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Q9BQE5

- APOL2_HUMAN

UniProt

Q9BQE5 - APOL2_HUMAN

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Protein

Apolipoprotein L2

Gene
APOL2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.

GO - Molecular functioni

  1. high-density lipoprotein particle binding Source: UniProtKB
  2. lipid binding Source: UniProtKB
  3. receptor binding Source: UniProtKB

GO - Biological processi

  1. acute-phase response Source: UniProtKB
  2. cholesterol metabolic process Source: UniProtKB
  3. lipid metabolic process Source: UniProtKB
  4. lipid transport Source: UniProtKB
  5. lipoprotein metabolic process Source: InterPro
  6. maternal process involved in female pregnancy Source: UniProtKB
  7. multicellular organismal development Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein L2
Alternative name(s):
Apolipoprotein L-II
Short name:
ApoL-II
Gene namesi
Name:APOL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:619. APOL2.

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. extracellular region Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24905.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 337337Apolipoprotein L2PRO_0000137601Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei250 – 2501Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9BQE5.
PaxDbiQ9BQE5.
PRIDEiQ9BQE5.

PTM databases

PhosphoSiteiQ9BQE5.

Expressioni

Tissue specificityi

Widely expressed; the highest levels are found in lung, thymus, pancreas, placenta, adult brain and prostate; also detected in spleen, liver, kidney, colon, small intestine, uterus, spinal cord, adrenal gland, salivary gland, trachea, mammary gland, skeletal muscle, testis and fetal brain and liver.

Gene expression databases

ArrayExpressiQ9BQE5.
BgeeiQ9BQE5.
GenevestigatoriQ9BQE5.

Organism-specific databases

HPAiHPA001078.

Interactioni

Protein-protein interaction databases

BioGridi117279. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9BQE5.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi157 – 1626Poly-Ala

Sequence similaritiesi

Belongs to the apolipoprotein L family.

Phylogenomic databases

eggNOGiNOG125779.
HOVERGENiHBG074468.
InParanoidiQ9BQE5.
KOiK14480.
OrthoDBiEOG7K9K41.
PhylomeDBiQ9BQE5.
TreeFamiTF334681.

Family and domain databases

InterProiIPR008405. ApoL.
[Graphical view]
PANTHERiPTHR14096. PTHR14096. 1 hit.
PfamiPF05461. ApoL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BQE5-1 [UniParc]FASTAAdd to Basket

« Hide

MNPESSIFIE DYLKYFQDQV SRENLLQLLT DDEAWNGFVA AAELPRDEAD    50
ELRKALNKLA SHMVMKDKNR HDKDQQHRQW FLKEFPRLKR ELEDHIRKLR 100
ALAEEVEQVH RGTTIANVVS NSVGTTSGIL TLLGLGLAPF TEGISFVLLD 150
TGMGLGAAAA VAGITCSVVE LVNKLRARAQ ARNLDQSGTN VAKVMKEFVG 200
GNTPNVLTLV DNWYQVTQGI GRNIRAIRRA RANPQLGAYA PPPHIIGRIS 250
AEGGEQVERV VEGPAQAMSR GTMIVGAATG GILLLLDVVS LAYESKHLLE 300
GAKSESAEEL KKRAQELEGK LNFLTKIHEM LQPGQDQ 337
Length:337
Mass (Da):37,092
Last modified:June 1, 2001 - v1
Checksum:i0A54640FCC029400
GO

Sequence cautioni

The sequence BAD92227.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti182 – 1821R → C.
Corresponds to variant rs7285167 [ dbSNP | Ensembl ].
VAR_024366
Natural varianti245 – 2451I → V.1 Publication
Corresponds to variant rs132760 [ dbSNP | Ensembl ].
VAR_012978

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti186 – 1861Q → R in BAD92227. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF305225 mRNA. Translation: AAK20211.1.
AF324223 mRNA. Translation: AAK11592.1.
AF324224 mRNA. Translation: AAK11593.1.
AF324230, AF324228, AF324229 Genomic DNA. Translation: AAK11598.1.
AF305429 mRNA. Translation: AAL09359.1.
AK056938 mRNA. Translation: BAB71315.1.
AB208990 mRNA. Translation: BAD92227.1. Different initiation.
AL031426, Z82215, Z95114 Genomic DNA. Translation: CAQ10954.1.
Z82215, AL031426, Z95114 Genomic DNA. Translation: CAQ09084.1.
Z95114, AL031426, Z82215 Genomic DNA. Translation: CAQ08516.1.
BC004395 mRNA. Translation: AAH04395.1.
CCDSiCCDS43014.1.
RefSeqiNP_112092.1. NM_030882.2.
NP_663612.1. NM_145637.1.
XP_006724281.1. XM_006724218.1.
UniGeneiHs.474740.

Genome annotation databases

EnsembliENST00000249066; ENSP00000249066; ENSG00000128335.
ENST00000358502; ENSP00000351292; ENSG00000128335.
GeneIDi23780.
KEGGihsa:23780.
UCSCiuc003aoz.3. human.

Polymorphism databases

DMDMi17433285.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF305225 mRNA. Translation: AAK20211.1 .
AF324223 mRNA. Translation: AAK11592.1 .
AF324224 mRNA. Translation: AAK11593.1 .
AF324230 , AF324228 , AF324229 Genomic DNA. Translation: AAK11598.1 .
AF305429 mRNA. Translation: AAL09359.1 .
AK056938 mRNA. Translation: BAB71315.1 .
AB208990 mRNA. Translation: BAD92227.1 . Different initiation.
AL031426 , Z82215 , Z95114 Genomic DNA. Translation: CAQ10954.1 .
Z82215 , AL031426 , Z95114 Genomic DNA. Translation: CAQ09084.1 .
Z95114 , AL031426 , Z82215 Genomic DNA. Translation: CAQ08516.1 .
BC004395 mRNA. Translation: AAH04395.1 .
CCDSi CCDS43014.1.
RefSeqi NP_112092.1. NM_030882.2.
NP_663612.1. NM_145637.1.
XP_006724281.1. XM_006724218.1.
UniGenei Hs.474740.

3D structure databases

ProteinModelPortali Q9BQE5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117279. 1 interaction.

PTM databases

PhosphoSitei Q9BQE5.

Polymorphism databases

DMDMi 17433285.

Proteomic databases

MaxQBi Q9BQE5.
PaxDbi Q9BQE5.
PRIDEi Q9BQE5.

Protocols and materials databases

DNASUi 23780.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000249066 ; ENSP00000249066 ; ENSG00000128335 .
ENST00000358502 ; ENSP00000351292 ; ENSG00000128335 .
GeneIDi 23780.
KEGGi hsa:23780.
UCSCi uc003aoz.3. human.

Organism-specific databases

CTDi 23780.
GeneCardsi GC22M036622.
HGNCi HGNC:619. APOL2.
HPAi HPA001078.
MIMi 607252. gene.
neXtProti NX_Q9BQE5.
PharmGKBi PA24905.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG125779.
HOVERGENi HBG074468.
InParanoidi Q9BQE5.
KOi K14480.
OrthoDBi EOG7K9K41.
PhylomeDBi Q9BQE5.
TreeFami TF334681.

Miscellaneous databases

ChiTaRSi APOL2. human.
GeneWikii APOL2.
GenomeRNAii 23780.
NextBioi 46771.
PROi Q9BQE5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9BQE5.
Bgeei Q9BQE5.
Genevestigatori Q9BQE5.

Family and domain databases

InterProi IPR008405. ApoL.
[Graphical view ]
PANTHERi PTHR14096. PTHR14096. 1 hit.
Pfami PF05461. ApoL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution."
    Page N.M., Butlin D.J., Lomthaisong K., Lowry P.J.
    Genomics 74:71-78(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene."
    Duchateau P.N., Pullinger C.R., Cho M.H., Eng C., Kane J.P.
    J. Lipid Res. 42:620-630(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Pancreas.
  3. "The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue."
    Monajemi H., Fontijn R.D., Pannekoek H., Horrevoets A.J.G.
    Genomics 79:539-546(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHROMOSOMAL LOCATION.
    Tissue: Endothelial cell.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Salivary gland.
  5. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-245.
    Tissue: Brain.
  6. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  8. Bienvenut W.V., Waridel P., Quadroni M.
    Submitted (MAR-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-14; 249-259 AND 271-296, ACETYLATION AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryonic kidney.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-250, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-250, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAPOL2_HUMAN
AccessioniPrimary (citable) accession number: Q9BQE5
Secondary accession number(s): B0QYK7
, O95915, Q59GW9, Q5TH96, Q969T6, Q9BT28, Q9UGT1, Q9UH10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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