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Q9BQL6 (FERM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fermitin family homolog 1
Alternative name(s):
Kindlerin
Kindlin syndrome protein
Kindlin-1
Unc-112-related protein 1
Gene names
Name:FERMT1
Synonyms:C20orf42, KIND1, URP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length677 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. Ref.8 Ref.9 Ref.11

Subunit structure

Interacts with the cytoplasmic domain of integrins ITGB1 and ITGB3. Ref.8

Subcellular location

Cytoplasmcytoskeleton. Cell junctionfocal adhesion. Cell projectionruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note: Constituent of focal adhesions. Localized at the basal aspect of skin keratinocytes, close to the cell membrane. Colocalizes with filamentous actin. Upon TGFB1 treatment, it localizes to membrane ruffles. Ref.2 Ref.8 Ref.9 Ref.11

Tissue specificity

Expressed in brain, skeletal muscle, kidney, colon, adrenal gland, prostate, and placenta. Weakly or not expressed in heart, thymus, spleen, liver, small intestine, bone marrow, lung and peripheral blood leukocytes. Overexpressed in some colon and lung tumors. In skin, it is localized within the epidermis and particularly in basal keratocytes. Not detected in epidermal melanocytes and dermal fibroblasts. Ref.1 Ref.2 Ref.7 Ref.8 Ref.9

Induction

By TGFB1. Ref.8

Domain

The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain. The FERM domain contains the subdomains F1, F2 and F3. It is preceded by a F0 domain with a ubiquitin-like fold. The F0 domain is required for integrin activation and for localization at focal adhesions. Ref.11

Involvement in disease

Kindler syndrome (KINDS) [MIM:173650]: Autosomal recessive skin disorder characterized by skin blistering, photosensitivity, progressive poikiloderma, and extensive skin atrophy. Additional clinical features include gingival erosions, ocular, esophageal, gastrointestinal and urogenital involvement, and an increased risk of mucocutaneous malignancy.
Note: The disease is caused by mutations affecting the gene represented in this entry. Although most FERMT1 mutations are predicted to lead to premature termination of translation, and to loss of FERMT1 function, significant clinical variability is observed among patients. There is an association of FERMT1 missense and in-frame deletion mutations with milder disease phenotypes, and later onset of complications (Ref.14). Ref.2 Ref.7 Ref.14

Sequence similarities

Belongs to the kindlin family.

Contains 1 FERM domain.

Contains 1 PH domain.

Sequence caution

The sequence BAA91358.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC03826.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9BQL6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9BQL6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     541-554: QNVAQMPLVEAKLR → LQAPFHSYRSLSHL
     555-677: Missing.
Isoform 3 (identifier: Q9BQL6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-447: Missing.
Isoform 4 (identifier: Q9BQL6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     458-495: ENQYAQWMAA...VLNILSFLRM → VSKTPKILSH...ALLCHSAIAL
     496-677: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 677677Fermitin family homolog 1
PRO_0000219452

Regions

Domain96 – 653558FERM
Domain377 – 47397PH
Compositional bias147 – 1548Poly-Lys

Amino acid modifications

Modified residue1701Phosphoserine Ref.10
Modified residue1791Phosphoserine Ref.10

Natural variations

Alternative sequence1 – 447447Missing in isoform 3.
VSP_003809
Alternative sequence458 – 49538ENQYA…SFLRM → VSKTPKILSHFTSTKPKSKT QKCFHKFRALLCHSAIAL in isoform 4.
VSP_009224
Alternative sequence496 – 677182Missing in isoform 4.
VSP_009225
Alternative sequence541 – 55414QNVAQ…EAKLR → LQAPFHSYRSLSHL in isoform 2.
VSP_003810
Alternative sequence555 – 677123Missing in isoform 2.
VSP_003811
Natural variant1001Missing in KINDS. Ref.14
VAR_066942
Natural variant1601I → T.
Corresponds to variant rs16991866 [ dbSNP | Ensembl ].
VAR_048368
Natural variant2411V → A.
Corresponds to variant rs55666319 [ dbSNP | Ensembl ].
VAR_061035
Natural variant4001S → P in KINDS. Ref.14
VAR_066943
Natural variant5261R → K. Ref.1 Ref.3
Corresponds to variant rs2232074 [ dbSNP | Ensembl ].
VAR_014398
Natural variant5341A → T.
Corresponds to variant rs2232078 [ dbSNP | Ensembl ].
VAR_014399
Natural variant5591W → R in KINDS. Ref.14
VAR_066944
Natural variant6231Missing in KINDS. Ref.14
VAR_066945

Experimental info

Sequence conflict1171V → A in BAC03826. Ref.4
Sequence conflict2621I → T in BAC03826. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 7354DCD84C516F90

FASTA67777,437
        10         20         30         40         50         60 
MLSSTDFTFA SWELVVRVDH PNEEQQKDVT LRVSGDLHVG GVMLKLVEQI NISQDWSDFA 

        70         80         90        100        110        120 
LWWEQKHCWL LKTHWTLDKY GVQADAKLLF TPQHKMLRLR LPNLKMVRLR VSFSAVVFKA 

       130        140        150        160        170        180 
VSDICKILNI RRSEELSLLK PSGDYFKKKK KKDKNNKEPI IEDILNLESS PTASGSSVSP 

       190        200        210        220        230        240 
GLYSKTMTPI YDPINGTPAS STMTWFSDSP LTEQNCSILA FSQPPQSPEA LADMYQPRSL 

       250        260        270        280        290        300 
VDKAKLNAGW LDSSRSLMEQ GIQEDEQLLL RFKYYSFFDL NPKYDAVRIN QLYEQARWAI 

       310        320        330        340        350        360 
LLEEIDCTEE EMLIFAALQY HISKLSLSAE TQDFAGESEV DEIEAALSNL EVTLEGGKAD 

       370        380        390        400        410        420 
SLLEDITDIP KLADNLKLFR PKKLLPKAFK QYWFIFKDTS IAYFKNKELE QGEPLEKLNL 

       430        440        450        460        470        480 
RGCEVVPDVN VAGRKFGIKL LIPVADGMNE MYLRCDHENQ YAQWMAACML ASKGKTMADS 

       490        500        510        520        530        540 
SYQPEVLNIL SFLRMKNRNS ASQVASSLEN MDMNPECFVS PRCAKRHKSK QLAARILEAH 

       550        560        570        580        590        600 
QNVAQMPLVE AKLRFIQAWQ SLPEFGLTYY LVRFKGSKKD DILGVSYNRL IKIDAATGIP 

       610        620        630        640        650        660 
VTTWRFTNIK QWNVNWETRQ VVIEFDQNVF TAFTCLSADC KIVHEYIGGY IFLSTRSKDQ 

       670 
NETLDEDLFH KLTGGQD 

« Hide

Isoform 2 [UniParc].

Checksum: 51FE18BC2DFE0542
Show »

FASTA55463,235
Isoform 3 [UniParc].

Checksum: 90D6CC89DBCA8BC6
Show »

FASTA23026,498
Isoform 4 [UniParc].

Checksum: 2DD52A11D0630636
Show »

FASTA49556,516

References

« Hide 'large scale' references
[1]"URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas."
Weinstein E.J., Bourner M., Head R., Zakeri H., Bauer C., Mazzarella R.
Biochim. Biophys. Acta 1637:207-216(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT LYS-526.
Tissue: Colon cancer.
[2]"Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome."
Siegel D.H., Ashton G.H.S., Penagos H.G., Lee J.V., Feiler H.S., Wilhelmsen K.C., South A.P., Smith F.J.D., Prescott A.R., Wessagowit V., Oyama N., Akiyama M., Al-Aboud D., Al-Aboud K., Al-Githami A., Al-Hawsawi K., Al-Ismaily A., Al-Suwaid R. expand/collapse author list , Atherton D.J., Caputo R., Fine J.-D., Frieden I.J., Fuchs E., Haber R.M., Harada T., Kitajima Y., Mallory S.B., Ogawa H., Sahin S., Shimizu H., Suga Y., Tadini G., Tsuchiya K., Wiebe C.B., Wojnarowska F., Zaghloul A.B., Hamada T., Mallipeddi R., Eady R.A.J., McLean W.H.I., McGrath J.A., Epstein E.H. Jr.
Am. J. Hum. Genet. 73:174-187(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INVOLVEMENT IN KINDS, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT LYS-526.
Tissue: Colon, Hepatoma and Teratocarcinoma.
[4]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Brain.
[7]"Identification of mutations in a new gene encoding a FERM family protein with a pleckstrin homology domain in Kindler syndrome."
Jobard F., Bouadjar B., Caux F., Hadj-Rabia S., Has C., Matsuda F., Weissenbach J., Lathrop M., Prud'homme J.-F., Fischer J.
Hum. Mol. Genet. 12:925-935(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN KINDS, TISSUE SPECIFICITY.
[8]"The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion."
Kloeker S., Major M.B., Calderwood D.A., Ginsberg M.H., Jones D.A., Beckerle M.C.
J. Biol. Chem. 279:6824-6833(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, INTERACTION WITH ITGB1 AND ITGB3.
[9]"Kindlin-1 is a phosphoprotein involved in regulation of polarity, proliferation, and motility of epidermal keratinocytes."
Herz C., Aumailley M., Schulte C., Schlotzer-Schrehardt U., Bruckner-Tuderman L., Has C.
J. Biol. Chem. 281:36082-36090(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, PHOSPHORYLATION.
[10]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-170 AND SER-179, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"The structure of the N-terminus of kindlin-1: a domain important for alphaIIbbeta3 integrin activation."
Goult B.T., Bouaouina M., Harburger D.S., Bate N., Patel B., Anthis N.J., Campbell I.D., Calderwood D.A., Barsukov I.L., Roberts G.C., Critchley D.R.
J. Mol. Biol. 394:944-956(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, DOMAIN.
[12]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[13]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"Kindler syndrome: extension of FERMT1 mutational spectrum and natural history."
Has C., Castiglia D., del Rio M., Diez M.G., Piccinni E., Kiritsi D., Kohlhase J., Itin P., Martin L., Fischer J., Zambruno G., Bruckner-Tuderman L.
Hum. Mutat. 32:1204-1212(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS KINDS ARG-100 DEL; PRO-400; ARG-559 AND ILE-623 DEL.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF443278 mRNA. Translation: AAN75822.1.
AY137240 mRNA. Translation: AAM94174.1.
AK000123 mRNA. Translation: BAA90957.1.
AK000747 mRNA. Translation: BAA91358.1. Different initiation.
AK092195 mRNA. Translation: BAC03826.1. Different initiation.
AL118505 Genomic DNA. Translation: CAC03433.2.
CH471133 Genomic DNA. Translation: EAX10392.1.
CH471133 Genomic DNA. Translation: EAX10393.1.
BC035882 mRNA. Translation: AAH35882.1.
CCDSCCDS13098.1. [Q9BQL6-1]
RefSeqNP_060141.3. NM_017671.4. [Q9BQL6-1]
UniGeneHs.472054.

3D structure databases

ProteinModelPortalQ9BQL6.
SMRQ9BQL6. Positions 1-96, 250-322, 370-497, 535-651.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120752. 1 interaction.
IntActQ9BQL6. 2 interactions.
MINTMINT-4538047.
STRING9606.ENSP00000217289.

PTM databases

PhosphoSiteQ9BQL6.

Polymorphism databases

DMDM26392456.

Proteomic databases

MaxQBQ9BQL6.
PaxDbQ9BQL6.
PRIDEQ9BQL6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000217289; ENSP00000217289; ENSG00000101311. [Q9BQL6-1]
GeneID55612.
KEGGhsa:55612.
UCSCuc002wmq.3. human. [Q9BQL6-3]
uc002wmr.3. human. [Q9BQL6-1]
uc002wms.3. human. [Q9BQL6-4]

Organism-specific databases

CTD55612.
GeneCardsGC20M006055.
H-InvDBHIX0015632.
HGNCHGNC:15889. FERMT1.
HPAHPA039778.
HPA041966.
MIM173650. phenotype.
607900. gene.
neXtProtNX_Q9BQL6.
Orphanet2907. Hereditary acrokeratotic poikiloderma, Weary type.
2908. Kindler syndrome.
PharmGKBPA162388314.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG238024.
HOGENOMHOG000231715.
HOVERGENHBG020688.
InParanoidQ9BQL6.
KOK17082.
OMAVSPRCAK.
OrthoDBEOG7T7GSC.
PhylomeDBQ9BQL6.
TreeFamTF314677.

Gene expression databases

ArrayExpressQ9BQL6.
BgeeQ9BQL6.
CleanExHS_FERMT1.
GenevestigatorQ9BQL6.

Family and domain databases

Gene3D1.20.80.10. 2 hits.
2.30.29.30. 2 hits.
InterProIPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR018979. FERM_N.
IPR011993. PH_like_dom.
IPR001849. Pleckstrin_homology.
[Graphical view]
PfamPF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
[Graphical view]
SMARTSM00295. B41. 1 hit.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMSSF47031. SSF47031. 1 hit.
PROSITEPS00661. FERM_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiC20orf42.
GenomeRNAi55612.
NextBio60184.
PROQ9BQL6.
SOURCESearch...

Entry information

Entry nameFERM1_HUMAN
AccessionPrimary (citable) accession number: Q9BQL6
Secondary accession number(s): D3DW10 expand/collapse secondary AC list , Q8IX34, Q8IYH2, Q9NWM2, Q9NXQ3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM