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Protein

Uncharacterized protein C17orf62

Gene

C17orf62

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C17orf62
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28672. C17orf62.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4223HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672245.

Polymorphism and mutation databases

BioMutaiC17orf62.
DMDMi74732825.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 187187Uncharacterized protein C17orf62PRO_0000281418Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei168 – 1681PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9BQA9.
MaxQBiQ9BQA9.
PaxDbiQ9BQA9.
PRIDEiQ9BQA9.
TopDownProteomicsiQ9BQA9-1. [Q9BQA9-1]

PTM databases

iPTMnetiQ9BQA9.
PhosphoSiteiQ9BQA9.

Expressioni

Gene expression databases

BgeeiQ9BQA9.
CleanExiHS_C17orf62.
ExpressionAtlasiQ9BQA9. baseline and differential.
GenevisibleiQ9BQA9. HS.

Organism-specific databases

HPAiHPA045696.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC155Q8N6L03EBI-2680384,EBI-749265
ETS1P149213EBI-2680384,EBI-913209

Protein-protein interaction databases

BioGridi122665. 7 interactions.
IntActiQ9BQA9. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9BQA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVNK. Eukaryota.
ENOG4111MD2. LUCA.
GeneTreeiENSGT00390000004691.
HOGENOMiHOG000111936.
HOVERGENiHBG081327.
InParanoidiQ9BQA9.
OMAiSSCLHLK.
PhylomeDBiQ9BQA9.
TreeFamiTF332389.

Family and domain databases

InterProiIPR027846. DUF4564.
[Graphical view]
PANTHERiPTHR31837. PTHR31837. 1 hit.
PfamiPF15169. DUF4564. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BQA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYLQVETRTS SRLHLKRAPG IRSWSLLVGI LSIGLAAAYY SGDSLGWKLF
60 70 80 90 100
YVTGCLFVAV QNLEDWEEAI FDKSTGKVVL KTFSLYKKLL TLFRAGHDQV
110 120 130 140 150
VVLLHDVRDV SVEEEKVRYF GKGYMVVLRL ATGFSHPLTQ SAVMGHRSDV
160 170 180
EAIAKLITSF LELHCLESPT ELSQSSDSEA GDPASQS
Length:187
Mass (Da):20,774
Last modified:June 1, 2001 - v1
Checksum:i363321B2FC5D36A7
GO
Isoform 2 (identifier: Q9BQA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-42: Missing.

Note: No experimental confirmation available.
Show »
Length:173
Mass (Da):19,436
Checksum:iA6E18600EE5C4C59
GO

Sequence cautioni

The sequence BAB70818.1 differs from that shown.Wrong choice of frame.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei29 – 4214Missing in isoform 2. 1 PublicationVSP_046335Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054876 mRNA. Translation: BAB70818.1. Sequence problems.
AC132938 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89786.1.
BC004171 mRNA. Translation: AAH04171.1.
BC003595 mRNA. Translation: AAH03595.1.
CCDSiCCDS32776.1. [Q9BQA9-1]
CCDS45817.1. [Q9BQA9-2]
RefSeqiNP_001028218.1. NM_001033046.3. [Q9BQA9-1]
NP_001093877.1. NM_001100407.2. [Q9BQA9-1]
NP_001093878.1. NM_001100408.2. [Q9BQA9-2]
NP_001180582.1. NM_001193653.1. [Q9BQA9-1]
NP_001180583.1. NM_001193654.1. [Q9BQA9-1]
NP_001180584.1. NM_001193655.1. [Q9BQA9-1]
NP_001180586.1. NM_001193657.1. [Q9BQA9-1]
XP_006722356.1. XM_006722293.2. [Q9BQA9-2]
UniGeneiHs.163113.

Genome annotation databases

EnsembliENST00000306645; ENSP00000307765; ENSG00000178927. [Q9BQA9-1]
ENST00000434650; ENSP00000401626; ENSG00000178927. [Q9BQA9-2]
ENST00000437807; ENSP00000388909; ENSG00000178927. [Q9BQA9-1]
ENST00000577436; ENSP00000464633; ENSG00000178927. [Q9BQA9-2]
ENST00000577732; ENSP00000463228; ENSG00000178927. [Q9BQA9-1]
ENST00000578919; ENSP00000464080; ENSG00000178927. [Q9BQA9-1]
ENST00000585064; ENSP00000463846; ENSG00000178927. [Q9BQA9-1]
ENST00000585080; ENSP00000462529; ENSG00000178927. [Q9BQA9-1]
GeneIDi79415.
KEGGihsa:79415.
UCSCiuc002kfa.5. human. [Q9BQA9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054876 mRNA. Translation: BAB70818.1. Sequence problems.
AC132938 Genomic DNA. No translation available.
CH471099 Genomic DNA. Translation: EAW89786.1.
BC004171 mRNA. Translation: AAH04171.1.
BC003595 mRNA. Translation: AAH03595.1.
CCDSiCCDS32776.1. [Q9BQA9-1]
CCDS45817.1. [Q9BQA9-2]
RefSeqiNP_001028218.1. NM_001033046.3. [Q9BQA9-1]
NP_001093877.1. NM_001100407.2. [Q9BQA9-1]
NP_001093878.1. NM_001100408.2. [Q9BQA9-2]
NP_001180582.1. NM_001193653.1. [Q9BQA9-1]
NP_001180583.1. NM_001193654.1. [Q9BQA9-1]
NP_001180584.1. NM_001193655.1. [Q9BQA9-1]
NP_001180586.1. NM_001193657.1. [Q9BQA9-1]
XP_006722356.1. XM_006722293.2. [Q9BQA9-2]
UniGeneiHs.163113.

3D structure databases

ProteinModelPortaliQ9BQA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122665. 7 interactions.
IntActiQ9BQA9. 3 interactions.

PTM databases

iPTMnetiQ9BQA9.
PhosphoSiteiQ9BQA9.

Polymorphism and mutation databases

BioMutaiC17orf62.
DMDMi74732825.

Proteomic databases

EPDiQ9BQA9.
MaxQBiQ9BQA9.
PaxDbiQ9BQA9.
PRIDEiQ9BQA9.
TopDownProteomicsiQ9BQA9-1. [Q9BQA9-1]

Protocols and materials databases

DNASUi79415.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306645; ENSP00000307765; ENSG00000178927. [Q9BQA9-1]
ENST00000434650; ENSP00000401626; ENSG00000178927. [Q9BQA9-2]
ENST00000437807; ENSP00000388909; ENSG00000178927. [Q9BQA9-1]
ENST00000577436; ENSP00000464633; ENSG00000178927. [Q9BQA9-2]
ENST00000577732; ENSP00000463228; ENSG00000178927. [Q9BQA9-1]
ENST00000578919; ENSP00000464080; ENSG00000178927. [Q9BQA9-1]
ENST00000585064; ENSP00000463846; ENSG00000178927. [Q9BQA9-1]
ENST00000585080; ENSP00000462529; ENSG00000178927. [Q9BQA9-1]
GeneIDi79415.
KEGGihsa:79415.
UCSCiuc002kfa.5. human. [Q9BQA9-1]

Organism-specific databases

CTDi79415.
GeneCardsiC17orf62.
H-InvDBHIX0014275.
HIX0039552.
HGNCiHGNC:28672. C17orf62.
HPAiHPA045696.
neXtProtiNX_Q9BQA9.
PharmGKBiPA142672245.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVNK. Eukaryota.
ENOG4111MD2. LUCA.
GeneTreeiENSGT00390000004691.
HOGENOMiHOG000111936.
HOVERGENiHBG081327.
InParanoidiQ9BQA9.
OMAiSSCLHLK.
PhylomeDBiQ9BQA9.
TreeFamiTF332389.

Miscellaneous databases

ChiTaRSiC17orf62. human.
GenomeRNAii79415.
PROiQ9BQA9.

Gene expression databases

BgeeiQ9BQA9.
CleanExiHS_C17orf62.
ExpressionAtlasiQ9BQA9. baseline and differential.
GenevisibleiQ9BQA9. HS.

Family and domain databases

InterProiIPR027846. DUF4564.
[Graphical view]
PANTHERiPTHR31837. PTHR31837. 1 hit.
PfamiPF15169. DUF4564. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung carcinoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCQ062_HUMAN
AccessioniPrimary (citable) accession number: Q9BQA9
Secondary accession number(s): E1B6X3, Q96NR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.