Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 47

Gene

TMEM47

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B. During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147027-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 47
Alternative name(s):
Brain cell membrane protein 1
Transmembrane 4 superfamily member 10
Gene namesi
Name:TMEM47
Synonyms:BCMP1, TM4SF10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:18515. TMEM47.

Subcellular locationi

  • Membrane Curated; Multi-pass membrane protein Curated
  • Cell junctionadherens junction By similarity

  • Note: Colocalizes with FYB at cell-cell contacts in podocytes.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi83604.
OpenTargetsiENSG00000147027.
PharmGKBiPA134971248.

Polymorphism and mutation databases

BioMutaiTMEM47.
DMDMi51316912.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725731 – 181Transmembrane protein 47Add BLAST181

Proteomic databases

EPDiQ9BQJ4.
PaxDbiQ9BQJ4.
PeptideAtlasiQ9BQJ4.
PRIDEiQ9BQJ4.

PTM databases

iPTMnetiQ9BQJ4.
PhosphoSitePlusiQ9BQJ4.
SwissPalmiQ9BQJ4.

Expressioni

Tissue specificityi

Expressed in adult brain, fetal brain, cerebellum, heart, lung, prostate and thyroid.1 Publication

Gene expression databases

BgeeiENSG00000147027.
CleanExiHS_TMEM47.
ExpressionAtlasiQ9BQJ4. baseline and differential.
GenevisibleiQ9BQJ4. HS.

Organism-specific databases

HPAiHPA046658.

Interactioni

Subunit structurei

Interacts with CTNNB1, CTNNA1, PRKCI, PARD6B, FYB.By similarity

Protein-protein interaction databases

MINTiMINT-4724637.
STRINGi9606.ENSP00000275954.

Structurei

3D structure databases

ProteinModelPortaliQ9BQJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM47 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4671. Eukaryota.
ENOG4111P5K. LUCA.
GeneTreeiENSGT00530000063484.
HOGENOMiHOG000124678.
HOVERGENiHBG080233.
InParanoidiQ9BQJ4.
OMAiIVHENQM.
OrthoDBiEOG091G0S9P.
PhylomeDBiQ9BQJ4.
TreeFamiTF312855.

Family and domain databases

InterProiIPR015664. P53_induced.
[Graphical view]
PANTHERiPTHR14399. PTHR14399. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BQJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAGSGMEE VRVSVLTPLK LVGLVCIFLA LCLDLGAVLS PAWVTADHQY
60 70 80 90 100
YLSLWESCRK PASLDIWHCE STLSSDWQIA TLALLLGGAA IILIAFLVGL
110 120 130 140 150
ISICVGSRRR FYRPVAVMLF AAVVLQVCSL VLYPIKFIET VSLKIYHEFN
160 170 180
WGYGLAWGAT IFSFGGAILY CLNPKNYEDY Y
Length:181
Mass (Da):19,998
Last modified:June 1, 2001 - v1
Checksum:iA73A03FD0C3B3FBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136550 mRNA. Translation: CAB66485.1.
AL596285 Genomic DNA. Translation: CAI40203.1.
BC039242 mRNA. Translation: AAH39242.1.
CCDSiCCDS14235.1.
RefSeqiNP_113630.1. NM_031442.3.
UniGeneiHs.8769.

Genome annotation databases

EnsembliENST00000275954; ENSP00000275954; ENSG00000147027.
GeneIDi83604.
KEGGihsa:83604.
UCSCiuc004ddh.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136550 mRNA. Translation: CAB66485.1.
AL596285 Genomic DNA. Translation: CAI40203.1.
BC039242 mRNA. Translation: AAH39242.1.
CCDSiCCDS14235.1.
RefSeqiNP_113630.1. NM_031442.3.
UniGeneiHs.8769.

3D structure databases

ProteinModelPortaliQ9BQJ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4724637.
STRINGi9606.ENSP00000275954.

PTM databases

iPTMnetiQ9BQJ4.
PhosphoSitePlusiQ9BQJ4.
SwissPalmiQ9BQJ4.

Polymorphism and mutation databases

BioMutaiTMEM47.
DMDMi51316912.

Proteomic databases

EPDiQ9BQJ4.
PaxDbiQ9BQJ4.
PeptideAtlasiQ9BQJ4.
PRIDEiQ9BQJ4.

Protocols and materials databases

DNASUi83604.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275954; ENSP00000275954; ENSG00000147027.
GeneIDi83604.
KEGGihsa:83604.
UCSCiuc004ddh.3. human.

Organism-specific databases

CTDi83604.
DisGeNETi83604.
GeneCardsiTMEM47.
HGNCiHGNC:18515. TMEM47.
HPAiHPA046658.
MIMi300698. gene.
neXtProtiNX_Q9BQJ4.
OpenTargetsiENSG00000147027.
PharmGKBiPA134971248.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4671. Eukaryota.
ENOG4111P5K. LUCA.
GeneTreeiENSGT00530000063484.
HOGENOMiHOG000124678.
HOVERGENiHBG080233.
InParanoidiQ9BQJ4.
OMAiIVHENQM.
OrthoDBiEOG091G0S9P.
PhylomeDBiQ9BQJ4.
TreeFamiTF312855.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147027-MONOMER.

Miscellaneous databases

GeneWikiiTMEM47.
GenomeRNAii83604.
PROiQ9BQJ4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147027.
CleanExiHS_TMEM47.
ExpressionAtlasiQ9BQJ4. baseline and differential.
GenevisibleiQ9BQJ4. HS.

Family and domain databases

InterProiIPR015664. P53_induced.
[Graphical view]
PANTHERiPTHR14399. PTHR14399. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTMM47_HUMAN
AccessioniPrimary (citable) accession number: Q9BQJ4
Secondary accession number(s): Q5JR44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.