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Q9BQG1 (SYT3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Synaptotagmin-3
Alternative name(s):
Synaptotagmin III
Short name=SytIII
Gene names
Name:SYT3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length590 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis By similarity.

Cofactor

Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.

Subunit structure

Homodimer. Can also form heterodimers with SYT6 By similarity.

Subcellular location

Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Single-pass membrane protein By similarity.

Domain

The first C2 domain mediates Ca2+-dependent phospholipid binding.

Sequence similarities

Belongs to the synaptotagmin family.

Contains 2 C2 domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 590590Synaptotagmin-3
PRO_0000183945

Regions

Topological domain1 – 5454Vesicular Potential
Transmembrane55 – 7521Helical; Potential
Topological domain76 – 590515Cytoplasmic Potential
Domain301 – 402102C2 1
Domain433 – 536104C2 2

Sites

Metal binding3301Calcium 1 By similarity
Metal binding3301Calcium 2 By similarity
Metal binding3361Calcium 1 By similarity
Metal binding3881Calcium 1 By similarity
Metal binding3881Calcium 2 By similarity
Metal binding3891Calcium 1; via carbonyl oxygen By similarity
Metal binding3901Calcium 1 By similarity
Metal binding3901Calcium 2 By similarity
Metal binding3901Calcium 3 By similarity
Metal binding3931Calcium 3 By similarity
Metal binding3961Calcium 2 By similarity
Metal binding3961Calcium 3 By similarity

Natural variations

Natural variant4741S → F in a breast cancer sample; somatic mutation. Ref.3
VAR_036389

Experimental info

Sequence conflict821P → H in AAH31067. Ref.2
Sequence conflict3241L → M in AAH28379. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9BQG1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 1E6B9F2CF44E7935

FASTA59063,304
        10         20         30         40         50         60 
MSGDYEDDLC RRALILVSDL CARVRDADTN DRCQEFNDRI RGYPRGPDAD ISVSLLSVIV 

        70         80         90        100        110        120 
TFCGIVLLGV SLFVSWKLCW VPWRDKGGSA VGGGPLRKDL GPGVGLAGLV GGGGHHLAAG 

       130        140        150        160        170        180 
LGGHPLLGGP HHHAHAAHHP PFAELLEPGS LGGSDTPEPS YLDMDSYPEA AAAAVAAGVK 

       190        200        210        220        230        240 
PSQTSPELPS EGGAGSGLLL LPPSGGGLPS AQSHQQVTSL APTTRYPALP RPLTQQTLTS 

       250        260        270        280        290        300 
QPDPSSEERP PALPLPLPGG EEKAKLIGQI KPELYQGTGP GGRRSGGGPG SGEAGTGAPC 

       310        320        330        340        350        360 
GRISFALRYL YGSDQLVVRI LQALDLPAKD SNGFSDPYVK IYLLPDRKKK FQTKVHRKTL 

       370        380        390        400        410        420 
NPVFNETFQF SVPLAELAQR KLHFSVYDFD RFSRHDLIGQ VVLDNLLELA EQPPDRPLWR 

       430        440        450        460        470        480 
DIVEGGSEKA DLGELNFSLC YLPTAGRLTV TIIKASNLKA MDLTGFSDPY VKASLISEGR 

       490        500        510        520        530        540 
RLKKRKTSIK KNTLNPTYNE ALVFDVAPES VENVGLSIAV VDYDCIGHNE VIGVCRVGPD 

       550        560        570        580        590 
AADPHGREHW AEMLANPRKP VEHWHQLVEE KTVTSFTKGS KGLSEKENSE

« Hide

References

[1]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Amygdala.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-474.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL136594 mRNA. Translation: CAB66529.1.
BC028379 mRNA. Translation: AAH28379.1.
BC031067 mRNA. Translation: AAH31067.1.
IPIIPI00031100.
RefSeqNP_001153800.1. NM_001160328.1.
NP_001153801.1. NM_001160329.1.
NP_115674.1. NM_032298.2.
UniGeneHs.515554.

3D structure databases

ProteinModelPortalQ9BQG1.
ModBaseSearch...

Protein-protein interaction databases

STRING9606.ENSP00000340914.

PTM databases

PhosphoSiteQ9BQG1.

Polymorphism databases

DMDM18202733.

Proteomic databases

PaxDbQ9BQG1.
PRIDEQ9BQG1.

Protocols and materials databases

DNASU84258.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000338916; ENSP00000340914; ENSG00000213023.
ENST00000544769; ENSP00000438883; ENSG00000213023.
ENST00000593901; ENSP00000468982; ENSG00000213023.
ENST00000600079; ENSP00000469398; ENSG00000213023.
GeneID84258.
KEGGhsa:84258.
UCSCuc002pst.3. human.

Organism-specific databases

CTD84258.
GeneCardsGC19M051125.
HGNCHGNC:11511. SYT3.
MIM600327. gene.
neXtProtNX_Q9BQG1.
PharmGKBPA36292.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5038.
HOGENOMHOG000232128.
HOVERGENHBG005010.
InParanoidQ9BQG1.
OMAPVEHWHQ.
OrthoDBEOG4SQWWQ.

Gene expression databases

BgeeQ9BQG1.
CleanExHS_SYT3.
GenevestigatorQ9BQG1.
GermOnlineENSG00000161681. Homo sapiens.

Family and domain databases

InterProIPR000008. C2_Ca-dep.
IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR020477. C2_dom.
IPR018029. C2_membr_targeting.
IPR001565. Synaptotagmin.
[Graphical view]
PfamPF00168. C2. 2 hits.
[Graphical view]
PRINTSPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTSM00239. C2. 2 hits.
[Graphical view]
SUPFAMSSF49562. C2_CaLB. 2 hits.
PROSITEPS50004. C2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi84258.
NextBio73778.
SOURCESearch...

Entry information

Entry nameSYT3_HUMAN
AccessionPrimary (citable) accession number: Q9BQG1
Secondary accession number(s): Q8N5Z1, Q8N640
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 1, 2001
Last modified: May 1, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents