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Q9BQF6

- SENP7_HUMAN

UniProt

Q9BQF6 - SENP7_HUMAN

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Protein
Sentrin-specific protease 7
Gene
SENP7, KIAA1707, SSP2, SUSP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.1 Publication

Catalytic activityi

Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei860 – 8601 By similarity
Active sitei992 – 9921 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC48.009.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sentrin-specific protease 7 (EC:3.4.22.68)
    Alternative name(s):
    SUMO-1-specific protease 2
    Sentrin/SUMO-specific protease SENP7
    Gene namesi
    Name:SENP7
    Synonyms:KIAA1707, SSP2, SUSP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:30402. SENP7.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: LIFEdb
    2. nucleus Source: LIFEdb
    Complete GO annotation...

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi775 – 7751F → W: Slightly increased deconjugation activity. 1 Publication
    Mutagenesisi779 – 7791V → E: Reduces deconjugation activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA134925171.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10501050Sentrin-specific protease 7
    PRO_0000101726Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei25 – 251Phosphoserine1 Publication
    Modified residuei443 – 4431Phosphoserine1 Publication
    Modified residuei444 – 4441Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9BQF6.
    PaxDbiQ9BQF6.
    PRIDEiQ9BQF6.

    PTM databases

    PhosphoSiteiQ9BQF6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9BQF6.
    BgeeiQ9BQF6.
    CleanExiHS_SENP7.
    GenevestigatoriQ9BQF6.

    Organism-specific databases

    HPAiHPA027259.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CBX5P459732EBI-766251,EBI-78219
    TRIM28Q132632EBI-766251,EBI-78139

    Protein-protein interaction databases

    BioGridi121491. 2 interactions.
    IntActiQ9BQF6. 3 interactions.
    MINTiMINT-4717645.
    STRINGi9606.ENSP00000377655.

    Structurei

    Secondary structure

    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi747 – 7526
    Beta strandi756 – 7583
    Beta strandi760 – 7634
    Helixi764 – 7685
    Helixi778 – 79114
    Helixi795 – 7995
    Beta strandi801 – 8033
    Helixi807 – 8126
    Helixi828 – 8336
    Helixi837 – 8404
    Helixi845 – 8473
    Beta strandi849 – 8579
    Beta strandi860 – 8678
    Beta strandi933 – 9386
    Helixi946 – 96520
    Turni973 – 9753
    Helixi992 – 100514
    Helixi1023 – 10275
    Helixi1029 – 104618

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3EAYX-ray2.40A728-1050[»]
    ProteinModelPortaliQ9BQF6.
    SMRiQ9BQF6. Positions 744-1047.

    Miscellaneous databases

    EvolutionaryTraceiQ9BQF6.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni760 – 1050291Protease
    Add
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C48 family.

    Phylogenomic databases

    eggNOGiCOG5160.
    HOVERGENiHBG079864.
    KOiK08596.
    OMAiFIFLELH.
    OrthoDBiEOG780RMX.
    PhylomeDBiQ9BQF6.
    TreeFamiTF350136.

    Family and domain databases

    InterProiIPR003653. Peptidase_C48.
    [Graphical view]
    PfamiPF02902. Peptidase_C48. 1 hit.
    [Graphical view]
    PROSITEiPS50600. ULP_PROTEASE. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Note: Experimental confirmation may be lacking for some isoforms.

    Isoform 1 (identifier: Q9BQF6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDKRKLGRRP SSSEIITEGK RKKSSSDLSE IRKMLNAKPE DVHVQSPLSK     50
    FRSSERWTLP LQWERSLRNK VISLDHKNKK HIRGCPVTSK SSPERQLKVM 100
    LTNVLWTDLG RKFRKTLPRN DANLCDANKV QSDSLPSTSV DSLETCQKLE 150
    PLRQSLNLSE RIPRVILTNV LGTELGRKYI RTPPVTEGSL SDTDNLQSEQ 200
    LSSSSDGSLE SYQNLNPHKS CYLSERGSQR SKTVDDNSAK QTAHNKEKRR 250
    KDDGISLLIS DTQPEDLNSG SRGCDHLEQE SRNKDVKYSD SKVELTLISR 300
    KTKRRLRNNL PDSQYCTSLD KSTEQTKKQE DDSTISTEFE KPSENYHQDP 350
    KLPEEITTKP TKSDFTKLSS LNSQELTLSN ATKSASAGST TETVENSNSI 400
    DIVGISSLVE KDENELNTIE KPILRGHNEG NQSLISAEPI VVSSDEEGPV 450
    EHKSSEILKL QSKQDRETTN ENESTSESAL LELPLITCES VQMSSELCPY 500
    NPVMENISSI MPSNEMDLQL DFIFTSVYIG KIKGASKGCV TITKKYIKIP 550
    FQVSLNEISL LVDTTHLKRF GLWKSKDDNH SKRSHAILFF WVSSDYLQEI 600
    QTQLEHSVLS QQSKSSEFIF LELHNPVSQR EELKLKDIMT EISIISGELE 650
    LSYPLSWVQA FPLFQNLSSK ESSFIHYYCV STCSFPAGVA VAEEMKLKSV 700
    SQPSNTDAAK PTYTFLQKQS SGCYSLSITS NPDEEWREVR HTGLVQKLIV 750
    YPPPPTKGGL GVTNEDLECL EEGEFLNDVI IDFYLKYLIL EKASDELVER 800
    SHIFSSFFYK CLTRKENNLT EDNPNLSMAQ RRHKRVRTWT RHINIFNKDY 850
    IFVPVNESSH WYLAVICFPW LEEAVYEDFP QTVSQQSQAQ QSQNDNKTID 900
    NDLRTTSTLS LSAEDSQSTE SNMSVPKKMC KRPCILILDS LKAASVQNTV 950
    QNLREYLEVE WEVKLKTHRQ FSKTNMVDLC PKVPKQDNSS DCGVYLLQYV 1000
    ESFFKDPIVN FELPIHLEKW FPRHVIKTKR EDIRELILKL HLQQQKGSSS 1050
    Length:1,050
    Mass (Da):119,658
    Last modified:July 13, 2010 - v4
    Checksum:iCB455A0B22709052
    GO
    Isoform 2 (identifier: Q9BQF6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-33: Missing.

    Show »
    Length:1,017
    Mass (Da):115,871
    Checksum:iF0C8278BCC440AA8
    GO
    Isoform 3 (identifier: Q9BQF6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-812: Missing.
         813-827: TRKENNLTEDNPNLS → MKKFLYIKSVFHTLR

    Show »
    Length:238
    Mass (Da):28,124
    Checksum:i9661C4384D6A30D7
    GO
    Isoform 4 (identifier: Q9BQF6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-33: Missing.
         95-225: Missing.

    Show »
    Length:886
    Mass (Da):101,195
    Checksum:iB03DA49EB00C0007
    GO
    Isoform 5 (identifier: Q9BQF6-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         95-160: Missing.

    Show »
    Length:984
    Mass (Da):112,159
    Checksum:iE5EBB74CAC3E39C5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti79 – 791K → Q.
    Corresponds to variant rs6809436 [ dbSNP | Ensembl ].
    VAR_029651
    Natural varianti612 – 6121Q → H.1 Publication
    Corresponds to variant rs2433031 [ dbSNP | Ensembl ].
    VAR_029652

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 812812Missing in isoform 3.
    VSP_039498Add
    BLAST
    Alternative sequencei1 – 3333Missing in isoform 2 and isoform 4.
    VSP_039499Add
    BLAST
    Alternative sequencei95 – 225131Missing in isoform 4.
    VSP_039501Add
    BLAST
    Alternative sequencei95 – 16066Missing in isoform 5.
    VSP_039500Add
    BLAST
    Alternative sequencei813 – 82715TRKEN…NPNLS → MKKFLYIKSVFHTLR in isoform 3.
    VSP_039502Add
    BLAST

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti90 – 901K → R in CAB66534. 1 Publication
    Sequence conflicti341 – 3411K → R in CAB66534. 1 Publication
    Sequence conflicti396 – 3961N → Y in CAB66534. 1 Publication
    Sequence conflicti785 – 7851L → H in AAL25651. 1 Publication
    Sequence conflicti894 – 8941N → S in CAB66534. 1 Publication
    Sequence conflicti947 – 9471Q → R in CAB66534. 1 Publication
    Sequence conflicti1006 – 10061D → N in AAL25651. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF199458 mRNA. Translation: AAL25651.1.
    AF217504 mRNA. Translation: AAG09703.1.
    AL136599 mRNA. Translation: CAB66534.1.
    BX537943 mRNA. Translation: CAD97911.1.
    AC068764 Genomic DNA. No translation available.
    AC073861 Genomic DNA. No translation available.
    AC110994 Genomic DNA. No translation available.
    BC129988 mRNA. Translation: AAI29989.1.
    AB051494 mRNA. Translation: BAB21798.1.
    CCDSiCCDS2941.2. [Q9BQF6-1]
    CCDS63704.1. [Q9BQF6-4]
    CCDS63705.1. [Q9BQF6-2]
    CCDS63706.1. [Q9BQF6-5]
    RefSeqiNP_001070671.1. NM_001077203.2.
    NP_001269730.1. NM_001282801.1. [Q9BQF6-5]
    NP_001269731.1. NM_001282802.1. [Q9BQF6-2]
    NP_001269732.1. NM_001282803.1. [Q9BQF6-4]
    NP_001269733.1. NM_001282804.1.
    NP_065705.3. NM_020654.4. [Q9BQF6-1]
    UniGeneiHs.529551.

    Genome annotation databases

    EnsembliENST00000314261; ENSP00000313624; ENSG00000138468. [Q9BQF6-5]
    ENST00000348610; ENSP00000342159; ENSG00000138468. [Q9BQF6-2]
    ENST00000358203; ENSP00000350936; ENSG00000138468. [Q9BQF6-4]
    ENST00000394085; ENSP00000377647; ENSG00000138468. [Q9BQF6-3]
    ENST00000394091; ENSP00000377651; ENSG00000138468. [Q9BQF6-4]
    ENST00000394095; ENSP00000377655; ENSG00000138468. [Q9BQF6-1]
    GeneIDi57337.
    KEGGihsa:57337.
    UCSCiuc003dus.3. human. [Q9BQF6-3]
    uc003dut.3. human. [Q9BQF6-1]
    uc003duw.3. human. [Q9BQF6-5]
    uc003dux.3. human. [Q9BQF6-4]

    Polymorphism databases

    DMDMi300669717.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF199458 mRNA. Translation: AAL25651.1 .
    AF217504 mRNA. Translation: AAG09703.1 .
    AL136599 mRNA. Translation: CAB66534.1 .
    BX537943 mRNA. Translation: CAD97911.1 .
    AC068764 Genomic DNA. No translation available.
    AC073861 Genomic DNA. No translation available.
    AC110994 Genomic DNA. No translation available.
    BC129988 mRNA. Translation: AAI29989.1 .
    AB051494 mRNA. Translation: BAB21798.1 .
    CCDSi CCDS2941.2. [Q9BQF6-1 ]
    CCDS63704.1. [Q9BQF6-4 ]
    CCDS63705.1. [Q9BQF6-2 ]
    CCDS63706.1. [Q9BQF6-5 ]
    RefSeqi NP_001070671.1. NM_001077203.2.
    NP_001269730.1. NM_001282801.1. [Q9BQF6-5 ]
    NP_001269731.1. NM_001282802.1. [Q9BQF6-2 ]
    NP_001269732.1. NM_001282803.1. [Q9BQF6-4 ]
    NP_001269733.1. NM_001282804.1.
    NP_065705.3. NM_020654.4. [Q9BQF6-1 ]
    UniGenei Hs.529551.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3EAY X-ray 2.40 A 728-1050 [» ]
    ProteinModelPortali Q9BQF6.
    SMRi Q9BQF6. Positions 744-1047.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 121491. 2 interactions.
    IntActi Q9BQF6. 3 interactions.
    MINTi MINT-4717645.
    STRINGi 9606.ENSP00000377655.

    Chemistry

    BindingDBi Q9BQF6.
    ChEMBLi CHEMBL1741213.

    Protein family/group databases

    MEROPSi C48.009.

    PTM databases

    PhosphoSitei Q9BQF6.

    Polymorphism databases

    DMDMi 300669717.

    Proteomic databases

    MaxQBi Q9BQF6.
    PaxDbi Q9BQF6.
    PRIDEi Q9BQF6.

    Protocols and materials databases

    DNASUi 57337.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314261 ; ENSP00000313624 ; ENSG00000138468 . [Q9BQF6-5 ]
    ENST00000348610 ; ENSP00000342159 ; ENSG00000138468 . [Q9BQF6-2 ]
    ENST00000358203 ; ENSP00000350936 ; ENSG00000138468 . [Q9BQF6-4 ]
    ENST00000394085 ; ENSP00000377647 ; ENSG00000138468 . [Q9BQF6-3 ]
    ENST00000394091 ; ENSP00000377651 ; ENSG00000138468 . [Q9BQF6-4 ]
    ENST00000394095 ; ENSP00000377655 ; ENSG00000138468 . [Q9BQF6-1 ]
    GeneIDi 57337.
    KEGGi hsa:57337.
    UCSCi uc003dus.3. human. [Q9BQF6-3 ]
    uc003dut.3. human. [Q9BQF6-1 ]
    uc003duw.3. human. [Q9BQF6-5 ]
    uc003dux.3. human. [Q9BQF6-4 ]

    Organism-specific databases

    CTDi 57337.
    GeneCardsi GC03M101043.
    H-InvDB HIX0003507.
    HGNCi HGNC:30402. SENP7.
    HPAi HPA027259.
    MIMi 612846. gene.
    neXtProti NX_Q9BQF6.
    PharmGKBi PA134925171.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5160.
    HOVERGENi HBG079864.
    KOi K08596.
    OMAi FIFLELH.
    OrthoDBi EOG780RMX.
    PhylomeDBi Q9BQF6.
    TreeFami TF350136.

    Miscellaneous databases

    EvolutionaryTracei Q9BQF6.
    GeneWikii SENP7.
    GenomeRNAii 57337.
    NextBioi 63454.
    PROi Q9BQF6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9BQF6.
    Bgeei Q9BQF6.
    CleanExi HS_SENP7.
    Genevestigatori Q9BQF6.

    Family and domain databases

    InterProi IPR003653. Peptidase_C48.
    [Graphical view ]
    Pfami PF02902. Peptidase_C48. 1 hit.
    [Graphical view ]
    PROSITEi PS50600. ULP_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. Choi S.J., Jeon Y.-J., Kim K.I., Nishimori S., Suzuki T., Uchida S., Shimbara N., Tanaka K., Chung C.H.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "SENP7, a novel human sentrin-specific protease."
      Gong L., Yeh E.T.H.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Tissue: Placenta.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Fetal kidney.
    5. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
      DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 295-1050, VARIANT HIS-612.
      Tissue: Brain.
    8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25; SER-443 AND SER-444, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    10. "Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7."
      Lima C.D., Reverter D.
      J. Biol. Chem. 283:32045-32055(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 728-1050, FUNCTION, MUTAGENESIS OF PHE-775 AND VAL-779.

    Entry informationi

    Entry nameiSENP7_HUMAN
    AccessioniPrimary (citable) accession number: Q9BQF6
    Secondary accession number(s): A1L3A5
    , A8MW39, B7WNW8, Q7Z3F4, Q96PS5, Q9C0F6, Q9HBT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: July 13, 2010
    Last modified: July 9, 2014
    This is version 108 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Peptidase families
      Classification of peptidase families and list of entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi