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Protein

Protein FAM110A

Gene

FAM110A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM110A
Gene namesi
Name:FAM110A
Synonyms:C20orf55, F10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16188. FAM110A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162385650.

Polymorphism and mutation databases

BioMutaiFAM110A.
DMDMi26392452.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Protein FAM110APRO_0000079435Add
BLAST

Proteomic databases

MaxQBiQ9BQ89.
PaxDbiQ9BQ89.
PRIDEiQ9BQ89.
TopDownProteomicsiQ9BQ89.

PTM databases

PhosphoSiteiQ9BQ89.

Expressioni

Tissue specificityi

Detected in thyroid, lymph node, trachea, adrenal gland, bone marrow, spleen, thymus, prostate, and peripheral blood leukocyte. Detected at lower levels in stomach, testis and spinal cord.1 Publication

Developmental stagei

During the cell cycle, expression is increased during S phase and G2/M phase.1 Publication

Inductioni

Up-regulated in stimulated lymphocytes.1 Publication

Gene expression databases

BgeeiQ9BQ89.
CleanExiHS_FAM110A.
ExpressionAtlasiQ9BQ89. baseline and differential.
GenevisibleiQ9BQ89. HS.

Organism-specific databases

HPAiCAB034110.

Interactioni

Subunit structurei

May interact with CSPP1.Curated

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-1752811,EBI-748961
CDR2Q018503EBI-1752811,EBI-1181367
GOLGA2Q083793EBI-1752811,EBI-618309
KRT15P190123EBI-1752811,EBI-739566
KRT31Q153233EBI-1752811,EBI-948001
MKRN3Q130643EBI-1752811,EBI-2340269
NCK1P163332EBI-1752811,EBI-389883
PNMA1Q8ND903EBI-1752811,EBI-302345
RINT1Q6NUQ13EBI-1752811,EBI-726876
STX11O755583EBI-1752811,EBI-714135
TRIM23P364063EBI-1752811,EBI-740098
TRIM27P143733EBI-1752811,EBI-719493
TRIM54Q9BYV23EBI-1752811,EBI-2130429
TRIM69Q86WT63EBI-1752811,EBI-749955
USHBP1Q8N6Y03EBI-1752811,EBI-739895

Protein-protein interaction databases

BioGridi123674. 18 interactions.
IntActiQ9BQ89. 22 interactions.
MINTiMINT-7241222.
STRINGi9606.ENSP00000246100.

Structurei

3D structure databases

ProteinModelPortaliQ9BQ89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi136 – 18247Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the FAM110 family.Curated

Phylogenomic databases

eggNOGiENOG410IIZB. Eukaryota.
ENOG4111K4M. LUCA.
GeneTreeiENSGT00530000063395.
HOGENOMiHOG000112424.
HOVERGENiHBG051171.
InParanoidiQ9BQ89.
OMAiAMPFRIL.
OrthoDBiEOG7NGQCF.
PhylomeDBiQ9BQ89.
TreeFamiTF330964.

Family and domain databases

InterProiIPR025740. FAM110.
IPR025741. FAM110_C.
IPR025739. FAM110_N.
[Graphical view]
PANTHERiPTHR14758. PTHR14758. 1 hit.
PfamiPF14160. FAM110_C. 1 hit.
PF14161. FAM110_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9BQ89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVHTLSPGA PSAPALPCRL RTRVPGYLLR GPADGGARKP SAVERLEADK
60 70 80 90 100
AKYVKSLHVA NTRQEPVQPL LSKQPLFSPE TRRTVLTPSR RALPGPCRRP
110 120 130 140 150
QLDLDILSSL IDLCDSPVSP AEASRTPGRA EGAGRPPPAT PPRPPPSTSA
160 170 180 190 200
VRRVDVRPLP ASPARPCPSP GPAAASSPAR PPGLQRSKSD LSERFSRAAA
210 220 230 240 250
DLERFFNFCG LDPEEARGLG VAHLARASSD IVSLAGPSAG PGSSEGGCSR
260 270 280 290
RSSVTVEERA RERVPYGVSV VERNARVIKW LYGLRQARES PAAEG
Length:295
Mass (Da):31,271
Last modified:June 1, 2001 - v1
Checksum:i49E4B4B874E1CF46
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti284 – 2841L → I.
Corresponds to variant rs6055290 [ dbSNP | Ensembl ].
VAR_060150

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ431181 mRNA. Translation: ABD92773.1.
AB196290 mRNA. Translation: BAD77807.1.
AL118502 Genomic DNA. Translation: CAC28879.1.
CH471133 Genomic DNA. Translation: EAX10655.1.
CH471133 Genomic DNA. Translation: EAX10656.1.
BC004222 mRNA. Translation: AAH04222.1.
BC012800 mRNA. Translation: AAH12800.1.
BC022238 mRNA. Translation: AAH22238.1.
CCDSiCCDS13008.1.
RefSeqiNP_001035812.1. NM_001042353.2.
NP_001276074.1. NM_001289145.1.
NP_001276075.1. NM_001289146.1.
NP_001276076.1. NM_001289147.1.
NP_113612.1. NM_031424.5.
NP_997004.1. NM_207121.4.
XP_011527683.1. XM_011529381.1.
XP_011527684.1. XM_011529382.1.
UniGeneiHs.574822.

Genome annotation databases

EnsembliENST00000246100; ENSP00000246100; ENSG00000125898.
ENST00000304189; ENSP00000354163; ENSG00000125898.
ENST00000381939; ENSP00000371365; ENSG00000125898.
ENST00000381941; ENSP00000371367; ENSG00000125898.
ENST00000541082; ENSP00000445228; ENSG00000125898.
GeneIDi83541.
KEGGihsa:83541.
UCSCiuc002wef.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ431181 mRNA. Translation: ABD92773.1.
AB196290 mRNA. Translation: BAD77807.1.
AL118502 Genomic DNA. Translation: CAC28879.1.
CH471133 Genomic DNA. Translation: EAX10655.1.
CH471133 Genomic DNA. Translation: EAX10656.1.
BC004222 mRNA. Translation: AAH04222.1.
BC012800 mRNA. Translation: AAH12800.1.
BC022238 mRNA. Translation: AAH22238.1.
CCDSiCCDS13008.1.
RefSeqiNP_001035812.1. NM_001042353.2.
NP_001276074.1. NM_001289145.1.
NP_001276075.1. NM_001289146.1.
NP_001276076.1. NM_001289147.1.
NP_113612.1. NM_031424.5.
NP_997004.1. NM_207121.4.
XP_011527683.1. XM_011529381.1.
XP_011527684.1. XM_011529382.1.
UniGeneiHs.574822.

3D structure databases

ProteinModelPortaliQ9BQ89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123674. 18 interactions.
IntActiQ9BQ89. 22 interactions.
MINTiMINT-7241222.
STRINGi9606.ENSP00000246100.

PTM databases

PhosphoSiteiQ9BQ89.

Polymorphism and mutation databases

BioMutaiFAM110A.
DMDMi26392452.

Proteomic databases

MaxQBiQ9BQ89.
PaxDbiQ9BQ89.
PRIDEiQ9BQ89.
TopDownProteomicsiQ9BQ89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246100; ENSP00000246100; ENSG00000125898.
ENST00000304189; ENSP00000354163; ENSG00000125898.
ENST00000381939; ENSP00000371365; ENSG00000125898.
ENST00000381941; ENSP00000371367; ENSG00000125898.
ENST00000541082; ENSP00000445228; ENSG00000125898.
GeneIDi83541.
KEGGihsa:83541.
UCSCiuc002wef.3. human.

Organism-specific databases

CTDi83541.
GeneCardsiFAM110A.
H-InvDBHIX0015558.
HGNCiHGNC:16188. FAM110A.
HPAiCAB034110.
MIMi611393. gene.
neXtProtiNX_Q9BQ89.
PharmGKBiPA162385650.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIZB. Eukaryota.
ENOG4111K4M. LUCA.
GeneTreeiENSGT00530000063395.
HOGENOMiHOG000112424.
HOVERGENiHBG051171.
InParanoidiQ9BQ89.
OMAiAMPFRIL.
OrthoDBiEOG7NGQCF.
PhylomeDBiQ9BQ89.
TreeFamiTF330964.

Miscellaneous databases

ChiTaRSiFAM110A. human.
GenomeRNAii83541.
NextBioi72459.
PROiQ9BQ89.
SOURCEiSearch...

Gene expression databases

BgeeiQ9BQ89.
CleanExiHS_FAM110A.
ExpressionAtlasiQ9BQ89. baseline and differential.
GenevisibleiQ9BQ89. HS.

Family and domain databases

InterProiIPR025740. FAM110.
IPR025741. FAM110_C.
IPR025739. FAM110_N.
[Graphical view]
PANTHERiPTHR14758. PTHR14758. 1 hit.
PfamiPF14160. FAM110_C. 1 hit.
PF14161. FAM110_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the FAM110 gene family."
    Hauge H., Patzke S., Aasheim H.-C.
    Genomics 90:14-27(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH CSPP1, DEVELOPMENTAL STAGE, INDUCTION, TISSUE SPECIFICITY.
  2. "Study of a new gene F10 in hydatidiform mole and association with trophoblastic tumor invasiveness."
    Zhou J., Chen S., Xin F., Pang Z., Li B., Zhou W., Fu X., Ding Y.
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Choriocarcinoma.
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Muscle.

Entry informationi

Entry nameiF110A_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ89
Secondary accession number(s): D3DVW2, Q5R1M7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: June 1, 2001
Last modified: April 13, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.