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Protein

Coiled-coil domain-containing protein 3

Gene

CCDC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (PubMed:25193116). Positively regulates lipid accumulation in adipose cells (By similarity).By similarity1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 3
Alternative name(s):
Fat/vessel-derived secretory protein
Short name:
Favine
Gene namesi
Name:CCDC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000151468.10.
HGNCiHGNC:23813. CCDC3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi83643.
OpenTargetsiENSG00000151468.
PharmGKBiPA134863738.

Polymorphism and mutation databases

BioMutaiCCDC3.
DMDMi50400629.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000002086222 – 270Coiled-coil domain-containing protein 3Add BLAST249

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9BQI4.
PeptideAtlasiQ9BQI4.
PRIDEiQ9BQI4.

PTM databases

PhosphoSitePlusiQ9BQI4.

Expressioni

Tissue specificityi

Expressed in umbilical vein endothelial cells (HUVEC), and at lower levels in aortic smooth muscle cells (HASMC).1 Publication

Inductioni

Up-regulated by pioglitazone and down-regulated by TNF in HUVEC.1 Publication

Gene expression databases

BgeeiENSG00000151468.
CleanExiHS_CCDC3.
GenevisibleiQ9BQI4. HS.

Organism-specific databases

HPAiHPA062425.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

MINTiMINT-4722366.
STRINGi9606.ENSP00000368102.

Structurei

3D structure databases

ProteinModelPortaliQ9BQI4.
SMRiQ9BQI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili188 – 251Sequence analysisAdd BLAST64

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410IICP. Eukaryota.
ENOG410Y2JM. LUCA.
GeneTreeiENSGT00390000014429.
HOGENOMiHOG000139934.
HOVERGENiHBG050821.
InParanoidiQ9BQI4.
OMAiCQLPSDW.
OrthoDBiEOG091G0FRS.
PhylomeDBiQ9BQI4.
TreeFamiTF331410.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BQI4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRQLLLAAL CLAGPPAPAR ACQLPSEWRP LSEGCRAELA ETIVYARVLA
60 70 80 90 100
LHPEAPGLYN HLPWQYHAGQ GGLFYSAEVE MLCDQAWGSM LEVPAGSRLN
110 120 130 140 150
LTGLGYFSCH SHTVVQDYSY FFFLRMDENY NLLPHGVNFQ DAIFPDTQEN
160 170 180 190 200
RRMFSSLFQF SNCSQGQQLA TFSSDWEIQE DSRLMCSSVQ KALFEEEDHV
210 220 230 240 250
KKLQQKVATL EKRNRQLRER VKKVKRSLRQ ARKKGRHLEL ANQKLSEKLA
260 270
AGALPHINAR GPVRPPYLRG
Length:270
Mass (Da):30,731
Last modified:June 1, 2001 - v1
Checksum:iBBC768A39B449FBB
GO
Isoform 2 (identifier: Q9BQI4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: Missing.

Note: No experimental confirmation available.
Show »
Length:145
Mass (Da):16,864
Checksum:i6695E6F49F2B6661
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0545511 – 125Missing in isoform 2. 1 PublicationAdd BLAST125

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136562 mRNA. Translation: CAB66497.1.
AK095792 mRNA. Translation: BAG53129.1.
AL355355, AL353586 Genomic DNA. Translation: CAI16546.1.
AL353586, AL355355 Genomic DNA. Translation: CAH72784.1.
AL596124 Genomic DNA. No translation available.
BC051334 mRNA. Translation: AAH51334.1.
CCDSiCCDS60484.1. [Q9BQI4-2]
CCDS7093.1. [Q9BQI4-1]
RefSeqiNP_001269587.1. NM_001282658.1. [Q9BQI4-2]
NP_113643.1. NM_031455.3. [Q9BQI4-1]
UniGeneiHs.498720.
Hs.738531.

Genome annotation databases

EnsembliENST00000378825; ENSP00000368102; ENSG00000151468. [Q9BQI4-1]
ENST00000378839; ENSP00000368116; ENSG00000151468. [Q9BQI4-2]
GeneIDi83643.
KEGGihsa:83643.
UCSCiuc001ilq.2. human. [Q9BQI4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCCDC3_HUMAN
AccessioniPrimary (citable) accession number: Q9BQI4
Secondary accession number(s): Q5VYV8, Q5VYV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM