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Protein

Receptor-transporting protein 3

Gene

RTP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43.1 Publication

GO - Molecular functioni

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of bitter taste Source: HGNC
  • protein insertion into membrane Source: GO_Central
  • protein targeting to membrane Source: HGNC

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-transporting protein 3
Alternative name(s):
3CxxC-type zinc finger protein 3
Transmembrane protein 7
Gene namesi
Name:RTP3
Synonyms:TMEM7, Z3CXXC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163825.3.
HGNCiHGNC:15572. RTP3.
MIMi607181. gene.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 211CytoplasmicSequence analysisAdd BLAST211
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi83597.
OpenTargetsiENSG00000163825.
PharmGKBiPA37981.

Polymorphism and mutation databases

BioMutaiRTP3.
DMDMi23822259.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001819931 – 232Receptor-transporting protein 3Add BLAST232

Proteomic databases

PaxDbiQ9BQQ7.
PeptideAtlasiQ9BQQ7.
PRIDEiQ9BQQ7.

PTM databases

iPTMnetiQ9BQQ7.
PhosphoSitePlusiQ9BQQ7.

Expressioni

Tissue specificityi

Expressed predominantly in adult liver (PubMed:11896456, PubMed:17693185). Expressed in testis (PubMed:16720576, PubMed:17693185). Also expressed in kidney, lung and fetal liver (PubMed:17693185). Low levels in heart, thyroid, adrenal gland, pancreas, ovary, prostate, skin, plasma leukocytes, bone marrow and fetal brain (PubMed:17693185). Not detected in brain, spleen, colon, small intestine, skeletal muscle, stomach, placenta, salivary gland and uterus (PubMed:17693185).3 Publications

Gene expression databases

BgeeiENSG00000163825.
CleanExiHS_RTP3.
GenevisibleiQ9BQQ7. HS.

Organism-specific databases

HPAiHPA075932.

Interactioni

Subunit structurei

Interacts with TAS2R16.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000296142.

Structurei

3D structure databases

ProteinModelPortaliQ9BQQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM7 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH22. Eukaryota.
ENOG4111X4F. LUCA.
GeneTreeiENSGT00530000063222.
HOGENOMiHOG000236274.
HOVERGENiHBG079159.
InParanoidiQ9BQQ7.
OMAiCCCVILI.
OrthoDBiEOG091G0DS4.
PhylomeDBiQ9BQQ7.
TreeFamiTF333246.

Family and domain databases

InterProiView protein in InterPro
IPR026096. R-trans_p.
IPR026691. RTP3.
IPR027377. Znf-3CxxC.
PANTHERiPTHR14402. PTHR14402. 2 hits.
PTHR14402:SF9. PTHR14402:SF9. 2 hits.
PfamiView protein in Pfam
PF13695. zf-3CxxC. 1 hit.
SMARTiView protein in SMART
SM01328. zf-3CxxC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BQQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGDTEVWKQ MFQELMREVK PWHRWTLRPD KGLLPNVLKP GWMQYQQWTF
60 70 80 90 100
ARFQCSSCSR NWASAQVLVL FHMNWSEEKS RGQVKMRVFT QRCKKCPQPL
110 120 130 140 150
FEDPEFTQEN ISRILKNLVF RILKKCYRGR FQLIEEVPMI KDISLEGPHN
160 170 180 190 200
SDNCEACLQG FCAGPIQVTS LPPSQTPRVH SIYKVEEVVK PWASGENVYS
210 220 230
YACQNHICRN LSIFCCCVIL IVIVVIVVKT AI
Length:232
Mass (Da):27,031
Last modified:June 1, 2001 - v1
Checksum:i352377BDF4110237
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312776 mRNA. Translation: CAC37401.1.
AY562237 mRNA. Translation: AAT70682.1.
CH471055 Genomic DNA. Translation: EAW64768.1.
BC131756 mRNA. Translation: AAI31757.1.
CCDSiCCDS2740.1.
RefSeqiNP_113628.1. NM_031440.1.
UniGeneiHs.196584.

Genome annotation databases

EnsembliENST00000296142; ENSP00000296142; ENSG00000163825.
GeneIDi83597.
KEGGihsa:83597.
UCSCiuc003cps.2. human.

Similar proteinsi

Entry informationi

Entry nameiRTP3_HUMAN
AccessioniPrimary (citable) accession number: Q9BQQ7
Secondary accession number(s): A2RRP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families