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Q9BQI0

- AIF1L_HUMAN

UniProt

Q9BQI0 - AIF1L_HUMAN

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Protein

Allograft inflammatory factor 1-like

Gene

AIF1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi60 – 71121PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. actin filament binding Source: UniProtKB
  2. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Allograft inflammatory factor 1-like
Alternative name(s):
Ionized calcium-binding adapter molecule 2
Gene namesi
Name:AIF1L
Synonyms:C9orf58, IBA2
ORF Names:UNQ672/PRO1306
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:28904. AIF1L.

Subcellular locationi

Cytoplasmcytoskeleton 1 Publication. Cell projectionruffle membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Note: Colocalizes with F-actin. Partially relocates to membrane ruffles in response to invading bacteria.

GO - Cellular componenti

  1. actin cytoskeleton Source: LIFEdb
  2. cell projection Source: UniProtKB-KW
  3. cytoplasm Source: UniProtKB-KW
  4. extracellular vesicular exosome Source: UniProt
  5. focal adhesion Source: LIFEdb
  6. plasma membrane Source: UniProtKB-KW
  7. protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164715250.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 150149Allograft inflammatory factor 1-likePRO_0000073870Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine2 Publications
Modified residuei2 – 21Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9BQI0.
PaxDbiQ9BQI0.
PRIDEiQ9BQI0.

PTM databases

PhosphoSiteiQ9BQI0.

Expressioni

Gene expression databases

BgeeiQ9BQI0.
CleanExiHS_AIF1L.
ExpressionAtlasiQ9BQI0. baseline and differential.
GenevestigatoriQ9BQI0.

Organism-specific databases

HPAiHPA020522.

Interactioni

Subunit structurei

Homodimer (Potential). Monomer.1 PublicationCurated

Protein-protein interaction databases

BioGridi123676. 4 interactions.
MINTiMINT-1137255.

Structurei

Secondary structure

1
150
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi17 – 3519Combined sources
Helixi37 – 393Combined sources
Helixi45 – 5713Combined sources
Helixi69 – 7810Combined sources
Helixi85 – 9612Combined sources
Beta strandi101 – 1033Combined sources
Helixi105 – 1139Combined sources
Beta strandi114 – 1163Combined sources
Helixi119 – 1268Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2JJZX-ray2.15B/C/D1-150[»]
2VTGX-ray2.45A1-150[»]
ProteinModelPortaliQ9BQI0.
SMRiQ9BQI0. Positions 13-127.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BQI0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 8236EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini83 – 11735EF-hand 2; degeneratePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG262998.
GeneTreeiENSGT00390000013846.
HOGENOMiHOG000231928.
HOVERGENiHBG004002.
InParanoidiQ9BQI0.
PhylomeDBiQ9BQI0.
TreeFamiTF320736.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR028453. Aif1_like.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR10356:SF3. PTHR10356:SF3. 1 hit.
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9BQI0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGELSNRFQ GGKAFGLLKA RQERRLAEIN REFLCDQKYS DEENLPEKLT
60 70 80 90 100
AFKEKYMEFD LNNEGEIDLM SLKRMMEKLG VPKTHLEMKK MISEVTGGVS
110 120 130 140 150
DTISYRDFVN MMLGKRSAVL KLVMMFEGKA NESSPKPVGP PPERDIASLP
Length:150
Mass (Da):17,068
Last modified:June 1, 2001 - v1
Checksum:i74614436B9DEB5F6
GO
Isoform 2 (identifier: Q9BQI0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-31: R → RYCAGREPQLQRISCSQHSCLLALLFQ

Show »
Length:176
Mass (Da):20,015
Checksum:i1F6AE2733802261E
GO
Isoform 3 (identifier: Q9BQI0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-67: Missing.

Show »
Length:142
Mass (Da):16,183
Checksum:iF3A22B50146CBE82
GO
Isoform 4 (identifier: Q9BQI0-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-102: VSDT → SHDV
     103-150: Missing.

Note: No experimental confirmation available.

Show »
Length:102
Mass (Da):11,817
Checksum:i5B0A3F4AE73E042D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331F → L in BAB14269. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei31 – 311R → RYCAGREPQLQRISCSQHSC LLALLFQ in isoform 2. 1 PublicationVSP_017150
Alternative sequencei60 – 678Missing in isoform 3. 1 PublicationVSP_017151
Alternative sequencei99 – 1024VSDT → SHDV in isoform 4. 1 PublicationVSP_017152
Alternative sequencei103 – 15048Missing in isoform 4. 1 PublicationVSP_017153Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136566 mRNA. Translation: CAB66501.1.
AY359067 mRNA. Translation: AAQ89426.1.
AK022845 mRNA. Translation: BAB14269.1.
AK091912 mRNA. Translation: BAC03770.1.
AK128526 mRNA. Translation: BAC87480.1.
AK314600 mRNA. Translation: BAG37171.1.
AL833896 mRNA. Translation: CAD38752.1.
AL157938 Genomic DNA. Translation: CAI41102.1.
AL157938 Genomic DNA. Translation: CAI41103.1.
AL157938 Genomic DNA. Translation: CAI41104.1.
CH471090 Genomic DNA. Translation: EAW87958.1.
BC021253 mRNA. Translation: AAH21253.1.
CCDSiCCDS55348.1. [Q9BQI0-2]
CCDS55349.1. [Q9BQI0-4]
CCDS6939.1. [Q9BQI0-1]
RefSeqiNP_001172024.1. NM_001185095.1. [Q9BQI0-2]
NP_001172025.1. NM_001185096.1. [Q9BQI0-4]
NP_113614.1. NM_031426.3. [Q9BQI0-1]
UniGeneiHs.4944.

Genome annotation databases

EnsembliENST00000247291; ENSP00000247291; ENSG00000126878. [Q9BQI0-1]
ENST00000372300; ENSP00000361374; ENSG00000126878. [Q9BQI0-4]
ENST00000372302; ENSP00000361376; ENSG00000126878. [Q9BQI0-3]
ENST00000372309; ENSP00000361383; ENSG00000126878. [Q9BQI0-2]
GeneIDi83543.
KEGGihsa:83543.
UCSCiuc004cab.2. human. [Q9BQI0-1]
uc004cad.2. human. [Q9BQI0-2]
uc004cae.2. human. [Q9BQI0-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136566 mRNA. Translation: CAB66501.1 .
AY359067 mRNA. Translation: AAQ89426.1 .
AK022845 mRNA. Translation: BAB14269.1 .
AK091912 mRNA. Translation: BAC03770.1 .
AK128526 mRNA. Translation: BAC87480.1 .
AK314600 mRNA. Translation: BAG37171.1 .
AL833896 mRNA. Translation: CAD38752.1 .
AL157938 Genomic DNA. Translation: CAI41102.1 .
AL157938 Genomic DNA. Translation: CAI41103.1 .
AL157938 Genomic DNA. Translation: CAI41104.1 .
CH471090 Genomic DNA. Translation: EAW87958.1 .
BC021253 mRNA. Translation: AAH21253.1 .
CCDSi CCDS55348.1. [Q9BQI0-2 ]
CCDS55349.1. [Q9BQI0-4 ]
CCDS6939.1. [Q9BQI0-1 ]
RefSeqi NP_001172024.1. NM_001185095.1. [Q9BQI0-2 ]
NP_001172025.1. NM_001185096.1. [Q9BQI0-4 ]
NP_113614.1. NM_031426.3. [Q9BQI0-1 ]
UniGenei Hs.4944.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2JJZ X-ray 2.15 B/C/D 1-150 [» ]
2VTG X-ray 2.45 A 1-150 [» ]
ProteinModelPortali Q9BQI0.
SMRi Q9BQI0. Positions 13-127.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123676. 4 interactions.
MINTi MINT-1137255.

PTM databases

PhosphoSitei Q9BQI0.

Proteomic databases

MaxQBi Q9BQI0.
PaxDbi Q9BQI0.
PRIDEi Q9BQI0.

Protocols and materials databases

DNASUi 83543.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000247291 ; ENSP00000247291 ; ENSG00000126878 . [Q9BQI0-1 ]
ENST00000372300 ; ENSP00000361374 ; ENSG00000126878 . [Q9BQI0-4 ]
ENST00000372302 ; ENSP00000361376 ; ENSG00000126878 . [Q9BQI0-3 ]
ENST00000372309 ; ENSP00000361383 ; ENSG00000126878 . [Q9BQI0-2 ]
GeneIDi 83543.
KEGGi hsa:83543.
UCSCi uc004cab.2. human. [Q9BQI0-1 ]
uc004cad.2. human. [Q9BQI0-2 ]
uc004cae.2. human. [Q9BQI0-4 ]

Organism-specific databases

CTDi 83543.
GeneCardsi GC09P133971.
HGNCi HGNC:28904. AIF1L.
HPAi HPA020522.
neXtProti NX_Q9BQI0.
PharmGKBi PA164715250.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG262998.
GeneTreei ENSGT00390000013846.
HOGENOMi HOG000231928.
HOVERGENi HBG004002.
InParanoidi Q9BQI0.
PhylomeDBi Q9BQI0.
TreeFami TF320736.

Miscellaneous databases

ChiTaRSi AIF1L. human.
EvolutionaryTracei Q9BQI0.
GeneWikii C9orf58.
GenomeRNAii 83543.
NextBioi 72467.
PROi Q9BQI0.

Gene expression databases

Bgeei Q9BQI0.
CleanExi HS_AIF1L.
ExpressionAtlasi Q9BQI0. baseline and differential.
Genevestigatori Q9BQI0.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR028453. Aif1_like.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view ]
PANTHERi PTHR10356:SF3. PTHR10356:SF3. 1 hit.
PROSITEi PS50222. EF_HAND_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Kidney, Placenta, Teratocarcinoma and Trachea.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Amygdala.
  5. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Placenta.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS), FUNCTION, SUBCELLULAR LOCATION, LACK OF CALCIUM-BINDING, SUBUNIT.

Entry informationi

Entry nameiAIF1L_HUMAN
AccessioniPrimary (citable) accession number: Q9BQI0
Secondary accession number(s): B2RBC4
, Q6ZR40, Q8NAX7, Q8WU47, Q9H9G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3