Q9BQ89 (F110A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM110A

Gene names

Name:	FAM110A
Synonyms:	C20orf55, F10

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	May interact with CSPP1 Potential.
Subcellular location	Cytoplasm. Cytoplasm › cytoskeleton › centrosome. Cytoplasm › cytoskeleton › spindle pole. Note: Distributed throughout the cytoplasm during mitosis, accumulating at spindle poles. Ref.1
Tissue specificity	Detected in thyroid, lymph node, trachea, adrenal gland, bone marrow, spleen, thymus, prostate, and peripheral blood leukocyte. Detected at lower levels in stomach, testis and spinal cord. Ref.1
Developmental stage	During the cell cycle, expression is increased during S phase and G2/M phase. Ref.1
Induction	Up-regulated in stimulated lymphocytes. Ref.1
Sequence similarities	Belongs to the FAM110 family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	microtubule organizing center Inferred from electronic annotation. Source: UniProtKB-SubCell spindle pole Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NCK1	P16333	2	EBI-1752811,EBI-389883

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 295	295	Protein FAM110A		PRO_0000079435
Regions
	Compositional bias	136 – 182	47	Pro-rich
Natural variations
	Natural variant	284	1	L → I. Corresponds to variant rs6055290 [ dbSNP | Ensembl ].		VAR_060150

Sequences

	Sequence		Length	Mass (Da)
	Q9BQ89 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 49E4B4B874E1CF46	FASTA	295	31,271
	10 20 30 40 50 60 MPVHTLSPGA PSAPALPCRL RTRVPGYLLR GPADGGARKP SAVERLEADK AKYVKSLHVA 70 80 90 100 110 120 NTRQEPVQPL LSKQPLFSPE TRRTVLTPSR RALPGPCRRP QLDLDILSSL IDLCDSPVSP 130 140 150 160 170 180 AEASRTPGRA EGAGRPPPAT PPRPPPSTSA VRRVDVRPLP ASPARPCPSP GPAAASSPAR 190 200 210 220 230 240 PPGLQRSKSD LSERFSRAAA DLERFFNFCG LDPEEARGLG VAHLARASSD IVSLAGPSAG 250 260 270 280 290 PGSSEGGCSR RSSVTVEERA RERVPYGVSV VERNARVIKW LYGLRQARES PAAEG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the FAM110 gene family." Hauge H., Patzke S., Aasheim H.-C. Genomics 90:14-27(2007) [PubMed: 17499476] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INTERACTION WITH CSPP1, DEVELOPMENTAL STAGE, INDUCTION, TISSUE SPECIFICITY.
[2]	"Study of a new gene F10 in hydatidiform mole and association with trophoblastic tumor invasiveness." Zhou J., Chen S., Xin F., Pang Z., Li B., Zhou W., Fu X., Ding Y. Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Choriocarcinoma.
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Muscle.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ431181 mRNA. Translation: ABD92773.1. AB196290 mRNA. Translation: BAD77807.1. AL118502 Genomic DNA. Translation: CAC28879.1. CH471133 Genomic DNA. Translation: EAX10655.1. CH471133 Genomic DNA. Translation: EAX10656.1. BC004222 mRNA. Translation: AAH04222.1. BC012800 mRNA. Translation: AAH12800.1. BC022238 mRNA. Translation: AAH22238.1.
IPI	IPI00027758.
RefSeq	NP_001035812.1. NM_001042353.1. NP_113612.1. NM_031424.4. NP_997004.1. NM_207121.3.
UniGene	Hs.574822.
3D structure databases
ProteinModelPortal	Q9BQ89.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9BQ89. 6 interactions.
MINT	MINT-7241222.
STRING	Q9BQ89.
PTM databases
PhosphoSite	Q9BQ89.
Polymorphism databases
DMDM	26392452.
Proteomic databases
PRIDE	Q9BQ89.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000246100; ENSP00000246100; ENSG00000125898. ENST00000304189; ENSP00000354163; ENSG00000125898. ENST00000381939; ENSP00000371365; ENSG00000125898. ENST00000381941; ENSP00000371367; ENSG00000125898.
GeneID	83541.
KEGG	hsa:83541.
UCSC	uc002wef.1. human.
Organism-specific databases
CTD	83541.
GeneCards	GC20P000762.
H-InvDB	HIX0015558.
HGNC	HGNC:16188. FAM110A.
HPA	CAB034110.
MIM	611393. gene.
neXtProt	NX_Q9BQ89.
PharmGKB	PA162385650.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG16048.
GeneTree	ENSGT00530000063395.
HOGENOM	HBG716517.
HOVERGEN	HBG051171.
InParanoid	Q9BQ89.
OMA	ERFFNFC.
OrthoDB	EOG4FN4K0.
PhylomeDB	Q9BQ89.
Gene expression databases
ArrayExpress	Q9BQ89.
Bgee	Q9BQ89.
CleanEx	HS_FAM110A.
Genevestigator	Q9BQ89.
GermOnline	ENSG00000125898. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	72459.
SOURCE	Search...

Entry information

Entry name

F110A_HUMAN

Accession

Primary (citable) accession number: Q9BQ89
Secondary accession number(s): D3DVW2, Q5R1M7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2002
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.