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Protein

Protein FAM110A

Gene

FAM110A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM110A
Gene namesi
Name:FAM110A
Synonyms:C20orf55, F10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125898.12
HGNCiHGNC:16188 FAM110A
MIMi611393 gene
neXtProtiNX_Q9BQ89

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi83541
OpenTargetsiENSG00000125898
PharmGKBiPA162385650

Polymorphism and mutation databases

BioMutaiFAM110A
DMDMi26392452

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000794351 – 295Protein FAM110AAdd BLAST295

Proteomic databases

EPDiQ9BQ89
MaxQBiQ9BQ89
PaxDbiQ9BQ89
PeptideAtlasiQ9BQ89
PRIDEiQ9BQ89
TopDownProteomicsiQ9BQ89

PTM databases

iPTMnetiQ9BQ89
PhosphoSitePlusiQ9BQ89

Expressioni

Tissue specificityi

Detected in thyroid, lymph node, trachea, adrenal gland, bone marrow, spleen, thymus, prostate, and peripheral blood leukocyte. Detected at lower levels in stomach, testis and spinal cord.1 Publication

Developmental stagei

During the cell cycle, expression is increased during S phase and G2/M phase.1 Publication

Inductioni

Up-regulated in stimulated lymphocytes.1 Publication

Gene expression databases

BgeeiENSG00000125898
CleanExiHS_FAM110A
ExpressionAtlasiQ9BQ89 baseline and differential
GenevisibleiQ9BQ89 HS

Organism-specific databases

HPAiCAB034110
HPA069240

Interactioni

Subunit structurei

May interact with CSPP1.Curated

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123674, 62 interactors
IntActiQ9BQ89, 50 interactors
MINTiQ9BQ89
STRINGi9606.ENSP00000246100

Structurei

3D structure databases

ProteinModelPortaliQ9BQ89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi136 – 182Pro-richAdd BLAST47

Sequence similaritiesi

Belongs to the FAM110 family.Curated

Phylogenomic databases

eggNOGiENOG410IIZB Eukaryota
ENOG4111K4M LUCA
GeneTreeiENSGT00530000063395
HOGENOMiHOG000112424
HOVERGENiHBG051171
InParanoidiQ9BQ89
OMAiAMPFRIL
OrthoDBiEOG091G0LV4
PhylomeDBiQ9BQ89
TreeFamiTF330964

Family and domain databases

InterProiView protein in InterPro
IPR025740 FAM110
IPR025741 FAM110_C
IPR025739 FAM110_N
PANTHERiPTHR14758 PTHR14758, 1 hit
PfamiView protein in Pfam
PF14160 FAM110_C, 1 hit
PF14161 FAM110_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q9BQ89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVHTLSPGA PSAPALPCRL RTRVPGYLLR GPADGGARKP SAVERLEADK
60 70 80 90 100
AKYVKSLHVA NTRQEPVQPL LSKQPLFSPE TRRTVLTPSR RALPGPCRRP
110 120 130 140 150
QLDLDILSSL IDLCDSPVSP AEASRTPGRA EGAGRPPPAT PPRPPPSTSA
160 170 180 190 200
VRRVDVRPLP ASPARPCPSP GPAAASSPAR PPGLQRSKSD LSERFSRAAA
210 220 230 240 250
DLERFFNFCG LDPEEARGLG VAHLARASSD IVSLAGPSAG PGSSEGGCSR
260 270 280 290
RSSVTVEERA RERVPYGVSV VERNARVIKW LYGLRQARES PAAEG
Length:295
Mass (Da):31,271
Last modified:June 1, 2001 - v1
Checksum:i49E4B4B874E1CF46
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060150284L → I. Corresponds to variant dbSNP:rs6055290Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ431181 mRNA Translation: ABD92773.1
AB196290 mRNA Translation: BAD77807.1
AL118502 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10655.1
CH471133 Genomic DNA Translation: EAX10656.1
BC004222 mRNA Translation: AAH04222.1
BC012800 mRNA Translation: AAH12800.1
BC022238 mRNA Translation: AAH22238.1
CCDSiCCDS13008.1
RefSeqiNP_001035812.1, NM_001042353.2
NP_001276074.1, NM_001289145.1
NP_001276075.1, NM_001289146.1
NP_001276076.1, NM_001289147.1
NP_113612.1, NM_031424.5
NP_997004.1, NM_207121.4
XP_011527683.1, XM_011529381.2
UniGeneiHs.574822

Genome annotation databases

EnsembliENST00000246100; ENSP00000246100; ENSG00000125898
ENST00000304189; ENSP00000354163; ENSG00000125898
ENST00000381939; ENSP00000371365; ENSG00000125898
ENST00000381941; ENSP00000371367; ENSG00000125898
ENST00000541082; ENSP00000445228; ENSG00000125898
GeneIDi83541
KEGGihsa:83541
UCSCiuc002wef.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF110A_HUMAN
AccessioniPrimary (citable) accession number: Q9BQ89
Secondary accession number(s): D3DVW2, Q5R1M7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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