ID   BPIA3_HUMAN             Reviewed;         254 AA.
AC   Q9BQP9; Q5JWG8; Q6NZ38;
DT   10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 3.
DT   27-MAR-2024, entry version 152.
DE   RecName: Full=BPI fold-containing family A member 3;
DE   AltName: Full=Short palate, lung and nasal epithelium carcinoma-associated protein 3;
DE   Flags: Precursor;
GN   Name=BPIFA3; Synonyms=C20orf71, SPLUNC3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9BQP9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9BQP9-2; Sequence=VSP_026471;
CC   -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
CC       {ECO:0000305}.
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DR   EMBL; AL121901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC066354; AAH66354.1; -; mRNA.
DR   CCDS; CCDS13216.2; -. [Q9BQP9-1]
DR   CCDS; CCDS42865.1; -. [Q9BQP9-2]
DR   RefSeq; NP_001035904.1; NM_001042439.2. [Q9BQP9-2]
DR   RefSeq; NP_848561.2; NM_178466.4. [Q9BQP9-1]
DR   AlphaFoldDB; Q9BQP9; -.
DR   SMR; Q9BQP9; -.
DR   BioGRID; 126167; 4.
DR   STRING; 9606.ENSP00000364603; -.
DR   GlyCosmos; Q9BQP9; 1 site, No reported glycans.
DR   GlyGen; Q9BQP9; 1 site.
DR   BioMuta; BPIFA3; -.
DR   DMDM; 152031690; -.
DR   EPD; Q9BQP9; -.
DR   jPOST; Q9BQP9; -.
DR   MassIVE; Q9BQP9; -.
DR   MaxQB; Q9BQP9; -.
DR   PaxDb; 9606-ENSP00000364603; -.
DR   PeptideAtlas; Q9BQP9; -.
DR   ProteomicsDB; 78704; -. [Q9BQP9-1]
DR   ProteomicsDB; 78705; -. [Q9BQP9-2]
DR   Antibodypedia; 25527; 35 antibodies from 12 providers.
DR   DNASU; 128861; -.
DR   Ensembl; ENST00000375452.3; ENSP00000364601.3; ENSG00000131059.12. [Q9BQP9-2]
DR   Ensembl; ENST00000375454.8; ENSP00000364603.3; ENSG00000131059.12. [Q9BQP9-1]
DR   GeneID; 128861; -.
DR   KEGG; hsa:128861; -.
DR   MANE-Select; ENST00000375454.8; ENSP00000364603.3; NM_178466.5; NP_848561.2.
DR   UCSC; uc002wyr.5; human. [Q9BQP9-1]
DR   AGR; HGNC:16204; -.
DR   CTD; 128861; -.
DR   DisGeNET; 128861; -.
DR   GeneCards; BPIFA3; -.
DR   HGNC; HGNC:16204; BPIFA3.
DR   HPA; ENSG00000131059; Tissue enriched (testis).
DR   neXtProt; NX_Q9BQP9; -.
DR   OpenTargets; ENSG00000131059; -.
DR   PharmGKB; PA25782; -.
DR   VEuPathDB; HostDB:ENSG00000131059; -.
DR   eggNOG; ENOG502T3DV; Eukaryota.
DR   GeneTree; ENSGT01100000263546; -.
DR   HOGENOM; CLU_101222_0_0_1; -.
DR   InParanoid; Q9BQP9; -.
DR   OMA; TNMQLDY; -.
DR   OrthoDB; 4727007at2759; -.
DR   PhylomeDB; Q9BQP9; -.
DR   TreeFam; TF337052; -.
DR   PathwayCommons; Q9BQP9; -.
DR   BioGRID-ORCS; 128861; 12 hits in 1145 CRISPR screens.
DR   GenomeRNAi; 128861; -.
DR   Pharos; Q9BQP9; Tdark.
DR   PRO; PR:Q9BQP9; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   RNAct; Q9BQP9; Protein.
DR   Bgee; ENSG00000131059; Expressed in sperm and 44 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR   InterPro; IPR032946; Bpifa3.
DR   InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR   PANTHER; PTHR47736; BPI FOLD-CONTAINING FAMILY A MEMBER 3; 1.
DR   PANTHER; PTHR47736:SF1; BPI FOLD-CONTAINING FAMILY A MEMBER 3; 1.
DR   Pfam; PF01273; LBP_BPI_CETP; 1.
DR   SUPFAM; SSF55394; Bactericidal permeability-increasing protein, BPI; 1.
DR   Genevisible; Q9BQP9; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Disulfide bond; Glycoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..254
FT                   /note="BPI fold-containing family A member 3"
FT                   /id="PRO_0000017187"
FT   REGION          233..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        239..254
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        36
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        165..209
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         93..129
FT                   /note="SINITNIQLDCGGIQISFHKEWFSANISLEFDLELRP -> R (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_026471"
FT   VARIANT         41
FT                   /note="A -> E (in dbSNP:rs17124391)"
FT                   /id="VAR_049754"
FT   VARIANT         136
FT                   /note="V -> I (in dbSNP:rs3818222)"
FT                   /id="VAR_049755"
SQ   SEQUENCE   254 AA;  28436 MW;  E03AFBE138CA073B CRC64;
     MMCPLWRLLI FLGLLALPLA PHKQPWPGLA QAHRDNKSTL ARIIAQGLIK HNAESRIQNI
     HFGDRLNASA QVAPGLVGWL ISGRKHQQQQ ESSINITNIQ LDCGGIQISF HKEWFSANIS
     LEFDLELRPS FDNNIVKMCA HMSIVVEFWL EKDEFGRRDL VIGKCDAEPS SVHVAILTEA
     IPPKMNQFLY NLKENLQKVL PHMVESQVCP LIGEILGQLD VKLLKSLIEQ EAAHEPTHHE
     TSQPSACQAG ESPS
//