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Q9BQI5

- SGIP1_HUMAN

UniProt

Q9BQI5 - SGIP1_HUMAN

Protein

SH3-containing GRB2-like protein 3-interacting protein 1

Gene

SGIP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis By similarity.By similarity

    GO - Molecular functioni

    1. microtubule binding Source: UniProtKB
    2. phospholipid binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. SH3 domain binding Source: UniProtKB

    GO - Biological processi

    1. endocytosis Source: UniProtKB-KW
    2. positive regulation of energy homeostasis Source: UniProtKB
    3. positive regulation of feeding behavior Source: UniProtKB
    4. positive regulation of receptor-mediated endocytosis Source: UniProtKB
    5. response to dietary excess Source: UniProtKB

    Keywords - Biological processi

    Endocytosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SH3-containing GRB2-like protein 3-interacting protein 1
    Alternative name(s):
    Endophilin-3-interacting protein
    Gene namesi
    Name:SGIP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25412. SGIP1.

    Subcellular locationi

    Membraneclathrin-coated pit 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication

    GO - Cellular componenti

    1. AP-2 adaptor complex Source: UniProtKB
    2. clathrin-coated vesicle Source: UniProtKB
    3. coated pit Source: UniProtKB
    4. cytoplasm Source: LIFEdb
    5. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Coated pit, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134909202.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 828828SH3-containing GRB2-like protein 3-interacting protein 1PRO_0000248395Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei300 – 3001PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9BQI5.
    PRIDEiQ9BQI5.

    PTM databases

    PhosphoSiteiQ9BQI5.

    Expressioni

    Tissue specificityi

    Specifically expressed in brain.1 Publication

    Gene expression databases

    ArrayExpressiQ9BQI5.
    BgeeiQ9BQI5.
    GenevestigatoriQ9BQI5.

    Organism-specific databases

    HPAiHPA017963.

    Interactioni

    Subunit structurei

    Interacts with proteins essential or regulating the formation of functional clathrin-coated pits. Interacts with CANX By similarity. Interacts with AP2A1 By similarity. Interacts with EPS15 By similarity. Interacts with SH3GL3. Interacts with AMPH. Interacts with ITSN1 (via SH3 domains). Interacts with and REPS1.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi123979. 4 interactions.
    IntActiQ9BQI5. 1 interaction.
    MINTiMINT-4534029.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BQI5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini559 – 827269MHDPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni649 – 828180Necessary and sufficient to mediate interaction with CANXBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi106 – 1127Poly-Glu
    Compositional biasi176 – 499324Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MHD (mu homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG324072.
    HOVERGENiHBG081524.
    OMAiNTEEKWV.
    OrthoDBiEOG712TVK.
    PhylomeDBiQ9BQI5.
    TreeFamiTF328986.

    Family and domain databases

    InterProiIPR028565. MHD.
    IPR018808. Muniscin_C.
    [Graphical view]
    PfamiPF10291. muHD. 1 hit.
    [Graphical view]
    SUPFAMiSSF49447. SSF49447. 1 hit.
    PROSITEiPS51072. MHD. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BQI5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMEGLKKRTR KAFGIRKKEK DTDSTGSPDR DGIQPSPHEP PYNSKAECAR    50
    EGGKKVSKKS NGAPNGFYAE IDWERYNSPE LDEEGYSIRP EEPGSTKGKH 100
    FYSSSESEEE EESHKKFNIK IKPLQSKDIL KNAATVDELK ASIGNIALSP 150
    SPVRKSPRRS PGAIKRNLSS EEVARPRRST PTPELISKKP PDDTTALAPL 200
    FGPPLESAFD EQKTEVLLDQ PEIWGSGQPI NPSMESPKLT RPFPTGTPPP 250
    LPPKNVPATP PRTGSPLTIG PGNDQSATEV KIEKLPSIND LDSIFGPVLS 300
    PKSVAVNAEE KWVHFSDTSP EHVTPELTPR EKVVSPPATP DNPADSPAPG 350
    PLGPPGPTGP PGPPGPPRNV LSPLNLEEVQ KKVAEQTFIK DDYLETISSP 400
    KDFGLGQRAT PPPPPPPTYR TVVSSPGPGS GPGPGTTSGA SSPARPATPL 450
    VPCRSTTPPP PPPRPPSRPK LPPGKPGVGD VSRPFSPPIH SSSPPPIAPL 500
    ARAESTSSIS STNSLSAATT PTVENEQPSL VWFDRGKFYL TFEGSSRGPS 550
    PLTMGAQDTL PVAAAFTETV NAYFKGADPS KCIVKITGEM VLSFPAGITR 600
    HFANNPSPAA LTFRVINFSR LEHVLPNPQL LCCDNTQNDA NTKEFWVNMP 650
    NLMTHLKKVS EQKPQATYYN VDMLKYQVSA QGIQSTPLNL AVNWRCEPSS 700
    TDLRIDYKYN TDAMTTAVAL NNVQFLVPID GGVTKLQAVL PPAVWNAEQQ 750
    RILWKIPDIS QKSENGGVGS LLARFQLSEG PSKPSPLVVQ FTSEGSTLSG 800
    CDIELVGAGY RFSLIKKRFA AGKYLADN 828
    Length:828
    Mass (Da):89,109
    Last modified:September 5, 2006 - v2
    Checksum:i86D2B6AE3099CDEA
    GO
    Isoform 2 (identifier: Q9BQI5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         35-57: PSPHEPPYNSKAECAREGGKKVS → GKKKTQKTQLLLTSCFWLRALSLTLSQ

    Show »
    Length:832
    Mass (Da):89,734
    Checksum:i67A0B74D0A09918D
    GO
    Isoform 3 (identifier: Q9BQI5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         35-57: PSPHEPPYNSKAECAREGGKKVS → GKKKTQKTQLLLTSCFWLRALSLTLSQ
         437-437: T → TSDGKTEAQRYQVICPSLQAGGNELDSY

    Note: No experimental confirmation available.

    Show »
    Length:859
    Mass (Da):92,646
    Checksum:i823A19AEAB727F86
    GO
    Isoform 4 (identifier: Q9BQI5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         34-57: Missing.
         154-161: Missing.
         272-438: Missing.

    Show »
    Length:629
    Mass (Da):68,240
    Checksum:iB42E8BBA6AF8B3A2
    GO
    Isoform 5 (identifier: Q9BQI5-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         34-57: Missing.
         154-161: Missing.
         272-438: Missing.
         524-543: ENEQPSLVWFDRGKFYLTFE → VSEDDVFYDKLPSFERRCETPA

    Show »
    Length:631
    Mass (Da):68,338
    Checksum:iAA5403263C766B24
    GO

    Sequence cautioni

    The sequence BAE06121.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti81 – 811L → V in CAH18344. (PubMed:17974005)Curated
    Sequence conflicti212 – 2121Q → R in CAH18344. (PubMed:17974005)Curated
    Sequence conflicti498 – 4981A → V in CAH18344. (PubMed:17974005)Curated
    Sequence conflicti772 – 7721L → S in CAH18344. (PubMed:17974005)Curated

    Polymorphismi

    Genetic variation in SGIP1 is associated with fat mass and SGIP1 may be a determinant of obesity-related traits.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti112 – 1121E → Q.
    Corresponds to variant rs17490057 [ dbSNP | Ensembl ].
    VAR_027297
    Natural varianti131 – 1311K → R.3 Publications
    Corresponds to variant rs7526812 [ dbSNP | Ensembl ].
    VAR_027298
    Natural varianti161 – 1611P → Q.1 Publication
    Corresponds to variant rs17855645 [ dbSNP | Ensembl ].
    VAR_027299
    Natural varianti575 – 5751K → E.1 Publication
    Corresponds to variant rs17854026 [ dbSNP | Ensembl ].
    VAR_027300

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei34 – 5724Missing in isoform 4 and isoform 5. 1 PublicationVSP_020273Add
    BLAST
    Alternative sequencei35 – 5723PSPHE…GKKVS → GKKKTQKTQLLLTSCFWLRA LSLTLSQ in isoform 2 and isoform 3. 2 PublicationsVSP_020274Add
    BLAST
    Alternative sequencei154 – 1618Missing in isoform 4 and isoform 5. 1 PublicationVSP_020275
    Alternative sequencei272 – 438167Missing in isoform 4 and isoform 5. 1 PublicationVSP_020276Add
    BLAST
    Alternative sequencei437 – 4371T → TSDGKTEAQRYQVICPSLQA GGNELDSY in isoform 3. 1 PublicationVSP_020277
    Alternative sequencei524 – 54320ENEQP…YLTFE → VSEDDVFYDKLPSFERRCET PA in isoform 5. 1 PublicationVSP_020278Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136561 mRNA. Translation: CAB66496.1.
    AB210039 mRNA. Translation: BAE06121.1. Different initiation.
    BX640813 mRNA. Translation: CAE45891.1.
    CR749541 mRNA. Translation: CAH18344.1.
    AL354978, AL139147, AL356913 Genomic DNA. Translation: CAH71845.1.
    AL354978, AL139147, AL356913 Genomic DNA. Translation: CAH71846.1.
    AL354978, AL139147, AL356913 Genomic DNA. Translation: CAH71847.1.
    AL139147, AL354978, AL356913 Genomic DNA. Translation: CAI21942.1.
    AL139147, AL354978, AL356913 Genomic DNA. Translation: CAI21943.1.
    AL139147, AL354978, AL356913 Genomic DNA. Translation: CAI21944.1.
    AL356913, AL139147, AL354978 Genomic DNA. Translation: CAI22672.1.
    AL356913, AL139147, AL354978 Genomic DNA. Translation: CAI22673.1.
    AL356913, AL139147, AL354978 Genomic DNA. Translation: CAI22674.1.
    BC040516 mRNA. Translation: AAH40516.1.
    CCDSiCCDS30744.1. [Q9BQI5-1]
    RefSeqiNP_115667.2. NM_032291.2. [Q9BQI5-1]
    XP_005271321.1. XM_005271264.2. [Q9BQI5-2]
    XP_005271327.1. XM_005271270.2. [Q9BQI5-4]
    UniGeneiHs.132121.

    Genome annotation databases

    EnsembliENST00000237247; ENSP00000237247; ENSG00000118473. [Q9BQI5-3]
    ENST00000371037; ENSP00000360076; ENSG00000118473. [Q9BQI5-1]
    ENST00000371039; ENSP00000360078; ENSG00000118473. [Q9BQI5-5]
    GeneIDi84251.
    KEGGihsa:84251.
    UCSCiuc001dcr.3. human. [Q9BQI5-1]
    uc009wat.3. human. [Q9BQI5-3]

    Polymorphism databases

    DMDMi114152158.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136561 mRNA. Translation: CAB66496.1 .
    AB210039 mRNA. Translation: BAE06121.1 . Different initiation.
    BX640813 mRNA. Translation: CAE45891.1 .
    CR749541 mRNA. Translation: CAH18344.1 .
    AL354978 , AL139147 , AL356913 Genomic DNA. Translation: CAH71845.1 .
    AL354978 , AL139147 , AL356913 Genomic DNA. Translation: CAH71846.1 .
    AL354978 , AL139147 , AL356913 Genomic DNA. Translation: CAH71847.1 .
    AL139147 , AL354978 , AL356913 Genomic DNA. Translation: CAI21942.1 .
    AL139147 , AL354978 , AL356913 Genomic DNA. Translation: CAI21943.1 .
    AL139147 , AL354978 , AL356913 Genomic DNA. Translation: CAI21944.1 .
    AL356913 , AL139147 , AL354978 Genomic DNA. Translation: CAI22672.1 .
    AL356913 , AL139147 , AL354978 Genomic DNA. Translation: CAI22673.1 .
    AL356913 , AL139147 , AL354978 Genomic DNA. Translation: CAI22674.1 .
    BC040516 mRNA. Translation: AAH40516.1 .
    CCDSi CCDS30744.1. [Q9BQI5-1 ]
    RefSeqi NP_115667.2. NM_032291.2. [Q9BQI5-1 ]
    XP_005271321.1. XM_005271264.2. [Q9BQI5-2 ]
    XP_005271327.1. XM_005271270.2. [Q9BQI5-4 ]
    UniGenei Hs.132121.

    3D structure databases

    ProteinModelPortali Q9BQI5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123979. 4 interactions.
    IntActi Q9BQI5. 1 interaction.
    MINTi MINT-4534029.

    PTM databases

    PhosphoSitei Q9BQI5.

    Polymorphism databases

    DMDMi 114152158.

    Proteomic databases

    PaxDbi Q9BQI5.
    PRIDEi Q9BQI5.

    Protocols and materials databases

    DNASUi 84251.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000237247 ; ENSP00000237247 ; ENSG00000118473 . [Q9BQI5-3 ]
    ENST00000371037 ; ENSP00000360076 ; ENSG00000118473 . [Q9BQI5-1 ]
    ENST00000371039 ; ENSP00000360078 ; ENSG00000118473 . [Q9BQI5-5 ]
    GeneIDi 84251.
    KEGGi hsa:84251.
    UCSCi uc001dcr.3. human. [Q9BQI5-1 ]
    uc009wat.3. human. [Q9BQI5-3 ]

    Organism-specific databases

    CTDi 84251.
    GeneCardsi GC01P066999.
    H-InvDB HIX0000678.
    HGNCi HGNC:25412. SGIP1.
    HPAi HPA017963.
    MIMi 611540. gene.
    neXtProti NX_Q9BQI5.
    PharmGKBi PA134909202.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG324072.
    HOVERGENi HBG081524.
    OMAi NTEEKWV.
    OrthoDBi EOG712TVK.
    PhylomeDBi Q9BQI5.
    TreeFami TF328986.

    Miscellaneous databases

    ChiTaRSi SGIP1. human.
    GeneWikii SGIP1.
    GenomeRNAii 84251.
    NextBioi 73748.
    PROi Q9BQI5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BQI5.
    Bgeei Q9BQI5.
    Genevestigatori Q9BQI5.

    Family and domain databases

    InterProi IPR028565. MHD.
    IPR018808. Muniscin_C.
    [Graphical view ]
    Pfami PF10291. muHD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49447. SSF49447. 1 hit.
    PROSITEi PS51072. MHD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-131.
      Tissue: Amygdala.
    2. "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
      Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-131.
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5), VARIANT ARG-131.
      Tissue: Colon endothelium and Small intestine.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS GLN-161 AND GLU-575.
      Tissue: Hippocampus.
    6. "Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance."
      Trevaskis J., Walder K., Foletta V., Kerr-Bayles L., McMillan J., Cooper A., Lee S., Bolton K., Prior M., Fahey R., Whitecross K., Morton G.J., Schwartz M.W., Collier G.R.
      Endocrinology 146:3757-3764(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INTERACTION WITH SH3GL3.
    7. "Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits."
      Dergai O., Novokhatska O., Dergai M., Skrypkina I., Tsyba L., Moreau J., Rynditch A.
      Biochem. Biophys. Res. Commun. 402:408-413(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AMPH; ITSN1 AND REPS1, SUBCELLULAR LOCATION.
    8. Cited for: POLYMORPHISM.

    Entry informationi

    Entry nameiSGIP1_HUMAN
    AccessioniPrimary (citable) accession number: Q9BQI5
    Secondary accession number(s): A6NL81
    , A6NLD1, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3