGIYMLIFDN
1460 1470
TFSRFVSKKV FYHLTVDRPV IYDGSDFL
Length:1,478
Mass (Da):166,983
Last modified:February 8, 2011 - v3
Checksum:i11AB671A9F2B3D21
GO
Isoform 2 (identifier: Q9BQS8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     376-380: QQKAD → LHVGD
     381-1478: Missing.

Note: No experimental confirmation available.

Show »
Length:380
Mass (Da):43,482
Checksum:i141833AF14C25727
GO
Isoform 3 (identifier: Q9BQS8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     376-380: QQKAD → HLSE
     381-1478: Missing.

Note: No experimental confirmation available.

Show »
Length:379
Mass (Da):43,427
Checksum:i4B54D9D20257275F
GO
Isoform 4 (identifier: Q9BQS8-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1315-1315: Q → QASVGASKGLGNLLCESSACR

Note: No experimental confirmation available.

Show »
Length:1,498
Mass (Da):168,888
Checksum:iBF5ABFEDF2712834
GO

Sequence cautioni

The sequence BAB84991.1 differs from that shown. Reason: Frameshift at position 1402.
The sequence AAH07218.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB14559.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti155 – 1551Y → C in CAD91151. (PubMed:17974005)Curated
Sequence conflicti359 – 3591D → G in CAD91151. (PubMed:17974005)Curated
Sequence conflicti365 – 3651L → S in BAB14559. (PubMed:14702039)Curated
Sequence conflicti381 – 3811T → S in CAC33883. (PubMed:11896456)Curated
Sequence conflicti916 – 9161T → I in CAD89924. (PubMed:17974005)Curated
Sequence conflicti964 – 9641K → E in CAD89924. (PubMed:17974005)Curated
Sequence conflicti1382 – 13821A → P in CAC33883. (PubMed:11896456)Curated
Sequence conflicti1385 – 13851G → A in CAC33883. (PubMed:11896456)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti250 – 2501R → Q.4 Publications
Corresponds to variant rs4683158 [ dbSNP | Ensembl ].
VAR_027006
Natural varianti282 – 2821R → H.
Corresponds to variant rs9875356 [ dbSNP | Ensembl ].
VAR_027007
Natural varianti321 – 3211G → A.4 Publications
Corresponds to variant rs3733100 [ dbSNP | Ensembl ].
VAR_027008
Natural varianti381 – 3811T → M.
Corresponds to variant rs3733101 [ dbSNP | Ensembl ].
VAR_027009
Natural varianti447 – 4471R → C.
Corresponds to variant rs33910087 [ dbSNP | Ensembl ].
VAR_056882
Natural varianti679 – 6791A → V.1 Publication
Corresponds to variant rs3796375 [ dbSNP | Ensembl ].
VAR_027010
Natural varianti994 – 9941E → K.
Corresponds to variant rs34801630 [ dbSNP | Ensembl ].
VAR_056883
Natural varianti1001 – 10011N → D.
Corresponds to variant rs13059238 [ dbSNP | Ensembl ].
VAR_027011
Natural varianti1376 – 13761L → P in CTRCT18. 1 Publication
VAR_065974

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei376 – 3805QQKAD → LHVGD in isoform 2. 1 PublicationVSP_019795
Alternative sequencei376 – 3805QQKAD → HLSE in isoform 3. 1 PublicationVSP_019796
Alternative sequencei381 – 14781098Missing in isoform 2 and isoform 3. 2 PublicationsVSP_019797Add
BLAST
Alternative sequencei1315 – 13151Q → QASVGASKGLGNLLCESSAC R in isoform 4. 1 PublicationVSP_054477

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ292348 mRNA. Translation: CAC33883.1.
AL833308 mRNA. Translation: CAD89924.1.
AL832358 mRNA. Translation: CAD91151.1.
AC099782 Genomic DNA. No translation available.
BC007218 mRNA. Translation: AAH07218.1. Different initiation.
BC101468 mRNA. Translation: AAI01469.1.
BC101470 mRNA. Translation: AAI01471.1.
BC143368 mRNA. Translation: AAI43369.1.
AK023397 mRNA. Translation: BAB14559.1. Different initiation.
AK074165 mRNA. Translation: BAB84991.1. Frameshift.
CCDSiCCDS2734.1. [Q9BQS8-1]
RefSeqiNP_078789.2. NM_024513.3. [Q9BQS8-1]
XP_006713396.1. XM_006713333.1. [Q9BQS8-1]
XP_006713397.1. XM_006713334.1. [Q9BQS8-1]
XP_006713398.1. XM_006713335.1. [Q9BQS8-1]
UniGeneiHs.200227.
Hs.739775.

Genome annotation databases

EnsembliENST00000296137; ENSP00000296137; ENSG00000163820. [Q9BQS8-1]
ENST00000535325; ENSP00000441178; ENSG00000163820. [Q9BQS8-4]
GeneIDi79443.
KEGGihsa:79443.
UCSCiuc003cpb.5. human. [Q9BQS8-1]
uc011bal.1. human.

Polymorphism databases

DMDMi322510128.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ292348 mRNA. Translation: CAC33883.1 .
AL833308 mRNA. Translation: CAD89924.1 .
AL832358 mRNA. Translation: CAD91151.1 .
AC099782 Genomic DNA. No translation available.
BC007218 mRNA. Translation: AAH07218.1 . Different initiation.
BC101468 mRNA. Translation: AAI01469.1 .
BC101470 mRNA. Translation: AAI01471.1 .
BC143368 mRNA. Translation: AAI43369.1 .
AK023397 mRNA. Translation: BAB14559.1 . Different initiation.
AK074165 mRNA. Translation: BAB84991.1 . Frameshift.
CCDSi CCDS2734.1. [Q9BQS8-1 ]
RefSeqi NP_078789.2. NM_024513.3. [Q9BQS8-1 ]
XP_006713396.1. XM_006713333.1. [Q9BQS8-1 ]
XP_006713397.1. XM_006713334.1. [Q9BQS8-1 ]
XP_006713398.1. XM_006713335.1. [Q9BQS8-1 ]
UniGenei Hs.200227.
Hs.739775.

3D structure databases

ProteinModelPortali Q9BQS8.
SMRi Q9BQS8. Positions 32-173, 1137-1230, 1385-1469.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122669. 36 interactions.
DIPi DIP-60600N.
IntActi Q9BQS8. 27 interactions.
MINTi MINT-8385159.
STRINGi 9606.ENSP00000296137.

PTM databases

PhosphoSitei Q9BQS8.

Polymorphism databases

DMDMi 322510128.

Proteomic databases

MaxQBi Q9BQS8.
PaxDbi Q9BQS8.
PRIDEi Q9BQS8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296137 ; ENSP00000296137 ; ENSG00000163820 . [Q9BQS8-1 ]
ENST00000535325 ; ENSP00000441178 ; ENSG00000163820 . [Q9BQS8-4 ]
GeneIDi 79443.
KEGGi hsa:79443.
UCSCi uc003cpb.5. human. [Q9BQS8-1 ]
uc011bal.1. human.

Organism-specific databases

CTDi 79443.
GeneCardsi GC03M045934.
H-InvDB HIX0003244.
HGNCi HGNC:14673. FYCO1.
HPAi HPA035526.
MIMi 607182. gene.
610019. phenotype.
neXtProti NX_Q9BQS8.
Orphaneti 98991. Nuclear cataract.
PharmGKBi PA28453.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG262828.
GeneTreei ENSGT00730000110715.
HOVERGENi HBG063805.
InParanoidi Q9BQS8.
OrthoDBi EOG7Z0JVJ.
PhylomeDBi Q9BQS8.
TreeFami TF341788.

Miscellaneous databases

ChiTaRSi FYCO1. human.
GenomeRNAii 79443.
NextBioi 35481191.
PROi Q9BQS8.
SOURCEi Search...

Gene expression databases

Bgeei Q9BQS8.
CleanExi HS_FYCO1.
ExpressionAtlasi Q9BQS8. baseline and differential.
Genevestigatori Q9BQS8.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR009038. GOLD.
IPR004012. Run.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF01363. FYVE. 1 hit.
PF02759. RUN. 1 hit.
[Graphical view ]
SMARTi SM00064. FYVE. 1 hit.
[Graphical view ]
SUPFAMi SSF101576. SSF101576. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEi PS50866. GOLD. 1 hit.
PS50826. RUN. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional map of the common eliminated region 1 (C3CER1) in 3p21.3."
    Kiss H., Yang Y., Kiss C., Andersson K., Klein G., Imreh S., Dumanski J.P.
    Eur. J. Hum. Genet. 10:52-61(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANTS GLN-250 AND ALA-321.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLN-250; ALA-321 AND VAL-679.
    Tissue: Skeletal muscle.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 41-1478 (ISOFORM 2), VARIANTS GLN-250 AND ALA-321.
    Tissue: Heart, Lung and Skin.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 56-1478 (ISOFORM 3), VARIANTS GLN-250 AND ALA-321.
    Tissue: Ovary.
  6. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1213-1478 (ISOFORM 1).
    Tissue: Spleen.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-878, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  9. "FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport."
    Pankiv S., Alemu E.A., Brech A., Bruun J.A., Lamark T., Overvatn A., Bjorkoy G., Johansen T.
    J. Cell Biol. 188:253-269(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH MAP1LC3B AND RAB7A.
  10. Cited for: SUBCELLULAR LOCATION, VARIANT CTRCT18 PRO-1376.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites."
    Tang Z., Lin M.G., Stowe T.R., Chen S., Zhu M., Stearns T., Franco B., Zhong Q.
    Nature 502:254-257(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MAP1LC3B.

Entry informationi

Entry nameiFYCO1_HUMAN
AccessioniPrimary (citable) accession number: Q9BQS8
Secondary accession number(s): B7ZKT7
, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: February 8, 2011
Last modified: October 29, 2014
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3