Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9BQI0

- AIF1L_HUMAN

UniProt

Q9BQI0 - AIF1L_HUMAN

Protein

Allograft inflammatory factor 1-like

Gene

AIF1L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi60 – 71121PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. actin filament binding Source: UniProtKB
    2. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Actin-binding, Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Allograft inflammatory factor 1-like
    Alternative name(s):
    Ionized calcium-binding adapter molecule 2
    Gene namesi
    Name:AIF1L
    Synonyms:C9orf58, IBA2
    ORF Names:UNQ672/PRO1306
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:28904. AIF1L.

    Subcellular locationi

    Cytoplasmcytoskeleton 1 Publication. Cell projectionruffle membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
    Note: Colocalizes with F-actin. Partially relocates to membrane ruffles in response to invading bacteria.

    GO - Cellular componenti

    1. actin cytoskeleton Source: LIFEdb
    2. cytoplasm Source: UniProtKB-KW
    3. extracellular vesicular exosome Source: UniProt
    4. focal adhesion Source: LIFEdb
    5. protein complex Source: Ensembl
    6. ruffle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164715250.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 150149Allograft inflammatory factor 1-likePRO_0000073870Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine2 Publications
    Modified residuei2 – 21Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9BQI0.
    PaxDbiQ9BQI0.
    PRIDEiQ9BQI0.

    PTM databases

    PhosphoSiteiQ9BQI0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BQI0.
    BgeeiQ9BQI0.
    CleanExiHS_AIF1L.
    GenevestigatoriQ9BQI0.

    Organism-specific databases

    HPAiHPA020522.

    Interactioni

    Subunit structurei

    Homodimer Potential. Monomer.1 PublicationCurated

    Protein-protein interaction databases

    BioGridi123676. 4 interactions.
    MINTiMINT-1137255.

    Structurei

    Secondary structure

    1
    150
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi17 – 3519
    Helixi37 – 393
    Helixi45 – 5713
    Helixi69 – 7810
    Helixi85 – 9612
    Beta strandi101 – 1033
    Helixi105 – 1139
    Beta strandi114 – 1163
    Helixi119 – 1268

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2JJZX-ray2.15B/C/D1-150[»]
    2VTGX-ray2.45A1-150[»]
    ProteinModelPortaliQ9BQI0.
    SMRiQ9BQI0. Positions 13-127.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9BQI0.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini47 – 8236EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini83 – 11735EF-hand 2; degeneratePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG262998.
    HOGENOMiHOG000231928.
    HOVERGENiHBG004002.
    PhylomeDBiQ9BQI0.
    TreeFamiTF320736.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR028453. Aif1_like.
    IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PANTHERiPTHR10356:SF3. PTHR10356:SF3. 1 hit.
    PROSITEiPS50222. EF_HAND_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9BQI0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGELSNRFQ GGKAFGLLKA RQERRLAEIN REFLCDQKYS DEENLPEKLT    50
    AFKEKYMEFD LNNEGEIDLM SLKRMMEKLG VPKTHLEMKK MISEVTGGVS 100
    DTISYRDFVN MMLGKRSAVL KLVMMFEGKA NESSPKPVGP PPERDIASLP 150
    Length:150
    Mass (Da):17,068
    Last modified:June 1, 2001 - v1
    Checksum:i74614436B9DEB5F6
    GO
    Isoform 2 (identifier: Q9BQI0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         31-31: R → RYCAGREPQLQRISCSQHSCLLALLFQ

    Show »
    Length:176
    Mass (Da):20,015
    Checksum:i1F6AE2733802261E
    GO
    Isoform 3 (identifier: Q9BQI0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         60-67: Missing.

    Show »
    Length:142
    Mass (Da):16,183
    Checksum:iF3A22B50146CBE82
    GO
    Isoform 4 (identifier: Q9BQI0-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         99-102: VSDT → SHDV
         103-150: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:102
    Mass (Da):11,817
    Checksum:i5B0A3F4AE73E042D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 331F → L in BAB14269. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei31 – 311R → RYCAGREPQLQRISCSQHSC LLALLFQ in isoform 2. 1 PublicationVSP_017150
    Alternative sequencei60 – 678Missing in isoform 3. 1 PublicationVSP_017151
    Alternative sequencei99 – 1024VSDT → SHDV in isoform 4. 1 PublicationVSP_017152
    Alternative sequencei103 – 15048Missing in isoform 4. 1 PublicationVSP_017153Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136566 mRNA. Translation: CAB66501.1.
    AY359067 mRNA. Translation: AAQ89426.1.
    AK022845 mRNA. Translation: BAB14269.1.
    AK091912 mRNA. Translation: BAC03770.1.
    AK128526 mRNA. Translation: BAC87480.1.
    AK314600 mRNA. Translation: BAG37171.1.
    AL833896 mRNA. Translation: CAD38752.1.
    AL157938 Genomic DNA. Translation: CAI41102.1.
    AL157938 Genomic DNA. Translation: CAI41103.1.
    AL157938 Genomic DNA. Translation: CAI41104.1.
    CH471090 Genomic DNA. Translation: EAW87958.1.
    BC021253 mRNA. Translation: AAH21253.1.
    CCDSiCCDS55348.1. [Q9BQI0-2]
    CCDS55349.1. [Q9BQI0-4]
    CCDS6939.1. [Q9BQI0-1]
    RefSeqiNP_001172024.1. NM_001185095.1. [Q9BQI0-2]
    NP_001172025.1. NM_001185096.1. [Q9BQI0-4]
    NP_113614.1. NM_031426.3. [Q9BQI0-1]
    UniGeneiHs.4944.

    Genome annotation databases

    EnsembliENST00000247291; ENSP00000247291; ENSG00000126878. [Q9BQI0-1]
    ENST00000372300; ENSP00000361374; ENSG00000126878. [Q9BQI0-4]
    ENST00000372302; ENSP00000361376; ENSG00000126878. [Q9BQI0-3]
    ENST00000372309; ENSP00000361383; ENSG00000126878. [Q9BQI0-2]
    GeneIDi83543.
    KEGGihsa:83543.
    UCSCiuc004cab.2. human. [Q9BQI0-1]
    uc004cad.2. human. [Q9BQI0-2]
    uc004cae.2. human. [Q9BQI0-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136566 mRNA. Translation: CAB66501.1 .
    AY359067 mRNA. Translation: AAQ89426.1 .
    AK022845 mRNA. Translation: BAB14269.1 .
    AK091912 mRNA. Translation: BAC03770.1 .
    AK128526 mRNA. Translation: BAC87480.1 .
    AK314600 mRNA. Translation: BAG37171.1 .
    AL833896 mRNA. Translation: CAD38752.1 .
    AL157938 Genomic DNA. Translation: CAI41102.1 .
    AL157938 Genomic DNA. Translation: CAI41103.1 .
    AL157938 Genomic DNA. Translation: CAI41104.1 .
    CH471090 Genomic DNA. Translation: EAW87958.1 .
    BC021253 mRNA. Translation: AAH21253.1 .
    CCDSi CCDS55348.1. [Q9BQI0-2 ]
    CCDS55349.1. [Q9BQI0-4 ]
    CCDS6939.1. [Q9BQI0-1 ]
    RefSeqi NP_001172024.1. NM_001185095.1. [Q9BQI0-2 ]
    NP_001172025.1. NM_001185096.1. [Q9BQI0-4 ]
    NP_113614.1. NM_031426.3. [Q9BQI0-1 ]
    UniGenei Hs.4944.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2JJZ X-ray 2.15 B/C/D 1-150 [» ]
    2VTG X-ray 2.45 A 1-150 [» ]
    ProteinModelPortali Q9BQI0.
    SMRi Q9BQI0. Positions 13-127.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123676. 4 interactions.
    MINTi MINT-1137255.

    PTM databases

    PhosphoSitei Q9BQI0.

    Proteomic databases

    MaxQBi Q9BQI0.
    PaxDbi Q9BQI0.
    PRIDEi Q9BQI0.

    Protocols and materials databases

    DNASUi 83543.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000247291 ; ENSP00000247291 ; ENSG00000126878 . [Q9BQI0-1 ]
    ENST00000372300 ; ENSP00000361374 ; ENSG00000126878 . [Q9BQI0-4 ]
    ENST00000372302 ; ENSP00000361376 ; ENSG00000126878 . [Q9BQI0-3 ]
    ENST00000372309 ; ENSP00000361383 ; ENSG00000126878 . [Q9BQI0-2 ]
    GeneIDi 83543.
    KEGGi hsa:83543.
    UCSCi uc004cab.2. human. [Q9BQI0-1 ]
    uc004cad.2. human. [Q9BQI0-2 ]
    uc004cae.2. human. [Q9BQI0-4 ]

    Organism-specific databases

    CTDi 83543.
    GeneCardsi GC09P133971.
    HGNCi HGNC:28904. AIF1L.
    HPAi HPA020522.
    neXtProti NX_Q9BQI0.
    PharmGKBi PA164715250.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG262998.
    HOGENOMi HOG000231928.
    HOVERGENi HBG004002.
    PhylomeDBi Q9BQI0.
    TreeFami TF320736.

    Miscellaneous databases

    ChiTaRSi AIF1L. human.
    EvolutionaryTracei Q9BQI0.
    GeneWikii C9orf58.
    GenomeRNAii 83543.
    NextBioi 72467.
    PROi Q9BQI0.

    Gene expression databases

    ArrayExpressi Q9BQI0.
    Bgeei Q9BQI0.
    CleanExi HS_AIF1L.
    Genevestigatori Q9BQI0.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR028453. Aif1_like.
    IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    PANTHERi PTHR10356:SF3. PTHR10356:SF3. 1 hit.
    PROSITEi PS50222. EF_HAND_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Amygdala.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Kidney, Placenta, Teratocarcinoma and Trachea.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Amygdala.
    5. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Placenta.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS), FUNCTION, SUBCELLULAR LOCATION, LACK OF CALCIUM-BINDING, SUBUNIT.

    Entry informationi

    Entry nameiAIF1L_HUMAN
    AccessioniPrimary (citable) accession number: Q9BQI0
    Secondary accession number(s): B2RBC4
    , Q6ZR40, Q8NAX7, Q8WU47, Q9H9G0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3