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Protein

Serine protease 27

Gene

PRSS27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei75 – 751Charge relay systemBy similarity
Active sitei124 – 1241Charge relay systemBy similarity
Active sitei229 – 2291Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.074.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease 27 (EC:3.4.21.-)
Alternative name(s):
Marapsin
Pancreasin
Gene namesi
Name:PRSS27
Synonyms:MPN
ORF Names:UNQ1884/PRO4327
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:15475. PRSS27.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33837.

Polymorphism and mutation databases

BioMutaiPRSS27.
DMDMi18202734.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 3412Activation peptideSequence analysisPRO_0000027506Add
BLAST
Chaini35 – 290256Serine protease 27PRO_0000027507Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi55 – 551N-linked (GlcNAc...)Sequence analysis
Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence analysis
Disulfide bondi158 ↔ 235PROSITE-ProRule annotation
Disulfide bondi191 ↔ 214PROSITE-ProRule annotation
Disulfide bondi225 ↔ 253PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9BQR3.
PeptideAtlasiQ9BQR3.
PRIDEiQ9BQR3.

Expressioni

Tissue specificityi

Expressed predominantly in the pancreas.1 Publication

Gene expression databases

BgeeiENSG00000172382.
CleanExiHS_PRSS27.
ExpressionAtlasiQ9BQR3. baseline and differential.
GenevisibleiQ9BQR3. HS.

Organism-specific databases

HPAiCAB024920.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000306390.

Structurei

3D structure databases

ProteinModelPortaliQ9BQR3.
SMRiQ9BQR3. Positions 35-278.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 277243Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118810.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9BQR3.
KOiK09628.
OMAiFETGMNC.
OrthoDBiEOG091G0AH5.
PhylomeDBiQ9BQR3.
TreeFamiTF351676.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9BQR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRPAAVPLL LLLCFGSQRA KAATACGRPR MLNRMVGGQD TQEGEWPWQV
60 70 80 90 100
SIQRNGSHFC GGSLIAEQWV LTAAHCFRNT SETSLYQVLL GARQLVQPGP
110 120 130 140 150
HAMYARVRQV ESNPLYQGTA SSADVALVEL EAPVPFTNYI LPVCLPDPSV
160 170 180 190 200
IFETGMNCWV TGWGSPSEED LLPEPRILQK LAVPIIDTPK CNLLYSKDTE
210 220 230 240 250
FGYQPKTIKN DMLCAGFEEG KKDACKGDSG GPLVCLVGQS WLQAGVISWG
260 270 280 290
EGCARQNRPG VYIRVTAHHN WIHRIIPKLQ FQPARLGGQK
Length:290
Mass (Da):31,940
Last modified:June 1, 2001 - v1
Checksum:i67BDC93EC70BFF7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306593 mRNA. Translation: CAC35467.1.
AB056161 mRNA. Translation: BAB85497.1.
AY030095 mRNA. Translation: AAK38168.1.
AY359106 mRNA. Translation: AAQ89464.1.
BC034294 mRNA. Translation: AAH34294.1.
CCDSiCCDS10476.1.
RefSeqiNP_001305324.1. NM_001318395.1.
NP_114154.1. NM_031948.4.
UniGeneiHs.332878.

Genome annotation databases

EnsembliENST00000302641; ENSP00000306390; ENSG00000172382.
GeneIDi83886.
KEGGihsa:83886.
UCSCiuc002crf.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306593 mRNA. Translation: CAC35467.1.
AB056161 mRNA. Translation: BAB85497.1.
AY030095 mRNA. Translation: AAK38168.1.
AY359106 mRNA. Translation: AAQ89464.1.
BC034294 mRNA. Translation: AAH34294.1.
CCDSiCCDS10476.1.
RefSeqiNP_001305324.1. NM_001318395.1.
NP_114154.1. NM_031948.4.
UniGeneiHs.332878.

3D structure databases

ProteinModelPortaliQ9BQR3.
SMRiQ9BQR3. Positions 35-278.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000306390.

Protein family/group databases

MEROPSiS01.074.

Polymorphism and mutation databases

BioMutaiPRSS27.
DMDMi18202734.

Proteomic databases

PaxDbiQ9BQR3.
PeptideAtlasiQ9BQR3.
PRIDEiQ9BQR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302641; ENSP00000306390; ENSG00000172382.
GeneIDi83886.
KEGGihsa:83886.
UCSCiuc002crf.4. human.

Organism-specific databases

CTDi83886.
GeneCardsiPRSS27.
HGNCiHGNC:15475. PRSS27.
HPAiCAB024920.
MIMi608018. gene.
neXtProtiNX_Q9BQR3.
PharmGKBiPA33837.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118810.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9BQR3.
KOiK09628.
OMAiFETGMNC.
OrthoDBiEOG091G0AH5.
PhylomeDBiQ9BQR3.
TreeFamiTF351676.

Miscellaneous databases

GenomeRNAii83886.
PROiQ9BQR3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172382.
CleanExiHS_PRSS27.
ExpressionAtlasiQ9BQR3. baseline and differential.
GenevisibleiQ9BQR3. HS.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRS27_HUMAN
AccessioniPrimary (citable) accession number: Q9BQR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.