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Protein

PH and SEC7 domain-containing protein 2

Gene

PSD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
PH and SEC7 domain-containing protein 2
Alternative name(s):
Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C
Short name:
Exchange factor for ARF6 C
Pleckstrin homology and SEC7 domain-containing protein 2
Gene namesi
Name:PSD2
Synonyms:EFA6C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000146005.3
HGNCiHGNC:19092 PSD2
neXtProtiNX_Q9BQI7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei622 – 639HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84249
OpenTargetsiENSG00000146005
PharmGKBiPA134885177

Polymorphism and mutation databases

BioMutaiPSD2
DMDMi313104198

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003341621 – 771PH and SEC7 domain-containing protein 2Add BLAST771

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei191PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9BQI7
PeptideAtlasiQ9BQI7
PRIDEiQ9BQI7

PTM databases

iPTMnetiQ9BQI7
PhosphoSitePlusiQ9BQI7

Expressioni

Gene expression databases

BgeeiENSG00000146005
CleanExiHS_PSD2
GenevisibleiQ9BQI7 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123977, 12 interactors
STRINGi9606.ENSP00000274710

Structurei

3D structure databases

ProteinModelPortaliQ9BQI7
SMRiQ9BQI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini260 – 462SEC7PROSITE-ProRule annotationAdd BLAST203
Domaini512 – 625PHPROSITE-ProRule annotationAdd BLAST114

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili651 – 680Sequence analysisAdd BLAST30

Sequence similaritiesi

Belongs to the PSD family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0932 Eukaryota
COG5307 LUCA
GeneTreeiENSGT00760000119036
HOGENOMiHOG000115732
HOVERGENiHBG108298
InParanoidiQ9BQI7
KOiK12494
OMAiSSMKKFC
OrthoDBiEOG091G0187
PhylomeDBiQ9BQI7
TreeFamiTF319755

Family and domain databases

Gene3Di1.10.1000.11, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001605 PH_dom-spectrin-type
IPR001849 PH_domain
IPR023394 Sec7_C_sf
IPR000904 Sec7_dom
IPR035999 Sec7_dom_sf
PfamiView protein in Pfam
PF01369 Sec7, 1 hit
PRINTSiPR00683 SPECTRINPH
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00222 Sec7, 1 hit
SUPFAMiSSF48425 SSF48425, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50190 SEC7, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BQI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEDKLLSAV PEEGDATRDP GPEPEEEPGV RNGMASEGLN SSLCSPGHER
60 70 80 90 100
RGTPADTEEP TKDPDVAFHG LSLGLSLTNG LALGPDLNIL EDSAESRPWR
110 120 130 140 150
AGVLAEGDNA SRSLYPDAED PQLGLDGPGE PDVRDGFSAT FEKILESELL
160 170 180 190 200
RGTQYSSLDS LDGLSLTDES DSCVSFEAPL TPLIQQRARD SPEPGAGLGI
210 220 230 240 250
GDMAFEGDMG AAGGDGELGS PLRRSISSSR SENVLSRLSL MAMPNGFHED
260 270 280 290 300
GPQGPGGDED DDEEDTDKLL NSASDPSLKD GLSDSDSELS SSEGLEPGSA
310 320 330 340 350
DPLANGCQGV SEAAHRLARR LYHLEGFQRC DVARQLGKNN EFSRLVAGEY
360 370 380 390 400
LSFFDFSGLT LDGALRTFLK AFPLMGETQE RERVLTHFSR RYCQCNPDDS
410 420 430 440 450
TSEDGIHTLT CALMLLNTDL HGHNIGKKMS CQQFIANLDQ LNDGQDFAKD
460 470 480 490 500
LLKTLYNSIK NEKLEWAIDE DELRKSLSEL VDDKFGTGTK KVTRILDGGN
510 520 530 540 550
PFLDVPQALS ATTYKHGVLT RKTHADMDGK RTPRGRRGWK KFYAVLKGTI
560 570 580 590 600
LYLQKDEYRP DKALSEGDLK NAIRVHHALA TRASDYSKKS NVLKLKTADW
610 620 630 640 650
RVFLFQAPSK EEMLSWILRI NLVAAIFSAP AFPAAVSSMK KFCRPLLPSC
660 670 680 690 700
TTRLCQEEQL RSHENKLRQL TAELAEHRCH PVERGIKSKE AEEYRLKEHY
710 720 730 740 750
LTFEKSRYET YIHLLAMKIK VGSDDLERIE ARLATLEGDD PSLRKTHSSP
760 770
ALSQGHVTGS KTTKDATGPD T
Length:771
Mass (Da):84,660
Last modified:November 30, 2010 - v3
Checksum:i3D7E08229429ED78
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04334631R → Q. Corresponds to variant dbSNP:rs34880693Ensembl.1
Natural variantiVAR_04334751R → M. Corresponds to variant dbSNP:rs3797902Ensembl.1
Natural variantiVAR_043348363G → R1 PublicationCorresponds to variant dbSNP:rs35714177Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136559 mRNA Translation: CAB66494.1
AC008667 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW62088.1
CH471062 Genomic DNA Translation: EAW62089.1
BC038233 mRNA Translation: AAH38233.1
AL834268 mRNA Translation: CAD38943.1
CCDSiCCDS4216.1
RefSeqiNP_115665.1, NM_032289.3
XP_016865465.1, XM_017009976.1
XP_016865466.1, XM_017009977.1
UniGeneiHs.21963

Genome annotation databases

EnsembliENST00000274710; ENSP00000274710; ENSG00000146005
GeneIDi84249
KEGGihsa:84249
UCSCiuc003leu.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPSD2_HUMAN
AccessioniPrimary (citable) accession number: Q9BQI7
Secondary accession number(s): D3DQD3, Q8N3J8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 30, 2010
Last modified: March 28, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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