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Protein

Kelch domain-containing protein 3

Gene

KLHDC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in meiotic recombination process.

GO - Molecular functioni

  • chromatin binding Source: UniProtKB

GO - Biological processi

  • IRE1-mediated unfolded protein response Source: Reactome
  • reciprocal meiotic recombination Source: UniProtKB

Keywordsi

Biological processMeiosis

Enzyme and pathway databases

ReactomeiR-HSA-381038. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch domain-containing protein 3
Alternative name(s):
Protein Peas
Testis intracellular mediator protein
Gene namesi
Name:KLHDC3
Synonyms:PEAS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124702.17.
HGNCiHGNC:20704. KLHDC3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000124702.
PharmGKBiPA134892782.

Polymorphism and mutation databases

BioMutaiKLHDC3.
DMDMi74752233.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002289951 – 382Kelch domain-containing protein 3Add BLAST382

Proteomic databases

EPDiQ9BQ90.
MaxQBiQ9BQ90.
PaxDbiQ9BQ90.
PeptideAtlasiQ9BQ90.
PRIDEiQ9BQ90.

PTM databases

iPTMnetiQ9BQ90.
PhosphoSitePlusiQ9BQ90.

Expressioni

Gene expression databases

BgeeiENSG00000124702.
CleanExiHS_KLHDC3.
ExpressionAtlasiQ9BQ90. baseline and differential.
GenevisibleiQ9BQ90. HS.

Organism-specific databases

HPAiHPA030131.
HPA030132.
HPA030133.
HPA030134.

Interactioni

Protein-protein interaction databases

BioGridi125478. 54 interactors.
IntActiQ9BQ90. 3 interactors.
STRINGi9606.ENSP00000313995.

Structurei

3D structure databases

ProteinModelPortaliQ9BQ90.
SMRiQ9BQ90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati25 – 77Kelch 1Add BLAST53
Repeati88 – 138Kelch 2Add BLAST51
Repeati139 – 189Kelch 3Add BLAST51
Repeati191 – 249Kelch 4Add BLAST59
Repeati251 – 301Kelch 5Add BLAST51

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG0379. Eukaryota.
ENOG410Y5WM. LUCA.
GeneTreeiENSGT00760000119086.
HOGENOMiHOG000276538.
HOVERGENiHBG071311.
InParanoidiQ9BQ90.
PhylomeDBiQ9BQ90.
TreeFamiTF354289.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiView protein in InterPro
IPR015915. Kelch-typ_b-propeller.
IPR011498. Kelch_2.
PfamiView protein in Pfam
PF07646. Kelch_2. 2 hits.
SUPFAMiSSF117281. SSF117281. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9BQ90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRWTVHLEG GPRRVNHAAV AVGHRVYSFG GYCSGEDYET LRQIDVHIFN
60 70 80 90 100
AVSLRWTKLP PVKSAIRGQA PVVPYMRYGH STVLIDDTVL LWGGRNDTEG
110 120 130 140 150
ACNVLYAFDV NTHKWFTPRV SGTVPGARDG HSACVLGKIM YIFGGYEQQA
160 170 180 190 200
DCFSNDIHKL DTSTMTWTLI CTKGSPARWR DFHSATMLGS HMYVFGGRAD
210 220 230 240 250
RFGPFHSNNE IYCNRIRVFD TRTEAWLDCP PTPVLPEGRR SHSAFGYNGE
260 270 280 290 300
LYIFGGYNAR LNRHFHDLWK FNPVSFTWKK IEPKGKGPCP RRRQCCCIVG
310 320 330 340 350
DKIVLFGGTS PSPEEGLGDE FDLIDHSDLH ILDFSPSLKT LCKLAVIQYN
360 370 380
LDQSCLPHDI RWELNAMTTN SNISRPIVSS HG
Length:382
Mass (Da):43,088
Last modified:June 1, 2001 - v1
Checksum:i49A3AB24BE7FFAFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB055925 mRNA. Translation: BAB63257.1.
AK290384 mRNA. Translation: BAF83073.1.
AL136304 Genomic DNA. No translation available.
CH471081 Genomic DNA. Translation: EAX04136.1.
BC000295 mRNA. Translation: AAH00295.1.
BC001789 mRNA. Translation: AAH01789.1.
BC001793 mRNA. Translation: AAH01793.1.
BC007296 mRNA. Translation: AAH07296.1.
BC021546 mRNA. Translation: AAH21546.1.
CCDSiCCDS4880.1.
RefSeqiNP_476502.1. NM_057161.3.
UniGeneiHs.412468.

Genome annotation databases

EnsembliENST00000326974; ENSP00000313995; ENSG00000124702.
GeneIDi116138.
KEGGihsa:116138.
UCSCiuc003otl.4. human.

Similar proteinsi

Entry informationi

Entry nameiKLDC3_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ90
Secondary accession number(s): A8K2W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot