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Protein

Myb-binding protein 1A

Gene

MYBBP1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter.By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to glucose starvation Source: UniProtKB
  • circadian regulation of gene expression Source: UniProtKB
  • intrinsic apoptotic signaling pathway by p53 class mediator Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • nucleocytoplasmic transport Source: UniProtKB
  • osteoblast differentiation Source: UniProtKB
  • positive regulation of anoikis Source: CACAO
  • positive regulation of cell cycle arrest Source: UniProtKB
  • positive regulation of gene expression, epigenetic Source: Reactome
  • regulation of transcription, DNA-templated Source: ProtInc
  • respiratory electron transport chain Source: Ensembl
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5250924. B-WICH complex positively regulates rRNA expression.
SIGNORiQ9BQG0.

Names & Taxonomyi

Protein namesi
Recommended name:
Myb-binding protein 1A
Gene namesi
Name:MYBBP1A
Synonyms:P160
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:7546. MYBBP1A.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • intracellular membrane-bounded organelle Source: HPA
  • membrane Source: UniProtKB
  • NLS-dependent protein nuclear import complex Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10514.
OpenTargetsiENSG00000132382.
PharmGKBiPA31346.

Polymorphism and mutation databases

BioMutaiMYBBP1A.
DMDMi71153825.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000962551 – 1328Myb-binding protein 1AAdd BLAST1328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineCombined sources1
Modified residuei71N6-acetyllysineCombined sources1
Modified residuei158N6-acetyllysineCombined sources1
Modified residuei775PhosphoserineCombined sources1
Modified residuei1159PhosphoserineCombined sources1
Modified residuei1163PhosphoserineCombined sources1
Modified residuei1186PhosphoserineCombined sources1
Modified residuei1190PhosphothreonineCombined sources1
Modified residuei1196PhosphothreonineCombined sources1
Modified residuei1207PhosphoserineCombined sources1
Modified residuei1232PhosphoserineCombined sources1
Modified residuei1239PhosphothreonineCombined sources1
Modified residuei1241PhosphoserineCombined sources1
Modified residuei1244PhosphothreonineBy similarity1
Modified residuei1248PhosphoserineCombined sources1
Modified residuei1267PhosphoserineCombined sources1
Modified residuei1269PhosphothreonineCombined sources1
Modified residuei1290PhosphoserineCombined sources1
Modified residuei1303PhosphoserineCombined sources1
Modified residuei1307CitrullineBy similarity1
Modified residuei1308PhosphoserineCombined sources1
Modified residuei1310PhosphoserineCombined sources1
Modified residuei1314PhosphoserineCombined sources1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Acetylation, Citrullination, Phosphoprotein

Proteomic databases

EPDiQ9BQG0.
MaxQBiQ9BQG0.
PaxDbiQ9BQG0.
PeptideAtlasiQ9BQG0.
PRIDEiQ9BQG0.

2D gel databases

SWISS-2DPAGEQ9BQG0.

PTM databases

iPTMnetiQ9BQG0.
PhosphoSitePlusiQ9BQG0.
SwissPalmiQ9BQG0.

Miscellaneous databases

PMAP-CutDBQ9BQG0.

Expressioni

Gene expression databases

BgeeiENSG00000132382.
CleanExiHS_MYBBP1A.
ExpressionAtlasiQ9BQG0. baseline and differential.
GenevisibleiQ9BQG0. HS.

Organism-specific databases

HPAiHPA005466.

Interactioni

Subunit structurei

Binds to and represses JUN and MYB via the leucine zipper regions present in these proteins. Also binds to and represses PPARGC1A: this interaction is abrogated when PPARGC1A is phosphorylated by MAPK1/ERK. Binds to and stimulates transcription by AHR. Binds to KPNA2. Interacts with CLOCK and CRY1 (By similarity). Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DHX30Q7L2E33EBI-676973,EBI-1211456
NR2E3Q9Y5X42EBI-676973,EBI-7216962

GO - Molecular functioni

  • transcription factor binding Source: ProtInc

Protein-protein interaction databases

BioGridi115770. 120 interactors.
IntActiQ9BQG0. 44 interactors.
MINTiMINT-1150245.
STRINGi9606.ENSP00000370968.

Structurei

3D structure databases

ProteinModelPortaliQ9BQG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 582Interaction with MYBBy similarityAdd BLAST582
Regioni1151 – 1328Required for nuclear and nucleolar localizationBy similarityAdd BLAST178

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi240 – 258Nuclear export signal 1By similarityAdd BLAST19
Motifi263 – 281Nuclear export signal 2By similarityAdd BLAST19

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi720 – 784Glu-richAdd BLAST65

Phylogenomic databases

eggNOGiKOG1926. Eukaryota.
ENOG410YFVF. LUCA.
GeneTreeiENSGT00390000017457.
HOGENOMiHOG000113488.
HOVERGENiHBG081961.
InParanoidiQ9BQG0.
KOiK02331.
OMAiEDKFPRF.
OrthoDBiEOG091G00YE.
PhylomeDBiQ9BQG0.
TreeFamiTF317401.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR007015. DNA_pol_V.
[Graphical view]
PANTHERiPTHR13213. PTHR13213. 2 hits.
PfamiPF04931. DNA_pol_phi. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BQG0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESRDPAQPM SPGEATQSGA RPADRYGLLK HSREFLDFFW DIAKPEQETR
60 70 80 90 100
LAATEKLLEY LRGRPKGSEM KYALKRLITG LGVGRETARP CYSLALAQLL
110 120 130 140 150
QSFEDLPLCS ILQQIQEKYD LHQVKKAMLR PALFANLFGV LALFQSGRLV
160 170 180 190 200
KDQEALMKSV KLLQALAQYQ NHLQEQPRKA LVDILSEVSK ATLQEILPEV
210 220 230 240 250
LKADLNIILS SPEQLELFLL AQQKVPSKLK KLVGSVNLFS DENVPRLVNV
260 270 280 290 300
LKMAASSVKK DRKLPAIALD LLRLALKEDK FPRFWKEVVE QGLLKMQFWP
310 320 330 340 350
ASYLCFRLLG AALPLLTKEQ LHLVMQGDVI RHYGEHVCTA KLPKQFKFAP
360 370 380 390 400
EMDDYVGTFL EGCQDDPERQ LAVLVAFSSV TNQGLPVTPT FWRVVRFLSP
410 420 430 440 450
PALQGYVAWL RAMFLQPDLD SLVDFSTNNQ KKAQDSSLHM PERAVFRLRK
460 470 480 490 500
WIIFRLVSIV DSLHLEMEEA LTEQVARFCL FHSFFVTKKP TSQIPETKHP
510 520 530 540 550
FSFPLENQAR EAVSSAFFSL LQTLSTQFKQ APGQTQGGQP WTYHLVQFAD
560 570 580 590 600
LLLNHSHNVT TVTPFTAQQR QAWDRMLQTL KELEAHSAEA RAAAFQHLLL
610 620 630 640 650
LVGIHLLKSP AESCDLLGDI QTCIRKSLGE KPRRSRTKTI DPQEPPWVEV
660 670 680 690 700
LVEILLALLA QPSHLMRQVA RSVFGHICSH LTPRALQLIL DVLNPETSED
710 720 730 740 750
ENDRVVVTDD SDERRLKGAE DKSEEGEDNR SSESEEESEG EESEEEERDG
760 770 780 790 800
DVDQGFREQL MTVLQAGKAL GGEDSENEEE LGDEAMMALD QSLASLFAEQ
810 820 830 840 850
KLRIQARRDE KNKLQKEKAL RRDFQIRVLD LVEVLVTKQP ENALVLELLE
860 870 880 890 900
PLLSIIRRSL RSSSSKQEQD LLHKTARIFT HHLCRARRYC HDLGERAGAL
910 920 930 940 950
HAQVERLVQQ AGRQPDSPTA LYHFNASLYL LRVLKGNTAE GCVHETQEKQ
960 970 980 990 1000
KAGTDPSHMP TGPQAASCLD LNLVTRVYST ALSSFLTKRN SPLTVPMFLS
1010 1020 1030 1040 1050
LFSRHPVLCQ SLLPILVQHI TGPVRPRHQA CLLLQKTLSM REVRSCFEDP
1060 1070 1080 1090 1100
EWKQLMGQVL AKVTENLRVL GEAQTKAQHQ QALSSLELLN VLFRTCKHEK
1110 1120 1130 1140 1150
LTLDLTVLLG VLQGQQQSLQ QGAHSTGSSR LHDLYWQAMK TLGVQRPKLE
1160 1170 1180 1190 1200
KKDAKEIPSA TQSPISKKRK KKGFLPETKK RKKRKSEDGT PAEDGTPAAT
1210 1220 1230 1240 1250
GGSQPPSMGR KKRNRTKAKV PAQANGTPTT KSPAPGAPTR SPSTPAKSPK
1260 1270 1280 1290 1300
LQKKNQKPSQ VNGAPGSPTE PAGQKQHQKA LPKKGVLGKS PLSALARKKA
1310 1320
RLSLVIRSPS LLQSGAKKKA QVRKAGKP
Length:1,328
Mass (Da):148,855
Last modified:July 19, 2005 - v2
Checksum:i0B053465D5B3511F
GO
Isoform 2 (identifier: Q9BQG0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1322-1328: VRKAGKP → TLRFTISSSKK

Note: May be due to competing donor and acceptor splice sites.
Show »
Length:1,332
Mass (Da):149,367
Checksum:iCF90678D49D64DB1
GO

Sequence cautioni

The sequence CAB66530 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti307R → H in AAF33021 (PubMed:10644447).Curated1
Sequence conflicti570R → H in AAF33021 (PubMed:10644447).Curated1
Sequence conflicti601L → F in AAF33021 (PubMed:10644447).Curated1
Sequence conflicti1028H → R in AAH50546 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0230648Q → E.Corresponds to variant rs3809849dbSNPEnsembl.1
Natural variantiVAR_051156680H → Y.Corresponds to variant rs899440dbSNPEnsembl.1
Natural variantiVAR_051157958H → P.Corresponds to variant rs879797dbSNPEnsembl.1
Natural variantiVAR_0511581208M → L.Corresponds to variant rs9905742dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0147861322 – 1328VRKAGKP → TLRFTISSSKK in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF147709 mRNA. Translation: AAF33021.1.
BC000641 mRNA. Translation: AAH00641.2.
BC050546 mRNA. Translation: AAH50546.1.
AL136595 mRNA. Translation: CAB66530.1. Different initiation.
AL133098 mRNA. Translation: CAB61409.1.
CCDSiCCDS11046.1. [Q9BQG0-1]
CCDS42238.1. [Q9BQG0-2]
PIRiT42680.
RefSeqiNP_001099008.1. NM_001105538.1. [Q9BQG0-2]
NP_055335.2. NM_014520.3. [Q9BQG0-1]
UniGeneiHs.22824.
Hs.701718.

Genome annotation databases

EnsembliENST00000254718; ENSP00000254718; ENSG00000132382. [Q9BQG0-1]
ENST00000381556; ENSP00000370968; ENSG00000132382. [Q9BQG0-2]
GeneIDi10514.
KEGGihsa:10514.
UCSCiuc002fxz.5. human. [Q9BQG0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF147709 mRNA. Translation: AAF33021.1.
BC000641 mRNA. Translation: AAH00641.2.
BC050546 mRNA. Translation: AAH50546.1.
AL136595 mRNA. Translation: CAB66530.1. Different initiation.
AL133098 mRNA. Translation: CAB61409.1.
CCDSiCCDS11046.1. [Q9BQG0-1]
CCDS42238.1. [Q9BQG0-2]
PIRiT42680.
RefSeqiNP_001099008.1. NM_001105538.1. [Q9BQG0-2]
NP_055335.2. NM_014520.3. [Q9BQG0-1]
UniGeneiHs.22824.
Hs.701718.

3D structure databases

ProteinModelPortaliQ9BQG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115770. 120 interactors.
IntActiQ9BQG0. 44 interactors.
MINTiMINT-1150245.
STRINGi9606.ENSP00000370968.

PTM databases

iPTMnetiQ9BQG0.
PhosphoSitePlusiQ9BQG0.
SwissPalmiQ9BQG0.

Polymorphism and mutation databases

BioMutaiMYBBP1A.
DMDMi71153825.

2D gel databases

SWISS-2DPAGEQ9BQG0.

Proteomic databases

EPDiQ9BQG0.
MaxQBiQ9BQG0.
PaxDbiQ9BQG0.
PeptideAtlasiQ9BQG0.
PRIDEiQ9BQG0.

Protocols and materials databases

DNASUi10514.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254718; ENSP00000254718; ENSG00000132382. [Q9BQG0-1]
ENST00000381556; ENSP00000370968; ENSG00000132382. [Q9BQG0-2]
GeneIDi10514.
KEGGihsa:10514.
UCSCiuc002fxz.5. human. [Q9BQG0-1]

Organism-specific databases

CTDi10514.
DisGeNETi10514.
GeneCardsiMYBBP1A.
H-InvDBHIX0013445.
HGNCiHGNC:7546. MYBBP1A.
HPAiHPA005466.
MIMi604885. gene.
neXtProtiNX_Q9BQG0.
OpenTargetsiENSG00000132382.
PharmGKBiPA31346.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1926. Eukaryota.
ENOG410YFVF. LUCA.
GeneTreeiENSGT00390000017457.
HOGENOMiHOG000113488.
HOVERGENiHBG081961.
InParanoidiQ9BQG0.
KOiK02331.
OMAiEDKFPRF.
OrthoDBiEOG091G00YE.
PhylomeDBiQ9BQG0.
TreeFamiTF317401.

Enzyme and pathway databases

ReactomeiR-HSA-5250924. B-WICH complex positively regulates rRNA expression.
SIGNORiQ9BQG0.

Miscellaneous databases

ChiTaRSiMYBBP1A. human.
GeneWikiiMYBBP1A.
GenomeRNAii10514.
PMAP-CutDBQ9BQG0.
PROiQ9BQG0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132382.
CleanExiHS_MYBBP1A.
ExpressionAtlasiQ9BQG0. baseline and differential.
GenevisibleiQ9BQG0. HS.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR007015. DNA_pol_V.
[Graphical view]
PANTHERiPTHR13213. PTHR13213. 2 hits.
PfamiPF04931. DNA_pol_phi. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMBB1A_HUMAN
AccessioniPrimary (citable) accession number: Q9BQG0
Secondary accession number(s): Q86VM3
, Q9BW49, Q9P0V5, Q9UF99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.