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Protein

PH and SEC7 domain-containing protein 2

Gene

PSD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
PH and SEC7 domain-containing protein 2
Alternative name(s):
Pleckstrin homology and SEC7 domain-containing protein 2
Gene namesi
Name:PSD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:19092. PSD2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei622 – 63918HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134885177.

Polymorphism and mutation databases

BioMutaiPSD2.
DMDMi313104198.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 771771PH and SEC7 domain-containing protein 2PRO_0000334162Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei191 – 1911PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BQI7.
PaxDbiQ9BQI7.
PeptideAtlasiQ9BQI7.
PRIDEiQ9BQI7.

PTM databases

iPTMnetiQ9BQI7.
PhosphoSiteiQ9BQI7.

Expressioni

Gene expression databases

BgeeiQ9BQI7.
CleanExiHS_PSD2.
GenevisibleiQ9BQI7. HS.

Organism-specific databases

HPAiHPA050416.
HPA054625.

Interactioni

Protein-protein interaction databases

BioGridi123977. 2 interactions.
STRINGi9606.ENSP00000274710.

Structurei

3D structure databases

ProteinModelPortaliQ9BQI7.
SMRiQ9BQI7. Positions 314-507, 535-740.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini260 – 462203SEC7PROSITE-ProRule annotationAdd
BLAST
Domaini512 – 625114PHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili651 – 68030Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the PSD family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 SEC7 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0932. Eukaryota.
COG5307. LUCA.
GeneTreeiENSGT00760000119036.
HOGENOMiHOG000115732.
HOVERGENiHBG108298.
InParanoidiQ9BQI7.
KOiK12494.
OMAiSSMKKFC.
OrthoDBiEOG7G7KNS.
PhylomeDBiQ9BQI7.
TreeFamiTF319755.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001605. PH_dom-spectrin-type.
IPR001849. PH_domain.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF01369. Sec7. 1 hit.
[Graphical view]
PRINTSiPR00683. SPECTRINPH.
SMARTiSM00233. PH. 1 hit.
SM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BQI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEDKLLSAV PEEGDATRDP GPEPEEEPGV RNGMASEGLN SSLCSPGHER
60 70 80 90 100
RGTPADTEEP TKDPDVAFHG LSLGLSLTNG LALGPDLNIL EDSAESRPWR
110 120 130 140 150
AGVLAEGDNA SRSLYPDAED PQLGLDGPGE PDVRDGFSAT FEKILESELL
160 170 180 190 200
RGTQYSSLDS LDGLSLTDES DSCVSFEAPL TPLIQQRARD SPEPGAGLGI
210 220 230 240 250
GDMAFEGDMG AAGGDGELGS PLRRSISSSR SENVLSRLSL MAMPNGFHED
260 270 280 290 300
GPQGPGGDED DDEEDTDKLL NSASDPSLKD GLSDSDSELS SSEGLEPGSA
310 320 330 340 350
DPLANGCQGV SEAAHRLARR LYHLEGFQRC DVARQLGKNN EFSRLVAGEY
360 370 380 390 400
LSFFDFSGLT LDGALRTFLK AFPLMGETQE RERVLTHFSR RYCQCNPDDS
410 420 430 440 450
TSEDGIHTLT CALMLLNTDL HGHNIGKKMS CQQFIANLDQ LNDGQDFAKD
460 470 480 490 500
LLKTLYNSIK NEKLEWAIDE DELRKSLSEL VDDKFGTGTK KVTRILDGGN
510 520 530 540 550
PFLDVPQALS ATTYKHGVLT RKTHADMDGK RTPRGRRGWK KFYAVLKGTI
560 570 580 590 600
LYLQKDEYRP DKALSEGDLK NAIRVHHALA TRASDYSKKS NVLKLKTADW
610 620 630 640 650
RVFLFQAPSK EEMLSWILRI NLVAAIFSAP AFPAAVSSMK KFCRPLLPSC
660 670 680 690 700
TTRLCQEEQL RSHENKLRQL TAELAEHRCH PVERGIKSKE AEEYRLKEHY
710 720 730 740 750
LTFEKSRYET YIHLLAMKIK VGSDDLERIE ARLATLEGDD PSLRKTHSSP
760 770
ALSQGHVTGS KTTKDATGPD T
Length:771
Mass (Da):84,660
Last modified:November 30, 2010 - v3
Checksum:i3D7E08229429ED78
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311R → Q.
Corresponds to variant rs34880693 [ dbSNP | Ensembl ].
VAR_043346
Natural varianti51 – 511R → M.
Corresponds to variant rs3797902 [ dbSNP | Ensembl ].
VAR_043347
Natural varianti363 – 3631G → R.1 Publication
Corresponds to variant rs35714177 [ dbSNP | Ensembl ].
VAR_043348

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136559 mRNA. Translation: CAB66494.1.
AC008667 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62088.1.
CH471062 Genomic DNA. Translation: EAW62089.1.
BC038233 mRNA. Translation: AAH38233.1.
AL834268 mRNA. Translation: CAD38943.1.
CCDSiCCDS4216.1.
RefSeqiNP_115665.1. NM_032289.2.
UniGeneiHs.21963.

Genome annotation databases

EnsembliENST00000274710; ENSP00000274710; ENSG00000146005.
GeneIDi84249.
KEGGihsa:84249.
UCSCiuc003leu.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136559 mRNA. Translation: CAB66494.1.
AC008667 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW62088.1.
CH471062 Genomic DNA. Translation: EAW62089.1.
BC038233 mRNA. Translation: AAH38233.1.
AL834268 mRNA. Translation: CAD38943.1.
CCDSiCCDS4216.1.
RefSeqiNP_115665.1. NM_032289.2.
UniGeneiHs.21963.

3D structure databases

ProteinModelPortaliQ9BQI7.
SMRiQ9BQI7. Positions 314-507, 535-740.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123977. 2 interactions.
STRINGi9606.ENSP00000274710.

PTM databases

iPTMnetiQ9BQI7.
PhosphoSiteiQ9BQI7.

Polymorphism and mutation databases

BioMutaiPSD2.
DMDMi313104198.

Proteomic databases

EPDiQ9BQI7.
PaxDbiQ9BQI7.
PeptideAtlasiQ9BQI7.
PRIDEiQ9BQI7.

Protocols and materials databases

DNASUi84249.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274710; ENSP00000274710; ENSG00000146005.
GeneIDi84249.
KEGGihsa:84249.
UCSCiuc003leu.2. human.

Organism-specific databases

CTDi84249.
GeneCardsiPSD2.
HGNCiHGNC:19092. PSD2.
HPAiHPA050416.
HPA054625.
neXtProtiNX_Q9BQI7.
PharmGKBiPA134885177.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0932. Eukaryota.
COG5307. LUCA.
GeneTreeiENSGT00760000119036.
HOGENOMiHOG000115732.
HOVERGENiHBG108298.
InParanoidiQ9BQI7.
KOiK12494.
OMAiSSMKKFC.
OrthoDBiEOG7G7KNS.
PhylomeDBiQ9BQI7.
TreeFamiTF319755.

Miscellaneous databases

GenomeRNAii84249.
PROiQ9BQI7.

Gene expression databases

BgeeiQ9BQI7.
CleanExiHS_PSD2.
GenevisibleiQ9BQI7. HS.

Family and domain databases

Gene3Di1.10.1000.11. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001605. PH_dom-spectrin-type.
IPR001849. PH_domain.
IPR023394. Sec7_alpha_orthog.
IPR000904. Sec7_dom.
[Graphical view]
PfamiPF01369. Sec7. 1 hit.
[Graphical view]
PRINTSiPR00683. SPECTRINPH.
SMARTiSM00233. PH. 1 hit.
SM00222. Sec7. 1 hit.
[Graphical view]
SUPFAMiSSF48425. SSF48425. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50190. SEC7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 339-771, VARIANT ARG-363.
    Tissue: Amygdala.

Entry informationi

Entry nameiPSD2_HUMAN
AccessioniPrimary (citable) accession number: Q9BQI7
Secondary accession number(s): D3DQD3, Q8N3J8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 30, 2010
Last modified: July 6, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.