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Q9BQG1

- SYT3_HUMAN

UniProt

Q9BQG1 - SYT3_HUMAN

Protein

Synaptotagmin-3

Gene

SYT3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.By similarity

    Cofactori

    Binds 3 calcium ions per subunit. The ions are bound to the C2 domains By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi330 – 3301Calcium 1By similarity
    Metal bindingi330 – 3301Calcium 2By similarity
    Metal bindingi336 – 3361Calcium 1By similarity
    Metal bindingi388 – 3881Calcium 1By similarity
    Metal bindingi388 – 3881Calcium 2By similarity
    Metal bindingi389 – 3891Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi390 – 3901Calcium 1By similarity
    Metal bindingi390 – 3901Calcium 2By similarity
    Metal bindingi390 – 3901Calcium 3By similarity
    Metal bindingi393 – 3931Calcium 3By similarity
    Metal bindingi396 – 3961Calcium 2By similarity
    Metal bindingi396 – 3961Calcium 3By similarity

    GO - Molecular functioni

    1. calcium-dependent phospholipid binding Source: Ensembl
    2. metal ion binding Source: UniProtKB-KW
    3. phosphatidylserine binding Source: Ensembl
    4. transporter activity Source: InterPro

    GO - Biological processi

    1. calcium ion-dependent exocytosis Source: InterPro
    2. positive regulation of vesicle fusion Source: Ensembl
    3. response to calcium ion Source: Ensembl

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptotagmin-3
    Alternative name(s):
    Synaptotagmin III
    Short name:
    SytIII
    Gene namesi
    Name:SYT3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:11511. SYT3.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. endosome Source: LIFEdb
    3. integral component of membrane Source: UniProtKB-KW
    4. synaptic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36292.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 590590Synaptotagmin-3PRO_0000183945Add
    BLAST

    Proteomic databases

    MaxQBiQ9BQG1.
    PaxDbiQ9BQG1.
    PRIDEiQ9BQG1.

    PTM databases

    PhosphoSiteiQ9BQG1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BQG1.
    BgeeiQ9BQG1.
    CleanExiHS_SYT3.
    GenevestigatoriQ9BQG1.

    Interactioni

    Subunit structurei

    Homodimer. Can also form heterodimers with SYT6 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi123985. 3 interactions.
    MINTiMINT-4724742.
    STRINGi9606.ENSP00000340914.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9BQG1.
    SMRiQ9BQG1. Positions 297-571.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5454VesicularSequence AnalysisAdd
    BLAST
    Topological domaini76 – 590515CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei55 – 7521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini301 – 402102C2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini433 – 536104C2 2PROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The first C2 domain mediates Ca2+-dependent phospholipid binding.

    Sequence similaritiesi

    Belongs to the synaptotagmin family.Curated
    Contains 2 C2 domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5038.
    HOGENOMiHOG000232128.
    HOVERGENiHBG005010.
    InParanoidiQ9BQG1.
    OMAiAVVDYDC.
    OrthoDBiEOG78PV8W.
    PhylomeDBiQ9BQG1.
    TreeFamiTF315600.

    Family and domain databases

    Gene3Di2.60.40.150. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    IPR028682. SYT3.
    [Graphical view]
    PANTHERiPTHR10024:SF176. PTHR10024:SF176. 1 hit.
    PfamiPF00168. C2. 2 hits.
    [Graphical view]
    PRINTSiPR00360. C2DOMAIN.
    PR00399. SYNAPTOTAGMN.
    SMARTiSM00239. C2. 2 hits.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 2 hits.
    PROSITEiPS50004. C2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9BQG1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGDYEDDLC RRALILVSDL CARVRDADTN DRCQEFNDRI RGYPRGPDAD    50
    ISVSLLSVIV TFCGIVLLGV SLFVSWKLCW VPWRDKGGSA VGGGPLRKDL 100
    GPGVGLAGLV GGGGHHLAAG LGGHPLLGGP HHHAHAAHHP PFAELLEPGS 150
    LGGSDTPEPS YLDMDSYPEA AAAAVAAGVK PSQTSPELPS EGGAGSGLLL 200
    LPPSGGGLPS AQSHQQVTSL APTTRYPALP RPLTQQTLTS QPDPSSEERP 250
    PALPLPLPGG EEKAKLIGQI KPELYQGTGP GGRRSGGGPG SGEAGTGAPC 300
    GRISFALRYL YGSDQLVVRI LQALDLPAKD SNGFSDPYVK IYLLPDRKKK 350
    FQTKVHRKTL NPVFNETFQF SVPLAELAQR KLHFSVYDFD RFSRHDLIGQ 400
    VVLDNLLELA EQPPDRPLWR DIVEGGSEKA DLGELNFSLC YLPTAGRLTV 450
    TIIKASNLKA MDLTGFSDPY VKASLISEGR RLKKRKTSIK KNTLNPTYNE 500
    ALVFDVAPES VENVGLSIAV VDYDCIGHNE VIGVCRVGPD AADPHGREHW 550
    AEMLANPRKP VEHWHQLVEE KTVTSFTKGS KGLSEKENSE 590
    Length:590
    Mass (Da):63,304
    Last modified:June 1, 2001 - v1
    Checksum:i1E6B9F2CF44E7935
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti82 – 821P → H in AAH31067. (PubMed:15489334)Curated
    Sequence conflicti324 – 3241L → M in AAH28379. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti474 – 4741S → F in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036389

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136594 mRNA. Translation: CAB66529.1.
    BC028379 mRNA. Translation: AAH28379.1.
    BC031067 mRNA. Translation: AAH31067.1.
    CCDSiCCDS12798.1.
    RefSeqiNP_001153800.1. NM_001160328.1.
    NP_001153801.1. NM_001160329.1.
    NP_115674.1. NM_032298.2.
    XP_006723478.1. XM_006723415.1.
    XP_006723479.1. XM_006723416.1.
    UniGeneiHs.515554.

    Genome annotation databases

    EnsembliENST00000338916; ENSP00000340914; ENSG00000213023.
    ENST00000544769; ENSP00000438883; ENSG00000213023.
    ENST00000593901; ENSP00000468982; ENSG00000213023.
    ENST00000600079; ENSP00000469398; ENSG00000213023.
    GeneIDi84258.
    KEGGihsa:84258.
    UCSCiuc002pst.3. human.

    Polymorphism databases

    DMDMi18202733.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136594 mRNA. Translation: CAB66529.1 .
    BC028379 mRNA. Translation: AAH28379.1 .
    BC031067 mRNA. Translation: AAH31067.1 .
    CCDSi CCDS12798.1.
    RefSeqi NP_001153800.1. NM_001160328.1.
    NP_001153801.1. NM_001160329.1.
    NP_115674.1. NM_032298.2.
    XP_006723478.1. XM_006723415.1.
    XP_006723479.1. XM_006723416.1.
    UniGenei Hs.515554.

    3D structure databases

    ProteinModelPortali Q9BQG1.
    SMRi Q9BQG1. Positions 297-571.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123985. 3 interactions.
    MINTi MINT-4724742.
    STRINGi 9606.ENSP00000340914.

    PTM databases

    PhosphoSitei Q9BQG1.

    Polymorphism databases

    DMDMi 18202733.

    Proteomic databases

    MaxQBi Q9BQG1.
    PaxDbi Q9BQG1.
    PRIDEi Q9BQG1.

    Protocols and materials databases

    DNASUi 84258.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338916 ; ENSP00000340914 ; ENSG00000213023 .
    ENST00000544769 ; ENSP00000438883 ; ENSG00000213023 .
    ENST00000593901 ; ENSP00000468982 ; ENSG00000213023 .
    ENST00000600079 ; ENSP00000469398 ; ENSG00000213023 .
    GeneIDi 84258.
    KEGGi hsa:84258.
    UCSCi uc002pst.3. human.

    Organism-specific databases

    CTDi 84258.
    GeneCardsi GC19M051125.
    HGNCi HGNC:11511. SYT3.
    MIMi 600327. gene.
    neXtProti NX_Q9BQG1.
    PharmGKBi PA36292.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5038.
    HOGENOMi HOG000232128.
    HOVERGENi HBG005010.
    InParanoidi Q9BQG1.
    OMAi AVVDYDC.
    OrthoDBi EOG78PV8W.
    PhylomeDBi Q9BQG1.
    TreeFami TF315600.

    Miscellaneous databases

    GeneWikii SYT3.
    GenomeRNAii 84258.
    NextBioi 73778.
    PROi Q9BQG1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BQG1.
    Bgeei Q9BQG1.
    CleanExi HS_SYT3.
    Genevestigatori Q9BQG1.

    Family and domain databases

    Gene3Di 2.60.40.150. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    IPR028682. SYT3.
    [Graphical view ]
    PANTHERi PTHR10024:SF176. PTHR10024:SF176. 1 hit.
    Pfami PF00168. C2. 2 hits.
    [Graphical view ]
    PRINTSi PR00360. C2DOMAIN.
    PR00399. SYNAPTOTAGMN.
    SMARTi SM00239. C2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 2 hits.
    PROSITEi PS50004. C2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-474.

    Entry informationi

    Entry nameiSYT3_HUMAN
    AccessioniPrimary (citable) accession number: Q9BQG1
    Secondary accession number(s): Q8N5Z1, Q8N640
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3