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Q9BQG1

- SYT3_HUMAN

UniProt

Q9BQG1 - SYT3_HUMAN

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Protein
Synaptotagmin-3
Gene
SYT3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis By similarity.

Cofactori

Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi330 – 3301Calcium 1 By similarity
Metal bindingi330 – 3301Calcium 2 By similarity
Metal bindingi336 – 3361Calcium 1 By similarity
Metal bindingi388 – 3881Calcium 1 By similarity
Metal bindingi388 – 3881Calcium 2 By similarity
Metal bindingi389 – 3891Calcium 1; via carbonyl oxygen By similarity
Metal bindingi390 – 3901Calcium 1 By similarity
Metal bindingi390 – 3901Calcium 2 By similarity
Metal bindingi390 – 3901Calcium 3 By similarity
Metal bindingi393 – 3931Calcium 3 By similarity
Metal bindingi396 – 3961Calcium 2 By similarity
Metal bindingi396 – 3961Calcium 3 By similarity

GO - Molecular functioni

  1. calcium-dependent phospholipid binding Source: Ensembl
  2. metal ion binding Source: UniProtKB-KW
  3. phosphatidylserine binding Source: Ensembl
  4. transporter activity Source: InterPro

GO - Biological processi

  1. calcium ion-dependent exocytosis Source: InterPro
  2. positive regulation of vesicle fusion Source: Ensembl
  3. response to calcium ion Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-3
Alternative name(s):
Synaptotagmin III
Short name:
SytIII
Gene namesi
Name:SYT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:11511. SYT3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5454Vesicular Reviewed prediction
Add
BLAST
Transmembranei55 – 7521Helical; Reviewed prediction
Add
BLAST
Topological domaini76 – 590515Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. endosome Source: LIFEdb
  3. integral component of membrane Source: UniProtKB-KW
  4. synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36292.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 590590Synaptotagmin-3
PRO_0000183945Add
BLAST

Proteomic databases

MaxQBiQ9BQG1.
PaxDbiQ9BQG1.
PRIDEiQ9BQG1.

PTM databases

PhosphoSiteiQ9BQG1.

Expressioni

Gene expression databases

ArrayExpressiQ9BQG1.
BgeeiQ9BQG1.
CleanExiHS_SYT3.
GenevestigatoriQ9BQG1.

Interactioni

Subunit structurei

Homodimer. Can also form heterodimers with SYT6 By similarity.

Protein-protein interaction databases

BioGridi123985. 3 interactions.
MINTiMINT-4724742.
STRINGi9606.ENSP00000340914.

Structurei

3D structure databases

ProteinModelPortaliQ9BQG1.
SMRiQ9BQG1. Positions 297-571.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini301 – 402102C2 1
Add
BLAST
Domaini433 – 536104C2 2
Add
BLAST

Domaini

The first C2 domain mediates Ca2+-dependent phospholipid binding.

Sequence similaritiesi

Belongs to the synaptotagmin family.
Contains 2 C2 domains.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5038.
HOGENOMiHOG000232128.
HOVERGENiHBG005010.
InParanoidiQ9BQG1.
OMAiAVVDYDC.
OrthoDBiEOG78PV8W.
PhylomeDBiQ9BQG1.
TreeFamiTF315600.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028682. SYT3.
[Graphical view]
PANTHERiPTHR10024:SF176. PTHR10024:SF176. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BQG1-1 [UniParc]FASTAAdd to Basket

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MSGDYEDDLC RRALILVSDL CARVRDADTN DRCQEFNDRI RGYPRGPDAD    50
ISVSLLSVIV TFCGIVLLGV SLFVSWKLCW VPWRDKGGSA VGGGPLRKDL 100
GPGVGLAGLV GGGGHHLAAG LGGHPLLGGP HHHAHAAHHP PFAELLEPGS 150
LGGSDTPEPS YLDMDSYPEA AAAAVAAGVK PSQTSPELPS EGGAGSGLLL 200
LPPSGGGLPS AQSHQQVTSL APTTRYPALP RPLTQQTLTS QPDPSSEERP 250
PALPLPLPGG EEKAKLIGQI KPELYQGTGP GGRRSGGGPG SGEAGTGAPC 300
GRISFALRYL YGSDQLVVRI LQALDLPAKD SNGFSDPYVK IYLLPDRKKK 350
FQTKVHRKTL NPVFNETFQF SVPLAELAQR KLHFSVYDFD RFSRHDLIGQ 400
VVLDNLLELA EQPPDRPLWR DIVEGGSEKA DLGELNFSLC YLPTAGRLTV 450
TIIKASNLKA MDLTGFSDPY VKASLISEGR RLKKRKTSIK KNTLNPTYNE 500
ALVFDVAPES VENVGLSIAV VDYDCIGHNE VIGVCRVGPD AADPHGREHW 550
AEMLANPRKP VEHWHQLVEE KTVTSFTKGS KGLSEKENSE 590
Length:590
Mass (Da):63,304
Last modified:June 1, 2001 - v1
Checksum:i1E6B9F2CF44E7935
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti474 – 4741S → F in a breast cancer sample; somatic mutation. 1 Publication
VAR_036389

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti82 – 821P → H in AAH31067. 1 Publication
Sequence conflicti324 – 3241L → M in AAH28379. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136594 mRNA. Translation: CAB66529.1.
BC028379 mRNA. Translation: AAH28379.1.
BC031067 mRNA. Translation: AAH31067.1.
CCDSiCCDS12798.1.
RefSeqiNP_001153800.1. NM_001160328.1.
NP_001153801.1. NM_001160329.1.
NP_115674.1. NM_032298.2.
XP_006723478.1. XM_006723415.1.
XP_006723479.1. XM_006723416.1.
UniGeneiHs.515554.

Genome annotation databases

EnsembliENST00000338916; ENSP00000340914; ENSG00000213023.
ENST00000544769; ENSP00000438883; ENSG00000213023.
ENST00000593901; ENSP00000468982; ENSG00000213023.
ENST00000600079; ENSP00000469398; ENSG00000213023.
GeneIDi84258.
KEGGihsa:84258.
UCSCiuc002pst.3. human.

Polymorphism databases

DMDMi18202733.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136594 mRNA. Translation: CAB66529.1 .
BC028379 mRNA. Translation: AAH28379.1 .
BC031067 mRNA. Translation: AAH31067.1 .
CCDSi CCDS12798.1.
RefSeqi NP_001153800.1. NM_001160328.1.
NP_001153801.1. NM_001160329.1.
NP_115674.1. NM_032298.2.
XP_006723478.1. XM_006723415.1.
XP_006723479.1. XM_006723416.1.
UniGenei Hs.515554.

3D structure databases

ProteinModelPortali Q9BQG1.
SMRi Q9BQG1. Positions 297-571.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123985. 3 interactions.
MINTi MINT-4724742.
STRINGi 9606.ENSP00000340914.

PTM databases

PhosphoSitei Q9BQG1.

Polymorphism databases

DMDMi 18202733.

Proteomic databases

MaxQBi Q9BQG1.
PaxDbi Q9BQG1.
PRIDEi Q9BQG1.

Protocols and materials databases

DNASUi 84258.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000338916 ; ENSP00000340914 ; ENSG00000213023 .
ENST00000544769 ; ENSP00000438883 ; ENSG00000213023 .
ENST00000593901 ; ENSP00000468982 ; ENSG00000213023 .
ENST00000600079 ; ENSP00000469398 ; ENSG00000213023 .
GeneIDi 84258.
KEGGi hsa:84258.
UCSCi uc002pst.3. human.

Organism-specific databases

CTDi 84258.
GeneCardsi GC19M051125.
HGNCi HGNC:11511. SYT3.
MIMi 600327. gene.
neXtProti NX_Q9BQG1.
PharmGKBi PA36292.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5038.
HOGENOMi HOG000232128.
HOVERGENi HBG005010.
InParanoidi Q9BQG1.
OMAi AVVDYDC.
OrthoDBi EOG78PV8W.
PhylomeDBi Q9BQG1.
TreeFami TF315600.

Miscellaneous databases

GeneWikii SYT3.
GenomeRNAii 84258.
NextBioi 73778.
PROi Q9BQG1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BQG1.
Bgeei Q9BQG1.
CleanExi HS_SYT3.
Genevestigatori Q9BQG1.

Family and domain databases

Gene3Di 2.60.40.150. 2 hits.
InterProi IPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028682. SYT3.
[Graphical view ]
PANTHERi PTHR10024:SF176. PTHR10024:SF176. 1 hit.
Pfami PF00168. C2. 2 hits.
[Graphical view ]
PRINTSi PR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.
SMARTi SM00239. C2. 2 hits.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 2 hits.
PROSITEi PS50004. C2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-474.

Entry informationi

Entry nameiSYT3_HUMAN
AccessioniPrimary (citable) accession number: Q9BQG1
Secondary accession number(s): Q8N5Z1, Q8N640
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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