Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sentrin-specific protease 7

Gene

SENP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.1 Publication

Catalytic activityi

Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-|-Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3, leading to the mature form of the protein. A second reaction involves the cleavage of an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei860By similarity1
Active sitei992By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138468-MONOMER.
BRENDAi3.4.22.B75. 2681.

Protein family/group databases

MEROPSiC48.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Sentrin-specific protease 7 (EC:3.4.22.68)
Alternative name(s):
SUMO-1-specific protease 2
Sentrin/SUMO-specific protease SENP7
Gene namesi
Name:SENP7
Synonyms:KIAA1707, SSP2, SUSP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30402. SENP7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi775F → W: Slightly increased deconjugation activity. 1 Publication1
Mutagenesisi779V → E: Reduces deconjugation activity. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000138468.
PharmGKBiPA134925171.

Chemistry databases

ChEMBLiCHEMBL1741213.

Polymorphism and mutation databases

BioMutaiSENP7.
DMDMi300669717.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017261 – 1050Sentrin-specific protease 7Add BLAST1050

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineCombined sources1
Modified residuei12PhosphoserineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei25PhosphoserineCombined sources1
Modified residuei373PhosphoserineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei443PhosphoserineCombined sources1
Modified residuei444PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BQF6.
MaxQBiQ9BQF6.
PaxDbiQ9BQF6.
PeptideAtlasiQ9BQF6.
PRIDEiQ9BQF6.

PTM databases

iPTMnetiQ9BQF6.
PhosphoSitePlusiQ9BQF6.

Expressioni

Gene expression databases

BgeeiENSG00000138468.
CleanExiHS_SENP7.
ExpressionAtlasiQ9BQF6. baseline and differential.
GenevisibleiQ9BQF6. HS.

Organism-specific databases

HPAiHPA027259.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CBX5P459734EBI-766251,EBI-78219
TRIM28Q132633EBI-766251,EBI-78139

Protein-protein interaction databases

BioGridi121491. 6 interactors.
IntActiQ9BQF6. 9 interactors.
MINTiMINT-4717645.
STRINGi9606.ENSP00000377655.

Chemistry databases

BindingDBiQ9BQF6.

Structurei

Secondary structure

11050
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi747 – 752Combined sources6
Beta strandi756 – 758Combined sources3
Beta strandi760 – 763Combined sources4
Helixi764 – 768Combined sources5
Helixi778 – 791Combined sources14
Helixi795 – 799Combined sources5
Beta strandi801 – 803Combined sources3
Helixi807 – 812Combined sources6
Helixi828 – 833Combined sources6
Helixi837 – 840Combined sources4
Helixi845 – 847Combined sources3
Beta strandi849 – 857Combined sources9
Beta strandi860 – 867Combined sources8
Beta strandi933 – 938Combined sources6
Helixi946 – 965Combined sources20
Turni973 – 975Combined sources3
Helixi992 – 1005Combined sources14
Helixi1023 – 1027Combined sources5
Helixi1029 – 1046Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EAYX-ray2.40A728-1050[»]
ProteinModelPortaliQ9BQF6.
SMRiQ9BQF6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BQF6.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni760 – 1050ProteaseAdd BLAST291

Sequence similaritiesi

Belongs to the peptidase C48 family.Curated

Phylogenomic databases

eggNOGiKOG0779. Eukaryota.
COG5160. LUCA.
GeneTreeiENSGT00530000063531.
HOVERGENiHBG079864.
InParanoidiQ9BQF6.
KOiK08596.
OMAiVPKKMCK.
OrthoDBiEOG091G012K.
PhylomeDBiQ9BQF6.
TreeFamiTF350136.

Family and domain databases

InterProiIPR003653. Peptidase_C48_C.
[Graphical view]
PfamiPF02902. Peptidase_C48. 1 hit.
[Graphical view]
PROSITEiPS50600. ULP_PROTEASE. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q9BQF6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDKRKLGRRP SSSEIITEGK RKKSSSDLSE IRKMLNAKPE DVHVQSPLSK
60 70 80 90 100
FRSSERWTLP LQWERSLRNK VISLDHKNKK HIRGCPVTSK SSPERQLKVM
110 120 130 140 150
LTNVLWTDLG RKFRKTLPRN DANLCDANKV QSDSLPSTSV DSLETCQKLE
160 170 180 190 200
PLRQSLNLSE RIPRVILTNV LGTELGRKYI RTPPVTEGSL SDTDNLQSEQ
210 220 230 240 250
LSSSSDGSLE SYQNLNPHKS CYLSERGSQR SKTVDDNSAK QTAHNKEKRR
260 270 280 290 300
KDDGISLLIS DTQPEDLNSG SRGCDHLEQE SRNKDVKYSD SKVELTLISR
310 320 330 340 350
KTKRRLRNNL PDSQYCTSLD KSTEQTKKQE DDSTISTEFE KPSENYHQDP
360 370 380 390 400
KLPEEITTKP TKSDFTKLSS LNSQELTLSN ATKSASAGST TETVENSNSI
410 420 430 440 450
DIVGISSLVE KDENELNTIE KPILRGHNEG NQSLISAEPI VVSSDEEGPV
460 470 480 490 500
EHKSSEILKL QSKQDRETTN ENESTSESAL LELPLITCES VQMSSELCPY
510 520 530 540 550
NPVMENISSI MPSNEMDLQL DFIFTSVYIG KIKGASKGCV TITKKYIKIP
560 570 580 590 600
FQVSLNEISL LVDTTHLKRF GLWKSKDDNH SKRSHAILFF WVSSDYLQEI
610 620 630 640 650
QTQLEHSVLS QQSKSSEFIF LELHNPVSQR EELKLKDIMT EISIISGELE
660 670 680 690 700
LSYPLSWVQA FPLFQNLSSK ESSFIHYYCV STCSFPAGVA VAEEMKLKSV
710 720 730 740 750
SQPSNTDAAK PTYTFLQKQS SGCYSLSITS NPDEEWREVR HTGLVQKLIV
760 770 780 790 800
YPPPPTKGGL GVTNEDLECL EEGEFLNDVI IDFYLKYLIL EKASDELVER
810 820 830 840 850
SHIFSSFFYK CLTRKENNLT EDNPNLSMAQ RRHKRVRTWT RHINIFNKDY
860 870 880 890 900
IFVPVNESSH WYLAVICFPW LEEAVYEDFP QTVSQQSQAQ QSQNDNKTID
910 920 930 940 950
NDLRTTSTLS LSAEDSQSTE SNMSVPKKMC KRPCILILDS LKAASVQNTV
960 970 980 990 1000
QNLREYLEVE WEVKLKTHRQ FSKTNMVDLC PKVPKQDNSS DCGVYLLQYV
1010 1020 1030 1040 1050
ESFFKDPIVN FELPIHLEKW FPRHVIKTKR EDIRELILKL HLQQQKGSSS
Length:1,050
Mass (Da):119,658
Last modified:July 13, 2010 - v4
Checksum:iCB455A0B22709052
GO
Isoform 2 (identifier: Q9BQF6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Show »
Length:1,017
Mass (Da):115,871
Checksum:iF0C8278BCC440AA8
GO
Isoform 3 (identifier: Q9BQF6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-812: Missing.
     813-827: TRKENNLTEDNPNLS → MKKFLYIKSVFHTLR

Show »
Length:238
Mass (Da):28,124
Checksum:i9661C4384D6A30D7
GO
Isoform 4 (identifier: Q9BQF6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.
     95-225: Missing.

Show »
Length:886
Mass (Da):101,195
Checksum:iB03DA49EB00C0007
GO
Isoform 5 (identifier: Q9BQF6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-160: Missing.

Show »
Length:984
Mass (Da):112,159
Checksum:iE5EBB74CAC3E39C5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90K → R in CAB66534 (PubMed:11230166).Curated1
Sequence conflicti341K → R in CAB66534 (PubMed:11230166).Curated1
Sequence conflicti396N → Y in CAB66534 (PubMed:11230166).Curated1
Sequence conflicti785L → H in AAL25651 (Ref. 1) Curated1
Sequence conflicti894N → S in CAB66534 (PubMed:11230166).Curated1
Sequence conflicti947Q → R in CAB66534 (PubMed:11230166).Curated1
Sequence conflicti1006D → N in AAL25651 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02965179K → Q.Corresponds to variant rs6809436dbSNPEnsembl.1
Natural variantiVAR_029652612Q → H.1 PublicationCorresponds to variant rs2433031dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0394981 – 812Missing in isoform 3. 1 PublicationAdd BLAST812
Alternative sequenceiVSP_0394991 – 33Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST33
Alternative sequenceiVSP_03950195 – 225Missing in isoform 4. 1 PublicationAdd BLAST131
Alternative sequenceiVSP_03950095 – 160Missing in isoform 5. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_039502813 – 827TRKEN…NPNLS → MKKFLYIKSVFHTLR in isoform 3. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199458 mRNA. Translation: AAL25651.1.
AF217504 mRNA. Translation: AAG09703.1.
AL136599 mRNA. Translation: CAB66534.1.
BX537943 mRNA. Translation: CAD97911.1.
AC068764 Genomic DNA. No translation available.
AC073861 Genomic DNA. No translation available.
AC110994 Genomic DNA. No translation available.
BC129988 mRNA. Translation: AAI29989.1.
AB051494 mRNA. Translation: BAB21798.1.
CCDSiCCDS2941.2. [Q9BQF6-1]
CCDS63704.1. [Q9BQF6-4]
CCDS63705.1. [Q9BQF6-2]
CCDS63706.1. [Q9BQF6-5]
RefSeqiNP_001070671.1. NM_001077203.2.
NP_001269730.1. NM_001282801.1. [Q9BQF6-5]
NP_001269731.1. NM_001282802.1. [Q9BQF6-2]
NP_001269732.1. NM_001282803.1. [Q9BQF6-4]
NP_001269733.1. NM_001282804.1.
NP_065705.3. NM_020654.4. [Q9BQF6-1]
XP_016862414.1. XM_017006925.1. [Q9BQF6-2]
UniGeneiHs.529551.

Genome annotation databases

EnsembliENST00000314261; ENSP00000313624; ENSG00000138468. [Q9BQF6-5]
ENST00000348610; ENSP00000342159; ENSG00000138468. [Q9BQF6-2]
ENST00000394085; ENSP00000377647; ENSG00000138468. [Q9BQF6-3]
ENST00000394091; ENSP00000377651; ENSG00000138468. [Q9BQF6-4]
ENST00000394095; ENSP00000377655; ENSG00000138468. [Q9BQF6-1]
GeneIDi57337.
KEGGihsa:57337.
UCSCiuc003dus.5. human. [Q9BQF6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF199458 mRNA. Translation: AAL25651.1.
AF217504 mRNA. Translation: AAG09703.1.
AL136599 mRNA. Translation: CAB66534.1.
BX537943 mRNA. Translation: CAD97911.1.
AC068764 Genomic DNA. No translation available.
AC073861 Genomic DNA. No translation available.
AC110994 Genomic DNA. No translation available.
BC129988 mRNA. Translation: AAI29989.1.
AB051494 mRNA. Translation: BAB21798.1.
CCDSiCCDS2941.2. [Q9BQF6-1]
CCDS63704.1. [Q9BQF6-4]
CCDS63705.1. [Q9BQF6-2]
CCDS63706.1. [Q9BQF6-5]
RefSeqiNP_001070671.1. NM_001077203.2.
NP_001269730.1. NM_001282801.1. [Q9BQF6-5]
NP_001269731.1. NM_001282802.1. [Q9BQF6-2]
NP_001269732.1. NM_001282803.1. [Q9BQF6-4]
NP_001269733.1. NM_001282804.1.
NP_065705.3. NM_020654.4. [Q9BQF6-1]
XP_016862414.1. XM_017006925.1. [Q9BQF6-2]
UniGeneiHs.529551.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EAYX-ray2.40A728-1050[»]
ProteinModelPortaliQ9BQF6.
SMRiQ9BQF6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121491. 6 interactors.
IntActiQ9BQF6. 9 interactors.
MINTiMINT-4717645.
STRINGi9606.ENSP00000377655.

Chemistry databases

BindingDBiQ9BQF6.
ChEMBLiCHEMBL1741213.

Protein family/group databases

MEROPSiC48.009.

PTM databases

iPTMnetiQ9BQF6.
PhosphoSitePlusiQ9BQF6.

Polymorphism and mutation databases

BioMutaiSENP7.
DMDMi300669717.

Proteomic databases

EPDiQ9BQF6.
MaxQBiQ9BQF6.
PaxDbiQ9BQF6.
PeptideAtlasiQ9BQF6.
PRIDEiQ9BQF6.

Protocols and materials databases

DNASUi57337.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314261; ENSP00000313624; ENSG00000138468. [Q9BQF6-5]
ENST00000348610; ENSP00000342159; ENSG00000138468. [Q9BQF6-2]
ENST00000394085; ENSP00000377647; ENSG00000138468. [Q9BQF6-3]
ENST00000394091; ENSP00000377651; ENSG00000138468. [Q9BQF6-4]
ENST00000394095; ENSP00000377655; ENSG00000138468. [Q9BQF6-1]
GeneIDi57337.
KEGGihsa:57337.
UCSCiuc003dus.5. human. [Q9BQF6-1]

Organism-specific databases

CTDi57337.
GeneCardsiSENP7.
H-InvDBHIX0003507.
HGNCiHGNC:30402. SENP7.
HPAiHPA027259.
MIMi612846. gene.
neXtProtiNX_Q9BQF6.
OpenTargetsiENSG00000138468.
PharmGKBiPA134925171.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0779. Eukaryota.
COG5160. LUCA.
GeneTreeiENSGT00530000063531.
HOVERGENiHBG079864.
InParanoidiQ9BQF6.
KOiK08596.
OMAiVPKKMCK.
OrthoDBiEOG091G012K.
PhylomeDBiQ9BQF6.
TreeFamiTF350136.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138468-MONOMER.
BRENDAi3.4.22.B75. 2681.

Miscellaneous databases

ChiTaRSiSENP7. human.
EvolutionaryTraceiQ9BQF6.
GeneWikiiSENP7.
GenomeRNAii57337.
PROiQ9BQF6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138468.
CleanExiHS_SENP7.
ExpressionAtlasiQ9BQF6. baseline and differential.
GenevisibleiQ9BQF6. HS.

Family and domain databases

InterProiIPR003653. Peptidase_C48_C.
[Graphical view]
PfamiPF02902. Peptidase_C48. 1 hit.
[Graphical view]
PROSITEiPS50600. ULP_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSENP7_HUMAN
AccessioniPrimary (citable) accession number: Q9BQF6
Secondary accession number(s): A1L3A5
, A8MW39, B7WNW8, Q7Z3F4, Q96PS5, Q9C0F6, Q9HBT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 13, 2010
Last modified: November 30, 2016
This is version 128 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.