Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kelch domain-containing protein 3

Gene

KLHDC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in meiotic recombination process.

GO - Molecular functioni

  • chromatin binding Source: UniProtKB

GO - Biological processi

  • IRE1-mediated unfolded protein response Source: Reactome
  • reciprocal meiotic recombination Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Meiosis

Enzyme and pathway databases

ReactomeiR-HSA-381038. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch domain-containing protein 3
Alternative name(s):
Protein Peas
Testis intracellular mediator protein
Gene namesi
Name:KLHDC3
Synonyms:PEAS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20704. KLHDC3.

Subcellular locationi

  • Cytoplasm

  • Note: Also found in meiotic chromatin.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: Reactome
  • nuclear chromatin Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134892782.

Polymorphism and mutation databases

BioMutaiKLHDC3.
DMDMi74752233.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Kelch domain-containing protein 3PRO_0000228995Add
BLAST

Proteomic databases

EPDiQ9BQ90.
MaxQBiQ9BQ90.
PaxDbiQ9BQ90.
PeptideAtlasiQ9BQ90.
PRIDEiQ9BQ90.

PTM databases

iPTMnetiQ9BQ90.

Expressioni

Gene expression databases

BgeeiENSG00000124702.
CleanExiHS_KLHDC3.
ExpressionAtlasiQ9BQ90. baseline and differential.
GenevisibleiQ9BQ90. HS.

Organism-specific databases

HPAiHPA030131.
HPA030132.
HPA030133.
HPA030134.

Interactioni

Protein-protein interaction databases

BioGridi125478. 52 interactions.
IntActiQ9BQ90. 3 interactions.
STRINGi9606.ENSP00000313995.

Structurei

3D structure databases

ProteinModelPortaliQ9BQ90.
SMRiQ9BQ90. Positions 20-358.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati25 – 7753Kelch 1Add
BLAST
Repeati88 – 13851Kelch 2Add
BLAST
Repeati139 – 18951Kelch 3Add
BLAST
Repeati191 – 24959Kelch 4Add
BLAST
Repeati251 – 30151Kelch 5Add
BLAST

Sequence similaritiesi

Contains 5 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG0379. Eukaryota.
ENOG410Y5WM. LUCA.
GeneTreeiENSGT00760000119086.
HOGENOMiHOG000276538.
HOVERGENiHBG071311.
InParanoidiQ9BQ90.
PhylomeDBiQ9BQ90.
TreeFamiTF354289.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR015915. Kelch-typ_b-propeller.
IPR011498. Kelch_2.
[Graphical view]
PfamiPF07646. Kelch_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BQ90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRWTVHLEG GPRRVNHAAV AVGHRVYSFG GYCSGEDYET LRQIDVHIFN
60 70 80 90 100
AVSLRWTKLP PVKSAIRGQA PVVPYMRYGH STVLIDDTVL LWGGRNDTEG
110 120 130 140 150
ACNVLYAFDV NTHKWFTPRV SGTVPGARDG HSACVLGKIM YIFGGYEQQA
160 170 180 190 200
DCFSNDIHKL DTSTMTWTLI CTKGSPARWR DFHSATMLGS HMYVFGGRAD
210 220 230 240 250
RFGPFHSNNE IYCNRIRVFD TRTEAWLDCP PTPVLPEGRR SHSAFGYNGE
260 270 280 290 300
LYIFGGYNAR LNRHFHDLWK FNPVSFTWKK IEPKGKGPCP RRRQCCCIVG
310 320 330 340 350
DKIVLFGGTS PSPEEGLGDE FDLIDHSDLH ILDFSPSLKT LCKLAVIQYN
360 370 380
LDQSCLPHDI RWELNAMTTN SNISRPIVSS HG
Length:382
Mass (Da):43,088
Last modified:June 1, 2001 - v1
Checksum:i49A3AB24BE7FFAFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055925 mRNA. Translation: BAB63257.1.
AK290384 mRNA. Translation: BAF83073.1.
AL136304 Genomic DNA. Translation: CAI19796.1.
CH471081 Genomic DNA. Translation: EAX04136.1.
BC000295 mRNA. Translation: AAH00295.1.
BC001789 mRNA. Translation: AAH01789.1.
BC001793 mRNA. Translation: AAH01793.1.
BC007296 mRNA. Translation: AAH07296.1.
BC021546 mRNA. Translation: AAH21546.1.
CCDSiCCDS4880.1.
RefSeqiNP_476502.1. NM_057161.3.
UniGeneiHs.412468.

Genome annotation databases

EnsembliENST00000326974; ENSP00000313995; ENSG00000124702.
GeneIDi116138.
KEGGihsa:116138.
UCSCiuc003otl.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055925 mRNA. Translation: BAB63257.1.
AK290384 mRNA. Translation: BAF83073.1.
AL136304 Genomic DNA. Translation: CAI19796.1.
CH471081 Genomic DNA. Translation: EAX04136.1.
BC000295 mRNA. Translation: AAH00295.1.
BC001789 mRNA. Translation: AAH01789.1.
BC001793 mRNA. Translation: AAH01793.1.
BC007296 mRNA. Translation: AAH07296.1.
BC021546 mRNA. Translation: AAH21546.1.
CCDSiCCDS4880.1.
RefSeqiNP_476502.1. NM_057161.3.
UniGeneiHs.412468.

3D structure databases

ProteinModelPortaliQ9BQ90.
SMRiQ9BQ90. Positions 20-358.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125478. 52 interactions.
IntActiQ9BQ90. 3 interactions.
STRINGi9606.ENSP00000313995.

PTM databases

iPTMnetiQ9BQ90.

Polymorphism and mutation databases

BioMutaiKLHDC3.
DMDMi74752233.

Proteomic databases

EPDiQ9BQ90.
MaxQBiQ9BQ90.
PaxDbiQ9BQ90.
PeptideAtlasiQ9BQ90.
PRIDEiQ9BQ90.

Protocols and materials databases

DNASUi116138.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326974; ENSP00000313995; ENSG00000124702.
GeneIDi116138.
KEGGihsa:116138.
UCSCiuc003otl.4. human.

Organism-specific databases

CTDi116138.
GeneCardsiKLHDC3.
HGNCiHGNC:20704. KLHDC3.
HPAiHPA030131.
HPA030132.
HPA030133.
HPA030134.
MIMi611248. gene.
neXtProtiNX_Q9BQ90.
PharmGKBiPA134892782.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0379. Eukaryota.
ENOG410Y5WM. LUCA.
GeneTreeiENSGT00760000119086.
HOGENOMiHOG000276538.
HOVERGENiHBG071311.
InParanoidiQ9BQ90.
PhylomeDBiQ9BQ90.
TreeFamiTF354289.

Enzyme and pathway databases

ReactomeiR-HSA-381038. XBP1(S) activates chaperone genes.

Miscellaneous databases

ChiTaRSiKLHDC3. human.
GeneWikiiKLHDC3.
GenomeRNAii116138.
PROiQ9BQ90.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124702.
CleanExiHS_KLHDC3.
ExpressionAtlasiQ9BQ90. baseline and differential.
GenevisibleiQ9BQ90. HS.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR015915. Kelch-typ_b-propeller.
IPR011498. Kelch_2.
[Graphical view]
PfamiPF07646. Kelch_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLDC3_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ90
Secondary accession number(s): A8K2W9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.