Q9BQF6 (SENP7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sentrin-specific protease 7
EC=3.4.22.68

Alternative name(s):
SUMO-1-specific protease 2
Sentrin/SUMO-specific protease SENP7

Gene names

Name:	SENP7
Synonyms:	KIAA1707, SSP2, SUSP2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1050 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms. Ref.10
Catalytic activity	Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.
Sequence similarities	Belongs to the peptidase C48 family.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Hydrolase Protease Thiol protease
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay. Source: LIFEdb
Molecular_function	cysteine-type peptidase activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q9BQF6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BQF6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Isoform 3 (identifier: Q9BQF6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-812: Missing.
     813-827: TRKENNLTEDNPNLS → MKKFLYIKSVFHTLR

Isoform 4 (identifier: Q9BQF6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.
     95-225: Missing.

Isoform 5 (identifier: Q9BQF6-5)

The sequence of this isoform differs from the canonical sequence as follows:
     95-160: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1050

1050

Sentrin-specific protease 7

PRO_0000101726

Regions

Region

760 – 1050

291

Protease

Sites

Active site

860

1

By similarity

Active site

992

1

By similarity

Amino acid modifications

Modified residue

25

1

Phosphoserine Ref.9

Modified residue

443

1

Phosphoserine Ref.9

Modified residue

444

1

Phosphoserine Ref.9

Natural variations

Alternative sequence

1 – 812

812

Missing in isoform 3.

VSP_039498

Alternative sequence

1 – 33

33

Missing in isoform 2 and isoform 4.

VSP_039499

Alternative sequence

95 – 225

131

Missing in isoform 4.

VSP_039501

Alternative sequence

95 – 160

66

Missing in isoform 5.

VSP_039500

Alternative sequence

813 – 827

15

TRKEN…NPNLS → MKKFLYIKSVFHTLR in isoform 3.

VSP_039502

Natural variant

79

1

K → Q.
Corresponds to variant rs6809436 [ dbSNP | Ensembl ].

VAR_029651

Natural variant

612

1

Q → H. Ref.7
Corresponds to variant rs2433031 [ dbSNP | Ensembl ].

VAR_029652

Experimental info

Mutagenesis

775

1

F → W: Slightly increased deconjugation activity. Ref.10

Mutagenesis

779

1

V → E: Reduces deconjugation activity. Ref.10

Sequence conflict

90

1

K → R in CAB66534. Ref.3

Sequence conflict

341

1

K → R in CAB66534. Ref.3

Sequence conflict

396

1

N → Y in CAB66534. Ref.3

Sequence conflict

785

1

L → H in AAL25651. Ref.1

Sequence conflict

894

1

N → S in CAB66534. Ref.3

Sequence conflict

947

1

Q → R in CAB66534. Ref.3

Sequence conflict

1006

1

D → N in AAL25651. Ref.1

Secondary structure

1

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1050

Helix Strand Turn

Details...

Beta strand

747 – 752

6

Beta strand

756 – 758

3

Beta strand

760 – 763

4

Helix

764 – 768

5

Helix

778 – 791

14

Helix

795 – 799

5

Beta strand

801 – 803

3

Helix

807 – 812

6

Helix

828 – 833

6

Helix

837 – 840

4

Helix

845 – 847

3

Beta strand

849 – 857

9

Beta strand

860 – 867

8

Beta strand

933 – 938

6

Helix

946 – 965

20

Turn

973 – 975

3

Helix

992 – 1005

14

Helix

1023 – 1027

5

Helix

1029 – 1046

18

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 13, 2010. Version 4. Checksum: CB455A0B22709052	FASTA	1,050	119,658
	10 20 30 40 50 60 MDKRKLGRRP SSSEIITEGK RKKSSSDLSE IRKMLNAKPE DVHVQSPLSK FRSSERWTLP 70 80 90 100 110 120 LQWERSLRNK VISLDHKNKK HIRGCPVTSK SSPERQLKVM LTNVLWTDLG RKFRKTLPRN 130 140 150 160 170 180 DANLCDANKV QSDSLPSTSV DSLETCQKLE PLRQSLNLSE RIPRVILTNV LGTELGRKYI 190 200 210 220 230 240 RTPPVTEGSL SDTDNLQSEQ LSSSSDGSLE SYQNLNPHKS CYLSERGSQR SKTVDDNSAK 250 260 270 280 290 300 QTAHNKEKRR KDDGISLLIS DTQPEDLNSG SRGCDHLEQE SRNKDVKYSD SKVELTLISR 310 320 330 340 350 360 KTKRRLRNNL PDSQYCTSLD KSTEQTKKQE DDSTISTEFE KPSENYHQDP KLPEEITTKP 370 380 390 400 410 420 TKSDFTKLSS LNSQELTLSN ATKSASAGST TETVENSNSI DIVGISSLVE KDENELNTIE 430 440 450 460 470 480 KPILRGHNEG NQSLISAEPI VVSSDEEGPV EHKSSEILKL QSKQDRETTN ENESTSESAL 490 500 510 520 530 540 LELPLITCES VQMSSELCPY NPVMENISSI MPSNEMDLQL DFIFTSVYIG KIKGASKGCV 550 560 570 580 590 600 TITKKYIKIP FQVSLNEISL LVDTTHLKRF GLWKSKDDNH SKRSHAILFF WVSSDYLQEI 610 620 630 640 650 660 QTQLEHSVLS QQSKSSEFIF LELHNPVSQR EELKLKDIMT EISIISGELE LSYPLSWVQA 670 680 690 700 710 720 FPLFQNLSSK ESSFIHYYCV STCSFPAGVA VAEEMKLKSV SQPSNTDAAK PTYTFLQKQS 730 740 750 760 770 780 SGCYSLSITS NPDEEWREVR HTGLVQKLIV YPPPPTKGGL GVTNEDLECL EEGEFLNDVI 790 800 810 820 830 840 IDFYLKYLIL EKASDELVER SHIFSSFFYK CLTRKENNLT EDNPNLSMAQ RRHKRVRTWT 850 860 870 880 890 900 RHINIFNKDY IFVPVNESSH WYLAVICFPW LEEAVYEDFP QTVSQQSQAQ QSQNDNKTID 910 920 930 940 950 960 NDLRTTSTLS LSAEDSQSTE SNMSVPKKMC KRPCILILDS LKAASVQNTV QNLREYLEVE 970 980 990 1000 1010 1020 WEVKLKTHRQ FSKTNMVDLC PKVPKQDNSS DCGVYLLQYV ESFFKDPIVN FELPIHLEKW 1030 1040 1050 FPRHVIKTKR EDIRELILKL HLQQQKGSSS
	Isoform 2 [UniParc]. Checksum: F0C8278BCC440AA8	FASTA	1,017	115,871
	10 20 30 40 50 60 MLNAKPEDVH VQSPLSKFRS SERWTLPLQW ERSLRNKVIS LDHKNKKHIR GCPVTSKSSP 70 80 90 100 110 120 ERQLKVMLTN VLWTDLGRKF RKTLPRNDAN LCDANKVQSD SLPSTSVDSL ETCQKLEPLR 130 140 150 160 170 180 QSLNLSERIP RVILTNVLGT ELGRKYIRTP PVTEGSLSDT DNLQSEQLSS SSDGSLESYQ 190 200 210 220 230 240 NLNPHKSCYL SERGSQRSKT VDDNSAKQTA HNKEKRRKDD GISLLISDTQ PEDLNSGSRG 250 260 270 280 290 300 CDHLEQESRN KDVKYSDSKV ELTLISRKTK RRLRNNLPDS QYCTSLDKST EQTKKQEDDS 310 320 330 340 350 360 TISTEFEKPS ENYHQDPKLP EEITTKPTKS DFTKLSSLNS QELTLSNATK SASAGSTTET 370 380 390 400 410 420 VENSNSIDIV GISSLVEKDE NELNTIEKPI LRGHNEGNQS LISAEPIVVS SDEEGPVEHK 430 440 450 460 470 480 SSEILKLQSK QDRETTNENE STSESALLEL PLITCESVQM SSELCPYNPV MENISSIMPS 490 500 510 520 530 540 NEMDLQLDFI FTSVYIGKIK GASKGCVTIT KKYIKIPFQV SLNEISLLVD TTHLKRFGLW 550 560 570 580 590 600 KSKDDNHSKR SHAILFFWVS SDYLQEIQTQ LEHSVLSQQS KSSEFIFLEL HNPVSQREEL 610 620 630 640 650 660 KLKDIMTEIS IISGELELSY PLSWVQAFPL FQNLSSKESS FIHYYCVSTC SFPAGVAVAE 670 680 690 700 710 720 EMKLKSVSQP SNTDAAKPTY TFLQKQSSGC YSLSITSNPD EEWREVRHTG LVQKLIVYPP 730 740 750 760 770 780 PPTKGGLGVT NEDLECLEEG EFLNDVIIDF YLKYLILEKA SDELVERSHI FSSFFYKCLT 790 800 810 820 830 840 RKENNLTEDN PNLSMAQRRH KRVRTWTRHI NIFNKDYIFV PVNESSHWYL AVICFPWLEE 850 860 870 880 890 900 AVYEDFPQTV SQQSQAQQSQ NDNKTIDNDL RTTSTLSLSA EDSQSTESNM SVPKKMCKRP 910 920 930 940 950 960 CILILDSLKA ASVQNTVQNL REYLEVEWEV KLKTHRQFSK TNMVDLCPKV PKQDNSSDCG 970 980 990 1000 1010 VYLLQYVESF FKDPIVNFEL PIHLEKWFPR HVIKTKREDI RELILKLHLQ QQKGSSS
	Isoform 3 [UniParc]. Checksum: 9661C4384D6A30D7	FASTA	238	28,124
	10 20 30 40 50 60 MKKFLYIKSV FHTLRMAQRR HKRVRTWTRH INIFNKDYIF VPVNESSHWY LAVICFPWLE 70 80 90 100 110 120 EAVYEDFPQT VSQQSQAQQS QNDNKTIDND LRTTSTLSLS AEDSQSTESN MSVPKKMCKR 130 140 150 160 170 180 PCILILDSLK AASVQNTVQN LREYLEVEWE VKLKTHRQFS KTNMVDLCPK VPKQDNSSDC 190 200 210 220 230 GVYLLQYVES FFKDPIVNFE LPIHLEKWFP RHVIKTKRED IRELILKLHL QQQKGSSS
	Isoform 4 [UniParc]. Checksum: B03DA49EB00C0007	FASTA	886	101,195
	10 20 30 40 50 60 MLNAKPEDVH VQSPLSKFRS SERWTLPLQW ERSLRNKVIS LDHKNKKHIR GCPVTSKSSP 70 80 90 100 110 120 ERGSQRSKTV DDNSAKQTAH NKEKRRKDDG ISLLISDTQP EDLNSGSRGC DHLEQESRNK 130 140 150 160 170 180 DVKYSDSKVE LTLISRKTKR RLRNNLPDSQ YCTSLDKSTE QTKKQEDDST ISTEFEKPSE 190 200 210 220 230 240 NYHQDPKLPE EITTKPTKSD FTKLSSLNSQ ELTLSNATKS ASAGSTTETV ENSNSIDIVG 250 260 270 280 290 300 ISSLVEKDEN ELNTIEKPIL RGHNEGNQSL ISAEPIVVSS DEEGPVEHKS SEILKLQSKQ 310 320 330 340 350 360 DRETTNENES TSESALLELP LITCESVQMS SELCPYNPVM ENISSIMPSN EMDLQLDFIF 370 380 390 400 410 420 TSVYIGKIKG ASKGCVTITK KYIKIPFQVS LNEISLLVDT THLKRFGLWK SKDDNHSKRS 430 440 450 460 470 480 HAILFFWVSS DYLQEIQTQL EHSVLSQQSK SSEFIFLELH NPVSQREELK LKDIMTEISI 490 500 510 520 530 540 ISGELELSYP LSWVQAFPLF QNLSSKESSF IHYYCVSTCS FPAGVAVAEE MKLKSVSQPS 550 560 570 580 590 600 NTDAAKPTYT FLQKQSSGCY SLSITSNPDE EWREVRHTGL VQKLIVYPPP PTKGGLGVTN 610 620 630 640 650 660 EDLECLEEGE FLNDVIIDFY LKYLILEKAS DELVERSHIF SSFFYKCLTR KENNLTEDNP 670 680 690 700 710 720 NLSMAQRRHK RVRTWTRHIN IFNKDYIFVP VNESSHWYLA VICFPWLEEA VYEDFPQTVS 730 740 750 760 770 780 QQSQAQQSQN DNKTIDNDLR TTSTLSLSAE DSQSTESNMS VPKKMCKRPC ILILDSLKAA 790 800 810 820 830 840 SVQNTVQNLR EYLEVEWEVK LKTHRQFSKT NMVDLCPKVP KQDNSSDCGV YLLQYVESFF 850 860 870 880 KDPIVNFELP IHLEKWFPRH VIKTKREDIR ELILKLHLQQ QKGSSS
	Isoform 5 [UniParc]. Checksum: E5EBB74CAC3E39C5	FASTA	984	112,159
	10 20 30 40 50 60 MDKRKLGRRP SSSEIITEGK RKKSSSDLSE IRKMLNAKPE DVHVQSPLSK FRSSERWTLP 70 80 90 100 110 120 LQWERSLRNK VISLDHKNKK HIRGCPVTSK SSPERIPRVI LTNVLGTELG RKYIRTPPVT 130 140 150 160 170 180 EGSLSDTDNL QSEQLSSSSD GSLESYQNLN PHKSCYLSER GSQRSKTVDD NSAKQTAHNK 190 200 210 220 230 240 EKRRKDDGIS LLISDTQPED LNSGSRGCDH LEQESRNKDV KYSDSKVELT LISRKTKRRL 250 260 270 280 290 300 RNNLPDSQYC TSLDKSTEQT KKQEDDSTIS TEFEKPSENY HQDPKLPEEI TTKPTKSDFT 310 320 330 340 350 360 KLSSLNSQEL TLSNATKSAS AGSTTETVEN SNSIDIVGIS SLVEKDENEL NTIEKPILRG 370 380 390 400 410 420 HNEGNQSLIS AEPIVVSSDE EGPVEHKSSE ILKLQSKQDR ETTNENESTS ESALLELPLI 430 440 450 460 470 480 TCESVQMSSE LCPYNPVMEN ISSIMPSNEM DLQLDFIFTS VYIGKIKGAS KGCVTITKKY 490 500 510 520 530 540 IKIPFQVSLN EISLLVDTTH LKRFGLWKSK DDNHSKRSHA ILFFWVSSDY LQEIQTQLEH 550 560 570 580 590 600 SVLSQQSKSS EFIFLELHNP VSQREELKLK DIMTEISIIS GELELSYPLS WVQAFPLFQN 610 620 630 640 650 660 LSSKESSFIH YYCVSTCSFP AGVAVAEEMK LKSVSQPSNT DAAKPTYTFL QKQSSGCYSL 670 680 690 700 710 720 SITSNPDEEW REVRHTGLVQ KLIVYPPPPT KGGLGVTNED LECLEEGEFL NDVIIDFYLK 730 740 750 760 770 780 YLILEKASDE LVERSHIFSS FFYKCLTRKE NNLTEDNPNL SMAQRRHKRV RTWTRHINIF 790 800 810 820 830 840 NKDYIFVPVN ESSHWYLAVI CFPWLEEAVY EDFPQTVSQQ SQAQQSQNDN KTIDNDLRTT 850 860 870 880 890 900 STLSLSAEDS QSTESNMSVP KKMCKRPCIL ILDSLKAASV QNTVQNLREY LEVEWEVKLK 910 920 930 940 950 960 THRQFSKTNM VDLCPKVPKQ DNSSDCGVYL LQYVESFFKD PIVNFELPIH LEKWFPRHVI 970 980 KTKREDIREL ILKLHLQQQK GSSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Choi S.J., Jeon Y.-J., Kim K.I., Nishimori S., Suzuki T., Uchida S., Shimbara N., Tanaka K., Chung C.H. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"SENP7, a novel human sentrin-specific protease." Gong L., Yeh E.T.H. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Placenta.
[3]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Brain.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Fetal kidney.
[5]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[7]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 295-1050, VARIANT HIS-612. Tissue: Brain.
[8]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25; SER-443 AND SER-444, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[10]	"Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7." Lima C.D., Reverter D. J. Biol. Chem. 283:32045-32055(2008) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 728-1050, FUNCTION, MUTAGENESIS OF PHE-775 AND VAL-779.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF199458 mRNA. Translation: AAL25651.1.
AF217504 mRNA. Translation: AAG09703.1.
AL136599 mRNA. Translation: CAB66534.1.
BX537943 mRNA. Translation: CAD97911.1.
AC068764 Genomic DNA. No translation available.
AC073861 Genomic DNA. No translation available.
AC110994 Genomic DNA. No translation available.
BC129988 mRNA. Translation: AAI29989.1.
AB051494 mRNA. Translation: BAB21798.1.

IPI

IPI00218776.
IPI00218777.
IPI00296449.
IPI00816671.
IPI00969153.

RefSeq

NP_001070671.1. NM_001077203.1.
NP_065705.3. NM_020654.3.

UniGene

Hs.529551.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3EAY	X-ray	2.40	A	728-1050	[»]

ProteinModelPortal

Q9BQF6.

SMR

Q9BQF6. Positions 744-1047.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9BQF6. 2 interactions.

STRING

9606.ENSP00000377655.

Protein family/group databases

MEROPS

C48.009.

PTM databases

PhosphoSite

Q9BQF6.

Polymorphism databases

DMDM

300669717.

Proteomic databases

PaxDb

Q9BQF6.

PRIDE

Q9BQF6.

Protocols and materials databases

DNASU

57337.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000314261; ENSP00000313624; ENSG00000138468.
ENST00000348610; ENSP00000342159; ENSG00000138468.
ENST00000358203; ENSP00000350936; ENSG00000138468.
ENST00000394085; ENSP00000377647; ENSG00000138468.
ENST00000394091; ENSP00000377651; ENSG00000138468.
ENST00000394095; ENSP00000377655; ENSG00000138468.

GeneID

57337.

KEGG

hsa:57337.

UCSC

uc003dus.3. human.
uc003dut.3. human.
uc003duw.3. human.
uc003dux.3. human.

Organism-specific databases

CTD

57337.

GeneCards

GC03M101043.

H-InvDB

HIX0003507.

HGNC

HGNC:30402. SENP7.

HPA

HPA027259.

MIM

612846. gene.

neXtProt

NX_Q9BQF6.

PharmGKB

PA134925171.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5160.

HOVERGEN

HBG079864.

KO

K08596.

OMA

FFKDPIV.

OrthoDB

EOG4ZW5C5.

Gene expression databases

Bgee

Q9BQF6.

CleanEx

HS_SENP7.

Genevestigator

Q9BQF6.

GermOnline

ENSG00000138468. Homo sapiens.

Family and domain databases

InterPro

IPR003653. Peptidase_C48.
[Graphical view]

Pfam

PF02902. Peptidase_C48. 1 hit.
[Graphical view]

PROSITE

PS50600. ULP_PROTEASE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

Q9BQF6.

ChEMBL

CHEMBL1741213.

EvolutionaryTrace

Q9BQF6.

GenomeRNAi

57337.

NextBio

63454.

SOURCE

Search...

Entry information

Entry name

SENP7_HUMAN

Accession

Primary (citable) accession number: Q9BQF6
Secondary accession number(s): A1L3A5 , A8MW39, B7WNW8, Q7Z3F4, Q96PS5, Q9C0F6, Q9HBT5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	July 13, 2010
Last modified:	April 3, 2013
This is version 95 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.