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Protein

SH3-containing GRB2-like protein 3-interacting protein 1

Gene

SGIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis (By similarity).By similarity

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • phospholipid binding Source: UniProtKB
  • SH3 domain binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Endocytosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118473-MONOMER.
ReactomeiR-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
SH3-containing GRB2-like protein 3-interacting protein 1
Alternative name(s):
Endophilin-3-interacting protein
Gene namesi
Name:SGIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25412. SGIP1.

Subcellular locationi

GO - Cellular componenti

  • AP-2 adaptor complex Source: UniProtKB
  • clathrin-coated pit Source: UniProtKB
  • clathrin-coated vesicle Source: UniProtKB
  • cytoplasm Source: LIFEdb
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84251.
OpenTargetsiENSG00000118473.
PharmGKBiPA134909202.

Polymorphism and mutation databases

BioMutaiSGIP1.
DMDMi114152158.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002483951 – 828SH3-containing GRB2-like protein 3-interacting protein 1Add BLAST828

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78PhosphoserineBy similarity1
Modified residuei104PhosphoserineBy similarity1
Modified residuei105PhosphoserineBy similarity1
Modified residuei107PhosphoserineBy similarity1
Modified residuei149PhosphoserineBy similarity1
Modified residuei151PhosphoserineBy similarity1
Modified residuei156PhosphoserineBy similarity1
Modified residuei169PhosphoserineBy similarity1
Modified residuei180PhosphothreonineBy similarity1
Modified residuei182PhosphothreonineBy similarity1
Modified residuei236PhosphoserineBy similarity1
Modified residuei247PhosphothreonineBy similarity1
Modified residuei259PhosphothreonineBy similarity1
Modified residuei265PhosphoserineBy similarity1
Modified residuei287PhosphoserineBy similarity1
Modified residuei300PhosphoserineBy similarity1
Modified residuei316PhosphoserineBy similarity1
Modified residuei319PhosphoserineBy similarity1
Modified residuei324PhosphothreonineBy similarity1
Modified residuei328PhosphothreonineBy similarity1
Modified residuei372PhosphoserineBy similarity1
Modified residuei399PhosphoserineBy similarity1
Modified residuei410PhosphothreonineBy similarity1
Modified residuei486PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9BQI5.
PeptideAtlasiQ9BQI5.
PRIDEiQ9BQI5.

PTM databases

iPTMnetiQ9BQI5.
PhosphoSitePlusiQ9BQI5.
SwissPalmiQ9BQI5.

Expressioni

Tissue specificityi

Specifically expressed in brain.1 Publication

Gene expression databases

BgeeiENSG00000118473.
ExpressionAtlasiQ9BQI5. baseline and differential.
GenevisibleiQ9BQI5. HS.

Organism-specific databases

HPAiHPA017963.

Interactioni

Subunit structurei

Interacts with proteins essential or regulating the formation of functional clathrin-coated pits. Interacts with CANX (By similarity). Interacts with AP2A1 (By similarity). Interacts with EPS15 (By similarity). Interacts with SH3GL3. Interacts with AMPH. Interacts with ITSN1 (via SH3 domains). Interacts with and REPS1.By similarity2 Publications

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • SH3 domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123979. 5 interactors.
IntActiQ9BQI5. 1 interactor.
MINTiMINT-4534029.
STRINGi9606.ENSP00000360076.

Structurei

Secondary structure

1828
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi560 – 575Combined sources16
Helixi579 – 581Combined sources3
Beta strandi583 – 597Combined sources15
Turni599 – 602Combined sources4
Beta strandi604 – 606Combined sources3
Beta strandi612 – 616Combined sources5
Helixi618 – 620Combined sources3
Beta strandi621 – 626Combined sources6
Turni628 – 630Combined sources3
Beta strandi631 – 633Combined sources3
Beta strandi643 – 647Combined sources5
Helixi649 – 662Combined sources14
Beta strandi667 – 678Combined sources12
Helixi682 – 685Combined sources4
Beta strandi687 – 696Combined sources10
Beta strandi698 – 709Combined sources12
Helixi711 – 713Combined sources3
Beta strandi714 – 716Combined sources3
Beta strandi720 – 728Combined sources9
Turni730 – 732Combined sources3
Beta strandi733 – 741Combined sources9
Beta strandi744 – 746Combined sources3
Turni747 – 750Combined sources4
Beta strandi751 – 760Combined sources10
Turni764 – 767Combined sources4
Beta strandi768 – 779Combined sources12
Beta strandi787 – 795Combined sources9
Beta strandi802 – 827Combined sources26

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5AWRX-ray2.50A552-828[»]
5AWSX-ray2.00A/B552-828[»]
5AWTX-ray2.70A552-828[»]
5AWUX-ray2.70A552-828[»]
ProteinModelPortaliQ9BQI5.
SMRiQ9BQI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini559 – 827MHDPROSITE-ProRule annotationAdd BLAST269

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni649 – 828Necessary and sufficient to mediate interaction with CANXBy similarityAdd BLAST180

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi106 – 112Poly-Glu7
Compositional biasi176 – 499Pro-richAdd BLAST324

Sequence similaritiesi

Contains 1 MHD (mu homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IU8J. Eukaryota.
ENOG410XTCY. LUCA.
GeneTreeiENSGT00510000046419.
HOVERGENiHBG081524.
InParanoidiQ9BQI5.
KOiK20065.
OMAiIDWDRYN.
OrthoDBiEOG091G0AB1.
PhylomeDBiQ9BQI5.
TreeFamiTF328986.

Family and domain databases

InterProiIPR028565. MHD.
IPR018808. Muniscin_C.
[Graphical view]
PfamiPF10291. muHD. 1 hit.
[Graphical view]
SUPFAMiSSF49447. SSF49447. 1 hit.
PROSITEiPS51072. MHD. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BQI5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMEGLKKRTR KAFGIRKKEK DTDSTGSPDR DGIQPSPHEP PYNSKAECAR
60 70 80 90 100
EGGKKVSKKS NGAPNGFYAE IDWERYNSPE LDEEGYSIRP EEPGSTKGKH
110 120 130 140 150
FYSSSESEEE EESHKKFNIK IKPLQSKDIL KNAATVDELK ASIGNIALSP
160 170 180 190 200
SPVRKSPRRS PGAIKRNLSS EEVARPRRST PTPELISKKP PDDTTALAPL
210 220 230 240 250
FGPPLESAFD EQKTEVLLDQ PEIWGSGQPI NPSMESPKLT RPFPTGTPPP
260 270 280 290 300
LPPKNVPATP PRTGSPLTIG PGNDQSATEV KIEKLPSIND LDSIFGPVLS
310 320 330 340 350
PKSVAVNAEE KWVHFSDTSP EHVTPELTPR EKVVSPPATP DNPADSPAPG
360 370 380 390 400
PLGPPGPTGP PGPPGPPRNV LSPLNLEEVQ KKVAEQTFIK DDYLETISSP
410 420 430 440 450
KDFGLGQRAT PPPPPPPTYR TVVSSPGPGS GPGPGTTSGA SSPARPATPL
460 470 480 490 500
VPCRSTTPPP PPPRPPSRPK LPPGKPGVGD VSRPFSPPIH SSSPPPIAPL
510 520 530 540 550
ARAESTSSIS STNSLSAATT PTVENEQPSL VWFDRGKFYL TFEGSSRGPS
560 570 580 590 600
PLTMGAQDTL PVAAAFTETV NAYFKGADPS KCIVKITGEM VLSFPAGITR
610 620 630 640 650
HFANNPSPAA LTFRVINFSR LEHVLPNPQL LCCDNTQNDA NTKEFWVNMP
660 670 680 690 700
NLMTHLKKVS EQKPQATYYN VDMLKYQVSA QGIQSTPLNL AVNWRCEPSS
710 720 730 740 750
TDLRIDYKYN TDAMTTAVAL NNVQFLVPID GGVTKLQAVL PPAVWNAEQQ
760 770 780 790 800
RILWKIPDIS QKSENGGVGS LLARFQLSEG PSKPSPLVVQ FTSEGSTLSG
810 820
CDIELVGAGY RFSLIKKRFA AGKYLADN
Length:828
Mass (Da):89,109
Last modified:September 5, 2006 - v2
Checksum:i86D2B6AE3099CDEA
GO
Isoform 2 (identifier: Q9BQI5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-57: PSPHEPPYNSKAECAREGGKKVS → GKKKTQKTQLLLTSCFWLRALSLTLSQ

Show »
Length:832
Mass (Da):89,734
Checksum:i67A0B74D0A09918D
GO
Isoform 3 (identifier: Q9BQI5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-57: PSPHEPPYNSKAECAREGGKKVS → GKKKTQKTQLLLTSCFWLRALSLTLSQ
     437-437: T → TSDGKTEAQRYQVICPSLQAGGNELDSY

Note: No experimental confirmation available.
Show »
Length:859
Mass (Da):92,646
Checksum:i823A19AEAB727F86
GO
Isoform 4 (identifier: Q9BQI5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-57: Missing.
     154-161: Missing.
     272-438: Missing.

Show »
Length:629
Mass (Da):68,240
Checksum:iB42E8BBA6AF8B3A2
GO
Isoform 5 (identifier: Q9BQI5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-57: Missing.
     154-161: Missing.
     272-438: Missing.
     524-543: ENEQPSLVWFDRGKFYLTFE → VSEDDVFYDKLPSFERRCETPA

Show »
Length:631
Mass (Da):68,338
Checksum:iAA5403263C766B24
GO

Sequence cautioni

The sequence BAE06121 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81L → V in CAH18344 (PubMed:17974005).Curated1
Sequence conflicti212Q → R in CAH18344 (PubMed:17974005).Curated1
Sequence conflicti498A → V in CAH18344 (PubMed:17974005).Curated1
Sequence conflicti772L → S in CAH18344 (PubMed:17974005).Curated1

Polymorphismi

Genetic variation in SGIP1 is associated with fat mass and SGIP1 may be a determinant of obesity-related traits.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027297112E → Q.Corresponds to variant rs17490057dbSNPEnsembl.1
Natural variantiVAR_027298131K → R.3 PublicationsCorresponds to variant rs7526812dbSNPEnsembl.1
Natural variantiVAR_027299161P → Q.1 PublicationCorresponds to variant rs17855645dbSNPEnsembl.1
Natural variantiVAR_027300575K → E.1 PublicationCorresponds to variant rs17854026dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02027334 – 57Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_02027435 – 57PSPHE…GKKVS → GKKKTQKTQLLLTSCFWLRA LSLTLSQ in isoform 2 and isoform 3. 2 PublicationsAdd BLAST23
Alternative sequenceiVSP_020275154 – 161Missing in isoform 4 and isoform 5. 1 Publication8
Alternative sequenceiVSP_020276272 – 438Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST167
Alternative sequenceiVSP_020277437T → TSDGKTEAQRYQVICPSLQA GGNELDSY in isoform 3. 1 Publication1
Alternative sequenceiVSP_020278524 – 543ENEQP…YLTFE → VSEDDVFYDKLPSFERRCET PA in isoform 5. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136561 mRNA. Translation: CAB66496.1.
AB210039 mRNA. Translation: BAE06121.1. Different initiation.
BX640813 mRNA. Translation: CAE45891.1.
CR749541 mRNA. Translation: CAH18344.1.
AL354978, AL139147, AL356913 Genomic DNA. Translation: CAH71845.1.
AL354978, AL139147, AL356913 Genomic DNA. Translation: CAH71846.1.
AL354978, AL139147, AL356913 Genomic DNA. Translation: CAH71847.1.
AL139147, AL354978, AL356913 Genomic DNA. Translation: CAI21942.1.
AL139147, AL354978, AL356913 Genomic DNA. Translation: CAI21943.1.
AL139147, AL354978, AL356913 Genomic DNA. Translation: CAI21944.1.
AL356913, AL139147, AL354978 Genomic DNA. Translation: CAI22672.1.
AL356913, AL139147, AL354978 Genomic DNA. Translation: CAI22673.1.
AL356913, AL139147, AL354978 Genomic DNA. Translation: CAI22674.1.
BC040516 mRNA. Translation: AAH40516.1.
CCDSiCCDS30744.1. [Q9BQI5-1]
CCDS76171.1. [Q9BQI5-5]
RefSeqiNP_001295132.1. NM_001308203.1. [Q9BQI5-5]
NP_115667.2. NM_032291.3. [Q9BQI5-1]
XP_005271321.1. XM_005271264.3. [Q9BQI5-2]
XP_005271327.1. XM_005271270.4. [Q9BQI5-4]
XP_006711037.1. XM_006710974.2. [Q9BQI5-5]
XP_016858000.1. XM_017002511.1. [Q9BQI5-1]
XP_016858001.1. XM_017002512.1. [Q9BQI5-1]
XP_016858023.1. XM_017002534.1. [Q9BQI5-4]
XP_016858024.1. XM_017002535.1. [Q9BQI5-4]
UniGeneiHs.132121.
Hs.159853.

Genome annotation databases

EnsembliENST00000237247; ENSP00000237247; ENSG00000118473. [Q9BQI5-3]
ENST00000371037; ENSP00000360076; ENSG00000118473. [Q9BQI5-1]
ENST00000371039; ENSP00000360078; ENSG00000118473. [Q9BQI5-5]
GeneIDi84251.
KEGGihsa:84251.
UCSCiuc001dcr.4. human. [Q9BQI5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136561 mRNA. Translation: CAB66496.1.
AB210039 mRNA. Translation: BAE06121.1. Different initiation.
BX640813 mRNA. Translation: CAE45891.1.
CR749541 mRNA. Translation: CAH18344.1.
AL354978, AL139147, AL356913 Genomic DNA. Translation: CAH71845.1.
AL354978, AL139147, AL356913 Genomic DNA. Translation: CAH71846.1.
AL354978, AL139147, AL356913 Genomic DNA. Translation: CAH71847.1.
AL139147, AL354978, AL356913 Genomic DNA. Translation: CAI21942.1.
AL139147, AL354978, AL356913 Genomic DNA. Translation: CAI21943.1.
AL139147, AL354978, AL356913 Genomic DNA. Translation: CAI21944.1.
AL356913, AL139147, AL354978 Genomic DNA. Translation: CAI22672.1.
AL356913, AL139147, AL354978 Genomic DNA. Translation: CAI22673.1.
AL356913, AL139147, AL354978 Genomic DNA. Translation: CAI22674.1.
BC040516 mRNA. Translation: AAH40516.1.
CCDSiCCDS30744.1. [Q9BQI5-1]
CCDS76171.1. [Q9BQI5-5]
RefSeqiNP_001295132.1. NM_001308203.1. [Q9BQI5-5]
NP_115667.2. NM_032291.3. [Q9BQI5-1]
XP_005271321.1. XM_005271264.3. [Q9BQI5-2]
XP_005271327.1. XM_005271270.4. [Q9BQI5-4]
XP_006711037.1. XM_006710974.2. [Q9BQI5-5]
XP_016858000.1. XM_017002511.1. [Q9BQI5-1]
XP_016858001.1. XM_017002512.1. [Q9BQI5-1]
XP_016858023.1. XM_017002534.1. [Q9BQI5-4]
XP_016858024.1. XM_017002535.1. [Q9BQI5-4]
UniGeneiHs.132121.
Hs.159853.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5AWRX-ray2.50A552-828[»]
5AWSX-ray2.00A/B552-828[»]
5AWTX-ray2.70A552-828[»]
5AWUX-ray2.70A552-828[»]
ProteinModelPortaliQ9BQI5.
SMRiQ9BQI5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123979. 5 interactors.
IntActiQ9BQI5. 1 interactor.
MINTiMINT-4534029.
STRINGi9606.ENSP00000360076.

PTM databases

iPTMnetiQ9BQI5.
PhosphoSitePlusiQ9BQI5.
SwissPalmiQ9BQI5.

Polymorphism and mutation databases

BioMutaiSGIP1.
DMDMi114152158.

Proteomic databases

PaxDbiQ9BQI5.
PeptideAtlasiQ9BQI5.
PRIDEiQ9BQI5.

Protocols and materials databases

DNASUi84251.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000237247; ENSP00000237247; ENSG00000118473. [Q9BQI5-3]
ENST00000371037; ENSP00000360076; ENSG00000118473. [Q9BQI5-1]
ENST00000371039; ENSP00000360078; ENSG00000118473. [Q9BQI5-5]
GeneIDi84251.
KEGGihsa:84251.
UCSCiuc001dcr.4. human. [Q9BQI5-1]

Organism-specific databases

CTDi84251.
DisGeNETi84251.
GeneCardsiSGIP1.
H-InvDBHIX0000678.
HGNCiHGNC:25412. SGIP1.
HPAiHPA017963.
MIMi611540. gene.
neXtProtiNX_Q9BQI5.
OpenTargetsiENSG00000118473.
PharmGKBiPA134909202.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IU8J. Eukaryota.
ENOG410XTCY. LUCA.
GeneTreeiENSGT00510000046419.
HOVERGENiHBG081524.
InParanoidiQ9BQI5.
KOiK20065.
OMAiIDWDRYN.
OrthoDBiEOG091G0AB1.
PhylomeDBiQ9BQI5.
TreeFamiTF328986.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000118473-MONOMER.
ReactomeiR-HSA-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-HSA-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

ChiTaRSiSGIP1. human.
GeneWikiiSGIP1.
GenomeRNAii84251.
PROiQ9BQI5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118473.
ExpressionAtlasiQ9BQI5. baseline and differential.
GenevisibleiQ9BQI5. HS.

Family and domain databases

InterProiIPR028565. MHD.
IPR018808. Muniscin_C.
[Graphical view]
PfamiPF10291. muHD. 1 hit.
[Graphical view]
SUPFAMiSSF49447. SSF49447. 1 hit.
PROSITEiPS51072. MHD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSGIP1_HUMAN
AccessioniPrimary (citable) accession number: Q9BQI5
Secondary accession number(s): A6NL81
, A6NLD1, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: November 2, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.