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Protein

Selenoprotein S

Gene

SELENOS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.1 Publication

GO - Molecular functioni

  • antioxidant activity Source: UniProtKB
  • ATPase binding Source: ParkinsonsUK-UCL
  • enzyme binding Source: UniProtKB
  • signaling receptor activity Source: UniProtKB
  • ubiquitin-specific protease binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • cell redox homeostasis Source: UniProtKB
  • cellular response to insulin stimulus Source: BHF-UCL
  • cellular response to lipopolysaccharide Source: BHF-UCL
  • cellular response to oxidative stress Source: BHF-UCL
  • endoplasmic reticulum unfolded protein response Source: UniProtKB
  • ER overload response Source: BHF-UCL
  • establishment of protein localization Source: UniProtKB
  • negative regulation of acute inflammatory response to antigenic stimulus Source: BHF-UCL
  • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: BHF-UCL
  • negative regulation of glucose import Source: BHF-UCL
  • negative regulation of glycogen biosynthetic process Source: BHF-UCL
  • negative regulation of inflammatory response Source: BHF-UCL
  • negative regulation of interleukin-6 production Source: BHF-UCL
  • negative regulation of macrophage apoptotic process Source: BHF-UCL
  • negative regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
  • negative regulation of tumor necrosis factor production Source: BHF-UCL
  • protein ubiquitination Source: Reactome
  • regulation of gluconeogenesis Source: BHF-UCL
  • regulation of nitric oxide metabolic process Source: BHF-UCL
  • response to glucose Source: UniProtKB
  • response to redox state Source: UniProtKB
  • retrograde protein transport, ER to cytosol Source: UniProtKB
  • ubiquitin-dependent ERAD pathway Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein S1 Publication
Short name:
SelS1 Publication
Alternative name(s):
VCP-interacting membrane protein1 Publication
Gene namesi
Name:SELENOS1 PublicationImported
Synonyms:SELS1 Publication, VIMP1 PublicationImported
ORF Names:AD-015, SBBI8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000131871.14
HGNCiHGNC:30396 SELENOS
MIMi607918 gene
neXtProtiNX_Q9BQE4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55829
OpenTargetsiENSG00000131871

Polymorphism and mutation databases

DMDMi172045769

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000976721 – 189Selenoprotein SAdd BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei140PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BQE4
MaxQBiQ9BQE4
PaxDbiQ9BQE4
PeptideAtlasiQ9BQE4
PRIDEiQ9BQE4
ProteomicsDBi78662

PTM databases

iPTMnetiQ9BQE4
PhosphoSitePlusiQ9BQE4

Expressioni

Gene expression databases

BgeeiENSG00000131871
ExpressionAtlasiQ9BQE4 baseline and differential
GenevisibleiQ9BQE4 HS

Organism-specific databases

HPAiHPA010025

Interactioni

Subunit structurei

Interacts with DERL1 and (via VIM motif) with VCP, suggesting that it forms a membrane complex with DERL1 that serves as a receptor for VCP. Also interacts with DERL2, DERL3 and SELENOK. The SELENOK-SELENOS complex interacts with VCP.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
VcpQ018534EBI-398970,EBI-80597From Mus musculus.

GO - Molecular functioni

  • ATPase binding Source: ParkinsonsUK-UCL
  • enzyme binding Source: UniProtKB
  • ubiquitin-specific protease binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi120934, 29 interactors
CORUMiQ9BQE4
IntActiQ9BQE4, 5 interactors
STRINGi9606.ENSP00000381282

Structurei

Secondary structure

1189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi53 – 68Combined sources16
Helixi72 – 121Combined sources50

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q2FX-ray1.50A52-122[»]
5KIUX-ray2.20A49-122[»]
5KIYX-ray2.79B49-122[»]
ProteinModelPortaliQ9BQE4
SMRiQ9BQE4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9BQE4

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni78 – 90VCP/p97-interacting motif (VIM)1 PublicationAdd BLAST13

Sequence similaritiesi

Belongs to the selenoprotein S family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW5T Eukaryota
ENOG41126EF LUCA
GeneTreeiENSGT00390000015688
HOGENOMiHOG000168422
HOVERGENiHBG044521
InParanoidiQ9BQE4
KOiK14025
OMAiYGWYILF
PhylomeDBiQ9BQE4
TreeFamiTF329454

Family and domain databases

InterProiView protein in InterPro
IPR009703 Selenoprotein_S
PANTHERiPTHR28621 PTHR28621, 1 hit
PfamiView protein in Pfam
PF06936 Selenoprotein_S, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BQE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERQEESLSA RPALETEGLR FLHTTVGSLL ATYGWYIVFS CILLYVVFQK
60 70 80 90 100
LSARLRALRQ RQLDRAAAAV EPDVVVKRQE ALAAARLKMQ EELNAQVEKH
110 120 130 140 150
KEKLKQLEEE KRRQKIEMWD SMQEGKSYKG NAKKPQEEDS PGPSTSSVLK
160 170 180
RKSDRKPLRG GGYNPLSGEG GGACSWRPGR RGPSSGGUG
Length:189
Mass (Da):21,163
Last modified:February 26, 2008 - v3
Checksum:i720DDCC597A7135A
GO

Sequence cautioni

The sequence AAF67483 differs from that shown. Reason: Frameshift at position 173.Curated
The sequence AAK15708 differs from that shown. Reason: Erroneous termination at position 188. Translated as Sec.Curated

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei188Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY324824 mRNA Translation: AAP85541.1
AF157317 mRNA Translation: AAF67483.1 Frameshift.
AF328864 mRNA Translation: AAK15708.1 Sequence problems.
AC023024 Genomic DNA No translation available.
BC005840 mRNA Translation: AAH05840.2
BC107774 mRNA Translation: AAI07775.1
CCDSiCCDS53979.1
RefSeqiNP_060915.2, NM_018445.5
NP_982298.2, NM_203472.2
UniGeneiHs.32148

Genome annotation databases

EnsembliENST00000398226; ENSP00000381282; ENSG00000131871
ENST00000526049; ENSP00000433541; ENSG00000131871
GeneIDi55829
KEGGihsa:55829
UCSCiuc021sxv.3 human

Keywords - Coding sequence diversityi

Selenocysteine

Similar proteinsi

Entry informationi

Entry nameiSELS_HUMAN
AccessioniPrimary (citable) accession number: Q9BQE4
Secondary accession number(s): Q3B771, Q9P0I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: February 26, 2008
Last modified: June 20, 2018
This is version 148 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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