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Protein

Synaptotagmin-3

Gene

SYT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ca2+ sensor involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain. Ca2+ induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).By similarity1 Publication

Cofactori

Ca2+By similarityNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi330Calcium 1By similarity1
Metal bindingi330Calcium 2By similarity1
Metal bindingi336Calcium 1By similarity1
Metal bindingi388Calcium 1By similarity1
Metal bindingi388Calcium 2By similarity1
Metal bindingi389Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi390Calcium 1By similarity1
Metal bindingi390Calcium 2By similarity1
Metal bindingi390Calcium 3By similarity1
Metal bindingi393Calcium 3By similarity1
Metal bindingi396Calcium 2By similarity1
Metal bindingi396Calcium 3By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDifferentiation
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-3
Alternative name(s):
Synaptotagmin III
Short name:
SytIII
Gene namesi
Name:SYT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000213023.9.
HGNCiHGNC:11511. SYT3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 54VesicularSequence analysisAdd BLAST54
Transmembranei55 – 75HelicalSequence analysisAdd BLAST21
Topological domaini76 – 590CytoplasmicSequence analysisAdd BLAST515

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000213023.
PharmGKBiPA36292.

Polymorphism and mutation databases

BioMutaiSYT3.
DMDMi18202733.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839451 – 590Synaptotagmin-3Add BLAST590

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei284Omega-N-methylarginineBy similarity1

Keywords - PTMi

Disulfide bond, Methylation

Proteomic databases

EPDiQ9BQG1.
MaxQBiQ9BQG1.
PaxDbiQ9BQG1.
PeptideAtlasiQ9BQG1.
PRIDEiQ9BQG1.

PTM databases

iPTMnetiQ9BQG1.
PhosphoSitePlusiQ9BQG1.

Expressioni

Tissue specificityi

Expressed in melanocytes (PubMed:23999003).1 Publication

Gene expression databases

BgeeiENSG00000213023.
CleanExiHS_SYT3.
ExpressionAtlasiQ9BQG1. baseline and differential.
GenevisibleiQ9BQG1. HS.

Interactioni

Subunit structurei

Homodimer; disulfide-linked via the cysteine motif. Can also form heterodimers with SYT6, SYT9 and SYT10.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi123985. 11 interactors.
ELMiQ9BQG1.
MINTiMINT-4724742.
STRINGi9606.ENSP00000340914.

Structurei

3D structure databases

ProteinModelPortaliQ9BQG1.
SMRiQ9BQG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini301 – 402C2 1PROSITE-ProRule annotationAdd BLAST102
Domaini433 – 536C2 2PROSITE-ProRule annotationAdd BLAST104

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni10 – 34Cysteine motifBy similarityAdd BLAST25

Domaini

The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.By similarity
The first C2 domain mediates Ca2+-dependent phospholipid binding.By similarity

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IT3M. Eukaryota.
COG5038. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232128.
HOVERGENiHBG005010.
InParanoidiQ9BQG1.
KOiK19903.
OMAiQRKLHFS.
OrthoDBiEOG091G0XMQ.
PhylomeDBiQ9BQG1.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiView protein in InterPro
IPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028682. SYT3.
PANTHERiPTHR10024:SF284. PTHR10024:SF284. 1 hit.
PfamiView protein in Pfam
PF00168. C2. 2 hits.
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiView protein in SMART
SM00239. C2. 2 hits.
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiView protein in PROSITE
PS50004. C2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9BQG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGDYEDDLC RRALILVSDL CARVRDADTN DRCQEFNDRI RGYPRGPDAD
60 70 80 90 100
ISVSLLSVIV TFCGIVLLGV SLFVSWKLCW VPWRDKGGSA VGGGPLRKDL
110 120 130 140 150
GPGVGLAGLV GGGGHHLAAG LGGHPLLGGP HHHAHAAHHP PFAELLEPGS
160 170 180 190 200
LGGSDTPEPS YLDMDSYPEA AAAAVAAGVK PSQTSPELPS EGGAGSGLLL
210 220 230 240 250
LPPSGGGLPS AQSHQQVTSL APTTRYPALP RPLTQQTLTS QPDPSSEERP
260 270 280 290 300
PALPLPLPGG EEKAKLIGQI KPELYQGTGP GGRRSGGGPG SGEAGTGAPC
310 320 330 340 350
GRISFALRYL YGSDQLVVRI LQALDLPAKD SNGFSDPYVK IYLLPDRKKK
360 370 380 390 400
FQTKVHRKTL NPVFNETFQF SVPLAELAQR KLHFSVYDFD RFSRHDLIGQ
410 420 430 440 450
VVLDNLLELA EQPPDRPLWR DIVEGGSEKA DLGELNFSLC YLPTAGRLTV
460 470 480 490 500
TIIKASNLKA MDLTGFSDPY VKASLISEGR RLKKRKTSIK KNTLNPTYNE
510 520 530 540 550
ALVFDVAPES VENVGLSIAV VDYDCIGHNE VIGVCRVGPD AADPHGREHW
560 570 580 590
AEMLANPRKP VEHWHQLVEE KTVTSFTKGS KGLSEKENSE
Length:590
Mass (Da):63,304
Last modified:June 1, 2001 - v1
Checksum:i1E6B9F2CF44E7935
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82P → H in AAH31067 (PubMed:15489334).Curated1
Sequence conflicti324L → M in AAH28379 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036389474S → F in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136594 mRNA. Translation: CAB66529.1.
BC028379 mRNA. Translation: AAH28379.1.
BC031067 mRNA. Translation: AAH31067.1.
CCDSiCCDS12798.1.
RefSeqiNP_001153800.1. NM_001160328.1.
NP_001153801.1. NM_001160329.1.
NP_115674.1. NM_032298.2.
XP_011525692.1. XM_011527390.2.
XP_011525693.1. XM_011527391.2.
UniGeneiHs.515554.

Genome annotation databases

EnsembliENST00000338916; ENSP00000340914; ENSG00000213023.
ENST00000593901; ENSP00000468982; ENSG00000213023.
ENST00000600079; ENSP00000469398; ENSG00000213023.
GeneIDi84258.
KEGGihsa:84258.
UCSCiuc002pst.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSYT3_HUMAN
AccessioniPrimary (citable) accession number: Q9BQG1
Secondary accession number(s): Q8N5Z1, Q8N640
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families