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Protein

PH and SEC7 domain-containing protein 2

Gene

PSD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
PH and SEC7 domain-containing protein 2
Alternative name(s):
Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C
Short name:
Exchange factor for ARF6 C
Pleckstrin homology and SEC7 domain-containing protein 2
Gene namesi
Name:PSD2
Synonyms:EFA6C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000146005.3.
HGNCiHGNC:19092. PSD2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei622 – 639HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84249.
OpenTargetsiENSG00000146005.
PharmGKBiPA134885177.

Polymorphism and mutation databases

BioMutaiPSD2.
DMDMi313104198.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003341621 – 771PH and SEC7 domain-containing protein 2Add BLAST771

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei191PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9BQI7.
PeptideAtlasiQ9BQI7.
PRIDEiQ9BQI7.

PTM databases

iPTMnetiQ9BQI7.
PhosphoSitePlusiQ9BQI7.

Expressioni

Gene expression databases

BgeeiENSG00000146005.
CleanExiHS_PSD2.
GenevisibleiQ9BQI7. HS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123977. 12 interactors.
STRINGi9606.ENSP00000274710.

Structurei

3D structure databases

ProteinModelPortaliQ9BQI7.
SMRiQ9BQI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini260 – 462SEC7PROSITE-ProRule annotationAdd BLAST203
Domaini512 – 625PHPROSITE-ProRule annotationAdd BLAST114

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili651 – 680Sequence analysisAdd BLAST30

Sequence similaritiesi

Belongs to the PSD family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0932. Eukaryota.
COG5307. LUCA.
GeneTreeiENSGT00900000140885.
HOGENOMiHOG000115732.
HOVERGENiHBG108298.
InParanoidiQ9BQI7.
KOiK12494.
OMAiSSMKKFC.
OrthoDBiEOG091G0187.
PhylomeDBiQ9BQI7.
TreeFamiTF319755.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR011993. PH-like_dom_sf.
IPR001605. PH_dom-spectrin-type.
IPR001849. PH_domain.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
IPR035999. Sec7_sf.
PfamiView protein in Pfam
PF01369. Sec7. 1 hit.
PRINTSiPR00683. SPECTRINPH.
SMARTiView protein in SMART
SM00233. PH. 1 hit.
SM00222. Sec7. 1 hit.
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS50003. PH_DOMAIN. 1 hit.
PS50190. SEC7. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BQI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEDKLLSAV PEEGDATRDP GPEPEEEPGV RNGMASEGLN SSLCSPGHER
60 70 80 90 100
RGTPADTEEP TKDPDVAFHG LSLGLSLTNG LALGPDLNIL EDSAESRPWR
110 120 130 140 150
AGVLAEGDNA SRSLYPDAED PQLGLDGPGE PDVRDGFSAT FEKILESELL
160 170 180 190 200
RGTQYSSLDS LDGLSLTDES DSCVSFEAPL TPLIQQRARD SPEPGAGLGI
210 220 230 240 250
GDMAFEGDMG AAGGDGELGS PLRRSISSSR SENVLSRLSL MAMPNGFHED
260 270 280 290 300
GPQGPGGDED DDEEDTDKLL NSASDPSLKD GLSDSDSELS SSEGLEPGSA
310 320 330 340 350
DPLANGCQGV SEAAHRLARR LYHLEGFQRC DVARQLGKNN EFSRLVAGEY
360 370 380 390 400
LSFFDFSGLT LDGALRTFLK AFPLMGETQE RERVLTHFSR RYCQCNPDDS
410 420 430 440 450
TSEDGIHTLT CALMLLNTDL HGHNIGKKMS CQQFIANLDQ LNDGQDFAKD
460 470 480 490 500
LLKTLYNSIK NEKLEWAIDE DELRKSLSEL VDDKFGTGTK KVTRILDGGN
510 520 530 540 550
PFLDVPQALS ATTYKHGVLT RKTHADMDGK RTPRGRRGWK KFYAVLKGTI
560 570 580 590 600
LYLQKDEYRP DKALSEGDLK NAIRVHHALA TRASDYSKKS NVLKLKTADW
610 620 630 640 650
RVFLFQAPSK EEMLSWILRI NLVAAIFSAP AFPAAVSSMK KFCRPLLPSC
660 670 680 690 700
TTRLCQEEQL RSHENKLRQL TAELAEHRCH PVERGIKSKE AEEYRLKEHY
710 720 730 740 750
LTFEKSRYET YIHLLAMKIK VGSDDLERIE ARLATLEGDD PSLRKTHSSP
760 770
ALSQGHVTGS KTTKDATGPD T
Length:771
Mass (Da):84,660
Last modified:November 30, 2010 - v3
Checksum:i3D7E08229429ED78
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04334631R → Q. Corresponds to variant dbSNP:rs34880693Ensembl.1
Natural variantiVAR_04334751R → M. Corresponds to variant dbSNP:rs3797902Ensembl.1
Natural variantiVAR_043348363G → R1 PublicationCorresponds to variant dbSNP:rs35714177Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136559 mRNA. Translation: CAB66494.1.
AC008667 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62088.1.
CH471062 Genomic DNA. Translation: EAW62089.1.
BC038233 mRNA. Translation: AAH38233.1.
AL834268 mRNA. Translation: CAD38943.1.
CCDSiCCDS4216.1.
RefSeqiNP_115665.1. NM_032289.3.
XP_016865465.1. XM_017009976.1.
XP_016865466.1. XM_017009977.1.
UniGeneiHs.21963.

Genome annotation databases

EnsembliENST00000274710; ENSP00000274710; ENSG00000146005.
GeneIDi84249.
KEGGihsa:84249.
UCSCiuc003leu.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPSD2_HUMAN
AccessioniPrimary (citable) accession number: Q9BQI7
Secondary accession number(s): D3DQD3, Q8N3J8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 30, 2010
Last modified: November 22, 2017
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families