Q9BQE4 (SELS_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Selenoprotein S
Short name=SelS

Alternative name(s):
VCP-interacting membrane protein

Gene names

Name:	VIMP
Synonyms:	SELS
ORF Names:	AD-015, SBBI8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination. Ref.6
Subunit structure	Interacts with DERL1 and VCP, suggesting that it forms a membrane complex with DERL1 that serves as a receptor for VCP. Ref.6 Ref.7 Ref.8
Subcellular location	Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm By similarity Ref.1 Ref.6.
Sequence similarities	Belongs to the selenoprotein S family.
Sequence caution	The sequence AAF67483.1 differs from that shown. Reason: Frameshift at position 173. The sequence AAK15708.1 differs from that shown. Reason: Erroneous termination at position 188. Translated as Sec.

Ontologies

Keywords
Cellular component	Cytoplasm Endoplasmic reticulum Membrane
Coding sequence diversity	Selenocysteine
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ER overload response Inferred from direct assay PubMed 16574427. Source: BHF-UCL ER-associated protein catabolic process Inferred from direct assay Ref.6. Source: UniProtKB cell redox homeostasis Inferred from direct assay PubMed 15063746. Source: UniProtKB cellular response to insulin stimulus Traceable author statement PubMed 12663463. Source: BHF-UCL cellular response to lipopolysaccharide Inferred from mutant phenotype PubMed 18675776. Source: BHF-UCL cellular response to oxidative stress Inferred from mutant phenotype PubMed 18675776. Source: BHF-UCL endoplasmic reticulum unfolded protein response Inferred from direct assay Ref.6. Source: UniProtKB negative regulation of acute inflammatory response to antigenic stimulus Inferred from mutant phenotype PubMed 18675776. Source: BHF-UCL negative regulation of apoptotic process Inferred from mutant phenotype PubMed 17210132. Source: BHF-UCL negative regulation of glucose import Traceable author statement PubMed 12663463. Source: BHF-UCL negative regulation of glycogen biosynthetic process Traceable author statement PubMed 12663463. Source: BHF-UCL negative regulation of interleukin-6 production Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of nitric-oxide synthase biosynthetic process Inferred from mutant phenotype PubMed 18675776. Source: BHF-UCL negative regulation of tumor necrosis factor production Inferred from sequence or structural similarity. Source: BHF-UCL regulation of gluconeogenesis Traceable author statement PubMed 12663463. Source: BHF-UCL regulation of nitric oxide metabolic process Inferred from mutant phenotype PubMed 18675776. Source: BHF-UCL response to glucose stimulus Inferred from expression pattern PubMed 15063746. Source: UniProtKB response to redox state Inferred from direct assay PubMed 15063746. Source: UniProtKB retrograde protein transport, ER to cytosol Inferred from direct assay Ref.6. Source: UniProtKB
Cellular_component	cytoplasmic microtubule Inferred from direct assay PubMed 23264731. Source: UniProtKB integral to endoplasmic reticulum membrane Inferred from direct assay Ref.6. Source: UniProtKB low-density lipoprotein particle Inferred from direct assay PubMed 17374524. Source: BHF-UCL plasma membrane Traceable author statement PubMed 12663463. Source: BHF-UCL very-low-density lipoprotein particle Inferred from direct assay PubMed 17374524. Source: BHF-UCL
Molecular_function	antioxidant activity Inferred from direct assay PubMed 15063746. Source: UniProtKB receptor activity Non-traceable author statement Ref.6. Source: UniProtKB selenium binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Vcp	Q01853	4	EBI-398970,EBI-80597	From a different organism.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 189

189

Selenoprotein S

PRO_0000097672

Regions

Transmembrane

28 – 48

21

Helical; Potential

Amino acid modifications

Non-standard residue

188

1

Selenocysteine

Modified residue

140

1

Phosphoserine Ref.9

Secondary structure

1

.

.

.

.

.

189

Helix Strand Turn

Details...

Helix

53 – 68

16

Helix

72 – 121

50

Sequences

	Sequence		Length	Mass (Da)
	Q9BQE4 [UniParc]. Last modified February 26, 2008. Version 3. Checksum: 720DDCC597A7135A	FASTA	189	21,163
	10 20 30 40 50 60 MERQEESLSA RPALETEGLR FLHTTVGSLL ATYGWYIVFS CILLYVVFQK LSARLRALRQ 70 80 90 100 110 120 RQLDRAAAAV EPDVVVKRQE ALAAARLKMQ EELNAQVEKH KEKLKQLEEE KRRQKIEMWD 130 140 150 160 170 180 SMQEGKSYKG NAKKPQEEDS PGPSTSSVLK RKSDRKPLRG GGYNPLSGEG GGACSWRPGR RGPSSGGUG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of mammalian selenoproteomes." Kryukov G.V., Castellano S., Novoselov S.V., Lobanov A.V., Zehtab O., Guigo R., Gladyshev V.N. Science 300:1439-1443(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
[2]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adrenal gland.
[3]	Li N., Wan T., Zhang W., Cao X. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[5]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol." Ye Y., Shibata Y., Yun C., Ron D., Rapoport T.A. Nature 429:841-847(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH VCP AND DERL1.
[7]	"Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane." Ye Y., Shibata Y., Kikkert M., van Voorden S., Wiertz E., Rapoport T.A. Proc. Natl. Acad. Sci. U.S.A. 102:14132-14138(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DERL1.
[8]	"Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane." Lilley B.N., Ploegh H.L. Proc. Natl. Acad. Sci. U.S.A. 102:14296-14301(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DERL1.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY324824 mRNA. Translation: AAP85541.1.
AF157317 mRNA. Translation: AAF67483.1. Frameshift.
AF328864 mRNA. Translation: AAK15708.1. Sequence problems.
AC023024 Genomic DNA. No translation available.
BC005840 mRNA. Translation: AAH05840.2.
BC107774 mRNA. Translation: AAI07775.1.

IPI

IPI00020468.

RefSeq

NP_060915.2. NM_018445.4.
NP_982298.1. NM_203472.1.

UniGene

Hs.32148.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2Q2F	X-ray	1.50	A	52-122	[»]

ProteinModelPortal

Q9BQE4.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9BQE4. 4 interactions.

STRING

9606.ENSP00000381282.

PTM databases

PhosphoSite

Q9BQE4.

Polymorphism databases

DMDM

172045769.

Proteomic databases

PaxDb

Q9BQE4.

PRIDE

Q9BQE4.

Protocols and materials databases

DNASU

55829.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000398226; ENSP00000381282; ENSG00000131871.
ENST00000526049; ENSP00000433541; ENSG00000131871.

GeneID

55829.

KEGG

hsa:55829.

UCSC

uc021sxu.1. human.

Organism-specific databases

CTD

55829.

GeneCards

GC15M101813.

HGNC

HGNC:30396. VIMP.

HPA

HPA010025.

MIM

607918. gene.

neXtProt

NX_Q9BQE4.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG76592.

HOGENOM

HOG000168422.

HOVERGEN

HBG044521.

InParanoid

Q9BQE4.

KO

K14025.

OMA

YGWYILF.

OrthoDB

EOG4H19X1.

PhylomeDB

Q9BQE4.

Gene expression databases

Genevestigator

Q9BQE4.

Family and domain databases

InterPro

IPR009703. Selenoprotein_S.
[Graphical view]

Pfam

PF06936. Selenoprotein_S. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9BQE4.

GenomeRNAi

55829.

NextBio

61032.

SOURCE

Search...

Entry information

Entry name

SELS_HUMAN

Accession

Primary (citable) accession number: Q9BQE4
Secondary accession number(s): Q3B771, Q9P0I6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 4, 2003
Last sequence update:	February 26, 2008
Last modified:	May 1, 2013
This is version 102 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.