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Protein

Ribosomal protein 63, mitochondrial

Gene

MRPL57

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • mitochondrial translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein 63, mitochondrial
Short name:
hMRP63
Alternative name(s):
Mitochondrial ribosomal protein 63
Mitochondrial ribosomal protein L57
Gene namesi
Name:MRPL57
Synonyms:MRP63
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:14514. MRPL57.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial ribosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30937.

Polymorphism and mutation databases

BioMutaiMRP63.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 102102Ribosomal protein 63, mitochondrialPRO_0000253541Add
BLAST

Proteomic databases

EPDiQ9BQC6.
MaxQBiQ9BQC6.
PaxDbiQ9BQC6.
PeptideAtlasiQ9BQC6.
PRIDEiQ9BQC6.
TopDownProteomicsiQ9BQC6.

PTM databases

iPTMnetiQ9BQC6.
PhosphoSiteiQ9BQC6.

Expressioni

Gene expression databases

BgeeiENSG00000173141.
CleanExiHS_MRP63.
ExpressionAtlasiQ9BQC6. baseline and differential.
GenevisibleiQ9BQC6. HS.

Organism-specific databases

HPAiHPA039779.
HPA059370.

Interactioni

Protein-protein interaction databases

BioGridi122459. 25 interactions.
IntActiQ9BQC6. 3 interactions.
MINTiMINT-8376032.
STRINGi9606.ENSP00000310726.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40o1-102[»]
3J9Melectron microscopy3.50o1-102[»]
ProteinModelPortaliQ9BQC6.
SMRiQ9BQC6. Positions 9-102.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J0KS. Eukaryota.
ENOG410XX1I. LUCA.
GeneTreeiENSGT00390000008171.
HOGENOMiHOG000230903.
HOVERGENiHBG079987.
InParanoidiQ9BQC6.
OMAiEAENEYW.
OrthoDBiEOG091G13M7.
PhylomeDBiQ9BQC6.
TreeFamiTF324466.

Family and domain databases

InterProiIPR016576. Ribosomal_MRP63_mit.
[Graphical view]
PfamiPF14978. MRP-63. 1 hit.
[Graphical view]
PIRSFiPIRSF011124. MRP63. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9BQC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLTALLWRG RIPGRQWIGK HRRPRFVSLR AKQNMIRRLE IEAENHYWLS
60 70 80 90 100
MPYMTREQER GHAAVRRREA FEAIKAAATS KFPPHRFIAD QLDHLNVTKK

WS
Length:102
Mass (Da):12,266
Last modified:June 1, 2001 - v1
Checksum:i2456F3E663C6F683
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049957 mRNA. Translation: BAB41010.1.
AL158032 Genomic DNA. Translation: CAM13061.1.
CH471075 Genomic DNA. Translation: EAX08296.1.
BC023616 mRNA. Translation: AAH23616.1.
BC068492 mRNA. Translation: AAH68492.1.
CCDSiCCDS9296.1.
RefSeqiNP_076931.1. NM_024026.4.
UniGeneiHs.458367.

Genome annotation databases

EnsembliENST00000309594; ENSP00000310726; ENSG00000173141.
GeneIDi78988.
KEGGihsa:78988.
UCSCiuc001unw.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049957 mRNA. Translation: BAB41010.1.
AL158032 Genomic DNA. Translation: CAM13061.1.
CH471075 Genomic DNA. Translation: EAX08296.1.
BC023616 mRNA. Translation: AAH23616.1.
BC068492 mRNA. Translation: AAH68492.1.
CCDSiCCDS9296.1.
RefSeqiNP_076931.1. NM_024026.4.
UniGeneiHs.458367.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40o1-102[»]
3J9Melectron microscopy3.50o1-102[»]
ProteinModelPortaliQ9BQC6.
SMRiQ9BQC6. Positions 9-102.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122459. 25 interactions.
IntActiQ9BQC6. 3 interactions.
MINTiMINT-8376032.
STRINGi9606.ENSP00000310726.

PTM databases

iPTMnetiQ9BQC6.
PhosphoSiteiQ9BQC6.

Polymorphism and mutation databases

BioMutaiMRP63.

Proteomic databases

EPDiQ9BQC6.
MaxQBiQ9BQC6.
PaxDbiQ9BQC6.
PeptideAtlasiQ9BQC6.
PRIDEiQ9BQC6.
TopDownProteomicsiQ9BQC6.

Protocols and materials databases

DNASUi78988.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309594; ENSP00000310726; ENSG00000173141.
GeneIDi78988.
KEGGihsa:78988.
UCSCiuc001unw.4. human.

Organism-specific databases

CTDi78988.
GeneCardsiMRPL57.
HGNCiHGNC:14514. MRPL57.
HPAiHPA039779.
HPA059370.
MIMi611997. gene.
neXtProtiNX_Q9BQC6.
PharmGKBiPA30937.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0KS. Eukaryota.
ENOG410XX1I. LUCA.
GeneTreeiENSGT00390000008171.
HOGENOMiHOG000230903.
HOVERGENiHBG079987.
InParanoidiQ9BQC6.
OMAiEAENEYW.
OrthoDBiEOG091G13M7.
PhylomeDBiQ9BQC6.
TreeFamiTF324466.

Miscellaneous databases

GenomeRNAii78988.
PROiQ9BQC6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173141.
CleanExiHS_MRP63.
ExpressionAtlasiQ9BQC6. baseline and differential.
GenevisibleiQ9BQC6. HS.

Family and domain databases

InterProiIPR016576. Ribosomal_MRP63_mit.
[Graphical view]
PfamiPF14978. MRP-63. 1 hit.
[Graphical view]
PIRSFiPIRSF011124. MRP63. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRT63_HUMAN
AccessioniPrimary (citable) accession number: Q9BQC6
Secondary accession number(s): A2A332
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Identified only in the intact 55S subunit. It is unknown whether it belongs to the 28S or to the 39S subunit. May localize at the subunit interface and dissociate from the 55S mitoribosome during subunit separation.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.