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Protein

Phosphatidate phosphatase LPIN3

Gene

LPIN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates fatty acid metabolism. Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis (By similarity).By similarity

Catalytic activityi

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

Cofactori

Mg2+By similarity

Enzyme regulationi

Inhibited by N-ethylmaleimide.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-1483191. Synthesis of PC.
R-HSA-1483213. Synthesis of PE.
R-HSA-4419969. Depolymerisation of the Nuclear Lamina.
R-HSA-75109. Triglyceride Biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate phosphatase LPIN3 (EC:3.1.3.4)
Alternative name(s):
Lipin-3
Lipin-3-like
Gene namesi
Name:LPIN3
Synonyms:LIPN3L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:14451. LPIN3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30438.

Polymorphism and mutation databases

BioMutaiLPIN3.
DMDMi71153524.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 851851Phosphatidate phosphatase LPIN3PRO_0000209883Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei159 – 1591PhosphothreonineCombined sources
Modified residuei161 – 1611PhosphoserineCombined sources
Modified residuei162 – 1621PhosphoserineCombined sources
Modified residuei224 – 2241PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BQK8.
MaxQBiQ9BQK8.
PaxDbiQ9BQK8.
PRIDEiQ9BQK8.

PTM databases

DEPODiQ9BQK8.
iPTMnetiQ9BQK8.
PhosphoSiteiQ9BQK8.

Expressioni

Tissue specificityi

Significant expression in intestine and other regions of the gastrointestinal tract.1 Publication

Gene expression databases

BgeeiQ9BQK8.
CleanExiHS_LPIN3.
ExpressionAtlasiQ9BQK8. baseline and differential.
GenevisibleiQ9BQK8. HS.

Organism-specific databases

HPAiHPA051466.
HPA052667.

Interactioni

Protein-protein interaction databases

BioGridi122340. 11 interactions.
IntActiQ9BQK8. 3 interactions.
STRINGi9606.ENSP00000362354.

Structurei

3D structure databases

ProteinModelPortaliQ9BQK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 108108N-LIPAdd
BLAST
Regioni590 – 792203C-LIPAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi141 – 1488Nuclear localization signalSequence analysis
Motifi644 – 6485DXDXT motif
Motifi655 – 6595LXXIL motif

Domaini

Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif.By similarity

Sequence similaritiesi

Belongs to the lipin family.Curated

Phylogenomic databases

eggNOGiKOG2116. Eukaryota.
COG5083. LUCA.
GeneTreeiENSGT00390000011286.
HOGENOMiHOG000230954.
HOVERGENiHBG052338.
InParanoidiQ9BQK8.
KOiK15728.
OMAiMGARRWS.
OrthoDBiEOG7QZG8X.
PhylomeDBiQ9BQK8.
TreeFamiTF314095.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR031703. Lipin_mid.
IPR007651. Lipin_N.
IPR013209. LNS2.
IPR031315. LNS2/PITP.
[Graphical view]
PfamiPF16876. Lipin_mid. 1 hit.
PF04571. Lipin_N. 1 hit.
PF08235. LNS2. 1 hit.
[Graphical view]
SMARTiSM00775. LNS2. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BQK8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNYVGQLAET VFGTVKELYR GLNPATLSGG IDVLVVKQVD GSFRCSPFHV
60 70 80 90 100
RFGKLGVLRS REKVVDIELN GEPVDLHMKL GDSGEAFFVQ ELESDDEHVP
110 120 130 140 150
PGLCTSPIPW GGLSGFPSDS QLGTASEPEG LVMAGTASTG RRKRRRRRKP
160 170 180 190 200
KQKEDAVATD SSPEELEAGA ESELSLPEKL RPEPPGVQLE EKSSLQPKDI
210 220 230 240 250
YPYSDGEWPP QASLSAGELT SPKSDSELEV RTPEPSPLRA ESHMQWAWGR
260 270 280 290 300
LPKVARAERP ESSVVLEGRA GATSPPRGGP STPSTSVAGG VDPLGLPIQQ
310 320 330 340 350
TEAGADLQPD TEDPTLVGPP LHTPETEESK TQSSGDMGLP PASKSWSWAT
360 370 380 390 400
LEVPVPTGQP ERVSRGKGSP KRSQHLGPSD IYLDDLPSLD SENAALYFPQ
410 420 430 440 450
SDSGLGARRW SEPSSQKSLR DPNPEHEPEP TLDTVDTIAL SLCGGLADSR
460 470 480 490 500
DISLEKFNQH SVSYQDLTKN PGLLDDPNLV VKINGKHYNW AVAAPMILSL
510 520 530 540 550
QAFQKNLPKS TMDKLEREKM PRKGGRWWFS WRRRDFLAEE RSAQKEKTAA
560 570 580 590 600
KEQQGEKTEV LSSDDDAPDS PVILEIPSLP PSTPPSTPTY KKSLRLSSDQ
610 620 630 640 650
IRRLNLQEGA NDVVFSVTTQ YQGTCRCKAT IYLWKWDDKV VISDIDGTIT
660 670 680 690 700
KSDALGHILP QLGKDWTHQG ITSLYHKIQL NGYKFLYCSA RAIGMADLTK
710 720 730 740 750
GYLQWVSEGG CSLPKGPILL SPSSLFSALH REVIEKKPEV FKVACLSDIQ
760 770 780 790 800
QLFLPHGQPF YAAFGNRPND VFAYRQVGLP ESRIFTVNPR GELIQELIKN
810 820 830 840 850
HKSTYERLGE VVELLFPPVA RGPSTDLANP EYSNFCYWRE PLPAVDLDTL

D
Length:851
Mass (Da):93,614
Last modified:July 19, 2005 - v3
Checksum:iBBDFDA0A53722625
GO
Isoform 2 (identifier: Q9BQK8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-186: G → GS

Note: No experimental confirmation available.
Show »
Length:852
Mass (Da):93,701
Checksum:iE4BF4891F1A1550A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti679 – 6791Q → H.
Corresponds to variant rs12625565 [ dbSNP | Ensembl ].
VAR_053489

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei186 – 1861G → GS in isoform 2. 1 PublicationVSP_036885

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132654, AL031667 Genomic DNA. Translation: CAI21064.1.
AL031667, AL132654 Genomic DNA. Translation: CAI42978.1.
BC140806 mRNA. Translation: AAI40807.1.
CCDSiCCDS33469.1. [Q9BQK8-2]
RefSeqiNP_001288789.1. NM_001301860.1. [Q9BQK8-2]
UniGeneiHs.25897.

Genome annotation databases

EnsembliENST00000373257; ENSP00000362354; ENSG00000132793. [Q9BQK8-1]
ENST00000632009; ENSP00000487971; ENSG00000132793. [Q9BQK8-2]
GeneIDi64900.
KEGGihsa:64900.
UCSCiuc002xjx.3. human. [Q9BQK8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132654, AL031667 Genomic DNA. Translation: CAI21064.1.
AL031667, AL132654 Genomic DNA. Translation: CAI42978.1.
BC140806 mRNA. Translation: AAI40807.1.
CCDSiCCDS33469.1. [Q9BQK8-2]
RefSeqiNP_001288789.1. NM_001301860.1. [Q9BQK8-2]
UniGeneiHs.25897.

3D structure databases

ProteinModelPortaliQ9BQK8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122340. 11 interactions.
IntActiQ9BQK8. 3 interactions.
STRINGi9606.ENSP00000362354.

PTM databases

DEPODiQ9BQK8.
iPTMnetiQ9BQK8.
PhosphoSiteiQ9BQK8.

Polymorphism and mutation databases

BioMutaiLPIN3.
DMDMi71153524.

Proteomic databases

EPDiQ9BQK8.
MaxQBiQ9BQK8.
PaxDbiQ9BQK8.
PRIDEiQ9BQK8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373257; ENSP00000362354; ENSG00000132793. [Q9BQK8-1]
ENST00000632009; ENSP00000487971; ENSG00000132793. [Q9BQK8-2]
GeneIDi64900.
KEGGihsa:64900.
UCSCiuc002xjx.3. human. [Q9BQK8-1]

Organism-specific databases

CTDi64900.
GeneCardsiLPIN3.
HGNCiHGNC:14451. LPIN3.
HPAiHPA051466.
HPA052667.
MIMi605520. gene.
neXtProtiNX_Q9BQK8.
PharmGKBiPA30438.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2116. Eukaryota.
COG5083. LUCA.
GeneTreeiENSGT00390000011286.
HOGENOMiHOG000230954.
HOVERGENiHBG052338.
InParanoidiQ9BQK8.
KOiK15728.
OMAiMGARRWS.
OrthoDBiEOG7QZG8X.
PhylomeDBiQ9BQK8.
TreeFamiTF314095.

Enzyme and pathway databases

ReactomeiR-HSA-1483191. Synthesis of PC.
R-HSA-1483213. Synthesis of PE.
R-HSA-4419969. Depolymerisation of the Nuclear Lamina.
R-HSA-75109. Triglyceride Biosynthesis.

Miscellaneous databases

GenomeRNAii64900.
NextBioi67045.
PROiQ9BQK8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BQK8.
CleanExiHS_LPIN3.
ExpressionAtlasiQ9BQK8. baseline and differential.
GenevisibleiQ9BQK8. HS.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR031703. Lipin_mid.
IPR007651. Lipin_N.
IPR013209. LNS2.
IPR031315. LNS2/PITP.
[Graphical view]
PfamiPF16876. Lipin_mid. 1 hit.
PF04571. Lipin_N. 1 hit.
PF08235. LNS2. 1 hit.
[Graphical view]
SMARTiSM00775. LNS2. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns."
    Donkor J., Sariahmetoglu M., Dewald J., Brindley D.N., Reue K.
    J. Biol. Chem. 282:3450-3457(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-159; SER-161 AND SER-162, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiLPIN3_HUMAN
AccessioniPrimary (citable) accession number: Q9BQK8
Secondary accession number(s): B2RTT5
, Q5TDB9, Q9NPY8, Q9UJE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: July 19, 2005
Last modified: May 11, 2016
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.