Q9BQR3 (PRS27_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine protease 27
EC=3.4.21.-

Alternative name(s):
Marapsin
Pancreasin

Gene names

Name:	PRSS27
Synonyms:	MPN
ORF Names:	UNQ1884/PRO4327

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted.
Tissue specificity	Expressed predominantly in the pancreas. Ref.3
Post-translational modification	N-glycosylated. Ref.3
Sequence similarities	Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase Protease Serine protease
PTM	Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Propeptide	23 – 34	12	Activation peptide Potential		PRO_0000027506
	Chain	35 – 290	256	Serine protease 27		PRO_0000027507
Regions
	Domain	35 – 277	243	Peptidase S1
Sites
	Active site	75	1	Charge relay system By similarity
	Active site	124	1	Charge relay system By similarity
	Active site	229	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	55	1	N-linked (GlcNAc...) Potential
	Glycosylation	79	1	N-linked (GlcNAc...) Potential
	Disulfide bond	60 ↔ 76		By similarity
	Disulfide bond	158 ↔ 235		By similarity
	Disulfide bond	191 ↔ 214		By similarity
	Disulfide bond	225 ↔ 253		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9BQR3 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 67BDC93EC70BFF7B	FASTA	290	31,940
	10 20 30 40 50 60 MRRPAAVPLL LLLCFGSQRA KAATACGRPR MLNRMVGGQD TQEGEWPWQV SIQRNGSHFC 70 80 90 100 110 120 GGSLIAEQWV LTAAHCFRNT SETSLYQVLL GARQLVQPGP HAMYARVRQV ESNPLYQGTA 130 140 150 160 170 180 SSADVALVEL EAPVPFTNYI LPVCLPDPSV IFETGMNCWV TGWGSPSEED LLPEPRILQK 190 200 210 220 230 240 LAVPIIDTPK CNLLYSKDTE FGYQPKTIKN DMLCAGFEEG KKDACKGDSG GPLVCLVGQS 250 260 270 280 290 WLQAGVISWG EGCARQNRPG VYIRVTAHHN WIHRIIPKLQ FQPARLGGQK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, sequencing and expression of marapsin, a human serine proteinase." Fortunato M., Dando P.M., Rawlings N.D., Barrett A.J. Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Okaze H., Hayashi A., Kozuma S., Saito T. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas." Bhagwandin V.J., Hau L.W.-T., Mallen-St Clair J., Wolters P.J., Caughey G.H. J. Biol. Chem. 278:3363-3371(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], GLYCOSYLATION, TISSUE SPECIFICITY.
[4]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ306593 mRNA. Translation: CAC35467.1. AB056161 mRNA. Translation: BAB85497.1. AY030095 mRNA. Translation: AAK38168.1. AY359106 mRNA. Translation: AAQ89464.1. BC034294 mRNA. Translation: AAH34294.1.
IPI	IPI00011192.
RefSeq	NP_114154.1. NM_031948.3.
UniGene	Hs.332878.
3D structure databases
ProteinModelPortal	Q9BQR3.
ModBase	Search...
Protein family/group databases
MEROPS	S01.074.
Polymorphism databases
DMDM	18202734.
Proteomic databases
PaxDb	Q9BQR3.
PRIDE	Q9BQR3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302641; ENSP00000306390; ENSG00000172382.
GeneID	83886.
KEGG	hsa:83886.
UCSC	uc002crf.3. human.
Organism-specific databases
CTD	83886.
GeneCards	GC16M002768.
HGNC	HGNC:15475. PRSS27.
HPA	CAB024920.
MIM	608018. gene.
neXtProt	NX_Q9BQR3.
PharmGKB	PA33837.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5640.
HOGENOM	HOG000251820.
HOVERGEN	HBG013304.
InParanoid	Q9BQR3.
KO	K09628.
OMA	CFPNTSE.
OrthoDB	EOG45TCNS.
PhylomeDB	Q9BQR3.
Gene expression databases
ArrayExpress	Q9BQR3.
Bgee	Q9BQR3.
CleanEx	HS_PRSS27.
Genevestigator	Q9BQR3.
GermOnline	ENSG00000172382. Homo sapiens.
Family and domain databases
InterPro	IPR001254. Peptidase_S1. IPR018114. Peptidase_S1_AS. IPR001314. Peptidase_S1A. IPR009003. Trypsin-like_Pept_dom. [Graphical view]
Pfam	PF00089. Trypsin. 1 hit. [Graphical view]
PRINTS	PR00722. CHYMOTRYPSIN.
SMART	SM00020. Tryp_SPc. 1 hit. [Graphical view]
SUPFAM	SSF50494. Pept_Ser_Cys. 1 hit.
PROSITE	PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	83886.
NextBio	72957.
SOURCE	Search...

Entry information

Entry name

PRS27_HUMAN

Accession

Primary (citable) accession number: Q9BQR3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	June 1, 2001
Last modified:	May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.