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Protein

Synaptotagmin-3

Gene

SYT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.By similarity

Cofactori

Ca2+By similarityNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi330 – 3301Calcium 1By similarity
Metal bindingi330 – 3301Calcium 2By similarity
Metal bindingi336 – 3361Calcium 1By similarity
Metal bindingi388 – 3881Calcium 1By similarity
Metal bindingi388 – 3881Calcium 2By similarity
Metal bindingi389 – 3891Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi390 – 3901Calcium 1By similarity
Metal bindingi390 – 3901Calcium 2By similarity
Metal bindingi390 – 3901Calcium 3By similarity
Metal bindingi393 – 3931Calcium 3By similarity
Metal bindingi396 – 3961Calcium 2By similarity
Metal bindingi396 – 3961Calcium 3By similarity

GO - Molecular functioni

  1. calcium-dependent phospholipid binding Source: ParkinsonsUK-UCL
  2. metal ion binding Source: UniProtKB-KW
  3. phosphatidylserine binding Source: Ensembl
  4. transporter activity Source: InterPro

GO - Biological processi

  1. calcium ion-dependent exocytosis Source: InterPro
  2. positive regulation of vesicle fusion Source: Ensembl
  3. response to calcium ion Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-3
Alternative name(s):
Synaptotagmin III
Short name:
SytIII
Gene namesi
Name:SYT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:11511. SYT3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5454VesicularSequence AnalysisAdd
BLAST
Transmembranei55 – 7521HelicalSequence AnalysisAdd
BLAST
Topological domaini76 – 590515CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. endosome Source: LIFEdb
  3. integral component of membrane Source: UniProtKB-KW
  4. synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36292.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 590590Synaptotagmin-3PRO_0000183945Add
BLAST

Proteomic databases

MaxQBiQ9BQG1.
PaxDbiQ9BQG1.
PRIDEiQ9BQG1.

PTM databases

PhosphoSiteiQ9BQG1.

Expressioni

Gene expression databases

BgeeiQ9BQG1.
CleanExiHS_SYT3.
ExpressionAtlasiQ9BQG1. baseline and differential.
GenevestigatoriQ9BQG1.

Interactioni

Subunit structurei

Homodimer. Can also form heterodimers with SYT6 (By similarity).By similarity

Protein-protein interaction databases

BioGridi123985. 4 interactions.
MINTiMINT-4724742.
STRINGi9606.ENSP00000340914.

Structurei

3D structure databases

ProteinModelPortaliQ9BQG1.
SMRiQ9BQG1. Positions 297-571.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini301 – 402102C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini433 – 536104C2 2PROSITE-ProRule annotationAdd
BLAST

Domaini

The first C2 domain mediates Ca2+-dependent phospholipid binding.

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5038.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232128.
HOVERGENiHBG005010.
InParanoidiQ9BQG1.
OMAiQEFNDLR.
OrthoDBiEOG78PV8W.
PhylomeDBiQ9BQG1.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028682. SYT3.
[Graphical view]
PANTHERiPTHR10024:SF176. PTHR10024:SF176. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BQG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGDYEDDLC RRALILVSDL CARVRDADTN DRCQEFNDRI RGYPRGPDAD
60 70 80 90 100
ISVSLLSVIV TFCGIVLLGV SLFVSWKLCW VPWRDKGGSA VGGGPLRKDL
110 120 130 140 150
GPGVGLAGLV GGGGHHLAAG LGGHPLLGGP HHHAHAAHHP PFAELLEPGS
160 170 180 190 200
LGGSDTPEPS YLDMDSYPEA AAAAVAAGVK PSQTSPELPS EGGAGSGLLL
210 220 230 240 250
LPPSGGGLPS AQSHQQVTSL APTTRYPALP RPLTQQTLTS QPDPSSEERP
260 270 280 290 300
PALPLPLPGG EEKAKLIGQI KPELYQGTGP GGRRSGGGPG SGEAGTGAPC
310 320 330 340 350
GRISFALRYL YGSDQLVVRI LQALDLPAKD SNGFSDPYVK IYLLPDRKKK
360 370 380 390 400
FQTKVHRKTL NPVFNETFQF SVPLAELAQR KLHFSVYDFD RFSRHDLIGQ
410 420 430 440 450
VVLDNLLELA EQPPDRPLWR DIVEGGSEKA DLGELNFSLC YLPTAGRLTV
460 470 480 490 500
TIIKASNLKA MDLTGFSDPY VKASLISEGR RLKKRKTSIK KNTLNPTYNE
510 520 530 540 550
ALVFDVAPES VENVGLSIAV VDYDCIGHNE VIGVCRVGPD AADPHGREHW
560 570 580 590
AEMLANPRKP VEHWHQLVEE KTVTSFTKGS KGLSEKENSE
Length:590
Mass (Da):63,304
Last modified:June 1, 2001 - v1
Checksum:i1E6B9F2CF44E7935
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821P → H in AAH31067 (PubMed:15489334).Curated
Sequence conflicti324 – 3241L → M in AAH28379 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti474 – 4741S → F in a breast cancer sample; somatic mutation. 1 Publication
VAR_036389

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136594 mRNA. Translation: CAB66529.1.
BC028379 mRNA. Translation: AAH28379.1.
BC031067 mRNA. Translation: AAH31067.1.
CCDSiCCDS12798.1.
RefSeqiNP_001153800.1. NM_001160328.1.
NP_001153801.1. NM_001160329.1.
NP_115674.1. NM_032298.2.
XP_006723478.1. XM_006723415.1.
XP_006723479.1. XM_006723416.1.
UniGeneiHs.515554.

Genome annotation databases

EnsembliENST00000338916; ENSP00000340914; ENSG00000213023.
ENST00000544769; ENSP00000438883; ENSG00000213023.
ENST00000593901; ENSP00000468982; ENSG00000213023.
ENST00000600079; ENSP00000469398; ENSG00000213023.
GeneIDi84258.
KEGGihsa:84258.
UCSCiuc002pst.3. human.

Polymorphism databases

DMDMi18202733.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136594 mRNA. Translation: CAB66529.1.
BC028379 mRNA. Translation: AAH28379.1.
BC031067 mRNA. Translation: AAH31067.1.
CCDSiCCDS12798.1.
RefSeqiNP_001153800.1. NM_001160328.1.
NP_001153801.1. NM_001160329.1.
NP_115674.1. NM_032298.2.
XP_006723478.1. XM_006723415.1.
XP_006723479.1. XM_006723416.1.
UniGeneiHs.515554.

3D structure databases

ProteinModelPortaliQ9BQG1.
SMRiQ9BQG1. Positions 297-571.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123985. 4 interactions.
MINTiMINT-4724742.
STRINGi9606.ENSP00000340914.

PTM databases

PhosphoSiteiQ9BQG1.

Polymorphism databases

DMDMi18202733.

Proteomic databases

MaxQBiQ9BQG1.
PaxDbiQ9BQG1.
PRIDEiQ9BQG1.

Protocols and materials databases

DNASUi84258.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338916; ENSP00000340914; ENSG00000213023.
ENST00000544769; ENSP00000438883; ENSG00000213023.
ENST00000593901; ENSP00000468982; ENSG00000213023.
ENST00000600079; ENSP00000469398; ENSG00000213023.
GeneIDi84258.
KEGGihsa:84258.
UCSCiuc002pst.3. human.

Organism-specific databases

CTDi84258.
GeneCardsiGC19M051125.
HGNCiHGNC:11511. SYT3.
MIMi600327. gene.
neXtProtiNX_Q9BQG1.
PharmGKBiPA36292.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5038.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232128.
HOVERGENiHBG005010.
InParanoidiQ9BQG1.
OMAiQEFNDLR.
OrthoDBiEOG78PV8W.
PhylomeDBiQ9BQG1.
TreeFamiTF315600.

Miscellaneous databases

GeneWikiiSYT3.
GenomeRNAii84258.
NextBioi73778.
PROiQ9BQG1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BQG1.
CleanExiHS_SYT3.
ExpressionAtlasiQ9BQG1. baseline and differential.
GenevestigatoriQ9BQG1.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028682. SYT3.
[Graphical view]
PANTHERiPTHR10024:SF176. PTHR10024:SF176. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-474.

Entry informationi

Entry nameiSYT3_HUMAN
AccessioniPrimary (citable) accession number: Q9BQG1
Secondary accession number(s): Q8N5Z1, Q8N640
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 1, 2001
Last modified: January 7, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.