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Protein

Heat shock protein beta-9

Gene

HSPB9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciZFISH:G66-32217-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-9
Short name:
HspB9
Alternative name(s):
Cancer/testis antigen 51
Short name:
CT51
Gene namesi
Name:HSPB9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30589. HSPB9.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi94086.
OpenTargetsiENSG00000260325.
PharmGKBiPA134875756.

Polymorphism and mutation databases

BioMutaiHSPB9.
DMDMi46576635.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259501 – 159Heat shock protein beta-9Add BLAST159

Proteomic databases

PaxDbiQ9BQS6.
PRIDEiQ9BQS6.

PTM databases

PhosphoSitePlusiQ9BQS6.

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiENSG00000197723.
CleanExiHS_HSPB9.
GenevisibleiQ9BQS6. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DYNLT1P631725EBI-1176448,EBI-1176455

Protein-protein interaction databases

BioGridi125108. 10 interactors.
IntActiQ9BQS6. 3 interactors.
STRINGi9606.ENSP00000347178.

Structurei

3D structure databases

ProteinModelPortaliQ9BQS6.
SMRiQ9BQS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00510000049735.
HOGENOMiHOG000230993.
HOVERGENiHBG052041.
InParanoidiQ9BQS6.
KOiK09547.
OMAiAMTCCLT.
OrthoDBiEOG091G0WOM.
PhylomeDBiQ9BQS6.
TreeFamiTF338684.

Family and domain databases

InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BQS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRVGNTFSN ESRVASRCPS VGLAERNRVA TMPVRLLRDS PAAQEDNDHA
60 70 80 90 100
RDGFQMKLDA HGFAPEELVV QVDGQWLMVT GQQQLDVRDP ERVSYRMSQK
110 120 130 140 150
VHRKMLPSNL SPTAMTCCLT PSGQLWVRGQ CVALALPEAQ TGPSPRLGSL

GSKASNLTR
Length:159
Mass (Da):17,486
Last modified:June 1, 2001 - v1
Checksum:iF28E40D0512C4997
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0220542Q → P.Corresponds to variant rs1122326dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302068 Genomic DNA. Translation: CAC35727.1.
AK093488 mRNA. Translation: BAG52728.1.
CH471152 Genomic DNA. Translation: EAW60804.1.
BC093991 mRNA. Translation: AAH93991.1.
BC093993 mRNA. Translation: AAH93993.1.
CCDSiCCDS11418.1.
RefSeqiNP_149971.1. NM_033194.2.
UniGeneiHs.620611.

Genome annotation databases

EnsembliENST00000565659; ENSP00000458018; ENSG00000260325.
GeneIDi94086.
KEGGihsa:94086.
UCSCiuc002hyy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ302068 Genomic DNA. Translation: CAC35727.1.
AK093488 mRNA. Translation: BAG52728.1.
CH471152 Genomic DNA. Translation: EAW60804.1.
BC093991 mRNA. Translation: AAH93991.1.
BC093993 mRNA. Translation: AAH93993.1.
CCDSiCCDS11418.1.
RefSeqiNP_149971.1. NM_033194.2.
UniGeneiHs.620611.

3D structure databases

ProteinModelPortaliQ9BQS6.
SMRiQ9BQS6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125108. 10 interactors.
IntActiQ9BQS6. 3 interactors.
STRINGi9606.ENSP00000347178.

PTM databases

PhosphoSitePlusiQ9BQS6.

Polymorphism and mutation databases

BioMutaiHSPB9.
DMDMi46576635.

Proteomic databases

PaxDbiQ9BQS6.
PRIDEiQ9BQS6.

Protocols and materials databases

DNASUi94086.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000565659; ENSP00000458018; ENSG00000260325.
GeneIDi94086.
KEGGihsa:94086.
UCSCiuc002hyy.3. human.

Organism-specific databases

CTDi94086.
DisGeNETi94086.
GeneCardsiHSPB9.
HGNCiHGNC:30589. HSPB9.
MIMi608344. gene.
neXtProtiNX_Q9BQS6.
OpenTargetsiENSG00000260325.
PharmGKBiPA134875756.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00510000049735.
HOGENOMiHOG000230993.
HOVERGENiHBG052041.
InParanoidiQ9BQS6.
KOiK09547.
OMAiAMTCCLT.
OrthoDBiEOG091G0WOM.
PhylomeDBiQ9BQS6.
TreeFamiTF338684.

Enzyme and pathway databases

BioCyciZFISH:G66-32217-MONOMER.

Miscellaneous databases

GenomeRNAii94086.
PROiQ9BQS6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197723.
CleanExiHS_HSPB9.
GenevisibleiQ9BQS6. HS.

Family and domain databases

InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSPB9_HUMAN
AccessioniPrimary (citable) accession number: Q9BQS6
Secondary accession number(s): B3KSG6, Q52LB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.