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Protein

Histone H4 transcription factor

Gene

HINFP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.7 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 39C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri129 – 153C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri169 – 193C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri199 – 221C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 278C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri284 – 306C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 337C2H2-type 8PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri345 – 368C2H2-type 9PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • chromatin binding Source: Ensembl
  • DNA binding Source: UniProtKB
  • DNA binding transcription factor activity Source: UniProtKB
  • enzyme binding Source: UniProtKB
  • histone binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
  • transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
  • transcription coactivator activity Source: UniProtKB
  • transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  • DNA damage checkpoint Source: UniProtKB
  • DNA repair Source: UniProtKB
  • establishment of protein localization Source: UniProtKB
  • G1/S transition of mitotic cell cycle Source: UniProtKB
  • in utero embryonic development Source: UniProtKB
  • myoblast differentiation Source: UniProtKB
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of gene expression Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription involved in G1/S transition of mitotic cell cycle Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ9BQA5

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4 transcription factor
Alternative name(s):
Histone nuclear factor P
Short name:
HiNF-P
MBD2-interacting zinc finger protein
Methyl-CpG-binding protein 2-interacting zinc finger protein
Gene namesi
Name:HINFP
Synonyms:MIZF, ZNF743
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000172273.12
HGNCiHGNC:17850 HINFP
MIMi607099 gene
neXtProtiNX_Q9BQA5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi381Y → A: Abolishes DNA-Binding. 1 Publication1

Organism-specific databases

DisGeNETi25988
OpenTargetsiENSG00000172273
PharmGKBiPA164720597

Polymorphism and mutation databases

BioMutaiHINFP
DMDMi322510032

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472181 – 517Histone H4 transcription factorAdd BLAST517

Post-translational modificationi

Ubiquitinated. Ubiquitination may lead to proteasome-mediated degradation.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ9BQA5
PaxDbiQ9BQA5
PeptideAtlasiQ9BQA5
PRIDEiQ9BQA5
ProteomicsDBi78648

PTM databases

iPTMnetiQ9BQA5
PhosphoSitePlusiQ9BQA5

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in brain, heart, skeletal muscle, spleen, kidney, small intestine, placenta and liver.1 Publication

Gene expression databases

BgeeiENSG00000172273
ExpressionAtlasiQ9BQA5 baseline and differential
GenevisibleiQ9BQA5 HS

Organism-specific databases

HPAiHPA061008

Interactioni

Subunit structurei

Binds MBD2 and a histone deacetylase complex. Interacts with NPAT.2 Publications

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi117469, 36 interactors
IntActiQ9BQA5, 6 interactors
MINTiQ9BQA5
STRINGi9606.ENSP00000318085

Structurei

3D structure databases

ProteinModelPortaliQ9BQA5
SMRiQ9BQA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni373 – 517Interaction with NPAT1 PublicationAdd BLAST145
Regioni374 – 407Required for activation of histone H4 transcription and contributes to DNA-bindingAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi49 – 56Poly-Glu8
Compositional biasi440 – 444Poly-Glu5

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 39C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri129 – 153C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri169 – 193C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri199 – 221C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 278C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri284 – 306C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 337C2H2-type 8PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri345 – 368C2H2-type 9PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3608 Eukaryota
ENOG410XQF8 LUCA
GeneTreeiENSGT00870000136508
HOGENOMiHOG000232129
InParanoidiQ9BQA5
OMAiHSKEPAY
OrthoDBiEOG091G089B
PhylomeDBiQ9BQA5
TreeFamiTF350923

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9BQA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPPGKVPRK ENLWLQCEWG SCSFVCSTME KFFEHVTQHL QQHLHGSGEE
60 70 80 90 100
EEEEEEDDPL EEEFSCLWQE CGFCSLDSSA DLIRHVYFHC YHTKLKQWGL
110 120 130 140 150
QALQSQADLG PCILDFQSRN VIPDIPDHFL CLWEHCENSF DNPEWFYRHV
160 170 180 190 200
EAHSLCCEYE AVGKDNPVVL CGWKGCTCTF KDRSKLREHL RSHTQEKVVA
210 220 230 240 250
CPTCGGMFAN NTKFLDHIRR QTSLDQQHFQ CSHCSKRFAT ERLLRDHMRN
260 270 280 290 300
HVNHYKCPLC DMTCPLPSSL RNHMRFRHSE DRPFKCDCCD YSCKNLIDLQ
310 320 330 340 350
KHLDTHSEEP AYRCDFENCT FSARSLCSIK SHYRKVHEGD SEPRYKCHVC
360 370 380 390 400
DKCFTRGNNL TVHLRKKHQF KWPSGHPRFR YKEHEDGYMR LQLVRYESVE
410 420 430 440 450
LTQQLLRQPQ EGSGLGTSLN ESSLQGIILE TVPGEPGRKE EEEEGKGSEG
460 470 480 490 500
TALSASQDNP SSVIHVVNQT NAQGQQEIVY YVLSEAPGEP PPAPEPPSGG
510
IMEKLQGIAE EPEIQMV
Length:517
Mass (Da):59,678
Last modified:February 8, 2011 - v2
Checksum:i2CE1910737B0B6EB
GO
Isoform 2 (identifier: Q9BQA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     381-419: YKEHEDGYMR...QEGSGLGTSL → LGHFCIPLPG...CGCSWFATRV
     420-517: Missing.

Note: No experimental confirmation available.
Show »
Length:419
Mass (Da):48,993
Checksum:i31245BA4887EEC8C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62E → G in BAG62976 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0265474P → S1 PublicationCorresponds to variant dbSNP:rs17850972Ensembl.1
Natural variantiVAR_02654878S → C1 PublicationCorresponds to variant dbSNP:rs17850974Ensembl.1
Natural variantiVAR_038793352K → R. Corresponds to variant dbSNP:rs34118252Ensembl.1
Natural variantiVAR_019424493A → V1 PublicationCorresponds to variant dbSNP:rs100803Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044719381 – 419YKEHE…LGTSL → LGHFCIPLPGFAALYAPTSP GTRNMKMAICGCSWFATRV in isoform 2. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_044720420 – 517Missing in isoform 2. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056362 mRNA Translation: BAG51688.1
AK301452 mRNA Translation: BAG62976.1
AP002956 Genomic DNA No translation available.
AP003391 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67461.1
BC001073 mRNA Translation: AAH01073.1
BC001945 mRNA Translation: AAH01945.1
BC012856 mRNA Translation: AAH12856.1
BC017234 mRNA Translation: AAH17234.1
AL080201 mRNA Translation: CAB45773.1
CCDSiCCDS58188.1 [Q9BQA5-2]
CCDS8414.1 [Q9BQA5-1]
PIRiT12509
RefSeqiNP_001230188.1, NM_001243259.1 [Q9BQA5-2]
NP_056332.2, NM_015517.4 [Q9BQA5-1]
NP_945322.1, NM_198971.2 [Q9BQA5-1]
XP_011541047.1, XM_011542745.2
UniGeneiHs.504091

Genome annotation databases

EnsembliENST00000350777; ENSP00000318085; ENSG00000172273 [Q9BQA5-1]
ENST00000527410; ENSP00000436815; ENSG00000172273 [Q9BQA5-2]
GeneIDi25988
KEGGihsa:25988
UCSCiuc001pvq.4 human [Q9BQA5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHINFP_HUMAN
AccessioniPrimary (citable) accession number: Q9BQA5
Secondary accession number(s): B3KPH6
, B4DWB4, E9PQF4, Q96E65, Q9Y4M7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: February 8, 2011
Last modified: June 20, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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