Q9BQI5 (SGIP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SH3-containing GRB2-like protein 3-interacting protein 1

Alternative name(s):
Endophilin-3-interacting protein

Gene names

Name:

SGIP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	828 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis By similarity.
Subunit structure	Interacts with proteins essential or regulating the formation of functional clathrin-coated pits. Interacts with CANX By similarity. Interacts with AP2A1 By similarity. Interacts with EPS15 By similarity. Interacts with SH3GL3. Interacts with AMPH. Interacts with ITSN1 (via SH3 domains). Interacts with and REPS1. Ref.6 Ref.7
Subcellular location	Membrane › clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side Probable Ref.7.
Tissue specificity	Specifically expressed in brain. Ref.6
Polymorphism	Genetic variation in SGIP1 is associated with fat mass and SGIP1 may be a determinant of obesity-related traits.
Sequence similarities	Contains 1 MUHD (Muniscin C-terminal mu homology domain) domain.
Sequence caution	The sequence BAE06121.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Endocytosis
Cellular component	Coated pit Membrane
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	endocytosis Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of energy homeostasis Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of feeding behavior Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of receptor-mediated endocytosis Inferred from sequence or structural similarity. Source: UniProtKB response to dietary excess Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	AP-2 adaptor complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	microtubule binding Inferred from sequence or structural similarity. Source: UniProtKB phospholipid binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9BQI5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BQI5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     35-57: PSPHEPPYNSKAECAREGGKKVS → GKKKTQKTQLLLTSCFWLRALSLTLSQ

Isoform 3 (identifier: Q9BQI5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     35-57: PSPHEPPYNSKAECAREGGKKVS → GKKKTQKTQLLLTSCFWLRALSLTLSQ
     437-437: T → TSDGKTEAQRYQVICPSLQAGGNELDSY

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9BQI5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     34-57: Missing.
     154-161: Missing.
     272-438: Missing.

Isoform 5 (identifier: Q9BQI5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     34-57: Missing.
     154-161: Missing.
     272-438: Missing.
     524-543: ENEQPSLVWFDRGKFYLTFE → VSEDDVFYDKLPSFERRCETPA

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 828	828	SH3-containing GRB2-like protein 3-interacting protein 1		PRO_0000248395
Regions
	Domain	559 – 826	268	MUHD
	Region	649 – 828	180	Necessary and sufficient to mediate interaction with CANX By similarity
	Compositional bias	106 – 112	7	Poly-Glu
	Compositional bias	176 – 499	324	Pro-rich
Amino acid modifications
	Modified residue	169	1	Phosphoserine By similarity
	Modified residue	180	1	Phosphothreonine By similarity
	Modified residue	182	1	Phosphothreonine By similarity
	Modified residue	259	1	Phosphothreonine By similarity
	Modified residue	263	1	Phosphothreonine By similarity
	Modified residue	265	1	Phosphoserine By similarity
	Modified residue	268	1	Phosphothreonine By similarity
	Modified residue	287	1	Phosphoserine By similarity
	Modified residue	300	1	Phosphoserine By similarity
	Modified residue	316	1	Phosphoserine By similarity
	Modified residue	319	1	Phosphoserine By similarity
	Modified residue	324	1	Phosphothreonine By similarity
	Modified residue	372	1	Phosphoserine By similarity
	Modified residue	410	1	Phosphothreonine By similarity
Natural variations
	Alternative sequence	34 – 57	24	Missing in isoform 4 and isoform 5.		VSP_020273
	Alternative sequence	35 – 57	23	PSPHE…GKKVS → GKKKTQKTQLLLTSCFWLRA LSLTLSQ in isoform 2 and isoform 3.		VSP_020274
	Alternative sequence	154 – 161	8	Missing in isoform 4 and isoform 5.		VSP_020275
	Alternative sequence	272 – 438	167	Missing in isoform 4 and isoform 5.		VSP_020276
	Alternative sequence	437	1	T → TSDGKTEAQRYQVICPSLQA GGNELDSY in isoform 3.		VSP_020277
	Alternative sequence	524 – 543	20	ENEQP…YLTFE → VSEDDVFYDKLPSFERRCET PA in isoform 5.		VSP_020278
	Natural variant	112	1	E → Q. Corresponds to variant rs17490057 [ dbSNP | Ensembl ].		VAR_027297
	Natural variant	131	1	K → R. Ref.1 Ref.2 Ref.3 Corresponds to variant rs7526812 [ dbSNP | Ensembl ].		VAR_027298
	Natural variant	161	1	P → Q. Ref.5 Corresponds to variant rs17855645 [ dbSNP | Ensembl ].		VAR_027299
	Natural variant	575	1	K → E. Ref.5 Corresponds to variant rs17854026 [ dbSNP | Ensembl ].		VAR_027300
Experimental info
	Sequence conflict	81	1	L → V in CAH18344. Ref.3
	Sequence conflict	212	1	Q → R in CAH18344. Ref.3
	Sequence conflict	498	1	A → V in CAH18344. Ref.3
	Sequence conflict	772	1	L → S in CAH18344. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 5, 2006. Version 2. Checksum: 86D2B6AE3099CDEA	FASTA	828	89,109
	10 20 30 40 50 60 MMEGLKKRTR KAFGIRKKEK DTDSTGSPDR DGIQPSPHEP PYNSKAECAR EGGKKVSKKS 70 80 90 100 110 120 NGAPNGFYAE IDWERYNSPE LDEEGYSIRP EEPGSTKGKH FYSSSESEEE EESHKKFNIK 130 140 150 160 170 180 IKPLQSKDIL KNAATVDELK ASIGNIALSP SPVRKSPRRS PGAIKRNLSS EEVARPRRST 190 200 210 220 230 240 PTPELISKKP PDDTTALAPL FGPPLESAFD EQKTEVLLDQ PEIWGSGQPI NPSMESPKLT 250 260 270 280 290 300 RPFPTGTPPP LPPKNVPATP PRTGSPLTIG PGNDQSATEV KIEKLPSIND LDSIFGPVLS 310 320 330 340 350 360 PKSVAVNAEE KWVHFSDTSP EHVTPELTPR EKVVSPPATP DNPADSPAPG PLGPPGPTGP 370 380 390 400 410 420 PGPPGPPRNV LSPLNLEEVQ KKVAEQTFIK DDYLETISSP KDFGLGQRAT PPPPPPPTYR 430 440 450 460 470 480 TVVSSPGPGS GPGPGTTSGA SSPARPATPL VPCRSTTPPP PPPRPPSRPK LPPGKPGVGD 490 500 510 520 530 540 VSRPFSPPIH SSSPPPIAPL ARAESTSSIS STNSLSAATT PTVENEQPSL VWFDRGKFYL 550 560 570 580 590 600 TFEGSSRGPS PLTMGAQDTL PVAAAFTETV NAYFKGADPS KCIVKITGEM VLSFPAGITR 610 620 630 640 650 660 HFANNPSPAA LTFRVINFSR LEHVLPNPQL LCCDNTQNDA NTKEFWVNMP NLMTHLKKVS 670 680 690 700 710 720 EQKPQATYYN VDMLKYQVSA QGIQSTPLNL AVNWRCEPSS TDLRIDYKYN TDAMTTAVAL 730 740 750 760 770 780 NNVQFLVPID GGVTKLQAVL PPAVWNAEQQ RILWKIPDIS QKSENGGVGS LLARFQLSEG 790 800 810 820 PSKPSPLVVQ FTSEGSTLSG CDIELVGAGY RFSLIKKRFA AGKYLADN
	Isoform 2 [UniParc]. Checksum: 67A0B74D0A09918D	FASTA	832	89,734
	10 20 30 40 50 60 MMEGLKKRTR KAFGIRKKEK DTDSTGSPDR DGIQGKKKTQ KTQLLLTSCF WLRALSLTLS 70 80 90 100 110 120 QKKSNGAPNG FYAEIDWERY NSPELDEEGY SIRPEEPGST KGKHFYSSSE SEEEEESHKK 130 140 150 160 170 180 FNIKIKPLQS KDILKNAATV DELKASIGNI ALSPSPVRKS PRRSPGAIKR NLSSEEVARP 190 200 210 220 230 240 RRSTPTPELI SKKPPDDTTA LAPLFGPPLE SAFDEQKTEV LLDQPEIWGS GQPINPSMES 250 260 270 280 290 300 PKLTRPFPTG TPPPLPPKNV PATPPRTGSP LTIGPGNDQS ATEVKIEKLP SINDLDSIFG 310 320 330 340 350 360 PVLSPKSVAV NAEEKWVHFS DTSPEHVTPE LTPREKVVSP PATPDNPADS PAPGPLGPPG 370 380 390 400 410 420 PTGPPGPPGP PRNVLSPLNL EEVQKKVAEQ TFIKDDYLET ISSPKDFGLG QRATPPPPPP 430 440 450 460 470 480 PTYRTVVSSP GPGSGPGPGT TSGASSPARP ATPLVPCRST TPPPPPPRPP SRPKLPPGKP 490 500 510 520 530 540 GVGDVSRPFS PPIHSSSPPP IAPLARAEST SSISSTNSLS AATTPTVENE QPSLVWFDRG 550 560 570 580 590 600 KFYLTFEGSS RGPSPLTMGA QDTLPVAAAF TETVNAYFKG ADPSKCIVKI TGEMVLSFPA 610 620 630 640 650 660 GITRHFANNP SPAALTFRVI NFSRLEHVLP NPQLLCCDNT QNDANTKEFW VNMPNLMTHL 670 680 690 700 710 720 KKVSEQKPQA TYYNVDMLKY QVSAQGIQST PLNLAVNWRC EPSSTDLRID YKYNTDAMTT 730 740 750 760 770 780 AVALNNVQFL VPIDGGVTKL QAVLPPAVWN AEQQRILWKI PDISQKSENG GVGSLLARFQ 790 800 810 820 830 LSEGPSKPSP LVVQFTSEGS TLSGCDIELV GAGYRFSLIK KRFAAGKYLA DN
	Isoform 3 [UniParc]. Checksum: 823A19AEAB727F86	FASTA	859	92,646
	10 20 30 40 50 60 MMEGLKKRTR KAFGIRKKEK DTDSTGSPDR DGIQGKKKTQ KTQLLLTSCF WLRALSLTLS 70 80 90 100 110 120 QKKSNGAPNG FYAEIDWERY NSPELDEEGY SIRPEEPGST KGKHFYSSSE SEEEEESHKK 130 140 150 160 170 180 FNIKIKPLQS KDILKNAATV DELKASIGNI ALSPSPVRKS PRRSPGAIKR NLSSEEVARP 190 200 210 220 230 240 RRSTPTPELI SKKPPDDTTA LAPLFGPPLE SAFDEQKTEV LLDQPEIWGS GQPINPSMES 250 260 270 280 290 300 PKLTRPFPTG TPPPLPPKNV PATPPRTGSP LTIGPGNDQS ATEVKIEKLP SINDLDSIFG 310 320 330 340 350 360 PVLSPKSVAV NAEEKWVHFS DTSPEHVTPE LTPREKVVSP PATPDNPADS PAPGPLGPPG 370 380 390 400 410 420 PTGPPGPPGP PRNVLSPLNL EEVQKKVAEQ TFIKDDYLET ISSPKDFGLG QRATPPPPPP 430 440 450 460 470 480 PTYRTVVSSP GPGSGPGPGT TSDGKTEAQR YQVICPSLQA GGNELDSYSG ASSPARPATP 490 500 510 520 530 540 LVPCRSTTPP PPPPRPPSRP KLPPGKPGVG DVSRPFSPPI HSSSPPPIAP LARAESTSSI 550 560 570 580 590 600 SSTNSLSAAT TPTVENEQPS LVWFDRGKFY LTFEGSSRGP SPLTMGAQDT LPVAAAFTET 610 620 630 640 650 660 VNAYFKGADP SKCIVKITGE MVLSFPAGIT RHFANNPSPA ALTFRVINFS RLEHVLPNPQ 670 680 690 700 710 720 LLCCDNTQND ANTKEFWVNM PNLMTHLKKV SEQKPQATYY NVDMLKYQVS AQGIQSTPLN 730 740 750 760 770 780 LAVNWRCEPS STDLRIDYKY NTDAMTTAVA LNNVQFLVPI DGGVTKLQAV LPPAVWNAEQ 790 800 810 820 830 840 QRILWKIPDI SQKSENGGVG SLLARFQLSE GPSKPSPLVV QFTSEGSTLS GCDIELVGAG 850 YRFSLIKKRF AAGKYLADN
	Isoform 4 [UniParc]. Checksum: B42E8BBA6AF8B3A2	FASTA	629	68,240
	10 20 30 40 50 60 MMEGLKKRTR KAFGIRKKEK DTDSTGSPDR DGIKKSNGAP NGFYAEIDWE RYNSPELDEE 70 80 90 100 110 120 GYSIRPEEPG STKGKHFYSS SESEEEEESH KKFNIKIKPL QSKDILKNAA TVDELKASIG 130 140 150 160 170 180 NIALSPSPVG AIKRNLSSEE VARPRRSTPT PELISKKPPD DTTALAPLFG PPLESAFDEQ 190 200 210 220 230 240 KTEVLLDQPE IWGSGQPINP SMESPKLTRP FPTGTPPPLP PKNVPATPPR TGSPLTIGPG 250 260 270 280 290 300 ASSPARPATP LVPCRSTTPP PPPPRPPSRP KLPPGKPGVG DVSRPFSPPI HSSSPPPIAP 310 320 330 340 350 360 LARAESTSSI SSTNSLSAAT TPTVENEQPS LVWFDRGKFY LTFEGSSRGP SPLTMGAQDT 370 380 390 400 410 420 LPVAAAFTET VNAYFKGADP SKCIVKITGE MVLSFPAGIT RHFANNPSPA ALTFRVINFS 430 440 450 460 470 480 RLEHVLPNPQ LLCCDNTQND ANTKEFWVNM PNLMTHLKKV SEQKPQATYY NVDMLKYQVS 490 500 510 520 530 540 AQGIQSTPLN LAVNWRCEPS STDLRIDYKY NTDAMTTAVA LNNVQFLVPI DGGVTKLQAV 550 560 570 580 590 600 LPPAVWNAEQ QRILWKIPDI SQKSENGGVG SLLARFQLSE GPSKPSPLVV QFTSEGSTLS 610 620 GCDIELVGAG YRFSLIKKRF AAGKYLADN
	Isoform 5 [UniParc]. Checksum: AA5403263C766B24	FASTA	631	68,338
	10 20 30 40 50 60 MMEGLKKRTR KAFGIRKKEK DTDSTGSPDR DGIKKSNGAP NGFYAEIDWE RYNSPELDEE 70 80 90 100 110 120 GYSIRPEEPG STKGKHFYSS SESEEEEESH KKFNIKIKPL QSKDILKNAA TVDELKASIG 130 140 150 160 170 180 NIALSPSPVG AIKRNLSSEE VARPRRSTPT PELISKKPPD DTTALAPLFG PPLESAFDEQ 190 200 210 220 230 240 KTEVLLDQPE IWGSGQPINP SMESPKLTRP FPTGTPPPLP PKNVPATPPR TGSPLTIGPG 250 260 270 280 290 300 ASSPARPATP LVPCRSTTPP PPPPRPPSRP KLPPGKPGVG DVSRPFSPPI HSSSPPPIAP 310 320 330 340 350 360 LARAESTSSI SSTNSLSAAT TPTVVSEDDV FYDKLPSFER RCETPAGSSR GPSPLTMGAQ 370 380 390 400 410 420 DTLPVAAAFT ETVNAYFKGA DPSKCIVKIT GEMVLSFPAG ITRHFANNPS PAALTFRVIN 430 440 450 460 470 480 FSRLEHVLPN PQLLCCDNTQ NDANTKEFWV NMPNLMTHLK KVSEQKPQAT YYNVDMLKYQ 490 500 510 520 530 540 VSAQGIQSTP LNLAVNWRCE PSSTDLRIDY KYNTDAMTTA VALNNVQFLV PIDGGVTKLQ 550 560 570 580 590 600 AVLPPAVWNA EQQRILWKIP DISQKSENGG VGSLLARFQL SEGPSKPSPL VVQFTSEGST 610 620 630 LSGCDIELVG AGYRFSLIKK RFAAGKYLAD N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-131. Tissue: Amygdala.
[2]	"Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method." Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-131. Tissue: Brain.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5), VARIANT ARG-131. Tissue: Colon endothelium and Small intestine.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANTS GLN-161 AND GLU-575. Tissue: Hippocampus.
[6]	"Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance." Trevaskis J., Walder K., Foletta V., Kerr-Bayles L., McMillan J., Cooper A., Lee S., Bolton K., Prior M., Fahey R., Whitecross K., Morton G.J., Schwartz M.W., Collier G.R. Endocrinology 146:3757-3764(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, INTERACTION WITH SH3GL3.
[7]	"Intersectin 1 forms complexes with SGIP1 and Reps1 in clathrin-coated pits." Dergai O., Novokhatska O., Dergai M., Skrypkina I., Tsyba L., Moreau J., Rynditch A. Biochem. Biophys. Res. Commun. 402:408-413(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH AMPH; ITSN1 AND REPS1, SUBCELLULAR LOCATION.
[8]	"Genetic variation in SH3-domain GRB2-like (endophilin)-interacting protein 1 has a major impact on fat mass." Cummings N., Shields K.A., Curran J.E., Bozaoglu K., Trevaskis J., Gluschenko K., Cai G., Comuzzie A.G., Dyer T.D., Walder K.R., Zimmet P., Collier G.R., Blangero J., Jowett J.B. Int. J. Obes. Relat. Metab. Disord. 36:201-206(2012) [PubMed] [Europe PMC] [Abstract] Cited for: POLYMORPHISM.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL136561 mRNA. Translation: CAB66496.1. AB210039 mRNA. Translation: BAE06121.1. Different initiation. BX640813 mRNA. Translation: CAE45891.1. CR749541 mRNA. Translation: CAH18344.1. AL354978, AL139147, AL356913 Genomic DNA. Translation: CAH71845.1. AL354978, AL139147, AL356913 Genomic DNA. Translation: CAH71846.1. AL354978, AL139147, AL356913 Genomic DNA. Translation: CAH71847.1. AL139147, AL354978, AL356913 Genomic DNA. Translation: CAI21942.1. AL139147, AL354978, AL356913 Genomic DNA. Translation: CAI21943.1. AL139147, AL354978, AL356913 Genomic DNA. Translation: CAI21944.1. AL356913, AL139147, AL354978 Genomic DNA. Translation: CAI22672.1. AL356913, AL139147, AL354978 Genomic DNA. Translation: CAI22673.1. AL356913, AL139147, AL354978 Genomic DNA. Translation: CAI22674.1. BC040516 mRNA. Translation: AAH40516.1.
IPI	IPI00031087. IPI00217265. IPI00426076. IPI00784625. IPI00785188.
RefSeq	NP_115667.2. NM_032291.2.
UniGene	Hs.132121.
3D structure databases
ProteinModelPortal	Q9BQI5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BQI5. 1 interaction.
PTM databases
PhosphoSite	Q9BQI5.
Polymorphism databases
DMDM	114152158.
Proteomic databases
PaxDb	Q9BQI5.
PRIDE	Q9BQI5.
Protocols and materials databases
DNASU	84251.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000237247; ENSP00000237247; ENSG00000118473. ENST00000371037; ENSP00000360076; ENSG00000118473. ENST00000371039; ENSP00000360078; ENSG00000118473.
GeneID	84251.
KEGG	hsa:84251.
UCSC	uc001dcr.3. human.
Organism-specific databases
CTD	84251.
GeneCards	GC01P066999.
H-InvDB	HIX0000678.
HGNC	HGNC:25412. SGIP1.
HPA	HPA017963.
MIM	611540. gene.
neXtProt	NX_Q9BQI5.
PharmGKB	PA134909202.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG324072.
HOVERGEN	HBG081524.
OMA	NTEEKWV.
Gene expression databases
ArrayExpress	Q9BQI5.
Bgee	Q9BQI5.
Genevestigator	Q9BQI5.
GermOnline	ENSG00000118473. Homo sapiens.
Family and domain databases
InterPro	IPR018808. Muniscin_C-term_mu_dom. [Graphical view]
Pfam	PF10291. muHD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SGIP1. human.
GenomeRNAi	84251.
NextBio	73748.
SOURCE	Search...

Entry information

Entry name

SGIP1_HUMAN

Accession

Primary (citable) accession number: Q9BQI5
Secondary accession number(s): A6NL81 , A6NLD1, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	April 3, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.