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Q9BQG2

- NUD12_HUMAN

UniProt

Q9BQG2 - NUD12_HUMAN

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Protein
Peroxisomal NADH pyrophosphatase NUDT12
Gene
NUDT12
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)+, ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle.1 Publication

Catalytic activityi

NAD+ + H2O = AMP + NMN.1 Publication

Cofactori

Magnesium or manganese By similarity.

Kineticsi

  1. KM=11 µM for NADH1 Publication
  2. KM=16 µM for NADPH
  3. KM=190 µM for NAD

pH dependencei

Optimum pH is 8-9.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi370 – 3701Magnesium or manganese By similarity
Metal bindingi374 – 3741Magnesium or manganese By similarity

GO - Molecular functioni

  1. NAD+ diphosphatase activity Source: UniProtKB
  2. NADH pyrophosphatase activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. NAD catabolic process Source: UniProtKB
  2. NADP catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal NADH pyrophosphatase NUDT12 (EC:3.6.1.22)
Alternative name(s):
Nucleoside diphosphate-linked moiety X motif 12
Short name:
Nudix motif 12
Gene namesi
Name:NUDT12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:18826. NUDT12.

Subcellular locationi

Peroxisome 1 Publication

GO - Cellular componenti

  1. nucleus Source: LIFEdb
  2. peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi460 – 4623Missing: Abolishes localization to peroxisomes. 1 Publication

Organism-specific databases

PharmGKBiPA38699.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Peroxisomal NADH pyrophosphatase NUDT12
PRO_0000056956Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei185 – 1851N6-succinyllysine By similarity
Modified residuei292 – 2921N6-succinyllysine By similarity

Proteomic databases

MaxQBiQ9BQG2.
PaxDbiQ9BQG2.
PRIDEiQ9BQG2.

PTM databases

PhosphoSiteiQ9BQG2.

Expressioni

Gene expression databases

ArrayExpressiQ9BQG2.
BgeeiQ9BQG2.
CleanExiHS_NUDT12.
GenevestigatoriQ9BQG2.

Organism-specific databases

HPAiHPA045449.

Interactioni

Protein-protein interaction databases

MINTiMINT-3060539.
STRINGi9606.ENSP00000230792.

Structurei

3D structure databases

ProteinModelPortaliQ9BQG2.
SMRiQ9BQG2. Positions 9-134, 206-453.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 4030ANK 1
Add
BLAST
Repeati45 – 7430ANK 2
Add
BLAST
Repeati78 – 9821ANK 3
Add
BLAST
Domaini319 – 453135Nudix hydrolase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi355 – 37622Nudix box
Add
BLAST
Motifi460 – 4623Microbody targeting signal Inferred

Sequence similaritiesi

Contains 3 ANK repeats.

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG2816.
HOGENOMiHOG000247937.
HOVERGENiHBG054394.
InParanoidiQ9BQG2.
KOiK03426.
OMAiQPEVRLC.
OrthoDBiEOG7N0C55.
PhylomeDBiQ9BQG2.
TreeFamiTF106352.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
3.90.79.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR015375. NADH_PPase-like_N.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR015376. Znr_NADH_PPase.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF00293. NUDIX. 1 hit.
PF09296. NUDIX-like. 1 hit.
PF09297. zf-NADH-PPase. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF55811. SSF55811. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BQG2-1 [UniParc]FASTAAdd to Basket

« Hide

MSSVKRSLKQ EIVTQFHCSA AEGDIAKLTG ILSHSPSLLN ETSENGWTAL    50
MYAARNGHPE IVQFLLEKGC DRSIVNKSRQ TALDIAVFWG YKHIANLLAT 100
AKGGKKPWFL TNEVEECENY FSKTLLDRKS EKRNNSDWLL AKESHPATVF 150
ILFSDLNPLV TLGGNKESFQ QPEVRLCQLN YTDIKDYLAQ PEKITLIFLG 200
VELEIKDKLL NYAGEVPREE EDGLVAWFAL GIDPIAAEEF KQRHENCYFL 250
HPPMPALLQL KEKEAGVVAQ ARSVLAWHSR YKFCPTCGNA TKIEEGGYKR 300
LCLKEDCPSL NGVHNTSYPR VDPVVIMQVI HPDGTKCLLG RQKRFPPGMF 350
TCLAGFIEPG ETIEDAVRRE VEEESGVKVG HVQYVACQPW PMPSSLMIGC 400
LALAVSTEIK VDKNEIEDAR WFTREQVLDV LTKGKQQAFF VPPSRAIAHQ 450
LIKHWIRINP NL 462
Length:462
Mass (Da):52,076
Last modified:June 1, 2001 - v1
Checksum:i1A470B93707DB1D5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti129 – 1291K → E.
Corresponds to variant rs35903418 [ dbSNP | Ensembl ].
VAR_034157
Natural varianti235 – 2351I → V.
Corresponds to variant rs34468716 [ dbSNP | Ensembl ].
VAR_034158

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136592 mRNA. Translation: CAB66527.1.
AK098066 mRNA. Translation: BAG53574.1.
CH471086 Genomic DNA. Translation: EAW49073.1.
BC026748 mRNA. Translation: AAH26748.1.
BC041099 mRNA. Translation: AAH41099.1.
CCDSiCCDS4096.1.
RefSeqiNP_113626.1. NM_031438.2.
XP_005272152.1. XM_005272095.1.
UniGeneiHs.434289.

Genome annotation databases

EnsembliENST00000230792; ENSP00000230792; ENSG00000112874.
GeneIDi83594.
KEGGihsa:83594.
UCSCiuc003koi.3. human.

Polymorphism databases

DMDMi68565930.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136592 mRNA. Translation: CAB66527.1 .
AK098066 mRNA. Translation: BAG53574.1 .
CH471086 Genomic DNA. Translation: EAW49073.1 .
BC026748 mRNA. Translation: AAH26748.1 .
BC041099 mRNA. Translation: AAH41099.1 .
CCDSi CCDS4096.1.
RefSeqi NP_113626.1. NM_031438.2.
XP_005272152.1. XM_005272095.1.
UniGenei Hs.434289.

3D structure databases

ProteinModelPortali Q9BQG2.
SMRi Q9BQG2. Positions 9-134, 206-453.
ModBasei Search...

Protein-protein interaction databases

MINTi MINT-3060539.
STRINGi 9606.ENSP00000230792.

PTM databases

PhosphoSitei Q9BQG2.

Polymorphism databases

DMDMi 68565930.

Proteomic databases

MaxQBi Q9BQG2.
PaxDbi Q9BQG2.
PRIDEi Q9BQG2.

Protocols and materials databases

DNASUi 83594.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000230792 ; ENSP00000230792 ; ENSG00000112874 .
GeneIDi 83594.
KEGGi hsa:83594.
UCSCi uc003koi.3. human.

Organism-specific databases

CTDi 83594.
GeneCardsi GC05M102912.
HGNCi HGNC:18826. NUDT12.
HPAi HPA045449.
MIMi 609232. gene.
neXtProti NX_Q9BQG2.
PharmGKBi PA38699.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2816.
HOGENOMi HOG000247937.
HOVERGENi HBG054394.
InParanoidi Q9BQG2.
KOi K03426.
OMAi QPEVRLC.
OrthoDBi EOG7N0C55.
PhylomeDBi Q9BQG2.
TreeFami TF106352.

Miscellaneous databases

GeneWikii NUDT12.
GenomeRNAii 83594.
NextBioi 72525.
PROi Q9BQG2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BQG2.
Bgeei Q9BQG2.
CleanExi HS_NUDT12.
Genevestigatori Q9BQG2.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
3.90.79.10. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR015375. NADH_PPase-like_N.
IPR020084. NUDIX_hydrolase_CS.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR015376. Znr_NADH_PPase.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
PF00293. NUDIX. 1 hit.
PF09296. NUDIX-like. 1 hit.
PF09297. zf-NADH-PPase. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
SSF55811. SSF55811. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Ovary.
  5. "Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein."
    Abdelraheim S.R., Spiller D.G., McLennan A.G.
    Biochem. J. 374:329-335(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, MUTAGENESIS OF 460-PRO--LEU-462.

Entry informationi

Entry nameiNUD12_HUMAN
AccessioniPrimary (citable) accession number: Q9BQG2
Secondary accession number(s): B3KUW2, Q8TAL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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